y amp y participate in check the boxes then add more activities to the list
Báo cáo y học: "In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008" potx
... careers have been indelibly shaped by his untiring enthusiasm for science and his ability to see the wood for the trees’ They continue to pursue many of the recent projects that Brian initiated Page ... up an Institute archive for laboratory books and Kristen was a prize-winning Nuffield summer scholar, investigating inflammatory signalling in adipose tissue Brian will be greatly missed by his ... was very proud His family were all well known at the Kennedy Institute, particularly his two daughters, who had spent summer vacations working at the Institute Kim was instrumental in setting up...
- 2
- 228
- 0
Báo cáo y học: "Activated protein C for H1N1 influenza? More work to do" potx
... with this dosing strategy [11,12] These data would suggest that the anti -in ammatory effects of APC vary by species, by type of infectious challenge, by means of APC dosing and by blood concentrations, ... relative to the levels achieved in this study [8] In both a human and a sheep pulmonary endotoxin study, recombinant human APC given as a continuous infusion of 24 μg/kg/hour was able to decrease the ... decrease the in ltration of neutrophils into the lung [9,10] In human septic patients and in an intravenous endotoxin challenge model in healthy human volunteers, no anti -in ammatory effects were...
- 2
- 257
- 0
Báo cáo y học: " FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease" pdf
... within KIAA1109 was missing because it was not listed in the genotyping array used in the WTCCC T1DM GWAS (Affymetrix 500K SNP array; Affymetrix Inc., Santa Clara, CA, USA) Interestingly, the ... Distinguishing T1DM genes from false positives in the top seven loci from GWASs using DER Distinguishing T1DM genes from false positives in the top seven loci from GWASs using DER Genes in the top ... control samples These methods have been integrated into molecular profiling to identify expression quantitative trait loci and to build pathways that are involved in various diseases, including type...
- 15
- 284
- 0
Báo cáo y học: "Interleukin-15 and interferon-γ participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production" docx
... importance of intercellular contacts in the pathogenic mechanisms underlying RA Indeed, the importance of these cell-cell interactions in the synthesis and release of pro-inflammatory cytokines and ... that the lymphocyte subset that becomes activated by IL-15 and is able to induce TNF production in macrophages seems to be a limiting factor NK cells induce TNF synthesis by monocytic cells Additional ... a phycoerythrin-conjugated anti-CD56 mAb (Becton Dickinson) for 20 minutes At least × 103 cells were analysed with a FACScan flow cytometer (Becton Dickinson) Quantification of cytokines in cell-free...
- 11
- 482
- 0
Báo cáo y học: "Decidual soluble factors participate in the control of HIV-1 infection at the" docx
... haematoxylin (Labonord, templars, France), mounted in permanent medium and analysed with a Nikon Eclipse 80i microscope Cytokine assays The main cytokines involved in the regulation of HIV-1 infection, ... measured every or days by detection of p24 antigen in cell culture supernatants by ELISA (Zeptometrix) Inhibition of viral production To examine the influence of the cytokine environment on the inhibition ... respectively) These results showed that dAPC were the main sources of CCL-3 and CCL-4 in the decidua Decidual soluble factors can inhibit HIV-1 infection To examine the role of the cytokine environment...
- 13
- 590
- 0
Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"
... for them to go on the roads and try to get [to clinic] The risks to personal safety were seen to vary based on the families' tribal affiliation, their location, and whether they were in the ethnic ... by involving additional investigators in reviewing the recordings and field notes and in confirming or disconfirming the codes and the subsequent themes Data triangulation was used by comparing ... comparing the information reported in the interview dialogue with clinic information recorded by the AMPATH care system about the services provided by individual clinics on each day of the crisis...
- 10
- 696
- 0
Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... biological factors known to affect pharmacokinetics are the drug transporters and the metabolizing enzymes [7,9] CYP3A, the primary subfamily of the cytochrome P450 (CYP) enzymatic system, is responsible ... who attended the Outpatient Clinic of Nephrology and treated with TAC as the primary immunosuppressant, were selected to participate in the study The protocol was approved by the Institution Ethics ... measures approach seems to be a more accurate methodology for the analysis of such data but it is more demanding in the quantity of available data In the LR analysis, the kinetic parameters were...
- 7
- 785
- 0
Báo cáo y học: "Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women"
... silver staining on polyacrylamid gel Statistical Analysis Allele frequencies were determined by gene counting and compared using the ²אtest The data was analysed using SPSS 12.0 software The association ... smoking, and BMI where appropriate Results The frequency of the C-allele was 0.24 and the genotypes were distributed according to the Hardy Weinberg Equilibrium Overall the C allele frequency was ... female subjects The effect remained significant after correcting for multiparametric testing according to Bonferoni and was seen only in subjects with a BMI below the median In addition, the non-corrected...
- 4
- 568
- 0
Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... the above findings not only provide a fundamental insight into the mechanism of CY-induced systemic cytotoxicity, particularly in the gastrointestinal system, but also propose a role for polysaccharides ... of CY in the stomach in this study was due to the activation of p53 and therefore leading to the suppression of the c-Myc/ODC pathway All these findings could explain the mechanism of CY on repression ... to G1 [27] Furthermore, c-Myc is known to induce the transcriptional activity of ODC gene [29], which is involved in polyamine synthesis It is likely that the cell cyclearresting action of CY...
- 6
- 655
- 0
Báo cáo y học: "An innovative method to evaluate the suture compliance in sealing the surgical wound lip"
... polyvildenfluoro-exafluoropropylene polymer braided indefinitely / braided indefinitely / very good very good monofilament indefinitely / NOVARFIL: polybutester polymer monofilament indefinitely ... until the remaining stain (if any) dried Such photos were then analyzed to measure the surface stain area using an image analysis system (IAS) We chose the above timing because we found by trial ... allowed the assessment of the water-proof property across the sutured line The clinical pilot study using epidermal hydrocolloid thin layer coating was found to be very effective in detecting the...
- 7
- 602
- 0
Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt
... by the addition of HU The tyrosyl radical completely decayed within 10 s of substrate addition The degree of tyrosyl radical loss was dependent on the concentration of substrate added Tyrosyl ... the radical is then rapidly passed back from the R1E subunit to the tyrosyl of the R2F subunit Subsequently, the dicysteine unit is re-reduced by an exogenous reductant and catalytic activity ... promotor, the proposed function of manganese in the transcriptional regulation of the nrd operon [35] may not be considered in the light of the results obtained in the present study Rather, the involvement...
- 14
- 872
- 0
Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... suggesting the importance of the hydrophobic NH2-end of the peptides In the same way, removing the CONH2-terminus of the peptides resulted in increased amyloid fibril formation This increase may be ... reported in our study are in keeping with these recent clinical reports, as they demonstrate the capacity of forming amyloid fibrils in vitro for all the peptides assessed, including the native ... Biochem 269) These local factors may also explain the corneal involvement in other forms of amyloidosis [26] In summary, autosomal dominant corneal diseases linked to mutations in the BIGH3 gene...
- 8
- 469
- 0
Tài liệu Báo cáo Y học: Structure of the O-polysaccharide and classification of Proteus mirabilis strain G1 in Proteus serogroup O3 potx
... analyser showed the presence of 2-amino-2-deoxygalactose and lysine The D configuration of GalA and GalN was determined by GLC of the acetylated (S)-2-butyl glycosides and the L configuration of lysine ... of the LPS of P mirabilis G1 and S1959 were sufficient to inhibit the reaction in both test systems, whereas two other cross-reactive LPS were significantly weaker inhibitors (minimal inhibitory ... 11 Zych, K., Kowalczyk, M., Knirel, Y. A & Sidorczyk, Z (2000) New serogroups of the genus Proteus consisting of Proteus penneri strains only In Genes and Proteins Underlying Microbial Urinary Tract...
- 7
- 465
- 0
Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx
... Glu207 into phytoene (the main labeled component of the lipidsoluble fraction) is systematically diminished by the addition of increasing amounts of [1-3H]2C-methyl-D -erythritol 4-phosphate Moreover, ... 2C-methyl-D -erythritol 4-phosphate into the 2,4-cyclodiphosphate in a process that displays saturation kinetics and that the product of this reaction is further processed efficiently into phytoene The ... lines denote bonds linking adjacent 13C atoms, numbers indicate the percentage molar fraction of the isotopomers The terminal moiety of phytoene is biosynthetically derived from dimethylalkyl...
- 9
- 572
- 0
Tài liệu Báo cáo Y học: Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity docx
... decrease in the activity for the 11b-hydroxylase, CYP11B1 Intriguingly, however, the 11b-hydroxylase activity of the aldosterone synthase CYP11B2 was basically unaffected whereas the 18-hydroxylation ... 6) for the remaining introns Finally, the 3¢ UTRs of the guinea pig CYP11B genes show only 42% similarity whereas the 3¢UTR of the guinea pig CYP11B2 gene shares up to 72% identity with the corresponding ... both CYP11B1 and CYP11B2 of the guinea pig are always more closely related (or equal) to the CYP11B2 sequences of other species Moreover, the guinea pig CYP11B2 is always more similar to CYP11B...
- 9
- 671
- 0
Báo cáo Y học: Interaction of the anterior fat body protein with the hexamerin receptor in the blowfly Calliphora vicina pot
... library of C vicina RNA from fat body by two-hybrid assays In addition to the conversant interactors arylphorin and LSP-2, which belong to the hexamerin family, we identified AFP as a strong interactor ... AFP-immunostaining appears only in the anterior fat body (B) In a single fat body cell of the anterior fat body, AFP immunostaining is restricted to the cytoplasm (C) AFP immunostaining can also ... of the interaction with AFP, most of the hexamerin receptor is inactivated in the anterior fat body preventing uptake of storage protein in this part of the tissue This study opens the way to...
- 7
- 408
- 0
Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... of ATP, curcumin is then able to bind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding (i.e inhibiting the ATPase in a ‘competitive ... re-arrangements within the three cytoplasmic domains need to occur They predicted that in going from E1 to E2, the nucleotide-binding domain has to ˚ move more than 25 A to come into close contact ... appear unlikely that curcumin can ‘occlude’ ATP binding, in the same way as chromium-ATP, by trapping the ATP in the binding site when the two domains come together [44], as our ATP binding data shows...
- 10
- 594
- 0
Báo cáo Y học: Expression of the V-ATPase proteolipid subunit of Acetabularia acetabulum in a VMA3-deficient strain of Saccharomyces cerevisiae and study of its complementation pdf
... AACEVAPD1–6 in yeast The whole reading frames of AACEVAPD1–6 were inserted into the site between the yeast glyceraldehyde 3-phosphate dehydrogenase (GraP DH) promoter and terminator of a pKT10DATG yeast–E ... Lincoln, NE, USA), according to the manufacturer’s instructions Expression of AACEVAPD1–6 in yeast The constructs prepared as described above were introduced into S cerevisiae YN45 strain by the ... V-ATPase complex in the vacuolar-membraneenriched fraction of the respective transformant The antibody against the subunit A in yeast V1 portion and that against the subunit a in the yeast VO portion...
- 8
- 391
- 0
Báo cáo Y học: Substrates modulate the rate-determining step for CO binding in cytochrome P450cam (CYP101) A high-pressure stopped-flow study pdf
... two-phase CO binding kinetics (substrate-free, camphane) In the following both these findings will be discussed Table Activation volume DV # and binding rate constant kon for the CO binding in cytochrome ... the heme for CO-iron bond formation appears to be ratelimiting In contrast, the CO entry into the protein and the CO migration through the protein to the heme iron favours statistically CO binding ... rate-determining when going from the ÔhypotheticalÕ protein-free heme to the protein This step is purely entropically driven The positive activation volume in P450 is therefore indicative rather for...
- 8
- 453
- 0
Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... ½Glyc dt ½13 Glc6P6 Measurement of the rate of into glycogen in the liver 13 C label incorporation Label incorporation into the glycogen C1 reflects glycogen synthesis via the direct pathway ... determine the potential labeling of the glycogen C2 and C5 resonance due to label scrambling from pyruvate carboxylase/phosphoenolpyruvate carboxykinase activity (Ôpyruvate recyclingÕ), the intensity ... possible due to activity of the indirect pathway of glycogen synthesis In addition, this study reports for the first time the simultaneous detection of increased signal intensity for the glycogen C2–C5...
- 9
- 465
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008