... dou-ble-helix hairpin buried in the core of the proteins. This domain has the capacity to bind strongly to lipidmembranes [26] and is regarded as being responsiblefor pore formation [27]. In line with ... concentration of the peptides typically yieldssigmoidal curves, indicative of co-operativity, with in exion points corresponding to peptide concentra-tions giving 50% of maximum activity (IC50). WithLUVs ... Valencia, Spain3 ITC-CNR Institute of Biophysics, Trento, Italy4 Institut fu¨r Biologie ⁄ Biophysik, Humboldt-Universita¨t zu Berlin, GermanyMitochondria provide a critical control point for...