will targeting stromal cells cure copd and ipf
báo cáo hóa học: " Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells" docx
... immunosuppressive activity of standard MSCs despite the appearance of a small number of senescent-like cells Materials and methods Production of MSCs and SB623 cells MSC and SB623 cells were produced as ... Receptor ligands such as Notch ligand and TGFb1 have immunomodulatory activity and can be presented by various environmental cells, including MSCs As SB623 cells express the Notch ligand Jagged-1 ... immunomdulatory property of TGFb1 and Notch ligands is in the regulation of regulatory T cells (Tregs) [13,16,21] As both TGFb and Notch ligand are expressed by SB623 cells and the parental MSCs, we...
- 14
- 408
- 0
Báo cáo y học: "Controlling Osteogenesis and Adipogenesis of Mesenchymal Stromal Cells by Regulating A Circadian Clock Protein with Laser Irradiation" pptx
... by osteoblasts that differentiate from mesenchymal stromal cells (MSCs) MSCs are multipotent cells that can replicate as undifferentiated cells and that have the potential to differentiate to lineages ... examine the effect of laser irradiation in other types of cells, such as primary osteoblasts and primary bone marrow stromal cells Those results will be reported in near future As this technique could ... irradiation can induce and reduce the osteogenesis and adipogenesis by altering the intracellular localization of the circadian rhythm protein CRY1 MATERIALS AND METHODS Cell culture and laser irradiation...
- 8
- 281
- 0
Báo cáo y học: "TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood" ppt
... Figure Figure cells inhibits stromal cell-derived factor expression by stromal TNF inhibits stromal cell-derived factor expression by ST2ST2 stromal cells ST2 cells, a bone marrow stromal cell ... cellsstromal cell-derived factor-1 expression in bone marDecreased stromal cell-derived factor-1 expression in bone marrow row stromal cells and bones of TNF-transgenic mice (a) Bone marrow stromal ... SDF-1-deficient and CXCR4-deficient mice die perinatally and have very few hematopoietic stem cells and progenitors within their bone marrow SDF-1 and CXCR4 have been implicated in OCP migration in vitro, and...
- 10
- 386
- 0
Báo cáo y học: "Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity" potx
... 5000 mononuclear cells were gated using a combination of forward-angle and side scatter to exclude dead cells and debris Data were analysed with FACSDiva software Western blot Cox2, and actin expression ... density of 3-4 × 106 cells/ well 24 h after addition of cocktail, adherent and non-adherent cells were washed in ice cold PBS Adherent cells were scraped off using a cell scraper and spun down Loading ... DC-produced cytokines and chemokines, and a circle marks a cytokine which is added as part of the cocktail (TNFa, IL-1b and IFNg) Cocktail stimulated Prostaglandin E2 secretion and its suppression...
- 12
- 377
- 0
Báo cáo y học: "TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways" pdf
... express mRNA for all TLR and that several known TLR ligands activate epithelial cells to express chemokines, cytokines, and host defense molecules, including acute phase proteins and complement proteins ... by stromal cells is Figure Consequences of TLR4 activation on pulmonary SCs TLR4 signalling on SCs is required for early chemokine production and neutrophil and DC recruitment to the lungs, and ... inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells J Leukoc Biol 2008, 83(1):80-88 Beg AA: Endogenous ligands...
- 8
- 296
- 0
Tissue engineering approaches to tendon repair studies on the use of bone marrow stromal cells and knitted poly (d, l lactide co glycolide scaffold
... on understanding the biology of tendon cells Tendons have a variety of cell types, including fibroblasts, fibrocartilage cells and occasional fat cells Fibroblasts are the most common and can be ... progenitor cells (e.g bone marrow stromal cells) according to the cell potential, or into autologous cells (e.g cell from one’s own body) and allogeneic cells (e.g cells from another human donor) ... the seed cells for tendon repair; the knitted PLGA scaffolds possess optimal material and structural properties for bMSCs delivery and tendon tissue formation; and the composite of bMSCs and knitted...
- 174
- 346
- 0
Báo cáo y học: "High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment"
... of 25 % diploid and 24 % aneuploid cells in the TMZ probe G1-phase: The comparison of the amount of aneuploid and diploid cells in the G1 phase shows a ratio of 49 % and 54% The cells in the G1 ... like drug delivery and targeting systems realizing high local TMZ concentrations in the nuclei of target cells To eradicate the target cells, without considering the HRPC cells resistance against ... concentrations and with our solvent The life/dead cells data are depicted in Figure For studies cells were seeded at a density of 1.8 × 106 cells/ ml After incubation with TMZ and TMZ-BioShuttle...
- 10
- 408
- 0
Báo cáo khoa học: Protein transport in organelles: Dual targeting of proteins to mitochondria and chloroplasts ppt
... provided, and the insights that may be gained from a greater understanding of the mechanism of dual targeting for the targeting of location-specific proteins is discussed Targeting signals and mature ... to fall between mitochondrial and chloroplastic targeting signals in terms of arginine and serine content (i.e not as high as in mitochondrial targeting signals) and may be slightly enriched in ... important for targeting to one organelle, the dual targeting signal is overlapping This is consistent with studies that have used tandem arrangements of mitochondrial and chloroplastidic targeting...
- 9
- 599
- 0
Is there Room for Forex Interventions under Inflation Targeting Framework? Evidence from Mexico and Turkey pptx
... literature see Sarno and Taylor (2001), Dominguez and Frankel (1993b), and Edison (1993) A detailed analysis and description of the portfolio effect can be found in Domínguez and Frenkel (1993a) ... September 2001 The Bank of England can intervene in the foreign exchange market Bank of England fact sheet on Foreign Exchange Market, Bank of England website Iceland New Zealand United Kingdom Emerging ... in frequency and magnitude have any impact on the evolution of the exchange rate and its volatility To this end, Tables and report the empirical results pertaining to the overall and individual...
- 33
- 441
- 0
Báo cáo khoa học: Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5¢AMP-activated protein kinase (AMPK) Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique potx
... coinfected H9c2 cells with Ad.MCD and Ad.CA-AMPK viruses (Ad.MCD + Ad.CA-AMPK) and compared our results to control cells coinfected with an equivalent number of viral particles /cells of Ad.MCD and Ad.GFP ... from H9c2 cells coinfected with Ad.MCD + Ad.GFP or Ad.MCD + Ad.CA-AMPK virus In the Western blot, lanes and are for Ad.MCD + Ad.GFP cells and lanes and are for Ad.MCD + Ad.CA-AMPK cells Western ... Ad.CAAMPK cells, P ¼ 0.058; Fig 2Biv) MCD expression and activity in subcellular fractions of H9c2 cells overexpressing both MCD and AMPK Fig AMPK overexpression by adenoviral gene transfer and endogenous...
- 10
- 399
- 0
Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
... leptin and progesterone on FAAH activity and expression (A) Effect of leptin on the activity of FAAH in human U937 and CHP100 cells and on the protein content and the mRNA of FAAH in U937 cells ... of AMT, NAT and PLD in the same cells (Figs 1A,B,D and data not shown) It should be recalled that also CHP100 cells are devoid of cannabinoid receptors [18] Both U937 and CHP100 cells have leptin ... dissociation constants (Kd) of 2.0 ± 0.1 and 2.2 ± 0.2 nM and maximum binding (Bmax) of 382 ± and 339 ± fmolÆmg protein)1, for U937 cells and CHP100 cells, respectively These values are in agreement...
- 11
- 468
- 0
normativity and the will selected essays on moral psychology and practical reason may 2006
... DESIRE, AND THE WILL How to Argue about Practical Reason Three Conceptions of Rational Agency Explanation, Deliberation, and Reasons Normativity and the Will Normativity, Commitment, and Instrumental ... prospective standpoint of practical deliberation and advice, within which normative considerations are front and center, and the retrospective standpoint of explanation From the latter standpoint, ... Philosophy and Public Affairs, 14 (1985), 223–51; T M Scanlon, ‘Contractualism and Utilitarianism’, in Amartya Sen and Bernard Williams (eds.), Utilitarianism and Beyond (Cambridge, England: Cambridge...
- 341
- 1,682
- 0
báo cáo hóa học:" Highly efficient transduction of human plasmacytoid dendritic cells without phenotypic and functional maturation" docx
... killer cells, B cells, T cells and myeloid DC [16] Human pDC not express lineage specific markers, but are characterized by the expression of HLA-DR, CD4, CD123, BDCA2 and BDCA4 [3] These scarce cells ... delivery vectors for dividing and non-dividing cells and were shown to be applicable to many cell types including human conventional DC and LC [21-26] Transduced DC and LC retained their immature ... hematopoietic cells [30-32] The elongation factor-1α (EF1α) and phoshoglycerate kinase (PGK) promoters were shown to have an activity in a human CD34+ cell and in cultured cord blood cells and transgene-expressing...
- 12
- 374
- 0
báo cáo hóa học:" Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function" ppt
... induced Foxp3 and CD25 expression in CD4+ and CD8+ T cells (Fig 1A, middle panel) Upon B/I activation, CD4+CD25+Foxp3+ T cells were increased from 1% to 23% (P = 0.016) and CD8+CD25+Foxp3+ T cells were ... Results and discussion Activation of T cells induces expression of CD25 and Foxp3 associated with effector and memory phenotype differentiation PBMC were stimulated with bryostatin-1 (5 nM) and ionomycin ... kinase C activity and intracellular calcium, respectively [18-20] Cells were washed three times and cultured at 106 cells/ mL in complete medium with 40 U/mL IL-2 (Peprotech) for days and expression...
- 7
- 404
- 0
Báo cáo hóa học: "Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects" ppt
... expand and differentiate [6] Their origin could be in embryonic cells or in progenitors unrelated to embryonic stem cells Adult stem cells are undifferentiated cells occurring in tissues and ... embryonic stem cells in acute spinal cord injuries [107,108] Human stem cells, mainly autologous bone marrow cells, autologous and allogeneic mesenchymal cells, and some allogeneic neural cells, are ... factors–as occurs in mesenchymal stem cells, which are able to differentiate into cells of an ectodermal (neurons and skin) and endodermal (hepatocytes, lung and intestinal cells) origin–or from the cell...
- 15
- 553
- 0
báo cáo hóa học: " Development and psychometric assessment of the COPD and Asthma Sleep Impact Scale (CASIS)" pdf
... correlations between baseline CASIS scores and overall health status, SGRQ, and LCOPD scores in the COPD sample and between CASIS scores and overall health status, ALIS, and AQLQ scores in the asthma sample ... clinical diagnosis of COPD or asthma; (2) age 18 years or older; and (3) willingness to provide consent to participate Patients were excluded if they had both asthma and COPD; had a severe comorbid ... problems in patients with asthma or COPD and the absence of respiratory-specific sleep measures, a new measure of sleep problems and impairment was developed, the COPD and Asthma Sleep Impact Scale...
- 10
- 650
- 2
Báo cáo sinh học: "Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes" pot
... expansion TILs K562 cells expressing CD64, CD137L and CD28 ligands CD80 and CD86, pulsed with anti-CD3 antibody efficiently activate and expand CD8+ CD28- T cells and antigen-specific T cells from peripheral ... costimulatory molecules can activate and expand T cells for transfer, while improving their potency and function The first generation of aAPC consisted of anti-CD3 and anti-CD28 monoclonal antibodies ... capacity to expand circulating T cells [15], we evaluated the relative efficiency of CD32 and CD64-expressing aAPCs for expanding TILs KT64/BBL aAPCs were superior to KT32/BBL aAPCs, and therefore...
- 13
- 383
- 0
Solar Cells New Aspects and Solutions Part 1 doc
... Solar Cells: Polymers and Devices Development 433 Enwei Zhu, Linyi Bian, Jiefeng Hai, Weihua Tang and Fujun Zhang 415 Contents Chapter 21 Conjugated Polymers for Organic Solar Cells Qun Ye and ... cell, the D and A materials are well blended and form the active layer Because the D and A domains are very small, we can neglect the complex reflection and transmission at D/A interfaces, and treat ... reducing Rs, FF and JSC are increased and thus the 18 Solar Cells – New Aspects and Solutions device performance is improved At the same time, it is also noted that although both FF and JSC can be...
- 35
- 387
- 0
Solar Cells New Aspects and Solutions Part 2 pptx
... Wavelength (nm) Fig Transmittance spectra, ZnO/Glass and ZnO/FTO (a), AZO/Glass and AZO/FTO (b), IZO/Glass and IZO/FTO (c) 35 36 Solar Cells – New Aspects and Solutions Fig Photoconductivity spectra versus ... flexibility, light-weight, and graded transparency Low cost production and easy processing of organic solar cells comparing to conventional silicon-based solar cells make them interesting and worth employing ... technology more attractive and smart7-12 Classification of solar cells Author has made an effort to classify the available solar cells Fig Classification of Solar cells Organic solar cells are discussed...
- 35
- 476
- 0
Solar Cells New Aspects and Solutions Part 3 docx
... cell materials and manufacturing techniques 66 Solar Cells – New Aspects and Solutions are suitable and applicable for flexible and non-transparent textiles, especially tapes and fibers, with ... development of organic and polymeric photovoltaics Solar Energy Materials and Solar Cells, 83, 125 [12] Granstrom, M., Petritsch, K., Arias, A.C., Lux, A., Andersson, M.R and Friend, R.H (1998) ... E and Krebs F C Low band gap polymers for organic photovoltaics Solar Energy Materials and Solar Cells 91 (11), 2007, 954-985 [34] Kroon R, Lenes M, Jan C Paul H, Blom W M, Boer B de “Small Bandgap...
- 35
- 622
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25