year of the cat
Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
... to the residue in the midpoint of the respective loop, as shown in Fig To the east of the active site the 37- and 60-loops border the S2¢ pocket of the proteinase The observed differences in the ... that the most similar regions of these proteinases mediate interaction of the two b-barrels, formation of the catalytic machinery and structures required for binding of the main chain of the substrate ... calculate the Rfree The final R and Rfree values of the model are 0.21 and 0.22 for the complete data ˚ set up to 1.6 A The electron density of the whole main chain of the catalytic domain (B-chain) of...
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Báo cáo khoa học: Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN ppt
... translocation of UDPglucose pyrophosphorylase to the plasma membrane, where it increases cell wall glucan synthesis at the expense of glycogen storage In the absence of PSKs, glycogen rather than ... phosphorylation of a microarray of 1176 peptides in the presence of [c-33P]ATP The magnified inset shows an example of the results obtained after detection by phosphorimaging (B) Peptide sequences of the ... identification of endogenous small molecule activators of PASKIN, we have obtained the first indication of the upstream regulators of PASKIN activity It will be interesting to examine how these...
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Compendium of the Catechism of the Catholic Church pot
... Mary, Mother of Christ, Mother of the Church 196 In what sense is the Blessed Virgin Mary the Mother of the Church? 963-964 973 The Blessed Virgin Mary is the Mother of the Church in the order of ... the members of the Church, who thus bear the fruits of the new life of the Spirit The Holy Spirit is also the Master of prayer “I BELIEVE IN THE HOLY CATHOLIC CHURCH” The Church in the Plan of ... to the life of the Church For the children of the Church, it is a confirmation of the faith, food for the soul and the fount of the spiritual life Sacred Scripture is the soul of theology and of...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... 6.1S; 87 kDa) (C) The masses of the different oligomers were determined by their proportionality to the product of the Stokes radius with the sedimentation coefficient The masses of the minor 8.5S ... we associated the catalytic domain of each enzyme with the t peptide of the other For convenience, the large catalytic domains are designated by capital letters (A and B), whereas the small t peptides ... influence the catalytic activity of AChE and BChE We examined the possible influence of the C-terminal peptides on the AChE and BChE activities by comparing the catalytic rates per active site The active...
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Báo cáo khoa học: Solution structure of the catalytic domain of RICH protein from goldfish pot
... structure of the RICH catalytic domain G Kozlov et al Results Structure of the RICH catalytic domain We determined the structure of the 24 kDa catalytic fragment of goldfish RICH protein (Fig 2) The ... (B) Representation of flexibility in the solution structure of the RICH catalytic domain The width of the sausage is reversely proportional to the heteronuclear NOE values The figure was generated ... with the crystal structure of human CNPase cata˚ lytic domain (rmsd of 2.3 A over 205 residues) Sequence alignment of the catalytic domain of RICH and related proteins (Fig 1B) identifies the biggest...
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Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf
... Among the three types of thioredoxin proteins, least is known about hTRXL Here, we report our work on the isolation of the gene, hTRXL, the functional identification of the gene product and the ... and the Cys73–Cys73 disulfide bond [23] The substitution of these hydrogen bond forming residues in hTRXL-N may account for the formation of a monomer, instead of a dimer in the case of TRX Furthermore, ... intermolecular contacts near the active site in the crystal, the conformation of the active site (-Cys-Gly-ProCys-) of the hTRXL-N determined in the present study is very close to those of human and E coli...
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Báo cáo khoa học: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site pdf
... that these residues stabilize the distortion of the NAG3 residue In these interactions, we particularly focused on the Trp664 residue, which is located at the bottom of the active site cleft The ... on the b4-strand (Fig 1) The Glu (E) in this motif acts as the catalytic proton donor, and the second Asp (D2) is supposed to contribute to the stabilization of the essential distortion of the ... Stereo figures of the model of the bound substrate in the AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars and the side-chains of three acidic residues in the conserved...
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Báo cáo khoa học: Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase – role of the catalytic center in mRNA recognition potx
... at the interface of the N- and C-terminal domains of the monomer The adenosine base of ATP is bound at the base of the left-handed b–a–b fold, where it interacts with a number of residues in the ... studies have shown that binding of MVK to LHR mRNA suppresses the translation of mRNA in vitro [14] As the mutation of any of the four amino acids at the active site of MVK decreases its binding ... preparations [14] The translation reactions were then performed in the presence of S100 fractions prepared from cells overexpressing each of the mutant proteins of MVK The results in Fig 8A,B indicate that...
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Báo cáo khoa học: Structural study of the catalytic domain of PKCf using infrared spectroscopy and two-dimensional infrared correlation spectroscopy pot
... study the secondary structure of the catalytic domain of PKCf and the effect of its substrate, MgATP, and also to study the effect of thermal unfolding in the presence and the absence of MgATP ... because the structure of 282 residues of a total of 344 have been solved [19] The catalytic domain of PKCh possesses a high degree of homology ( 80%) with the 3280 catalytic domain of other isoforms ... dashed line represents the curve-fitted spectrum, i.e the dotted line is the sum of the individual components consequence of the use of D2O buffer This is the consequence of the H–D exchange that...
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Báo cáo khoa học: Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates potx
... features None of the other known C splice variants are encoded with the same N-terminus as Ca1 and Cb1 and it is not expected that they undergo the same type of modifications Thus, they may harbor ... representation of the human PKA Cb gene structure Location of the Cb primers used in RT-PCR is indicated and refers to primers listed in Table The SspI restriction site in exon is also shown (B) The common ... variants are catalytically inactive (A) Three dimensional structure of Ca1 The exon encoded sequence is outlined in yellow and indicated by a thin arrow The thick arrow indicates the catalytic cleft...
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Báo cáo khoa học: Structural aspects and biological properties of the cathelicidin PMAP-36 pot
... to other cathelicidins such as SMAP-29, BMAP-27 and BMAP-28 The amidated form would further increase the charge of the dimer to +28 (see Table 1) Here we further investigated the expression of ... at the proform level of the cathelicidin [21], and this structure is likely to persist in the mature peptide Indeed, it may explain the different activity spectra and potencies observed for the ... only the highly cationic helical region, allowing us to discern the effect of the hydrophobic tail also The two peptides were synthesized in good yields, and air oxidation of PMAP-36(1–35) in the...
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Báo cáo Y học: Barley a-amylase Met53 situated at the high-affinity subsite )2 belongs to a substrate binding motif in the bfia loop 2 of the catalytic (b/a)8-barrel and is critical for activity and substrate specificity pot
... view of the global structure of the AMY2 (top) and TAA (bottom) complexes [16,17] The inhibitors are in green and the arrow indicates the nitrogen (in dark blue) that corresponds to the oxygen of ... Activ./(kcat/Km) (Uặmg)1ặsặmM)1) BS/Amyl Activ./kcat (Uặmg)1ặs) Km (s)1ặmM)1) Km (mM) kcat (s)1) kcat/Km (s)1ặmLặmg)1) Cl-PNPG7 Km (mgặmL)1) kcat (s)1) Fig Comparison of the structure of complexes of ... in the rate of accumulation of the different products, Met53Tyr and Met53Ala AMY1 thus both formed higher amounts of PNPG3 and PNPG4 than of 4-nitrophenol (Fig 4), in contrast to the ratio of these...
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How group work is used in speaking lesson of the first year major students of english at viet nam university of commerce
... understanding of using group work in the speaking lesson at VUC 1.2 Aims of the study The purpose of this study is to explore the reality of the use of group work in the speaking lesson of 1st- year English ... For the former, 83.3% of the teacher often grouped students of the same sex while only 20% of the students chose it and for the latter, group students of different sexes was the choice of 80% of ... skill for the first -year students is The number of the first -year English major students is estimated at more than 300 They come from various parts of the country Their levels of English proficiency...
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An evaluation of the material “basic english iii” for the second year non- english major students at bac giang teachers’ training college
... 2 Significance of the thesis The findings of the thesis will be useful not only to the researcher, and the course book designers but also to the teaching staff and the second year non- English ... appropriateness of the material to the aims of the course, the author has based upon the analysis of the syllabus objectives and that of the material 3.1.1 Syllabus objectives analysis The course ... Results 3.2.1 The Suitability of the Material to the Aims of the Course 31 Results from teachers’ questionnaire (Questions 1-6) about the suitability of the material to the aims of the course are...
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Motivation in learning english speaking of the second year tourism major students at tourism and foreign language department, sao do college of industry
... Almost of them came from Northern provinces of Vietnam The majority of the population is from the countryside The average score of English they got in the entrnace exam ranges from to These students ... O.K The content of the textbook was suitable for the students The kinds of the exercises in the books were designed suitably, able to develop speaking skills of the students However, most of the ... Order of lessons 0 The result of the question (questionaire for the students) revealed that the topics and the content of the textbooks attracted the students very much Among 11 t opics in the...
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DESIGNING AN END OF YEAR ENGLISH OBJECTIVE TEST FOR 1ST YEAR NON MAJOR ENGLISH STUDENTS OF THE ACADEMY OF FINANCE
... tendency: • The mode: 6.0 • The median: 6.5 • The mean: (M) The formula for the mean is: ∑ fx M= N Note: M – the mean ∑ - sum of (or add up) N – the number of the test-takers x – the raw score f – the ... for the students III.2.4.2 The item discrimination - The formula of item discrimination is: CU – CL in which: CU – the number of the correct answers of the upper half CL - the number of the correct ... year non-major English students of the Academy of Finance was designed after the relative weights of the different parts of the test were clearly pointed out Then, the information regarding the...
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