... (2001) observed a similar inhibitory effect of parthenolide on IL -12 production induced by LPS The p40 promoter activity of IL -12 which contains a NF-κB binding sequence has been greatly suppressed ... parthenolide may due to the alkylation and cross-linking of two cysteine residues (cys 38 and cys 120 ) located on the p65 subunit of NF-κB (Rungeler et al., 1999) Subsequently, two hypotheses emerged ... isolated from feverfew in 1965 (Berry, 1984) Parthenolide is a 4,5-epoxygermacra-(10), 11(13)-dien -12, 6-lactone and its structure is shown in Fig 1.1 CH3 CH2 O H3C O O Fig 1.1 Feverfew and chemical...
... FROM CELL DEATH…………………………………………… 120 4.1 Induction of cytosolic acidification by H2O2 and C1 is reduced in hTERT overexpressing Cells…………………………………………….… .120 4.2 Mitochondrial Bax translocation ... hTERT overexpressing cells…… ………… 124 4.3 Dissipation of the mitochondrial membrane potential (m) is reduced in hTERT overexpressing cells… .…………………………………… 126 4.4 hTERT overexpression can protect ... mitochondria…………………………………….…110 2.2.2 hTERT expression increases Cytochrome c oxidase activity……………… 112 THE EFFECTS OF hTERT EXPRESSION IN AN ALTERNATIVE MODEL; SH-SY5Y CELLS ………………………………… ………….114...
... either on ice, at 37 °C (rhodamine 123 ) or at 23 °C (other rhodamine dyes), for 15 in the absence or presence of CCCP (1 lM) Subsequently, 25 lM of rhodamine 123 , TMR, TMRM or rhodamine 6G was ... concentrations ratio (cell/medium) Innate multidrug resistance to rhodamines 12 D Yeheskely-Hayon et al 250 – CCCP 200 40 150 Rhodamine 123 TMR TMRM 100 60 + CCCP 50 10 100 20 On ice + CCCP 10 100 10 100 ... for h, either at 23 °C (TMR and TMRM) or at 37 °C (rhodamine 123 ), in the presence of various concentrations of TMRM, TMR or rhodamine 123 The incubation medium contained CCCP in the absence or...
... FEBS D F Fiol and D Kultz ¨ ANK Osmotic stress sensing and signaling in fishes ION_TRANS 3e -12 4e-10 1e -12 7e-10 3e-10 4e-10 M/P 1e-52 3e-45 1e-53 RHD IPT_NFAT 9e-18 3e-35 2e-18 4e-35 4e-19 5e-32 ... calciumsensing receptor and its tissue distribution in sea bream (Sparus aurata) Gen Comp Endocrinol 127 , 117 127 Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W & Shoback D (2004) cDNA cloning and functional ... osmoreception is mediated by stretch-activated ion channels in tilapia Am J Physiol Cell Physiol 284, C1290–C1296 Hyde GN, Seale AP, Grau EG & Borski RJ (2004) Cortisol rapidly suppresses intracellular...
... physicochemical and enzyme kinetic properties and concentrations in biological fluids J Biol Chem 261, 1128 2– 1128 9 Laemmli, U.K (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage ... above, 10 lL of Cm-papain coupled to Sepharose-4B resin (with capacity to bind 10 lg cystatin) [12] was added The solution was incubated for days at °C on a rocking table Following incubation ... while CST7 only has one (at )314) Two GC-box elements can be found in CST3 while CST7 has one at ) 312 At position )500 a CAATT/enhancer binding protein a (C/EBPa) site is found in CST7, with no counterpart...
... span Psychol Aging 1996;11(1) :127 -39 Whitty MT Coping and defending: age differences in maturity of defense mechanisms and coping strategies Aging Ment Health 2003;7(2) :123 -32 Stress symptoms and ... style (problem or emotion) on the SSL scores All data were coded and inserted in SPSS software (12. 0 version) and significance was 5% RESULTS AND DISCUSSION The sample of the current study was ... previous study conducted in elderly individuals, in which a mean score of 41.2 on the SSL was observed (12) However, given the expressive variability (SD= ± 20.3) in SSL scores, an analysis was performed...
... obtained by MOLFEAT version 2.1 (Fiatlux, Tokyo) FEBS Journal 273 (2006) 121 0 122 3 ª 2006 The Authors Journal compilation ª 2006 FEBS 121 1 Heme electronic states of Leu mutants of Ec DOS N Yokota et ... Met95, an axial ligand in the Fe(II) complex, FEBS Journal 273 (2006) 121 0 122 3 ª 2006 The Authors Journal compilation ª 2006 FEBS 121 3 Heme electronic states of Leu mutants of Ec DOS N Yokota et ... the wild-type and the other mutant proteins FEBS Journal 273 (2006) 121 0 122 3 ª 2006 The Authors Journal compilation ª 2006 FEBS 121 5 Heme electronic states of Leu mutants of Ec DOS N Yokota et...
... 6, 120 5 121 1 Mumford AD, Parry LJ & Summerlee AJ (1989) Lesion of the subfornical organ affects the haemotensive response to centrally administered relaxin in anaesthetized rats J Endocrinol 122 , ... dense-core vesicles in the perikarya, and it was also observed in the synaptic terminals of axons [12] The NI comprises a distinct cell group in the caudoventral region of the pontine periventricular ... to be GABAergic and to co-express corticotropin-releasing factor (CRF) type receptors (CRFR1) [12, 17] mlf Relaxin-3 receptor B RSC Hippocampus LS MS PAG DR DB NI Hypothalamus IP Fig (A) Relaxin-3...
... 18,6% 14.3% 18.2% 18.8% 18.2% 12 17,1% 7–9 14.3% 22.7% 0% 0% 11,4% 10 12 4.8% 9.1% 6.3% 0% 5,7% over 12 Total N B 4–6 Length of psychiatric nursing experience A 12 57.1% 31.8% 43.8% 63.6% 33 ... No reminders were sent out Of the 70 respondents, 33 (47.1%) had >12 years of nursing experience in psychiatry, 24 (34.2%) had 4 12 years of experience and only 13 (18.6%) had less than years of ... risk for post traumatic stress disorder (PTSD) after assaults against nurses is demonstrated high [12] Since psychiatric units and especially forensic psychiatric units have a high degree of violence...
... family life since the entire nucleus has to adapt to the single patient, in these situations [7 -12] Hostility towards relatives represents another variable that negatively affects the health of ... this situation stems from the overwhelming responsibilities related to the role that they cover [12, 13] The burden of responsibility significantly increases in relationship to the complexity of ... Activities of Daily Living; CBI: Caregiver Burden Inventory http://www.hqlo.com/content/6/1/93 10 11 12 13 14 15 16 17 18 Competing interests The authors declare that they have no competing interests...
... and the veterinarian J Trauma 1988, 28 :125 5 -125 9 Gardner DH, Hini D: Work-related stress in the veterinary profession in New Zealand N Z Vet J 2006, 54:119 -124 Heath TJ: Longitudinal study of veterinarians ... questionnaire: validation of a new alcoholism screening instrument Am J Psychiatry 1974, 131: 1121 - 1123 Augustin R, Semmler C, Rösner S, Kraus L: Use and misuse of prescription medications Results ... consumption in Germany Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2005, 48 :123 1 -124 1 Schulze A, Lampert T: Bundes-Gesundheitssurvey: Soziale Unterschiede im Rauchverhalten und...
... Primary school 10 (14.5) (12. 1) 10 (14.9) 12 (12. 9) Secondary school College degree 49 (71.0) (10.1) 25 (75.8) (6.1) 39 (56.7) (13.4) (4.3) (6.1) 10 (14.9) 14 (20.6) (12. 5) 48 (51.10) 98 (73.7) ... day 16 (22.9) (22.5) 12 (12. 8) 13 (9.7) No physical activity 21 (29.4) (17.9) 18 (19.8) 11 (9.2) Occasionally 35 (51.5) 18 (46.2) 44 (48.4) 45 (37.5) Once a week (2.9) (12. 8) 15 (16.5) 23 (19.23) ... totaled 510-810 ms; echo time 14-17 ms The slice thickness was 2-3 mm Field of view was 120 -180 mm with matrix of 512 × 256 In order to suppress possible bias, radiologists were unaware of the patient’s...
... Vibration 12. 2.5 Distributed Transfer Function Method 12. 3 Dynamic Response 12. 3.1 Modal Expansion 12. 3.2 Specification of Damping 12. 3.3 Free Vibration 12. 3.4 Forced Vibration 12. 3.5 Total Response 12. 3.6 ... Chapter 12 Dynamics and Control of Euler-Bernoulli Beams 12. 1 Getting Started 12. 2 System Description 12. 2.1 Governing Equation 12. 2.2 Eigenvalue Problem 12. 2.3 System Setup by the Toolbox 12. 2.4 ... Response 12. 3.7 Frequency Response 12. 4 Feedback Control 12. 4.1 Control System Formulation 12. 4.2 Solution by the Toolbox 12. 5 Dynami cs and Control of Nonuniform Beams 12. 5.1 Problem Statement 12. 5.2...
... reactivity processes Headaches, 46(8), 128 1 129 0 Arnold, M B (1967) Stress and emotion In M H Appley & R Trumbull (Eds.), Psychological stress: Issues in research (pp 123 –150) New York, NY: Appleton-Century-Crofts ... activation of beliefs, values, or goals that help define the positive significance of events” (p 121 5) Folkman cites many studies that support her conclusion that finding positive meaning in a ... and quality of life Despite the common origin of the word health from hoelth, an Old English word 12 PART I. INTRODUCTION meaning safe or sound and whole of body (Dolfman, 1973), there is no one...
... currency After devaluation in foreign currency After devaluation in domestic currency 150 IOO 120 80 180 120 50 so 67 40 67 60 67 ECONORIIC I l I P L I C A T I O N S The conditions which have been ... t , + t , > cisely when this will happen as the condition for the ratio of exports to imSince (12) , the condition for a favorable ports to increase upon devaluation effect of devaluation on the...
... morsitans: milk protein production, symbiont populations and fecundity J Insect Physiol 2008, 54 :123 6 -124 2 Volume 8, Article 31 Feldhaar and Gross 31.5 10 Wilkinson TL, Fukatsu T, Ishikawa H: Transmission ... has happened, for example, for the parasitic endosymbiont Wolbachia and several insect hosts [11 ,12] Host genome sequencing is required to clarify this issue If these considerations turn out to ... garden against the pathogenic fungus Escovopsis Proc Natl Acad Sci USA 2009, doi:10.1073_pnas.0 8120 82106 Breznak JA, Brune A: Role of microorganisms in the digestion of lignocellulose by termites...
... http://jbiol.com/content/8/6/58 (a) H1 H5 H3 H2 H4 H6 h34 h12 Loop M1 h56 Loop M2 Loop M3 C2 (b) C1 N-ter C-ter H4 Ouside H5 H3 H6 H1 H2 Inner mitochondrial membrane Inside h12 h34 h56 The mitochondrial carrier superfamily ... UCP1 in the liver decreases when fish are exposed to cold, thus ruling out a thermogenic function [12] The evolution of the UCP family To throw more light on the diversification of the UCP family ... biochemical characterization of carp UCP1 revealed no nucleotidesensitive basal proton conductance [12] In addition, several groups have searched for the domain that confers the high affinity for...