điều 84 các thiết bị đóng cắt ở các nhánh rẽ các phân đoạn giữa đường ký hiệu như sau
Tài liệu Molecular Neurobiology of Alzheimer Disease and Related Disorders doc
... (Osaka) 79 Hydrogen Sulfide Is Severely Decreased in Alzheimer Disease Brains Kimura, H (Tokyo) 84 Functional Analysis of the Presenilin Complex and ␥-Secretase Activity Tomita, T.; Takasugi, ... include partial identification of the amino acid sequence of amyloid precursor protein (APP) (1 984) , identification of amyloid precursor protein gene on chromosome 21 (1987), detection of mutations ... Most microglia in APP transgenics are not phagocytic when analyzed at the ultrastructural level [84] and appear to fit the description of being arrested at the ‘bystander microglia’ stage Consistent...
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Báo cáo khoa học: "Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis" pot
... (13–138) 0.10 Platelet count (× 109/l) 185 (48–738) 208 (40–530) 0.38 HLA-DR% 46 (8–82) 44 (11 84) 0.80 Data presented as median (range) 0.027), whereas the PC level and the APC/PC ratio did ... randomized, doubleblinded, placebo-controlled, dose-finding study Crit Care Med 2003, 31:1839- 1847 Bradley E III: A clinically based classification system for acute pancreatitis Summary of the...
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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx
... beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch EMBO Rep 2, 835 841 Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio...
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The effect of s1p lyase deficiency on the metabolism of the alzheimer’s related amyloid precursor protein
... to be associated with a number of neurodegenerative disorders, like Parkinson’s disease (Swan & Saunders-Pullman, 2013), Prion disease (Schengrund, 2010) and Huntington’s disease (Desplats et...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... critical for neuritic toxicity in a mouse model of Alzheimer’s disease Proc Natl Acad Sci USA 99, 1 0843 –1 0848 DeMattos RB, Cirrito JR, Parsadanian M, May PC, O’Dell MA, Taylor JW, Harmony JA, Aronow ... Council (2009-4567, LL; 2009-4389, LN) provided financial support References Glenner GG & Wong CW (1 984) Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular ... (1969) Presenile dementia and Alzheimer’s disease in mongolism Brain 92, 147–156 1402 10 Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL & Pericak-Vance...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... His Lys Arg 4 2 3 3.9917 2.1648 4.0643 6.0117 3.0265 5.0813 1.7661 1.1517 1.9935 0.96174 2.9287 2 .842 6 2.0270 0.99652 a Ile–Ile peptide bonds are known to be inefficiently hydrolyzed methods proved ... 1280 16 Walsh DM & Selkoe DJ (2007) Ab oligomers – a decade of discovery J Neurochem 101, 1172–1 184 17 Walsh DM, Hartley DM & Selkoe DJ (2003) The many faces of Ab: structures and activity Curr...
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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
... b-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch EMBO Rep 2, 835 841 48 Kimberly, W.T., LaVoie, M.J., Ostaszewski, B.L.Ye, W., Wolfe, M.S & Selkoe, D.J (2002) Complex...
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Báo cáo khoa học: Amyloid-b protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx
... 14, 837 842 Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S & Malinow R (2006) AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss Neuron 52, 831 843 Snyder ... Hardy JA & Higgins GA (1992) Alzheimer’s disease: the amyloid cascade hypothesis Science 256, 184 185 Arriagada PV, Growdon JH, Hedley-Whyte ET & Hyman BT (1992) Neurofibrillary tangles but not ... 853–862 Walsh DM & Selkoe DJ (2007) A beta oligomers – a decade of discovery J Neurochem 101, 1172–1 184 Harper JD, Wong SS, Lieber CM & Lansbury PT (1997) Observation of metastable Abeta amyloid protofibrils...
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Báo cáo khoa học: Amyloid–cholinesterase interactions Implications for Alzheimer’s disease pot
... < 0.001 and ns, not significant Inhibitors Active site IC50 Tacrine(10)9M) Edrophonium(10)6M) BW284c51 (10)9M) Peripheral site IC50 Propidium (1Q)6M) Gallamine (1Q)3M) (+)-Tubocuranine (10)6M) ... sulphate proteoglycans in cortical amyloid deposits of Alzheimer’s disease Neuroscience 51, 177– 184 Mimori Y, Nakamura S & Yukawa M (1997) Abnormalities of acetylcholinesterase in Alzheimer’s disease ... molecule confer selectivity for acetyland butyrylcholinesterase inhibitors Biochemistry 32, 12074–12 084 51 Diamant S, Podoly E, Friedler A, Ligumsky H, Livnah O & Soreq H (2006) Butyrylcholinesterase...
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Báo cáo khoa học: High-resolution NMR studies of the zinc-binding site of the Alzheimer’s amyloid b-peptide pdf
... Natural oligomers of the amyloid-b protein specifically disrupt cognitive function Nat Neurosci 8, 79 84 11 Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson...
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Báo cáo khoa học: Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases Retinoic acid-induced upregulation of substrate and proteinase ADAM10 during neuronal cell differentiation ppt
... overexpression of a dominant negative form of ADAM10 (Fig 4F) This mutant protein carries the E384A point mutation in the zinc-binding region of ADAM10, which is known in Drosophila melanogaster ... the amyloid protein precursor supergene family tells us about its function Neurochem Int 36, 175– 184 5817 APLP2-shedding by disintegrin-metalloproteinases Slunt HH, Von Thinakaran GKC, Lo AC, Tanzi...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
... of microglia with amyloid plaques in brains of APP23 transgenic mice Am J Pathol 1999, 154:1673 -84 Wegiel J, Wang KC, Imaki H, Rubenstein R, Wronska A, Osuchowski M, Lipinski WJ, Walker LC, LeVine ... interferon gamma J Clin Endocrinol Metab 1996, 81:1666-9 Blasko I, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B: Costimulatory effects of interferon-gamma...
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báo cáo hóa học: " Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer’s disease" potx
... allele significantly raised the risk of developing LOAD (OR = 1.31, 95%CI = 1.07-1.60, Power = 84. 9%) In subjects without ApoE ε4 allele, the allele and genotype distributions between LOAD patients ... August 2011 Accepted: 11 October 2011 Published: 11 October 2011 References Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, Perry RT, Collins JS, Harrell LE, Go RC, Mahoney ... 1-42 and delay the cognitive decline in a mouse model of Alzheimer’s disease J Neurosci 2008, 28:5 784- 5793 Takeda K, Kaisho T, Akira S: Toll-like receptors Annu Rev Immunol 2003, 21:335-376 Yu JT,...
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Báo cáo y học: " Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer''''s disease" doc
... for Trp84 and Trp279 side chains were maintained [Tolerance = 0.9 Å, Strength = 1.0 Å, Torsional angles = (each), Max T = 23.03 for Trp84 and 32.22 for Trp279, and Mean T = 16.962 for Trp84 and ... Pose -125.374 71.119 -4.192 -4.192 -124.1 -104.41 Pose -122.393 65. 184 -5.026 -7.415 -123.899 -97.385 Pose -122.31 75.752 -6 .849 -7.294 -121.124 -92.751 Pose -120.076 71.516 -2.5 -2.5 -119.209 ... Pose -125.374 71.119 -4.192 -4.192 -124.1 -104.41 Pose -122.393 65. 184 -5.026 -7.415 -123.899 -97.385 Pose -122.31 75.752 -6 .849 -7.294 -121.124 -92.751 Pose -120.076 71.516 -2.5 -2.5 -119.209...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
... the devil 15 16 Alzheimer’s Disease and Other Dementias French psychiatrist Jean Esquirol (1772– 1840 ) provided the first modern description of dementia In his classic early 19thcentury work Mental...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... 684 R Mayeux et al / Neurobiology of Aging 22 (2001) 683– 689 other APOE genotypes, individuals with ... in humans with the APOE-4 allele References [1] Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, Fishman CE, DeLong CA, Piccardo P, Petegnief V, Ghetti B, Paul SM 1999 Apolipoprotein E ... of dementia A test of the brain reserve hypothesis Psychol Med 27(6):1337– 44 [49] Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... DOI 10.1007/978-0-387-76420-7 e-ISBN 978-0-387-76420-7 Library of Congress Control Number: 200894 0848 © Springer Science + Business Media, LLC 2009 All rights reserved This work may not be translated ... from progressive amnestic MCI, particularly in combination with memory test performance scores .84 Some patients with a normal initial evaluation request a PET study because they are concerned ... auspices of Department of Health and Human Services Task Force on Alzheimer’s disease Neurology 1 984; 34:939–944 Ferri CP, Prince M, Brayne C, et al Global prevalence of dementia: a Delphi consensus...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... increased availability of Cu [84] Collectively, these data present a strong case for the native role of APP ⁄ Ab in regulating intracellular Cu: Cu alters APP gene expression [83 ,84] , and the APP ⁄ Ab ... Hardy JA & Higgins GA (1992) Alzheimer’s disease: the amyloid cascade hypothesis Science 256, 184 185 45 Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB & Selkoe DJ (1999) ... electrophysiological changes and progressive neurotoxicity in cortical neurons J Neurosci 19, 8876–8 884 46 Hoshi M, Sato M, Matsumoto S, Noguchi A, Yasutake K, Yoshida N & Sato K (2003) Spherical aggregates...
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Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot
... 83 Walsh DM & Selkoe DJ (2007) Abeta oligomers ) a decade of discovery J Neurochem 101, 1172–1 184 84 Demuro A, Mina E, Kayed R, Milton SC, Parker I & Glabe CG (2005) Calcium dysregulation and ... and neurotoxic properties of the prion peptide PrP106–126 Biochemistry 40, 8073– 8 084 FEBS Journal 274 (2007) 3 784 3798 ª 2007 The Authors Journal compilation ª 2007 FEBS 3797 Therapy for prion ... melatonin [76], can interact with Ab and prevent its aggregation into fibrils FEBS Journal 274 (2007) 3 784 3798 ª 2007 The Authors Journal compilation ª 2007 FEBS 3787 Therapy for prion disease and AD...
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