ß deposition in patients with alzheimer s disease using positron emission tomography
Báo cáo y học: " Sigma-1 receptor agonist fluvoxamine for delirium in patients with Alzheimer’s disease pot
... detailed study is necessary Delirium is regarded as syndrome that consists of several domains of symptoms, such as disturbance of consciousness, cognitions, and perceptions [17] At present, it is unclear ... the selective sigma-1 receptor agonists (for example, cutamesine (SA4503)) in patients with delirium would also be of interest Previously, it has been reported that the combination of SSRIs with ... is currently stable Discussion To our knowledge, this is the first report demonstrating that fluvoxamine monotherapy is effective for treating the delirium of patients with Alzheimer s disease...
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Báo cáo hóa học: " Audio-Biofeedback training for posture and balance in Patients with Parkinson’s disease" doc
... Five patients also received several training sessions (up to training sessions) in their home to explore the possibility for future independent home training with the ABF system The home sessions ... net training time of 30-45 minutes in each session Assessments Assessments included standardized tests of balance and, postural control as well as ADL s to evaluate the effects of training Balance ... rise (5CR) test was used to assess the ability to perform sit-to-stand and stand-to-sit transfers Patients were instructed to stand up and sit down five times as fast as possible Page of starting...
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báo cáo hóa học: " The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson''''s disease" docx
... Comorbidity Postural hypotension5 Prior surgery related to Parkinson 's disease6 Pain symptoms Assistive device (walking indoors) Assistive device (walking outdoors) Falls within the past months7 Median ... destabilizing visual tilts [9,15-17] In some cases, assessment of quiet stance on a firm surface lacks the sensitivity to distinguish healthy subjects from patients with balance disorders [18] A method ... minutes in- between the tests (eyes open, eyes closed) The same test order was maintained during the DBS OFF and ON measurements In every test situation, spontaneous sway was recorded for 30 seconds...
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Báo cáo y học: "Current pharmacologic options for patients with Alzheimer''''s disease" pps
... measures The standard psychometric tool used to assess cognition in the majority of these studies is the Alzheimer' s Disease Assessment Scale (ADAS) [15] The section of the scale from which scores ... time was measured with a questionnaire documenting time spent supervising and assisting with ADL, untreated patients required increased supervision by the caregiver and increased assistance with ... Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M and Ferris S An inventory to assess activities of daily living for clinical trials in Alzheimer' s disease The Alzheimer' s Disease...
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Báo cáo y học: " Natural killer cells control a T-helper 1 response in patients with Behçet''''s disease" doc
... These results strongly suggest that an NK2 shift was associated with disease remission In addition, the expression level of perforin was reduced when the patients' disease status changed to remission ... modulates disease flare/ remission in BD patients by controlling the pathogenic Th1 response This situation is analogous to multiple sclerosis, another Th1-mediated disease, in which NK2 bias is associated ... the results Our results suggest that the NK2 cells in iBD patients can suppress the Th1 response through at least two distinct mechanisms First, the NK2 cells in iBD patients were intrinsically...
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Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot
... complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal cord, kidney, liver, ... control tissues (a representative western blot is shown in Fig 3A) As human brain tissue is difficult to obtain, we focused on the most interesting regions for further studies These regions included ... identified using an antisense RNA probe against exon Expression was examined in neurons, astrocytes and microglia, by labeling cells with antibodies against each of these specific cell types We first created...
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Báo cáo y học: " γ δ Vγ9/Vδ2 T lymphocytes in Italian patients with Behçet’s disease – evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor β1 expression in active disease" pptx
... populations of patients and/or stages of disease progression in those studies [33] Indeed, Vγ9/Vδ2 cells from patients with active Behçet s disease, but not from inactive patients or control individuals, ... Disease Research Committee of Japan [25] At time of sampling, disease was active in 15 patients and inactive in 10 All patients were using colchicine, an immunosuppressant agent such as ciclosporin ... International Study Group for Behçet s disease [24], were studied The activity of Behçet s disease was assessed by the 1994 criteria for disease activity of Behçet s disease, proposed by the Behçet s Disease...
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báo cáo khoa học: " Connectedness of healthcare professionals involved in the treatment of patients with Parkinson’s disease: a social networks study" pot
... was also significant but lower in professionals with ≥10 PD patients No statistical difference was found for three measures: density, incloseness centrality, and outcloseness centrality Regarding ... knowledge is not delayed by network characteristics Primary care professionals were less connected in the network than professionals based in hospital settings This finding should be interpreted in the ... Visual display of the total network of health professionals in ParkinsonNet Legend: health professionals with ≥10 PD patients in red, those with < 10 PD patients in blue One strength of this study...
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Báo cáo y học: " Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer''''s disease" doc
... been classified into two types, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), on the basis of distinct substrate specificities and inhibitor sensitivities AChE (EC 3.1.1.7) is a key ... pose was evaluated by considering the RMSDs values, docking scores and similarity scores The selected re-docked pose was further evaluated by its interactions and energetic analysis to investigate ... of cholinesterases inhibitors using in silico methods: Currents status and future prospects New Biotech 2009, 25:331-346 51 Nachon F, Asojo OA, Borgstahl GEO, Masson P: Role of water in aging of...
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Báo cáo y học: "Hypoalbuminaemia – A Marker of Cardiovascular Disease in Patients with Chronic Kidney Disease Stages II - IV"
... confounders selected based on prior studies and clinical relevance, including age, sex, HTN, DM and DLP were used in final model STATISTICAL ANALYSIS Results were expressed as mean ± SD for continuous ... diseases such as systemic lupus, rheumatoid arthritis, other connective tissue diseases, liver disease, malnutrition from other causes, and does not just represent cardiovascular disease In addition, ... Kaysen GA, Dubin JA, Muller HG, Rosales L, Levin NW, Mitch WE, HEMO study group Inflammation and reduced albumin systhesis associated with stable decline in serum albumin in hemodialysis patients...
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Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study docx
... resulted in intestinal colonization in all the patients, including those taking metronidazole All patients in this study had active Crohn s disease, despite use of steroids and immunomodulatory drugs ... screening visit Patients were allowed to decrease the steroid dose during the study period as clinically indicated Patients with intestinal strictures that are likely to necessitate surgery, patients ... effective in treatment of Crohn s disease by several potential mechanisms such as altering the intestinal mucins, promoting local immune response, and stabilizing the gut mucosal barrier Lactobacillus...
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báo cáo hóa học: " Replication of the association of HLA-B7 with Alzheimer''''s disease: a role for homozygosity?" pptx
... cohorts involved in the study [9], it remains possible that these contrasts were due to geographical differences, for instance in the fine structure of linkage disequilibrium or in interactions with ... 0.36) Similar patterns were seen both in controls and in cases Possible associations of AD with HLA-B & C alleles Tables and show the overall results for the 26 studied alleles Apart from the associations ... undertaken blind to diagnosis Unadjusted p values were by Fisher 's exact test; odds ratios were also adjusted for age, gender and APOE4 status by logistic regression analysis Potential interactions were...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
... measuring betaamyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease Arch Neurol 2009, 66:190-199 41 Sehlin D, S llvander S, Paulie S, Brundin R, Ingelsson ... with this approach Methods Serum samples Serum samples were obtained from the Rush Alzheimer s Disease Center (Chicago, IL) from individuals whose diagnosis on the basis of post-mortem clinical ... encouraging results were obtained in two clinical trials in which IvIg was administered to AD patients [22,23] and a multi-site phase trial is in progress In our ELISA studies we found that in addition...
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báo cáo hóa học:" Structural ambiguity of the Chinese version of the hospital anxiety and depression scale in patients with coronary heart disease" doc
... depression using the HADS is consistent with previous studies conducted in China or in western countries [3,5,34,35] The CFA findings are in many respects, rather surprising It has been suggested that ... and screening issues Current Psychiatry Reviews 2005, in press: Wang XC, Xiong BW, Chen HJ: Depression and anxiety in patients with coronary heart disease Chinese Journal of Infrequent Disease ... F, Frasure-Smith N: Depression in patients with cardiac disease: a practical review J Psychosom Res 2000, 48:379-391 Martin CR, Thompson DR: Depression in coronary heart disease patients: Etiological...
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báo cáo hóa học:" Comparison of the SF-6D and the EQ-5D in patients with coronary heart disease" pdf
... was assessed by computing the percentage of patients reporting no problems To reduce the number of missing scores in the SF6D, we imputed missing items in the SF-36 from the SF36 domain scores ... intraclass correlation coefficient (ICC) Statistical analyses were done with Statistica version 5.5 (Statsoft, 1999) and SPSS version 10.1 (SPSS Inc, 2000) Results Instruments The EQ-5D health status ... at baseline between the patients with or without a missing utility score post-intervention, so we assumed these missing scores to be at random Baseline and change scores from both measures were...
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báo cáo hóa học: " Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey" ppt
... Helsinki Page of Statistics Statistical analysis was conducted using a licensed version of statistical software STATISTICA PL 9.0 for Windows Power considerations indicated that a sample size ... Outcomes 2011, 9:77 http://www.hqlo.com/content/9/1/77 measured using both disease- specific surveys and generic instruments, has been shown in patients without cardiovascular diseases but with ... patient numbers and inclusion criteria, as our patients did not suffer from clinically manifested gastrointestinal symptoms and symptoms associated with aspirin use were not analyzed As mentioned...
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báo cáo hóa học:" Mapping of the EQ-5D index from clinical outcome measures and demographic variables in patients with coronary heart disease" pptx
... measure of HRQoL If interest centres on mapping the EQ-5D index in another disease area, disease specific measures for the disease in question may also be important The mapping exercise was initially ... different disease groups, since the most effective predictors may vary between diseases Also, mapping models need to incorporate variables that are commonly measured when studying the disease in question ... index Several studies have looked at mapping using other generic or disease- specific HRQoL measures, with one Page of 13 other using clinical measures to map to the EQ-5D index [13,15] This study...
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báo cáo hóa học:" Psychometric validation of the Dutch translation of the quality of life in reflux and dyspepsia (QOLRAD) questionnaire in patients with gastroesophageal reflux disease" ppt
... esophagitis grade C or D, presence or history of other gastrointestinal diseases and conditions, and presence or history of other non-gastrointestinal serious diseases and conditions Patients ... satisfied Quite satisfied - 71.2 24.1 79.1 15.8 Quite dissatisfied - 3.9 3.8 Completely dissatisfied - 0.8 1.0 Regurgitationb Responsiveness to change Responsiveness to change was assessed using ... score, indicates that the scales will have poor discrimination Thus sensitivity and responsiveness is reduced Construct validity Construct validity assesses whether an indicator actually measures...
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Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease pot
... atorvastatin had a ol levels below 100 mg per deciliter is associated persistent elevation in alanine aminotransferase, with substantial clinical benefit in patients with aspartate aminotransferase, ... cause In both groups, cancer (mainly lung and gastrointestinal) was the leading noncardiovascular cause of death; other causes included respiratory diseases, infection, degenerative diseases, ... 2005 Massachusetts Medical Society All rights reserved intensive atorvastatin therapy for stable coronary disease Table Characteristics of Five Patients with Rhabdomyolysis.* Characteristic Patient...
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Báo cáo y học: " Lymphocyte Responses to Chymotrypsin- or Trypsin VDigested b-Lactoglobulin in Patients with Cow’s Milk Allergy" doc
... desensitization using intact cow s milk was reported in a few patients with cow s milk allergy.8 It took to months with increasing doses of milk intake During the desensitization process, some ... digestive sites of BLG polypeptides by these enzymes Digestion with chymotrypsin resulted in small peptides ranging from 3- to 31-amino acid residues whereas digestion with trypsin V produced smaller ... peptides Chymotrypsin digestion decreased the lymphocyte responses compared with intact BLG but retained significant responses in PBMCs from some patients with cow s milk allergy Hence, chymotrypsin-digested...
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