wnt catenin signaling pathway in the adrenal cortex and in adrenocortical tumors
Tài liệu Báo cáo khoa học: a-Defensins increase lung fibroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc
Ngày tải lên :
18/02/2014, 06:20
... b -catenin, suggesting that a-defensins activate the b -catenin signaling pathway We then studied the role of the b -catenin signaling pathway in a-defensininduced increases in the proliferation and ... fibronectin, endothelin, surviving, etc We have obtained data indicating that a-defensin-1 and a-defensins-2 induce an increase in the protein content of cyclin D and that quercetin inhibits the a-defensininduced ... b -catenin pathway [31] The results obtained in the present study indicate that activation of the b -catenin signaling pathway mediates a-defensin-induced increases in cell proliferation and collagen-I...
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Báo cáo sinh học: "Nuclear localization is required for Dishevelled function in Wnt/ -catenin signaling" pps
Ngày tải lên :
06/08/2014, 18:21
... protein, promotes RhoA activation by Dsh [9], whereas Frodo, another Dsh-binding protein, is required for Wnt/  -catenin signaling in the nucleus [14] These interactions may take place in various ... requires the DEP domain [7,18,19] The DIX domain is essential for the Wnt/  -catenin pathway, whereas the DEP domain plays a role in the planar cell polarity pathway [7,8,16,18,20,21] Thus, the specific ... DAPI staining of nuclei in the same field as in (c) Nuclear staining is marked by arrowheads (c,d) (e,f) The Ds3 construct, lacking amino acids 334-381, remained in the cytoplasm in the (e) absence...
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Báo cáo y học: "κ The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation" ppsx
Ngày tải lên :
09/08/2014, 06:23
... cell signaling pathways regulate survival and activation in the periphery and in the thymus, the immune system must balance antigen presentation and proinflammatory outcomes in the periphery in ... participate through the canonical pathway as ‘central mediators of the immune response’ [13] These include cytokines, adhesion and costimulatory molecules, and genes regulating the oxidative burst ... production The pathway is described in the text Deficient strains marked in red display defects in thymic organization and negative selection with increased numbers of peripheral autoreactive T cells The...
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
Ngày tải lên :
21/02/2014, 01:21
... Suppression of urokinase expression and Invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun – dependent signaling pathways J Biol Chem ... (1999) The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation Endocrinology ... with the indicated NAMI-A concentration (NAMI-A) Cells were then stimulated for h with medium M199 containing either 100 nM PMA (B) or 10% fetal bovine serum (C), in the presence of the indicated...
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Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats potx
Ngày tải lên :
10/08/2014, 05:21
... hrs after the administration of morning dose of insulin and curcumin The results were expressed in terms of milligram per decilitre of blood Total Dopamine receptor binding studies in the cerebellum ... receptor binding parameters were determined using Scatchard analysis [32] The specific binding was deter- Page of 11 mined by subtracting non-specific binding from the total The binding parameters, ... activity in diabetic mice, but not in non diabetic mice [46] In our study, curcumin and insulin increased the dopamine D1 receptor expression levels in the cerebellum, which suggests that the curcumin...
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CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes ppt
Ngày tải lên :
12/08/2014, 15:23
... useful in blocking the JAK/STAT-mediated proinflammatory responses including IL-6-mediated signaling in RA The MAPKs play an important role in the induction of pro-inflammatory cytokines in rheumatoid ... activation of the JAK/STAT -signaling pathway, but also to the induction of MAPK [17] The relationship between the JAK/STAT pathway and the Ras/MAPK pathway is complex and these pathways cross ... cascades and a critical role of the JAK/STAT pathway in the oncostatin M-mediated IL-6 synthesis Furthermore, we showed that interference of the JAK/STAT pathway using CP690,550, a JAK kinase inhibitor,...
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Multi strategies for control of motility via mora signaling pathway in pseudomonas putida
Ngày tải lên :
09/09/2015, 17:53
... bidomain proteins include GcpC and GcpF involved in the cellulose synthesis and YciR, which regulates the transcription of CgsD, a curli and cellulose regulator In the first two instances, in vivo ... in bacterial behavior and physiological studies, Adler, Koshland and many other researchers had uncovered new and distinctive signaling systems (Aravind et al., 2010) The mainstream view in the ... quorum sensing, two-component phosphorelays and second messenger signaling Genomic and signaling studies on new models led to the finding that signaling proteins are typically modular in nature...
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Genetic and molecular dissection of DELLA related GA signaling pathway in regulating arabidopsis seed germination
Ngày tải lên :
13/09/2015, 20:31
... might be involved in the induction of flowering by GA The expression of MYB33 is induced by GA in the shoot apex during the induction of flowering In addition, MYB33 binds to the promoter of the floral ... also appear in armadillo and β -catenin proteins involved in Wnt signaling in Drosophila and vertebrates (Dale, 1998; Willert and Nusse, 1998) These data indicate that GA may stimulate the expression ... overexpressed the SHI protein (Friborg et al., 1999) SHI protein contains a RING fingerclass zinc finger motif, which indicates that it may play a potential role in protein-protein interaction involved in...
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Regulation of chondrocyte differentiation potential involvement of wnt ß catenin signaling
Ngày tải lên :
16/10/2015, 15:38
... tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the knee, the ankle, bronchial tubes and the intervertebral ... frizzled-related proteins (sFRPs) and Dickkopf sFRP exert their inhibitory effect by binding to the Wnt ligands, preventing them from binding to the receptors, LRP-5 and -6 receptors Dickkopf exert their action ... (Figure 5B and 5C) clearly showed the reduction in β -catenin levels at higher seeding and in the presence of curcumin 40 Immunohistochemical staining for the detection of ß -catenin proteins (Figure...
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Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes docx
Ngày tải lên :
08/03/2014, 09:20
... activity of the enzyme, i.e substrate docking and binding, the active site including the heme-binding domain and redox partner binding domain [10] Baboon and human CYP17 are excellent candidates ... differences in the primary sequences of human and baboon CYP17 lie in the predicted substrate access and binding regions which include helices F and G and the F-G loop The differences between the two ... activities in all mammals, including man There appears to be only one form of CYP17, encoded by a single gene, expressed in both the adrenals and gonads [5] Mutations in the human gene result in the...
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Regulation of WNT beta catenin pathway in the disease progression of osteosarcoma
Ngày tải lên :
11/09/2015, 10:18
... of the 19 Wnt ligands, including Wnt 1, Wnt 2, Wnt 3, Wnt 3a, Wnt and Wnt 8b, have been reported to activate the canonical Wnt/ β -catenin pathway while Wnt 4, Wnt 5a and Wnt 11 can activate the ... directly squelching Wnt ligands, thus preventing FZD -Wnt binding, while the Dickkopf (DKK) family inhibits Wnt signaling by binding to LRP and Kremen receptors, and sterically hindering Wnt interaction ... protein; LRP: Low density lipoprotein receptor-related protein; WIFs: Wnt inhibitory factor-1 On the cell surface: Initiation of Wnt/ β -catenin signaling cascade Canonical Wnt/ β -catenin signaling pathway...
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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
Ngày tải lên :
16/03/2014, 11:20
... to the inhibitor were slight, amounting to a modest reduction in amplitude and a delay in the rst oscillatory peak It is interesting to speculate on the failure of the inhibitor to eliminate the ... a is the ratio of apparent dissociation constants for binding GST-IjBa in the presence and absence of ATP, and the value of a indicates whether the binding of one substrate (ATP) affects the afnity ... (see Fig 3H in [52]) and with comparable frequency to the original model (see Fig 3D) These ndings indicate that substituting previously reported kinetic data in the original model with the experimental...
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Báo cáo khoa học: The gp130⁄STAT3 signaling pathway mediates b-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes ppt
Ngày tải lên :
23/03/2014, 07:20
... activate the mitogen-activated protein kinase (MAPK) signaling pathway [15,16] On the other hand, the MAPK pathway has been shown to have an important role in the regulation of STAT3 signaling [17,18] ... production in the NRCM culture medium (Fig 4C) The involvement of STAT3 in b-AR-induced ANF expression was further supported by investigation of the instant upstream signaling of STAT3, in that both inhibition ... regulated kinase (ERK)1 ⁄ but not p38 or Jun N-terminal kinase (JNK) played an important role in b-AR-induced STAT3 activation We further investigated the signaling pathway of b-ARinduced STAT3...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
Ngày tải lên :
08/08/2014, 21:20
... JK, JP, and LN and KN aiding in obtaining biopsy and blood samples NR and LH were involved in enrolling and consenting patients JH drafted the manuscript All authors read and approved the final ... increase in FGF and ERK pathways was closely associated with the severity of the disease and endoscopic findings in the EoE patients; further patients will help determine if FGF and other immune indicators ... eotaxin via the ERK signaling pathway The data may be used in the possible diagnosis and prognosis of EoE In addition, our results could provide an explanation for increased eosinophil numbers, and...
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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
Ngày tải lên :
11/08/2014, 08:22
... participated in the design of the study, its coordination and drafted the manuscript BS conceived of the study, participated in the design and coordination of the study, and drafted the manuscript ... vs h Furthermore, AS101 treatment attenuated p50 subunit DNA-binding abilities in the iNOS promoter Furthermore, the secretion of the inflammatory cytokine IL-6, regulated by the NFkB pathway, ... Thus, the effect of AS101 in our experimental system may be mediated by inhibition of two steps in the NFB pathway by modifying specific cysteine residues in IKKa and in the p50-subunit resulting...
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Báo cáo y học: " Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method" pdf
Ngày tải lên :
13/08/2014, 16:21
... been used and extended to examine the effect of Apc mutations on the wnt signaling pathway [10], cross-talk with the ERK pathway [11], and the interaction of axin2 proteins with the wnt pathway ... β -catenin and axin with transient wnt signaling Solid line: the original Lee-Heinrich model Other lines: kG parameter was varied Long dashed line: kG = 0.1 min-1 Short dashed line: kG = 0.5 min-1 ... phosphorylations Initially, I examined these two effects without including the β -catenin degradation step (step 20 in Figure 1) in computing β -catenin concentration, and assumed that catenin non-GSK3β...
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Signaling pathway inhibitor library screening reveals b catenin TCF4 as a novel telomerase regulator in cancer cell lines
Ngày tải lên :
02/10/2015, 17:14
... cancer therapy List of Wnt inhibitors examined in the screen List of EGFR inhibitors examined in the screen List of JAK/STAT inhibitors examined in the screen List of primers used in the project ... (containing telomere template and the pseudoknot domain) and the other region is between nucleotides 241 to 330 (containing the box H/ACA domain and CR4-CR5 domain) (Mitchell et al 2000) In vitro ... also found to be part of the Wnt/ β -catenin signaling pathway Initial documentation of a link between catenin and TERT came from studies of the multi-potent stem cells in the hair follicle Expression...
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Chemical modifications of DNA activate the cGAS STING signaling pathway even in the presence of the cytosolic exonuclease TREX1
Ngày tải lên :
26/11/2015, 10:17
... bind to the binding sites of the specific target protein and not to unspecific binding sites of the membrane After blocking, the proteins of interest were labeled with an antibody Thereby, either ... ! 6! Introduction Figure 2: RLR signaling (Bruns and Hovarth, 2012) Upon ligand binding, RIG-I and MDA5 recruit the adaptor protein IPS-1, which activates TANK-binding kinase (TBK1) and inhibitor ... deprotonated reduced flavin adenine dinucleotide which then donates an electron to the pyrimidine dimer, resulting in the splitting of the dimer into two monomeric units (Cook, 1970; Sutherland, 1974; Kim...
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The ubiquitin-proteasome pathway in cell cycle control
Ngày tải lên :
25/10/2013, 21:20
... contain an F-box motif near their amino termini and one of several protein-protein interaction motifs carboxy ter- The ubiquitin-proteasome pathway in cell cycle control 157 minal to the F-box In ... ubiquitin addition, the predominant linkage for protein turnover is through lysine 48 (Chen and Pickart 1990) Once chains of significant length have been produced, the Fig The ubiquitin proteasome pathway ... at either end (Pickart and Cohen 2004) The regulatory particle is responsible for recognizing ubiquitylated targets, removing the polyubiquitin chains for recycling of ubiquitin, unfolding the...
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Tài liệu Báo cáo khoa học: Implication of the glutamine synthetase ⁄glutamate synthase pathway in conditioning the amino acid metabolism in bundle sheath and mesophyll cells of maize leaves doc
Ngày tải lên :
18/02/2014, 18:20
... compounds in the phloem exudates, amounting to 51% of the total amino acids in the light and 56% in the dark (Fig 7A) The total amount of alanine, serine and glycine was reduced from 33% in the light ... light to 25% in the dark (Fig 7A) Glutamine and asparagine were the major amino acids in the xylem sap in both the light (63% of the total amino acids) and dark (60%) (Fig 7B) The amino acid percentage ... molecular signalling in the expression of the genes and encoded enzymes involved in nitrate assimilation and amino acid synthesis [7] The stalk and leaves below and above the ear act as the source...
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