Tài liệu Báo cáo " Common pronunciation problems of vietnamese learners of english " docx

... Common pronunciation problems of vietnamese learners of english Ha Cam Tam 1. Problem statement Since English is one of the core subjects at school, more and more schools are teaching English ... results of our study, although small but the results were fairly impressive in terms of the coverage of sounds mispronounced as well as the seriousness of errors. Given the pronunciation problems, ... the distinctive sounds of English, French, Vietnamese and other languages. In this sense, we can talk about pronunciation as the production and reception of sounds of speech. In addition,...

Tài liệu Báo cáo " Fully parallel methods for a class of linear partial differential-algebraic equations " pptx

... convergence of these methods are studied. Finally in section 4 some numerical examples are discussed.2. Properties of nonnegative pencils of matricesIn what follows we will consider a pencil of matrices ... number of iterations needed for convergence and the total time for the serial computation of Red- Black SOR and Jacobi method are given in the following tables.Table 5. Number of Iterations of ... properties of the so callednonnegative pencils of matrices. In Section 3 we describe two parallel methods for solving linearPDAEs, whose coefficients found a nonnegative pencil of matrices....

Tài liệu Báo cáo khoa học: Afﬁnity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

... determined bythe rate of association. It should be noted that quanti-tative analysis of the more rapid phase of associationrequires measurement of the binding on time scales of minutes, a time ... presence of unlabeled PCSK9 (Fig. 4A). In the presence of a highconcentration of unlabeled wild-type PCSK9, the half-time of the rapid phase was reduced from 19 to 16 minand the half-time of the ... monophasic processwith a rate constant [koff] of 0.0009 ± 0.00012 min)1(n = 3), which corresponds to a half-time of dissocia-tion of 770 min. Lowering the pH of dissociation med-ium to 6.2 also...

Tài liệu Báo cáo khoa học: The tandemly repeated domains of a b-propeller phytase act synergistically to increase catalytic efﬁciency doc

... analysis of purified PhyH, PhyH-DI and PhyH-DII. LaneM, molecular weight markers; lane 1, culture supernatant of PhyH;lane 2, culture supernatant of PhyH-DII; lane 3, culture supernatant of PhyH-DI; ... Environmental factors that affect the catalytic activities of PhyH and PhyH-DII. (A) Effect of 0–5.0 mM Ca2+at 37 °C. (B) Effect of pHat 37 °C. (C) Effect of temperature at pH 7.0. (D) pH stability. Residual ... catalytic efficiency of PhyH-DII. Further-more, the catalytic efficiency of PhyH was much greaterthan that of PhyH-DI and PhyH-DII combined (5.73fold) or twice the amount of PhyH-DII (5.45 fold).This...

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... University of Bath, UK2 Department of Biochemistry, University of Wisconsin–Madison, USA3 Department of Chemistry, University of Wisconsin–Madison, USAIntroductionUpon catalyzing the cleavage of ... regarding a new class of surrogates for the phosphoryl group.Results and DiscussionSulfonimides as inhibitors of RNase AWe began by determining the ability of three backboneanalogs of RNA to inhibit ... hydrogen bondsin each of its conformations. Thus, in either observedconformation of N-acylsulfonamide 7, there are a total of four hydrogen bonds formed by the uridine ribose. Of the two hydrogen...

Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc

... transfer of phosphate esteriﬁed in the 5¢ position of 6-hydroxypu-rine monophosphate nucleosides [1]. The transfer of phosphate can lead to phosphorylation of inosine,guanosine and a number of their ... disappearance of theheavier inactive peak. Furthermore, FPLC analysis of the recombinant wild-type cN-II showed the presence of the tetrameric active form irrespective of the pres-ence of effectors. ... alteration of this ratio for amutant was considered as caused either by an alteration of the Kmvalue for one of the two substrates or by a variation of the kcatvalue for one of the two activities....

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... Km) of PRTFDC1 towards hypoxanthine and guanine wasonly 0.26% and 0.09%, respectively, of that of HPRT. This low activitycould be explained by the fact that PRTFDC1 has a Gly in the position of the ... metabolic consequences of having HPRT deﬁciency are an overproduction of uric acid and elevated levels of PRPP [3]. Patients hav-ing mutations resulting in partial HPRT deﬁciencyoften suffer from ... binding of N7 of the purine base and Asp137 was observed in HPRTin complex with ImmGP, indicating a role in transitionstate stabilization during catalysis [17].A series of mutations were made of...

Tài liệu Báo cáo khoa học: A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics ppt

... previouslydemonstrated the application of this method to thedetermination of the glycan structure of a form of AFP [10]. However, identification of the details of aglycan structural change on a ... methylesteri-fication of sialic acid moieties. All spectra wereobtained in the positive ion mode using MALDI–quadrupole ion trap (QIT)-TOF MS.A strategy for discovery of cancerglyco-biomarkersOn the basis of ... and provides a list of hundreds of candidate glyco-biomarkers with their sites of N-glycosylation within approximately 1 week. Thus,this method allows reliable identification of core N-gly-cosylated...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebraﬁsh, Danio rerio docx

... The expression of T-bet has beenseen within a wide variety of tissues and cells in theGinbuna crucian carp [27] and, in mammals, in thelung tissue of mouse and spleen and thymus of humanand ... kidney,gill, gut, liver and skin tissue of healthy fish (data notshown). After stimulation of kidney cells with a variety of immunostimulants, the expression of t-bet, stat6and foxp3, together with ... first time in fish. The availability of sequenced fish genomes has allowed the discovery of a number of immune relevant genes using the synte-ny (conservation of gene order) found between thehuman...

Tài liệu Báo cáo khoa học: Post-translational modiﬁcation of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion pptx

... KesslerDepartment of Clinical Medicine, University of Oxford, UKIntroductionThe genus Yersinia consists of three pathogenic speciesthat are agents of a variety of diseases, one of whichwas historically ... GTPase-bindingcapacity of YpkA and OTUB1-mediated increase insusceptibility to infection (Fig. 6). The binding of smallGTPases has been reported to be independent of thekinase activity of YpkA [16]. ... can be achieved either by induction of RhoA mRNA expression, deubiquitination of RhoAitself or promoting activation of RhoA, possiblythrough the manipulation of RhoA-speciﬁc guaninenucleotide...

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