Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt
... connectivity, CysI-CysIII and CysII-CysIV. The disulfide bonds are shown in blue. (C) A three-dimensional structure of the ribbon disulfide bond isomer of AuIB, where theconnectivities are CysI-CysIV ... provided insightinto approaches aimed at improving the bioavailability of conotoxins. In particular, two lipophilic analogues of theconotoxin MII were recently developed [53], by adding alipidic ... implications forits mechanism of action as this residue is thought to beimportant for activity in ImI. This is supported by the factthat although ImII is still active at the a7 nAChR, it appearsto...
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Tài liệu Báo cáo khoa học: "Arabic Tokenization, Part-of-Speech Tagging and Morphological Disambiguation in One Fell Swoop" pdf
... ApproachArabic words are often ambiguous in their morpho-logical analysis. This is due to Arabic’s rich system of affixation and clitics and the omission of disam-biguating short vowels and other ... no-tion of ambiguity class in the feature classifiers; in-stead we investigate different ways of using the re-sults of the individual feature classifiers in directlychoosing among the options produced ... literature,Rogati et al. (2003) investigate unsupervised learn-ing of stemming (a variant of tokenization in whichonly the stem is retained) using Arabic as the exam-ple language. Unsurprisingly, the...
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Tài liệu Báo cáo khoa học: Multi-targeted activity of maslinic acid as an antimalarial natural compound pdf
... cultures (Fig. 1), indicating that the ini-tial hydrolysis of haemoglobin is not inhibited by MA.In addition, the morphology of infected erythrocytesincubated in the presence of MA is visibly differentfrom ... insulysin and pitrilysin [32], possibly involved in theprocessing of apicoplast protein leader sequence.Inhibition of any of these activities could contribute toMA interference in the maturation of ... (artemis-in and derivatives, primaquine).Maslinic acid (MA) is a natural pentacyclic triter-pene found in the olive fruit [3]. Different activitieshave been reported for MA in a variety of biologicalsystems....
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... closely linked binding sites within adiscrete region. A corollary of this concept is thatbinding sites for transcription factors are not normally Active chromatin and DNase I hypersensitive sites ... premature ini-tiation of transcription elongation [137].The initiation and elongating phases of the tran-scription cycle are characterized by distinct sets of his-tone and Pol II modifications ... open up chromatin structure ahead of Pol II and enable efficient transcription, and (b) what specific mechanisms might acetylate active genes in association with the elongating Pol II. Inaddition...
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Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx
... (1989)Kinetic characterization of the recombinant ribonucle-ase from Bacillus amyloliquefaciens (barnase) and inves-tigation of key residues in catalysis by site-directedmutagenesis. Biochemistry ... docking of mononucleotides, dinucleotides and trinucleotidesinto the active site of RNase Sa2 contributed to a betterunderstanding of enzyme–substrate recognition.ResultsDescription of the structuresCrystal ... through their active sites, so their active sites are occluded (Fig. 2A). The dimer interfaceis stabilized by six hydrogen bonds and a salt bridge.In the previously solved structure of RNase...
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Tài liệu Báo cáo khoa học: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory doc
... formation of quinonoid intermediate bythe addition of 10 mm glycine and varying FTHF con-centrations. As shown in Fig. 6 the double reciprocalplot for the formation of quinonoid intermediate ... on the formation of a quinonoid intermediate and gem-diamine complex and a slow dissociation of FTHF also indicate thatE53QbsSHMT exhibits enzyme memory. This is thefirst instance of such a phenomenon ... and a corre-sponding increase at 495 nm, indicating the presence of small amount of quinonoid intermediate. The for-mation of the quinonoid intermediate requires abstrac-tion of a proton from...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
... prosegment is present in all APs and is involvedeither in the inactivation or in the correct folding, stability and intracellular sorting of several zymogens [16], the PSI isan insertion only identified ... likely becausetheir enzymatic properties are atypical and their localiza-tions are unexpected.New questions concerning functional significance and specialization of this multigene family of ... species and have been purified from a variety of tissues. They are most active at acidic pH, are specificallyinhibited by pepstatin A and contain two aspartic residuesindispensible for catalytic...
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Tài liệu Báo cáo khoa học: Structure and membrane interaction of the internal fusion peptide of avian sarcoma leukosis virus pdf
... lipid mixing as de fined in Experimentalprocedures is plotted against peptide to lipid ratio i ndicatesthat the peptide is capable of promoting lipid mixing of vesicles consisting of DMPC and ... Additionally, apeptide d erived from randomized sequence of IFP–wt (seeSupplementary data) exhibited insignifi cant lipid mixingactivity, demonstrating the specificity of the activity of theIFP–wt ... mixing activity of IFP–wt and its relationshipto the secondary structure Lipid m ixing measurements on the internal and N-terminalfusion peptides indicate that the IFP has higher fusionactivity...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... linked to N9 of adenine iscalled the ‘southern’ ribose; Fig. 1) and the N1 of theadenine ring [4].Besides d-myo-inositol 1,4,5-trisphosphate (InsP3) and nicotinic acid adenine dinucleotide phosphate(NAADP; ... MINIREVIEWSecond messenger function and the structure activityrelationship of cyclic adenosine diphosphoribose (cADPR)Andreas H. GuseUniversity Medical Center Hamburg-Eppendorf, Center of ... part of the original ribose (Fig. 4; [46]). Despitethis enormous modification the compound was a par-tial agonist in permeabilized T-cells and induced bothlocal and global Ca2+signalling in intact...
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Tài liệu Báo cáo khoa học: "An Alignment Algorithm using Belief Propagation and a Structure-Based Distortion Model" pdf
... reported for a similar size of train-ing data. At the time of this paper, we did nothave the time to investigate if it is a problem of non-optimal settings in GIZA++, or if the train-ing data we ... arise often (and are often intractable) in the use of a proba-bilistic model: “what are the marginal probabili-ties of each individual variable?” and “what is theset of values with the highest ... pair (e, f).We will consider Psizeto be a uniform distribu-tion over the integers up to a sufficiently big value(since it is not possible to have a uniform distri-bution over an infinite discrete...
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