... intense interest in the roles of the entire MT family in the brain, with particularfocus on the role of these proteins in the injured orneurodegenerative brain.Discovery of GIFAD is a neurodegenerative ... in all of these conditions [22]. In the trau-matically injured brain, however, the synthesis of MT1and MT2, as well as the synthesis of GIF, are up-regu-lated by reactive astrocytes in the vicinity ... partly explaining the vast neuronal lossin the AD brain. Further investigation of the increasedneurotrophic activity of the AD brain revealed that itcorrelated with the loss of a specific neuroinhibitoryfactor,...