worn protocol of surgical team randomized controlled trials and meta analyses
Báo cáo y học: " Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies" ppt
... shortage of randomized controlled trials on this topic is a limitation, and larger randomized controlled trials are needed to better understand the role of CYC in the care of these patients In our meta- analysis, ... age and height The methodological features of all randomized clinical trials most relevant to the prevention of bias (including the Jadad criteria of randomization, blinding and completeness of ... pooled analysis of the treatment arms of the randomized clinical trials and of the observational studies suggested that both the FVC and DLCO predicted values improved after 12 months of therapy,...
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Báo cáo y học: " The study protocol of the Norwegian randomized controlled trial of electroconvulsive therapy in treatment resistant depression in bipolar disorder" doc
... medication in contradiction to the study protocol is t 1/2 for patients randomized to ECT and a varying time for patients randomized to treatment as usual Randomized treatment Phase - treatment ... be signed and dated before any study data collection procedures begin A synopsis of the study protocol is given as additional file Discussion This study protocol presents a randomized controlled ... Acknowledgements The original concept of the study and the first drafts of the protocol were written by late professor Dag Neckelmann Professor Neckelmann also recruited study centres and investigators to participate...
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Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx
... amounts of data about the drug, and has eliminated the least promising agents before the design process for randomized controlled trials occurs Design bias Design bias, on the other hand, occurs ... Accept trial VERSUS Randomization Decision Node Decline trial Expected outcomes of usual care Personal, societal interest and selfinterest Presentation of a randomized trial protocol for consideration ... Community-equipoise and the ethics of randomized clinical trials Bioethics 1995, 9:127-148 Djulbegovic B: Acknowledgement of uncertainty: a fundamental means to ensure scientific and ethical validity...
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Báo cáo y học: "Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis" pps
... will be an upsurge in randomized controlled trials investigating novel biological agents and small molecules in terms of their safety and efficacy Thus, sensitive, validated and reliable measurements ... three observers (OB1 t0, OB2 and OB3) Table Estimates of the variance components (between and within patients) and of the intraclass correlations (single rater and average of raters) Cell type Intra-observer ... pivotal The use of computerized or digital image analysis (DIA) has greatly facilitated the evaluation of ST The major advantage of DIA is standardization of image acquisition and processing,...
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Báo cáo y học: "Several clinical interests regarding lung volume reduction surgery for severe emphysema: meta-analysis and systematic review of randomized controlled trials." docx
... meta- analysis and systematic review of randomized controlled trials (RCTs) Methods: Eight RCTs published from 1999 to 2010 were identified and synthesized to compare the efficacy and safety of ... surgery for severe emphysema: meta- analysis and systematic review of randomized controlled trials Wei Huang, 1Wen R Wang, 1Bo Deng, 1You Q Tan, 1Guang Y Jiang, Hai Jing Zhou and 1Yong He 1 Thoracic ... insufficient published Randomized Clinical Trials (RCTs) evaluating surgical risks and long term sequels [9-12] Besides, there are controversial points regarding the efficacy and safety of two approaches...
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báo cáo khoa học: "Improved delivery of cardiovascular care (IDOCC) through outreach facilitation: study protocol and implementation details of a cluster randomized controlled trial in primary care" doc
... with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials BMJ 2007, 334:786 Donner A, Klar N: Design and Analysis of Cluster Randomization Trials ... Design and analysis of stepped wedge cluster randomized trials Contemp Clin Trials 2007, 28:182-191 49 Crabtree BF, Miller WL: Using Codes and Code Manuals: A Template Organizing Style of Interpretation ... Making trials matter: pragmatic and explanatory trials and the problem of applicability Trials 2009, 10:37 51 Tunis SR, Stryer DB, Clancy CM: Practical clinical trials: increasing the value of clinical...
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báo cáo khoa học: "Design, rationale, and baseline characteristics of a cluster randomized controlled trial of pay for performance for hypertension treatment: study protocol" ppt
... Kingdom (UK) and the US [7,8] However, research evidence of effectiveness of pay-for-performance programs, particularly randomized trials, is limited [9,10] Using a cluster randomized controlled ... Petersen et al.: Design, rationale, and baseline characteristics of a cluster randomized controlled trial of pay for performance for hypertension treatment: study protocol Implementation Science ... the control of the provider Thus, a combined approach potentially capitalizes upon the advantages and complementary nature of both types of quality -of- care measures [9] The design of our trial...
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Báo cáo y học: " Study protocol for a group randomized controlled trial of a classroom-based intervention aimed at preventing early risk factors for drug abuse: integrating effectiveness and implementation research" ppt
... shows the random assignment and design status of a cohort of students from initial random assignment prior to the start of first grade to the end of the first grade year WD = students randomized ... Science and Methodology Group: Methods for testing theory and evaluating impact in randomized field trials: intent-to-treat analyses for integrating the perspectives of person, place, and time ... to create two teams to support the effectiveness trial and the goal of sustaining and scaling-up practices in the school system the Core Team and the Schools Committee The Core Team comprised...
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Báo cáo y học: " Study designs of randomized controlled trials not based on Chinese medicine theory are improper" ppt
... searched and analyzed randomized controlled trials of ginseng in PubMed The inclusion criteria were single herb ginseng trials with a sample size of ≥20 We selected trials of single herb ginseng ... arrest bleeding and removes stagnant Xue 14 15 16 Conclusion Our analysis of 19 randomized controlled clinical trials of single herb ginseng shows that all the trials with both negative and positive ... Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996, 17:1-12 Ellis JM, Reddy P: Effects of Panax ginseng on quality of life Ann Pharmacother...
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Báo cáo y học: "Are acupoints specific for diseases? A systematic review of the randomized controlled trials with sham acupuncture controls" pps
... acupuncture) and feixueweizhen (non-acupoint acupuncture) and the search result was limited to the reports of human studies published between 1998 and 2009 Inclusion criteria The randomized controlled trials ... acupuncture; and no random allocation Trial quality Of the 12 included trials, six (50%) had a low risk of bias, while five trails (41.7%) had an unclear risk of bias, and one trial had a high risk of ... acupuncture treatments in the randomized controlled trials were based on traditional Chinese acupuncture principles Six out of the 12 trials had a standardized treatment protocol with the same acupoints...
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Báo cáo y học: "Are acupoints specific for diseases? A systematic review of the randomized controlled trials with sham acupuncture controls" pdf
... thank the editorial team of Chinese Medicine for their input and advice Author details Yale Center for Medical Informatics and Departments of Anesthesiology and Genetics, School of Medicine, Computer ... question of how much information needs to be provided for describing different types of CM data for reproducibility, quality, and safety purposes In the fields of genomics and proteomics, standards ... human body and organs based on Chinese philosophical ideas of “yin-yang” and “five-elements” They are aware of the efficacy of the herb, Huperzia serrata (HS), in aging disorders, and interpret...
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Báo cáo y học: "Effects of moxibustion for constipation treatment: a systematic review of randomized controlled trials" pptx
... Page of Authors’ contributions MSL and EE designed the study and interpreted the data TYC and JEP searched and selected the trials, and extracted, analyzed the data MSL drafted the manuscript and ... effects of publication bias and location bias on systematic reviews and meta- analyses may still have played a role in the present review [20-22] Further limitations include the paucity and often ... al.: Effects of moxibustion for constipation treatment: a systematic review of randomized controlled trials Chinese Medicine 2010 5:28 Submit your next manuscript to BioMed Central and take full...
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Báo cáo y học: "Delta inflation: a bias in the design of randomized controlled trials in critical care medicine" ppsx
... in randomized controlled trials • In the design of randomized controlled trials, investigators must determine a realistic estimate of the effect size (delta) of the therapy on an outcome of interest ... research and practice Materials and methods One author (SKA) performed a search of the tables of contents of five high-impact medical journals (BMJ, New England Journal of Medicine, Journal of the ... trial design, is common in randomized controlled trials of mortality in critical care medicine Reliable methods for predicting delta during study design and better reporting of the basis for these...
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Báo cáo y học: "A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patient" ppt
... sepsis, and mortality remain unchanged Other interventions are needed The objective of this paper is to systematically review the randomized controlled trials (RCTs) that investigate the effect of ... placebo or standard therapy on infection, MOF, and mortality in trauma patients Materials and methods Search Studies were found via computerized searches of the MEDLINE and EMBASE databases and the ... with five trials studying over 100 patients [19-23] Of the smaller trials, six were pilot studies [14,24-27] Three of the trials were phase II trials primarily powered to test dosage and safety,...
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Báo cáo y học: "Effect of histamine-2-receptor antagonists versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients: a meta-analysis of 10 randomized controlled trials" pot
... Rennie D, Stroup DF: Improving the quality of reports of meta- analyses of randomised controlled trials: the QUOROM statement Quality of Reporting of Meta- analyses Lancet 1999, 354:1896-1900 Prakash ... severity of disease, intervention dosage, measurements, and management This work was performed in accordance with the Quality of Reporting of Meta- analyses (QUOROM) guidelines for meta- analysis of randomized ... assessment of the trials Treatment assignments were the typical method of ‘randomization’ across studies in this meta- analysis Randomized treatment allocation sequences were generated in six trials...
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Báo cáo y học: "The acute management of trauma hemorrhage: a systematic review of randomized controlled trials" ppsx
... Page of 10 the methodology of the trials and to assess a broad range of outcomes focusing on bleeding and transfusion requirements, correction of coagulopathy and mortality generation of random ... groups of patients examined, intervention and comparator arms and main clinical outcomes of each study Additional file 3: Quality assessment of included published randomized controlled trials ... acquisition of data, and revision of the article CH and KB contributed to study conception and design, and revision of the article SS contributed to study conception and design, acquisition of data,...
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Báo cáo y học: " Implementation research design: integrating participatory action research into randomized controlled trials" potx
... work practices, and on understanding the effect of the research or intervention as part of the research process It explicitly calls for making sense of the impact of change, and refining actions ... final presentation of results and discussion of their implications; reciprocal transfer of expertise; shared decision making power; mutual ownership of the processes and products of the research ... The timing of these reflective cycles and the timing of endpoint measurement could be modified based on these discussions As part of the analysis of the results of the study, the themes of the reflections...
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Báo cáo y học: " Comparative efficacy of the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for early onset chronic depression: design and rationale of a multisite randomized controlled trial" ppt
... design of this multisite, observer blind, prospective, parallel-group, randomized, controlled trial with an active control and two treatment phases (acute and continuation) A stratified block randomization ... worsening of symptoms and transient risk of suicidality at the beginning of therapy (due to breaking out of avoidance behavior), but was rarely observed [28] Therapist training and monitoring of adherence ... a separate team of independent raters trained to reliability will randomly evaluate several of the tapes from early, middle, and late therapy phase of each treatment for adherence and therapist...
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