κb patent could have broad implications for biotech 827

Báo cáo y học: "Maternal Smoking in Pregnancy: Do the Effects on Innate (Toll-Like Receptor) Function Have Implications for Subsequent Allergic Disease" pps

Ngày tải lên : 08/08/2014, 21:20

... receptor (TLR) innate defence pathways (below), which could both explain an increased susceptibility to infection and have implications for subsequent allergen-specific immune development Role ... and genetic differences could account for some of the differences between studies Our recent findings could provide an important pathway through which maternal smoking could potentiate the development ... mothers (for TLR-2, p 014; TLR-3, p 048; and TLR-4, p 014), with no significant effects of smoking in the nonatopic group Although there was a trend in the nonatopic group for smokers to have impaired...

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Báo cáo y học: " Ageing, autoimmunity and arthritis: Senescence of the B cell compartment — implications for humoral immunity" pptx

Ngày tải lên : 09/08/2014, 01:23

... the absence of T cell help) [45] This requirement for entry into the B1 pathway selects for cells that bear receptors that have low affinity for environmental/self antigens Importantly, the CD5+ ... describing a shift in T cell subsets from naïve to memory in aged humans (for review see [3]) Unfortunately, a paucity of information exists regarding the nature of the B cell compartment in these ... unpublished observation) We have not yet measured the impact of this treatment on humoral immunity but we have high hopes We are also investigating other strategies for improving B cell output...

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Báo cáo y học: "T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB: implications for rheumatoid arthritis" docx

Ngày tải lên : 09/08/2014, 08:23

... NFκB Figure To inhibit NFκB with specificity we employed an efficient adenoviral gene transfer method to overexpress IκBα in human macrophages We have previously shown that high levels of IκBα ... achieved by AdvIκBα transduction that remain elevated even after LPS stimulation [30] As IκBα is a major inhibitory component of the NFκB pathway, increased expression of IκBα blocks NFκB nuclear ... (MOI) for hours Following incubation, the medium was removed and replaced with complete medium Monocytes were cultured for a further days before stimulation to enable adenoviral production of IκBα...

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Báo cáo y học: "κ The roles of the classical and alternative nuclear factor-κB pathways: potential implications for autoimmunity and rheumatoid arthritis" ppsx

Ngày tải lên : 09/08/2014, 10:23

... survival (see text) IκB, inhibitor of NF -κB; IKK, IκB kinase; MALT, mucosa-associated lymphoid tissue lymphoma translocation gene; NEMO, NF -κB essential modulator; NF -κB, nuclear factor -κB; RIP, receptor ... function as classical inhibitors of the NF -κB activity); dimeriz., dimerization domain; DNA, DNA binding; NF -κB, nuclear factor -κB; IκB, inhibitor of NF -κB; RHD, Rel homology domain; NLS, nuclear ... B-cell activating factor receptor; IKK, IκB kinase; LT, lymphotoxin; NF -κB, nuclear factor -κB; NIK, NF -κB- inducing kinase; RANK, receptor activator of NF -κB; TNFR, tumor necrosis factor receptor;...

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Service quality: implications for management development

Ngày tải lên : 28/01/2013, 10:57

... was used to collect data for all the three types of services: a fastfood restaurant for pure service, an airline for mixed service, and a longdistance telephone company for quasi-manufacturing ... customers SERVQUAL, an instrument for measuring service quality was developed on the basis of the above five dimensions SERVQUAL has been gaining acceptance as a platform for work in service quality ... of the reasons for the importance of service quality are: q The economy of the USA and other western nations has become a service economy For example, in the USA service accounts for approximately...

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Could do and could have done & Must and can’t

Ngày tải lên : 19/10/2013, 17:15

... work so hard I couldn’t it Tôi hiểu bạn làm việc chăm đến Tôi làm Could have (done) = would have been able to (do) (đã có khả làm việc đó) Why didn’t Liz apply for the job? She could have got it ... phía bờ tường Anh không nhìn thấy anh đâu Có thể dùng couldn’t have thay cho can’t have She couldn’t have seen me Cô trông thấy Tom couldn’t have been looking where he was going Tom nhìn thấy ... could có nghĩa tương tự might (xem UNIT 29, UNIT 30) The phone is ringing It might be Tim Điện thoại reo Có thể Tim gọi C Hãy so sánh could (do) could have (done) I’m so tired I could sleep for...

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Democratization in taiwan implications for china”

Ngày tải lên : 17/12/2013, 23:42

... the short term For the China, though the recovery of Taiwan is a must for any Chinese leaders, a forceful measure is too costly and risky For the U.S., Taiwan remains crucial for its strategy ... including programs for compensation for job-related death, injury, or illness; programs for health and life insurance; programs for annual, sick, and other statutory leave; and programs for retirement ... mainland China as well sought for strong independence for Taiwan The strongest action in seeking independence for Taiwan under Chen Shui-bian in 2000- 25 2008 was his promotion for Taiwan’s Congress...

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Rrational expectations implications for policy

Ngày tải lên : 05/01/2014, 17:02

... to forecast and to evaluate policy • Lucas critique, based on rational expectations, argues that policy evaluation should not be made with these models – The way in which expectations are formed ... in which expectations are formed (the relationship of expectations to past information) changes when the behavior of forecasted variables changes – The public’s expectations about a policy will ... Response to Anticipated Expansionary Policy Can Expansionary Policy Lead to a Decline in Output? Implications for Policymakers • Distinction between effects of anticipated and unanticipated policy actions...

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Tài liệu Central Office Implications for Deploying FTTP pdf

Ngày tải lên : 17/01/2014, 12:20

... architectures pose significant implications for the CO in meeting the same levels of performance required for transport segments First up – architecture decisions Before specific product selections ... Inc views its patent portfolio as an important corporate asset and vigorously enforces its patents Products or features contained herein may be covered by one or more U.S or foreign patents An Equal ... provided and maintenance is accomplished within the CO for FTTP architectures For example, typical service outage windows may not be available for performing maintenance in an FTTP network Rather, because...

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Environmental barriers to trade of the united states and implications for vietnam

Ngày tải lên : 06/02/2014, 20:27

... soát nhập sản phẩm liên quan đến môi trường bảo vệ ngành sản xuất có liên quan nước Được Công ty Ford Việt Nam tài trợ, năm 2007, Công ty Pi C&E biên soạn phát hành "Sổ tay hướng dẫn "Rào cản xanh" ... mại quốc tế hàng hóa dịch vụ Mỹ từ tháng năm 2010 đến tháng năm 2012 Nguồn: http://www.census.gov/foreign-trade Nhìn vào biểu đồ ta thấy đường nhập nằm phía trên, có xu hướng lên có độ dốc so với ... Trade Barriers and the Rising Threat to Prosperity through Trade Website 16 http://www.census.gov/foreign-trade/statistics/index.html 17 http://vietnamese.vietnam.usembassy.gov/ambassador.html 18...

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Tài liệu Báo cáo " English - A global language and its implications for students " ppt

Ngày tải lên : 12/02/2014, 20:20

... school as a compulsory subject for children or even for adults who need it Take Russian for example, that language received education priority not only in the countries of former Soviet Union but also ... good opportunities for foreigners to invest into Vietnam, for tourists to visit the country As a result, English is not only an interest but also a practical and a great demand for many people Especially ... people use English as an important tool to access information and to gain knowledge for their needs For students, English also has important implications to their study as well as their future...

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Tài liệu SEXUALITY EDUCATION IN SCHOOLS: THE INTERNATIONAL EXPERIENCE AND IMPLICATIONS FOR NIGERIA pdf

Ngày tải lên : 14/02/2014, 14:20

... World Program of Action for Youth to the Year 2000 and Beyond, and the 2001 U.N General Assembly Special Session on HIV/AIDS have affirmed the needs of young people for information, counseling, ... nontreatment or delayed treatment; the need for early and effective treatment; the need to inform sexual partners and to treat them for STIs; and the effective methods for preventing STIs, especially correct ... education? Inform the debate Accurate and understandable information can defuse conflict and mobilize support for programs by demonstrating the magnitude of adolescent health problems Such information...

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Tài liệu the supply oF money – banK behaViour and the implications For monetary analysis doc

Ngày tải lên : 16/02/2014, 11:20

... as an information variable for monetary policy”, European Economic Review, Vol 49, No 4, May 2005, pp 975-1006 chart broad money and loan growth (annual percentage changes; adjusted for seasonal ... switching costs for depositors or deposit insurance.11 These considerations support the view that developments related to banks’ access to liquid deposits have significant implications for the intermediation ... Chart 2) An important element for assessing the funding situation is the counterpart sector holding the claims A deposit can have very different funding implications for the bank, depending on whether...

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Tài liệu The Decline of Traditional Banking: Implications for Financial Stability and Regulatory Policy doc

Ngày tải lên : 16/02/2014, 11:20

... Derivative Forwards Forward rate agreements Foreign exchange forwardsa Total forwards Swaps Interest rate swaps Currency swaps Total swaps Total derivativesb Total derivativesc Sources: Bank for International ... have an advantage in making loans.4 An effort is being made in the United States to develop a market for securitized small business loans as well U.S banks have also been beset by increased foreign ... deregulation and fundamental economic forces abroad have improved the availability of information in securities markets, making it easier and less costly for business ﬁrms to ﬁnance their activities...

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Tài liệu Faultlines of Conflict in Central Asia and the South Caucasus - Implications for the U.S. Army docx

Ngày tải lên : 17/02/2014, 11:20

... Scorecard for Evaluating Nuclear-Armed Opponents Table 3.1 Zapf 18 Future Roles of U.S Nuclear Forces: Implications for U.S Strategy Contemporary Roles for U.S Nuclear Weapons 19 they are doing for ... weapons would have deterrent value because they could be assembled and delivered in spite of an attacker’s best efforts to prevent it 24 Future Roles of U.S Nuclear Forces: Implications for U.S Strategy ... strategic nuclear forces are structured basically the same way they have always been (U.S tactical nuclear forces have largely been eliminated.) U.S operational procedures have in the main changed...

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Tài liệu Báo cáo khoa học: Expression and secretion of interleukin-1b, tumour necrosis factor-a and interleukin-10 by hypoxia- and serum-deprivation-stimulated mesenchymal stem cells Implications for their paracrine roles ppt

Ngày tải lên : 18/02/2014, 04:20

... to hypoxia ⁄ SD for h The cells were then ﬁxed in 2% paraformaldehyde in NaCl ⁄ Pi for 30 min, washed twice with NaCl ⁄ Pi and permeabilized with 0.3% Triton X-100 in NaCl ⁄ Pi for 10 Next, the ... presence or absence of LPS for the indicated number of hours (A) Representative western blots for pro-IL-1b and mature IL-1b in MSCs (B) Representative western blots for pro-caspase and cleaved ... Representative western blots for pro-IL-1b and TNF-a expression in MSCs stimulated by hypoxia ⁄ SD for the indicated number of hours (B) Representative western blots for pro-IL-1b and TNF-a expression...

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Tài liệu Báo cáo khoa học: Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects Implications for a mechanism linking obesity and type 2 diabetes pdf

Ngày tải lên : 19/02/2014, 05:20

... palmitoyl-CoA affected the properties it would be expected to affect for its direct action on the ANT, and to see if we could account for the observation that some properties were affected more than ... (Jp) for both respiratory substrates are summarized in Table The distribution pattern of the control over Jp among the modules was similar to that of Jo for both substrates used except for the ... 5302 48 49 50 51 ﬂuxes in biotechnological processes Biotechnol Bioeng 30, 101–107 Echtay KS, Winkler E & Klingenberg M (2000) Coenzyme Q is an obligatory cofactor for uncoupling protein function...

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Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt

Ngày tải lên : 19/02/2014, 13:20

... considering pseudoatoms [23] performed for 20 ps to explore several possible conformations that the peptide can acquire The trajectory from high temperature dynamics was analyzed for similarities between ... derived structures for the cyclic peptides with average structure for (A) cER and (B) cVY Only heavy atoms are shown for clarity The residues which are involved in b-turn conformation are labeled ... Determination of peptide structures Conformational space was searched for the peptides using the DISCOVER program version 2000 (Accelrys Inc., San Diego, CA, USA) to identify conformations consistent with...

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Tài liệu China’s Economic Rise: History, Trends, Challenges, and Implications for the United States pdf

Ngày tải lên : 20/02/2014, 20:20

... Challenges, and Implications for the U.S Foreign Direct Investment (FDI) in China China’s trade and investment reforms and incentives led to a surge in FDI beginning in the early 1990s Such flows have been ... History, Trends, Challenges, and Implications for the U.S China’s Merchandise Trade Patterns Economic reforms and trade and investment liberalization have helped transform China into a major trading ... Rise: History, Trends, Challenges, and Implications for the U.S Several economists have concluded that productivity gains (i.e., increases in efficiency) have been another major factor in China’s...

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Tài liệu China’s Holdings of U.S. Securities: Implications for the U.S. Economy pptx

Ngày tải lên : 20/02/2014, 20:20

... securities have also been favored by China because, historically, they have been considered to be safe and liquid (i.e., easily sold) relative to other 12 For additional information on foreign ownership ... Securities: Implications for the U.S Economy Table Top 10 Foreign Holders of U.S.Treasury Securities as of September 2012 Total Foreign Holdings ($ billions) Country Holdings as a Share of Total Foreign ... the investments that people have made—in your case up to $1.7 trillion total out of a very large economy is not to worry about We could not afford—we could not afford not to make good on that...

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