định hướng về phát triển cho vay tiêu dùng của ngân hàng nông nghiệp và phát triển nông thôn chi nhánh huyện đông triều trong những năm tới
Basic immunology functions and disorders of the immune system
... University of California San Francisco, School of Medicine San Francisco, California Andrew H Lichtman, MD, PhD Professor of Pathology Harvard Medical School Brigham and Women’s Hospital Boston, ... is compounded by the development of integrated curricula in many medical schools, with reduced time for didactic teaching and an increasing emphasis on social and behavioral sciences and primary ... address the perceived needs of both medical school and undergraduate curricula and to take advantage of the new understanding of immunology We have tried to achieve several goals First, we have presented...
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Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot
... cytokines Recombinant mouse IFN-γ was derived from the supernatant fluid of Mick cells, a Chinese hamster ovary (CHO) cell line developed in our laboratory [18] IFN-γ was purified by affinity chromatography ... characteristics of IL-17 using the CIA model As IFN-γ is counteracting the development of Th17 cells, we chose to induce CIA in IFN-γR knock out (KO) mice Through neutralization of IL-17 using monoclonal ... are transforming growth factor (TGF)-β, IL-6 and IL-23 [7] Interferon (IFN)-γ, as a contrast, strongly inhibits development of Th17 cells both in vitro and in vivo [1,3,8] Anti-IFN-γ added during...
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Báo cáo y học: " Ageing, autoimmunity and arthritis: Senescence of the B cell compartment — implications for humoral immunity" pptx
... in the spleens of many aged animals This overproduction of IL-10, and particularly IFN-γ, may strongly influence the ratio of naïve follicular to antigen-experienced B cells in the aged spleen ... these observations by demonstrating that antibodies produced by aged mice immunized with phosphorylcholine immunogens are not only of lower affinity and avidity but are also less protective against ... adult, humans have increased levels of IL-4, IFN-γ, and IL-12 [83,84] These cytokines all have strong potential to sustain long-lived antigen-experienced B cells Conclusion As illustrated in Fig...
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Báo cáo y học: "Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis" ppsx
... these antibodies could be pathogenic to chondrocytes even in the absence of inflammatory mediators, being involved in impaired cartilage formation [48], strong inhibition of collagen fibrillogenesis ... 2006, 54:1390-1400 Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R, Newman RA, Hanna N, Anderson DR: Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20 ... autoimmunity? Clin Immunol 2002, 104:1-13 Neumann E, Barnum SR, Tarner IH, Echols J, Fleck M, Judex M, Kullmann F, Mountz JD, Scholmerich J, Gay S, et al.: Local production of complement proteins in...
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Báo cáo y học: "Tumor-infiltrating effector cells of α-galactosylceramide-induced antitumor immunity in metastatic liver tumor" pdf
... Sato H, Kondo E, Koseki H, Taniguchi M: CD1drestricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides Science 1997, 278:1626-1629 Brossay L, Chioda M, Burdin N, Koezuka Y, Casorati ... ratio; α-GalCer: 20.0 ± 3.2 pg/ml, Vehicle: 19.5 ± 3.7 pg/ml) Discussion α-GalCer can elicit a very strong antitumor immune response in many tumor models of mice Recent studies have demonstrated that ... NK1.1 molecule as a NKT cell marker However, it was hard to determine the optimal conditions to achieve constant numbers of discrete nodules, since MC38 cells sometimes showed diffuse invasive...
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Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
... particular rhinovirus infections, in school-age children hospitalized due to CAP [19] Such infections have to be considered in the context of asthma attacks in children as well as in asthma and COPD ... TLR2 in bronchial epithelial cells, but displayed no effect on TLR4 and TLR6 expression [74] In mice, inhalation of LPS induced a strong increase in TLR4 protein expression in the bronchial epithelium ... (MyD88)dependent way, whereas bronchoconstriction depended on resident cells as indicated by experiments with chimeric mice [223] In studies using TLR4-deficient chimeric mice, expression of TLR4...
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A study of the mechanisms of immunity to pasteurella haemolytica infection
... pneumonic Intrabronchial P by numbers of heat-killed of numbers large had of to in achieved which form failed suspension A, acute 1964) of was material success was three infected chorioallantoic ... Titrations of sera types of P haemolytica antigens dilution conjugate using at 1/200 comparable achieve at absorbance 4Experiment of cross-reaction P haemolytica and 161-163 SSE Al-A12 to 400 nm ... Vaccines against protected Pasteurella challenge When non-specific haemoly-" P observed the Escherichia also The of P of in spleen investigated little intraperitoneal against protected T10 of 12...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
... There are two major intracellular apoptosis-signaling cascades; mitochondrial pathways and death receptor pathways [4] Mitochondrial pathways are regulated by various proapototic and antiapoptotic ... proteins involved in apoptosis, including the expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig 2) ... hypoxia-related markers of trophoblastic cells Materials and methods Cell line and cell cultures The human choricarcinoma cell line JAR was obtained from American Type Culture Collection (Manassas, VA, USA)...
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Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta
... dramatic peribronchial and perivascular infiltration was produced in all mice (Figure 2) Airway reactivity measurements Airway hyper-responsiveness (AHR) to metacholine (Acetyl-β methylcholine chloride, ... the presence of increasing concentration of metacholine Mice challenged i.n with OVA (black symbols) had significantly greater responsiveness to metacholine than their respective PBS controls (white ... presenting cells recruited into the inflammatory tissue B220 staining revealed a strong perivascular and peribronchial accumulation of B cells (A, B, C) while dendritic cells (CD11c positive cells)...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
... limits the process The development of novel vacuum light (VUV) sources over the last few years (Chiron et al., 2000), has opened up new possibilities for in-situ generation of hydroxyl radicals ... 102, 5542-5550 Chemviron Carbon (1997) The AOT Handbook, Advanced Oxidation Technologies, Brussels Chiron, S., Fernandez-Alba, Rodriguez, A., and Garcia-Calvo, E (2000) Pesticide chemical oxidation: ... homogentisic acid, a tyrosine metabolite, FEBS Letters, 432, 13-16 Hoffmann, M.R., Martin, S.T., Choi, W Bahnemann, D.W (1995) Environmental applications of semiconductors photocatalysis, Chem...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
... including Ti, Y, U, and Th in freshwater (e.g Pokrovsky and Schott, 2002) Indeed, in this case their concentrations in river water are strongly correlated each other Taking into account these reported ... Epstein, S and Mayeda, T (1953) Variation of 18O content of waters from natural sources Geochim Cosmochim Acta, Vol.4, 213-24 Fiella, M., Belzile, N and Chen, Yu-Wei (2002) Antimony in the environment: ... precipitations varied from -4.9 to -8.7 ‰ in separate samples Its amount-weighed mean was -6.0 ‰ (Fig 4) Machida and Kondoh (2001) showed that the relationship between δD and δ18O in shallow ground water...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake
... tests, since there are no reports on aerobic nitrite denitrification by PAOs However, our results strongly suggest that unstable response of PAOs to nitrite exposure, must come from their different ... denitrification ability of PAOs Another interesting point is that aerobic phosphate uptake of AO sludge was strongly inhibited, though it has no anoxic phosphate uptake activity and, hence no nitric oxide ... even in the presence of nitrite (Kucera et al., 1986) While, aerobic activity of AO sludge was strongly inhibited One of the reasons is that nitric oxide was produced with nitrite reductase AO...
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Transmission mechanisms of monetary policy the evidence
... policy • Weak link between nominal interest rates and investment spending does not rule out a strong link between real interest rates and investment spending • Interest-rate effects are only ... growth rate of the money supply is soon followed by a decline in output in these episodes, much stronger evidence is presented that money growth is the driving force behind the business cycle •...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
... measure the choices and actual behaviours directly, but only the hypothetical choices: we asked whether women would consider using and would stop or continue using In addition, hypothetical choices ... action of FP in terms of whether these may influence a woman's decision to choose an FP method or continue to use the chosen method We also investigated which opinions and characteristics were ... "My faith is the most important influence in my life"?, with a five point scale from "strongly agree" to "strongly disagree") Women who attended church once per week or more often and considered...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
... Nyrkova IA, Bell M, Harding R, Carrick L, McLeish TCB, Semenov AN & Boden N (2001) Hierarchical self-assembly of chiral rod-like molecules as a model for peptide b-sheet tapes, ribbons, fibrils, and ... The electrostatic interaction between polar C=O and NH groups in the peptide backbone depends strongly on the peptide backbone conformation [37,38] In the extended b-strand conformation, C=O ... result in oligomerization and fibrillation [14,61–64] In general, amyloid formation in vitro can be achieved by destabilizing the native state of the protein under conditions in which noncovalent interactions...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt
... 100 ing protein in Escherichia coli Mol Microbiol 5, 951– 957 Britton RA, Powell BS, Court DL & Lupski JR (1997) Characterization of mutations affecting the Escherichia coli essential GTPase ... potential growth rate-regulated checkpoint in Escherichia coli Mol Microbiol 27, 739– 750 March PE, Lerner CG, Ahnn J, Cui X & Inouye M (1988) The Escherichia coli Ras-like protein (Era) has GTPase activity ... has an essential role in growth rate and cell cycle control in Escherichia coli J Bacteriol 173, 2265–2270 Okamoto S & Ochi K (1998) An essential GTPbinding protein functions as a regulator for...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
... differences in body fatness in children and adolescents? Nutr Metab Cardiovasc Dis 16, 294– 301 Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, Rosenbaum M, Luke A, Schoeller DA, DeLany JP, Butte ... Clin Endocrinol Metab 92, 2041–2045 Stefan N, Kantartzis K, Machann J, Schick F, Thamer C, Rittig K, Balletshofer B, Machicao F, Fritsche A & Haring HU (2008) Identification and characterization ... Corona G, Mannucci E, Schulman C, Petrone L, Mansani R, Cilotti A, Balercia G, Chiarini V, Forti G & Maggi M (2006) Psychobiologic correlates of the metabolic syndrome and associated sexual dysfunction...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf
... F, Bernadac A & Hatchikian EC (1995) Isolation and characterization of the pyruvate-ferredoxin oxidoreductase from the sulfate-reducing bacterium Desulfovibrio africanus Biochim Et Biophys Acta-Protein ... Crystalline pyruvate oxidase from Escherichia coli II Activation by phospholipids J Biol Chem 246, 1575–1582 49 Bertagnolli BL & Hager LP (1991) Activation of Escherichia coli pyruvate oxidase enhances ... medial cluster [28] Rapid depletion of the thiamin radical and reduction of all clusters is only achieved after addition of CoA What is the special role of CoA for propagation of the second electron...
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Tài liệu Báo cáo khoa học: Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters pdf
... acetylcholinesterase indicate that BuChE can act in the central nervous system as a surrogate acetylcholine-hydrolysing enzyme [5] Both cholinesterases also display noncholinergic activities Cholinesterase ... catalytic centre Cholinesterases are structurally related hydrolases [1] Acetylcholinesterase (EC 3.1.1.7) plays a key role in the cholinergic system in terminating the action of acetylcholine, but ... cholinergic pathway and can use butyrylcholinesterase to hydrolyze acetylcholine Neuroscience 110, 627639 Grisaru D, Sternfeld M, Eldor A, Glick D & Soreq H (1999) Structural roles of acetylcholinesterase...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4 Proc Natl Acad Sci USA 93, 46444648 Raner, G.M., Chiang, E.W., Vaz, A.D.N & Coon, M.J ... optical perturbations were also observed upon O2 binding to so-called class I P450s, comprising mitochondrial and bacterial isozymes such as CYP11A1 [2224] and CYP101 [25,26], respectively The rapid ... protonation, the calculated proton afnity being )442.1 kcalặmol)1 [45] The proton-delivering machinery has been recognized to involve a highly conserved active-site threonine residue [46,47]...
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