zero order absorption drug delivery

Drug Delivery Systems

Ngày tải lên : 25/10/2013, 08:20

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... a drug delivery system for kinetic control Dissolution of drug is too slow Drug and/or formulation is physically removed from the site of action too rapidly Metabolism or excretion of the drug ... containing numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal-based drug delivery systems are under development...

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Transdermal and Topical Drug Delivery Principles and Practice doc

Ngày tải lên : 05/03/2014, 22:21

... intercellular route is the main route of absorption for these drugs.6–8 Processes for Percutaneous Absorption Drug absorption from a transdermal drug delivery system into the systemic circulation ... medication Drug delivery systems Skin absorption I Benson, Heather A E II Watkinson, Adam C [DNLM: Administration, Cutaneous Administration, Topical Drug Delivery Systems–methods Skin Absorption ... experience in drug delivery with particular focus in transdermal and topical delivery She is an Associate Professor at Curtin University, Perth, Australia, where she leads the Drug Delivery Research...

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Chemical Aspects of Drug Delivery Systems pptx

Ngày tải lên : 28/03/2014, 10:20

... for Drug Delivery and Targeting P York The Use of Bioadhesive Polymers as a Means of Improving Drug Delivery Slobodanka Tamburic and Duncan Q.M Craig Some Novel Aspects of Transdermal Drug Delivery ... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS (e.g ... carrier materials incorporated into drug delivery systems 4 DRUG LEAKAGE+ +NON TARGET +METABOLISM /CLEARANCE IB ROUTE OF ADMINISTRATION IDRUG + CARRIER Ic IDRUG IDRUG + CARRIER P + CARRIER +NON...

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electrochemotherapy, electrogenetherapy and transdermal drug delivery

Ngày tải lên : 11/04/2014, 00:29

... molecule to be delivered: drug versus genes In vivo EP requires techniques for the delivery of the drug/ gene to the tissue site, and techniques for the delivery of the field The delivery of the field ... purposes of gene transfer and drug delivery into the cells In electrochemotherapy, for instance, the optimization of the electroporative channeling of the cytotoxic drugs into the tissue cells ... old drug [Review] Gen Pharmacol 27, 745–748 Gehl, J., Skovsgaard, T., and Mir, L (1998) Enhancement of cytoxicity by electropermeabilization: An improved method for screening drugs Anticancer Drugs...

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THE CHEMISTRY OF DRUG DELIVERY SYSTEMS (hoá học các hệ dẫn truyền thuốc)

Ngày tải lên : 18/04/2014, 15:37

... Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM ... multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug?  Prodrug is an inactive precursor of a drug  Prodrug reconversion occurs in the ... Buccal delivery Surface area: 100 cm2 Local delivery SUBLINGUAL AND BUCCAL DELIVERY Sublingual delivery Buccal delivery High permeability Less permeability Higher rate of absorption Low rate of absorption...

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nanotherapeutics. drug delivery concepts in nanoscience, 2009, p.293

Ngày tải lên : 04/06/2014, 14:31

... nanoparticule drug delivery systems allowing innovative therapeutic approaches Nanotechnology as a delivery platform offers very promising applications in drug delivery Due to their small size such drug delivery ... targeted drug delivery towards a specific tissue or organ, enhanced drug transport across biological barriers (leading to an increased bioavailability of the entrapped drug) or intracellular drug delivery ... Nanosized Drug Substance Direct nanosizing of drugs, as reviewed by Merisko-Liversidge et al [2003] provides for delivery of poorly water-soluble drugs to enhance their solubility Micron-size drug...

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nanoparticulate drug delivery systems, 2007, p.382

Ngày tải lên : 04/06/2014, 14:47

... define drug- delivery systems of a certain size range Reflecting this trend of size definition, Nanoparticulate Drug Delivery Systems is a worthy attempt to bring together a wide range of drug- delivery ... nanoparticulate drug- delivery systems The first chapter covers a complete overview of the nanoparticulate drugdelivery system, covering wide applications and evaluation of the nanoparticulate drug- delivery ... finding a place in drug discovery as well as NPDDS (27–31) DRUG- DELIVERY SYSTEMS An ideal drug- delivery system possesses two elements: the ability to target and to control the drug release Targeting...

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nanoparticle technology for drug delivery, 2006, p.427

Ngày tải lên : 04/06/2014, 15:15

... Specialized Drug Delivery Systems: Manufacturing and Production Technology, edited by Praveen Tyle 42 Topical Drug Delivery Formulations, edited by David W Osborne and Anton H Amann 43 Drug Stability: ... purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, ... Nixon Drug Metabolism: Chemical and Biochemical Aspects, Bernard Testa and Peter Jenner New Drugs: Discovery and Development, edited by Alan A Rubin Sustained and Controlled Release Drug Delivery...

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báo cáo hóa học:" Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life" pot

Ngày tải lên : 18/06/2014, 15:20

... transvascular delivery of small chemotherapy drugs across the BBTB of malignant gliomas by increasing the blood half-life of the co-infused drug The selectivity of the increase in drug delivery into ... allow for the selective transvascular passage of small conventional chemotherapy drugs, such as carboplatin, these drugs not achieve sufficiently high concentrations within tumor tissue after systemic ... tissue than in normal tissues, it is thought that the bradykinin B2 agonists selectively increase drug delivery across the blood-brain tumor barrier of tumor microvasculature, and in the case of peripheral...

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Báo cáo hóa học: " Nanotechnology-based drug delivery systems" pdf

Ngày tải lên : 20/06/2014, 00:20

... the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of disease ... the uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown in ... therapy The effectiveness of drug delivery systems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics and...

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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx

Ngày tải lên : 20/06/2014, 22:20

... advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro experiments have unique advantages, ... as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted to the ... the lymphatic system Drug delivery targeted to tumor To deliver anticancer drugs into cancer focus is the prerequisite for the drugs to develop their effects However, some drugs cannot arrive...

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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt

Ngày tải lên : 21/06/2014, 02:20

... transition metals and any drug molecule in general from a delivery are major factors that ultimately determine the success or failure of that vector when applied to targeted drug delivery One of the ... targeted drug delivery, such as PLGA, chitosan, or dextran Thus, the metal/ligand chemistry is readily adaptable to, and independent from, the desired polymeric material used as the delivery ... Pt(IV) prodrug-PLGA-PEG nanoparticles Proc Natl Acad Sci USA 2008, 105:17356-17361 Rieter WJ, Pott KM, Taylor KML, Lin WB: Nanoscale coordination polymers for platinum-based anticancer drug delivery...

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Báo cáo hóa học: " Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery" doc

Ngày tải lên : 21/06/2014, 03:20

... new drug entities in early drug discovery: the potential impact of formulation on pharmacokinetic parameters Curr Op Drug Discov Devel 2002, 5(1):59-71 17 Barrett R: Nanosuspensions in drug delivery ... sustained drug coverage and lower P/T ratio Despite the described advantages, the SC route of dosing is not free of problems Drug exposure via SC route of delivery can be still limited by absorption, ... Secondly, the SC drug depot should continuously provide a slow release of drug to the bloodstream providing a longer and sometimes steady drug supply Combined, both effects may result in a drug plasma...

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Báo cáo hóa học: " Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Leve" pptx

Ngày tải lên : 22/06/2014, 00:20

... Morinville, Drug delivery to the nervous system Trend Biotechnol 15, 410–418 (1997) doi:10.1016/S01677799(97)01095-0 M Danckwerts, A Fassihi, Implantable controlled release drug delivery systems: ... structure that could be exploited for the deposition of a polymeric thin ﬁlm acting as drug delivery device For drug release kinetics investigation, bovine serum albumin (BSA, A3156 from Sigma, MW ... differentiation [5] In this study, we propose a combination of drug delivery system with such CNT array, exploiting a thin ﬁlm of calcium alginate as drug reservoir embedded into the platform Among polymers,...

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Báo cáo hóa học: "Single-component Polymer Nanocapsules for Drug Delivery Application" docx

Ngày tải lên : 22/06/2014, 01:20

... polypeptide -drug conjugates [PGA-Doxorubicin (Dox)] The researchers also investigated the applicability of thick-walled polymer nanocapsules for tumor therapy via drug delivery They prepared drug- loaded ... cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death Bansal notes that it is highly desirable for antitumor applications, that the size of the delivery vehicle ... attachment of targeting ligands to the drug- conjugated capsules through established coupling protocols will further provide functional capsules for targeted drug delivery applications 267 Overall,...

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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps

Ngày tải lên : 09/08/2014, 06:22

... internalization determined the strategy of drug delivery We here employed the mechanism of lipid-coupled drug transfer between membranes to achieve intracellular drug delivery When anti-CD134 liposomes ... similar results, is shown pled drug transfer between membranes to achieve intracellular drug delivery The lipid-derivatized cytostatic agent FUdR-dP was used as a model drug [13] Activated, CD134+ ... cell subset We also studied drug delivery to CD134+ T cells both in vitro and in vivo using liposomes coated with a CD134-directed monoclonal antibody (mAb) as a drug targeting system To investigate...

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Báo cáo y học: "Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice" doc

Ngày tải lên : 09/08/2014, 14:20

... investigated magnetically retainable drug delivery systems, an approach as yet clinically unexploited despite the intense need for the development of novel i-a delivery modalities Thus, our aim ... their retention in the joint The first objective of this study was to choose the most suitable drug delivery system for the local treatment of joint inflammation In this respect, we intra-articularly ... microparticles containing DXM and SPIONs (referred to as complete microparticles) as an anti-inflammatory drug delivery system in an experimental model of antigen-induced arthritis (AIA) in mice Figure Materials...

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Intraocular Drug DelIvery - part 1 pps

Ngày tải lên : 09/08/2014, 20:22

... drug delivery, barriers to getting drugs into the vitreous and retina, mechanisms by which drugs are cleared, and drug delivery for some speciﬁc ophthalmic problems BASIC PRINCIPLES OF DRUG DELIVERY ... I: GENERAL Retinal Drug Delivery Paul Ashton Basic Principles of Drug Delivery Drug Delivery to the Posterior Segment of the Eye Drug Elimination Mechanisms ... Microdialysis Probes as Sustained-Release Drug Delivery Systems 216 Microelectromechanical Systems Drug Delivery Devices 219 References 222 PART III: LOCAL DRUG DELIVERY APPROACH TO SPECIFIC...

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Intraocular Drug DelIvery - part 2 ppt

Ngày tải lên : 09/08/2014, 20:22

... order for a drug product to be marketed in the United States, it must be approved by the U.S Food and Drug Administration (FDA) The authority for the FDA was established by the Federal Food Drug ... blood supply In conclusion, the future of neuroprotectant drug delivery is exciting Multiple targets have been identiﬁed, and novel, sustained delivery systems are under development Difﬁculties remain, ... 1976:59–71 128 Herrero-Vanrell R, Refojo MF Biodegradable microspheres for vitreoretinal drug delivery Adv Drug Deliv Rev 2001; 52:5–16 129 Jonhagen ME Nerve growth factor treatment in dementia...

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Intraocular Drug DelIvery - part 3 ppt

Ngày tải lên : 09/08/2014, 20:22

... intravitreal drug levels Pharmacokinetic studies are important in the development of local ocular drug delivery Although a beneﬁt of ocular drug delivery is the ability to achieve higher intraocular drug ... are achieved with both systemic and intravitreal drug delivery Some drugs may have a systemic effect contributing to their efﬁcacy For other drugs, drug levels at the level of the retinal pigment ... understanding of the absorption, distribution, metabolism, and excretion of the drug is established in nonclinical studies prior to administering the drug to humans Ocular drug delivery, whether...

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