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Báo cáo khoa học: Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate doc
Ngày tải lên :
07/03/2014, 05:20
... CHO cells and mutant CHO cells with aberrant ERAD activity (A,B) Intoxication with LT IIb (A) or saporin (B) was monitored in mutant cell lines with accelerated ERAD activity (clones 23 and 24) ... cells that were shocked with dimethylsulfoxide before the addition of saporin and for cells shocked with dimethylsulfoxide after a °C toxin incubation (Figs 2B and 3A) Sandvig et al [28] have ... media (Gibco BRL, Grand Island, NY, USA) supplemented with 10% fetal bovine serum (Atlanta Biologicals, Lawrenceville, GA, USA) and penicillin ⁄ streptomycin (Gibco BRL) LB6 and LB6 clone 19 cells...
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Ceylon; an Account of the Island Physical, Historical, and Topographical with Notices of Its Natural History, Antiquities and Productions, Volume doc
Ngày tải lên :
07/03/2014, 14:20
... hills, they arrive at the beach laden with sand and alluvium, and at their junction with the ocean being met transversely by the gulf-streams, the sand and soil with which CHAPTER I 44 they are laden, ... the Red Sea and the Persian Gulf met those from China and the Oriental Archipelago; thus effecting an exchange of merchandise from East and West; and discovering that the Arabian and Persian ... them The rich and black soil to the south of the Nilgherries presents a strong contrast to the red and sandy earth of the opposite coast; and both in the flora and fauna of the island there are...
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Báo cáo Y học: Two GPX-like proteins from Lycopersicon esculentum and Helianthus annuus are antioxidant enzymes with phospholipid hydroperoxide glutathione peroxidase and thioredoxin peroxidase activities pptx
Ngày tải lên :
08/03/2014, 22:20
... Dual activities for plant antioxidant enzymes (Eur J Biochem 269) 2415 MATERIALS AND METHODS Plant materials and chemicals Tomato (Lycopersicon esculentum Mill cv VFN8) and sunflower plants (Helianthus ... transformed with pET15b vector alone (data not shown) Enzymatic properties of GPXle1 and GPXha2 The glutathione peroxidase activities of GPXle1 and GPXha2 towards several physiological and nonphysiological ... for plant antioxidant enzymes (Eur J Biochem 269) 2417 Fig Analysis of GPXle1- and GPXha2-catalyzed reduction of t-butyl hydroperoxide (100 lM) with different concentrations of GSH (A) and thioredoxin...
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Báo cáo khoa học: Contribution of a central proline in model amphipathic a-helical peptides to self-association, interaction with phospholipids, and antimicrobial mode of action ppt
Ngày tải lên :
23/03/2014, 10:21
... membrane binding, and membrane-disrupting activity of antimicrobial peptides, we generated amphipathic a-helical peptides with different chain lengths (17, 21, and 25 residues) and containing or ... by PFPs and PCPs It is widely believed that many membrane-active antimicrobial peptides pass through the peptidoglycan layer and then kill the target micro-organism by interacting with and permeabilizing ... for understanding the mechanism of permeabilization and improving antimicrobial selectivity The interaction of PCPs with negatively charged membranes is thought to confer selective antimicrobial...
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Báo cáo hóa học: " A predominance of R5-like HIV genotypes in vaginal secretions is associated with elevated plasma HIV-1 RNA levels and the absence of anti-retroviral therapy" docx
Ngày tải lên :
20/06/2014, 01:20
... identify viral and clinical factors associated with vaginal X4- or R5-like genotypes, we evaluated plasma and vaginal viral levels, ART use, and CD4+ T lymphoctye counts using Chi-square and Fisher's ... acid (EDTA) anticoagulant tubes, and plasma aliquots were stored frozen at -80°C HIV contained in plasma and vaginal secretion supernatant samples was collected by centrifugation and virion-associated ... swabs and subsequently eluted in phosphatebuffered solution Supernatant and cell fractions were stored at -80°C within three hours of collection Samples were not collected during menses, and overtly...
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báo cáo hóa học:"Early initiation of antiretroviral therapy results in decreased morbidity and mortality among patients with TB and HIV" ppt
Ngày tải lên :
20/06/2014, 08:20
... study size is small and limited by non-contemporaneous treatment approaches, this study suggests that immediate treatment with antiretroviral therapy in patients with TB and advanced HIV markedly ... cells/mm3 During this time period, all TB patients received antituberculosis medications as directly observed therapy and in accordance with standard Category (CAT-1) regimens Group I was made up of ... death The baseline demographic and clinical characteristics of subjects in Groups I and II are provided in Table The mean age in Group I and Group II was 33.3 ± 7.9 and 37.8 ± 6.3 respectively All...
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![Báo cáo hóa học: " New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and nanosized liposomes" pptx](https://media.store123doc.com/images/document/2014_06/21/medium_gkb1403295602.jpg)
Báo cáo hóa học: " New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and nanosized liposomes" pptx
Ngày tải lên :
21/06/2014, 03:20
... fluorescence of compounds and can be used to monitor interactions with DNA and compounds behaviour when encapsulated in liposomes Both compounds and were tested for their interaction with natural salmon ... cb/[DNA] and cb and cf the concentrations of bound and free compound, respectively, calculated by Table Maximum absorption (labs) and emission (lem) wavelengths, molar absorption coefficients (ε) and ... The absorption and fluorescence properties of compounds and were studied in several solvents (Table 1) The normalized fluorescence spectra of compounds and are shown in Figures and The fluorescence...
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Báo cáo hóa học: " Research Article Existence and Stability of Antiperiodic Solution for a Class of Generalized Neural Networks with Impulses and Arbitrary Delays on Time Scales" ppt
Ngày tải lên :
21/06/2014, 07:20
... 2004 Y K Li and Z Xing, “Existence and global exponential stability of periodic solution of CNNs with impulses,” Chaos, Solitons and Fractals, vol 33, no 5, pp 1686–1693, 2007 Y K Li and L Lu, ... with multiple delays,” Neurocomputing, vol 73, no 1-3, pp 213–218, 2009 J Zhang and Z Gui, “Existence and stability of periodic solutions of high-order Hopfield neural networks with impulses and ... equations with anti- periodic boundary conditions,” Nonlinear Times and Digest, vol 2, no 1, pp 83–94, 1995 15 A R Aftabizadeh, S Aizicovici, and N H Pavel, “On a class of second-order anti- periodic...
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Báo cáo y học: "A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis" potx
Ngày tải lên :
09/08/2014, 01:23
... SE+ and anti- CCP Ab+ 16 66.8 SE- and IgA-RF- 12 67 1.0 SE+ and IgA-RF- 20 38 2.9 1.3–6.7 SE- and IgA-RF+ 11 12.3 3.6–41.7 SE+ and IgA-RF+ 14 39.2 7.9–193.9 SE- and IgM-RF- 18 71 1.0 SE+ and IgM-RF- ... disease and in controls Combinations of variables Patients (no.) Controls (no.) OR SE- and anti- CCP Ab- 17 71 1.0 SE+ and anti- CCP Ab- 18 39 1.9 0.9–4.2 25.1 2.8–222.2 8.3–539.4 SE- and 95%CI anti- CCP ... predicted the development of RA, with the highest predictive value for anti- CCP antibodies, indicating that citrullination and production of anti- CCP antibodies and RF are early processes in the...
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Báo cáo y học: "Osteogenic protein 1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: relationship with disease and levels of hyaluronan and antigenic keratan sulfate" ppt
Ngày tải lên :
09/08/2014, 08:22
... Nonreduced conditions with anti- pro-osteogenic protein (OP-1) antibody (R2854) (b) Nonreduced conditions with anti- mature OP-1 antibody (MAB354) (c) Reduced gel with anti- mature OP-1 antibody (MAB354) ... incubated with primary antibody at the manufacturers' suggested dilutions in 1:250 TBS/Tween for R2854 and MAB354 anti- OP-1 antibodies Secondary antibodies were used, either ImmunoPure goat anti- mouse ... [19] For the sandwich ELISA, two anti- OP-1 antibodies, sc-9305 and 1B12, were used Briefly, 96-well plates (Nalge Nunc, Rochester, NY, USA) were coated with the polyclonal anti- OP-1 antibody sc-9305...
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Báo cáo khoa học: " Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy" pps
Ngày tải lên :
09/08/2014, 10:21
... overall and cancer-specific survival was observed (Figure and 2) The 1-year OS in the matched HIV-seropositive and -seronegative cohort was 90 % and 100 %, and the 5year OS was 70 % and 69 %, ... HAART and stage and age matched HIVseronegative patients Patients and methods Patients Ninety-one patients presenting with histologically proven invasive carcinoma of the anal canal between 1988 and ... HIV-seropositive and HIV-seronegative patients and whether the outcome in respect of treatment toxicity and survival after standard curative 3-D conformal RT with or without chemotherapy (CT) of invasive...
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Báo cáo y học: "Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study" pps
Ngày tải lên :
09/08/2014, 10:21
... coated antigen in the absence of NaSCN had been eluted from the antigen Statistical analysis Levels of autoantibodies, antibodies and immunohistochemical scores within patients were compared with ... ACPA-IgG autoantibodies with low avidity (a) Low avidity of antibodies against anti- cyclic citrullinated of ACPA-IgG autoantibodies with low avidity protein (ACPA)-IgG (solid lines) before and after ... ACPA-IgG and RF-IgM in comparison with antibody levels against control antigens, respectively RL-IgG and PC-IgM (selected because of the high prevalence of seropositivity in the Dutch population), and...
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Báo cáo y học: "Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study" ppt
Ngày tải lên :
09/08/2014, 10:23
... macrophages and has immune stimulatory and pro-inflammatory properties [15,16] We have focused on the role of antibodies against PC (anti- PCs) and recently demonstrated that high anti- PC IgM ... internal standard and was tested on every plate The plateau of antibody binding was reached with the antigen concentration of 10 μg/mL An F96 microtiter polysorp plate, therefore, was coated with PC-BSA ... to standardize [15,50] Instead of aOxLDLs, we have focused on anti- PCs, and one major finding is that anti- PC levels of IgM and IgA subclasses were raised after a vegan diet Low levels of anti- PC...
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Báo cáo y học: "Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis" docx
Ngày tải lên :
09/08/2014, 10:23
... alter this vigorous antigen-specific antibody production on day Treatment of mice with CTLA-4Ig resulted in downregulation of anti- GPI antibody production, whereas anti- TNF-α and anti- IL-6 mAb therapy ... treatments tend to alter anti- GPI antibody production Anti- GPI antibodies have potent arthritogenic capacity in K/ B × N mice However, anti- GPI antibodies from mice with GPI-induced arthritis ... (TNF)-α mAb; (b) anti- IFN-γ mAb or anti- IL-12 mAb; (c) cytotoxic T-lymphocyte antigen immunoglobulin (CTLA-4Ig; on days and 12); (d) CTLA-4Ig (on days 12 and 16); and (e) or anti- IL-6 mAb just...
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Báo cáo y học: "Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study" pdf
Ngày tải lên :
09/08/2014, 13:22
... correlated with disease duration (r = -0.30, p = 0.008), in contrast to FM Relationship between body composition and serum lipids as well as anti- PC antibodies and inflammatory markers Patients with ... atherosclerosis in patients with established hypertension [10] Further, low levels of anti- PC antibodies are associated with an increased risk of development of CVD [11] In RA, anti- PC have not been ... associated with increased fat mass (FM) and thus, with little or no weight loss, also with a maintained body mass index (BMI) [15,16] This condition has been named 'rheumatoid cachexia' [13] and is...
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Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity pps
Ngày tải lên :
10/08/2014, 05:21
... infected with influenza virus A/WSN/33 (MOI = 5) and incubated with or without μM BPR1P0034 in the adsorption and postinfection stages The cells were fixed at or h p.i and reacted with primary anti- NP ... coverslips were incubated with or without BPR1P0034 during viral adsorption and after infection The cells were fixed for the indicated times and reacted with primary anti- NP antibody and Alexa-Fluor-488-labeled ... MDCK cells infected with virus and treated with or without BPR1P0034 Total RNA was extracted and subjected to quantitative PCR analysis in the infected MDCK cells at 3, 6, and hours post adsorption...
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Báo cáo y học: "Sustained remission of rheumatoid arthritis with a specific serotonin reuptake inhibitor antidepressant: a case report and review of the literature" ppsx
Ngày tải lên :
11/08/2014, 00:23
... have anti- inflammatory and analgesic properties Antidepressants with a dual action (inhibiting serotonin and norepinephrine reuptake) have been shown to have Page of analgesic properties and are ... it was decided gradually Page of to taper and stop his antidepressants On stopping the antidepressants, his joint pain and stiffness started to worsen, and in two weeks, at the patient’s request, ... Psychosomatics 2002, 43:36-41 Baune BT, Eyre H: Anti- inflammatory effects of antidepressant and atypical antipsychotic medication for the treatment of major depression and comorbid arthritis: a case report...
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Báo cáo y học: "Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant" ppt
Ngày tải lên :
11/08/2014, 10:23
... specific and sensitive for the detection of rhesus macaque IgM, IgA, IgE, IgG4 and total IgG Low cross reactivity was seen with the anti- IgG1 and IgG2 antibodies to purified human IgG2 and IgG1 ... IgM, IgA, IgG1 and IgG4 antibody titers HPV L1-VLP specific IgM, IgA, IgG1 and IgG4 antibody titers Sera from rhesus macaques immunized at week 0, and 24 with µg each of HPV 6, 11, 16 and 18 L1-VLPs ... HPV 6, 11, 16 and 18 L1 VLP-specific total IgG antibody titers HPV 6, 11, 16 and 18 L1 VLP-specific total IgG antibody titers Sera from rhesus macaques immunized at week 0, and 24 with µg each...
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Báo cáo y học: " Prevalence of metabolic syndrome in patients with schizophrenia, and metabolic changes after 3 months of treatment with antipsychotics results from a German observational study" doc
Ngày tải lên :
11/08/2014, 16:20
... were inand outpatients (≥ 18 years) diagnosed with schizophrenia according to ICD-10 criteria, who either entered the study untreated and were initiated on antipsychotic therapy, or were on antipsychotic ... baseline and at month-3 At baseline, patient demographics and characteristics were recorded At both visits, vital and physical parameters were collected, and fasting blood samples were drawn and analyzed ... only the AHA/ NHLB-definition additionally includes the treatment with antihypertensives, antidiabetics and lipid lowering drugs and was therefore regarded the more sensitive instrument At baseline,...
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Báo cáo y học: " Dynamics of HEV viremia, fecal shedding and its relationship with transaminases and antibody response in patients with sporadic acute hepatitis E" ppt
Ngày tải lên :
12/08/2014, 01:21
... antibody and HEV RNA for final analysis and those were failing these criteria excluded from the study Patients with concomitant positive IgM anti HAV, IgM anti HBc or anti HCV (i.e dual infection) and ... Clinical parameter and pregnancy The maximum duration of viremia was 42 days and 36 days, fecal shedding 28 days and 19 days and IgM anti HEV 46 days and 49 days in pregnant females and nonpregnant ... Days† IgM anti HEV HEV RNA in sera Fecal Viral shedding 1-7 There were thirteen patients with negative IgM anti HEV but positive HEV RNA There were eight patients with positive IgM anti HEV and negative...
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