which play a deciding role in the phagocytosis process
Báo cáo khoa học: Trigger factor interacts with the signal peptide of nascent Tat substrates but does not play a critical role in Tat-mediated export pptx
... pTorA/P2 [ 17] a s a template and the primersRRTorA-SacI-fw (5¢-GCGCGGAGCTCAAGAAGGAAGAAAAATAATGAAC-3¢, SacI site underlined) andTorA/Lep2-BamHI-rv (5¢-GCATGGATCCCGCGCGCTTGATGTAATC-3¢, BamHI site ... (5¢-ACTGATCGATCTAGATTACGCATAGTCAGGAACATCGTATGGGTAGCCGCCTGGCGGTACCGGATTGACCAAC- 3¢, ClaI site underlined,XbaI site in italics, HA-epito pe sequence in boldface). The resulting fragments were cloned into ... post-translational targeting/trans-location pathway t hat operates i ndependently of the Secpathway (reviewed in [11]). In contrast to the Sec pathway, the Tat pathway has the striking a bility...
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Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx
... FAD49 lacking its PX domain (GFP–SH3),individual DNA fragments encoding full-length FAD49(amino acids 1–910), the FAD49 PX domain (amino acids1–130) and FAD49 lacking the PX domain (amino acids126–910) ... initiation (A/ GCCATGA/G). A 1809 bp cDNA fragment con-taining a stop codon was isolated by RT-PCR. A 1007 bp cDNA containing a poly (A) tail was obtainedby 3¢ RACE. By combining these cDNA fragments,fad49 ... control. The PXXP motif was found in the FAD49 PXdomain, as in many PX domains, suggesting that the PX domain could bind to an SH3 domain of FAD49.To test whether the PX domain could interact with anSH3...
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Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf
... for the PA–substrate inter-actions in the transition state are missing and only a GRIDcomputational modelling approach to the tetrahedral inter-mediate in PA presents some indications of the ... substrates docked in the active site of penicillin acylase by AM1 calculations. Amino acid residues of the enzyme are at their X-ray coordinates [19]. Substrates having local symmetry of the leaving ... could be involved both in catalysis andproductive binding.Graphic simulation of the interactions of arylamidesubstrates with the nucleophile binding subsite of PAindicates that the arylamide...
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Báo cáo khoa học: Nuclear aggregates of polyamines are supramolecular structures that play a crucial role in genomic DNA protection and conformation potx
... correlated with the chain length ofinteracting polyamines [24–27] and (c) that a trans-ition of the DNA chain from a dispersed coil stateto a condensed-collapsed state parallels an increase in ... is the charge attraction between DNA phosphates and the amino groups of polyamines. As the amino groupsof polyamines are already engaged in ionic bonds with the phosphates of NAPs, secondary amino ... Poly-amine-stimulated binding of diamine oxidase to DNA.Acta Chem Scand 52, 921–929.36 D’Agostino L, D’Argenio G, Ciacci C, Daniele B,Macchia V & Mazzacca G (1984) Diamine oxidase in rat...
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Báo cáo khoa học: Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide ppt
... decreasingTNF -a mRNA levels in MonoMac-6 cells. Taken together, the data from these studies suggest that LPCAT is a keyenzyme in both the pathways of activation (priming) and the in ammatory ... of the cell walls of Gram-negative bacteria, is an importantmicrobial molecular pattern that initiates in ammatoryand coagulation reactions as part of the host innate immuneresponse to infection. ... plate was incubated in the dark for20 min and the reaction stopped by the addition of 50 lLof0.5Msulfuric acid. The plate was read on a LabsystemsMultiskan plate reader using the absorbance...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... Chalfont, UK).Statistical analysisStatistical analysis was performed using the graphpadprism, version 5 (GraphPad Software, Inc., San Diego, CA,USA). Statistical significance was calculated ... GRASP55 and TGF-aD152 (lacking the lasteight amino acids of the ICD) compared to the TGF -a D158 construct lacking only the last two valine resi-dues, suggesting a role for an internal motif in ... expression of a catalyticallyinactive dominant negative furin construct affected the processing of pro-MT1-MMP. Taken together, thesedata reveal a new cellular function for GRASP55 as a molecular bridge...
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Tài liệu Báo cáo khoa học: The role in the substrate specificity and catalysis of residues forming the substrate aglycone-binding site of a b-glycosidase docx
... 5¢-gagagatttgctttgcgggttatggatctgc-3¢; mutation K20 1A, 5¢-gttatggatctgctaccgcggctccgatcctaaacg-3¢; mutation K201F, 5¢-ggttatggatctgctacttcgctccgatcctaaacgc-3¢; and mutation M45 3A, 5¢-ggacaactttgaatgggcggagggttatattgag-3¢. ... corresponding to the sense strand are listed, as follows: mutation E19 0A, 5¢-caacgagcctagagcgatttgctttgagg-3¢; mutation E190Q, 5¢-caacgagcctagacagatttgctttgagg-3¢; mutation E19 4A, 5¢-gagagatttgctttgcgggttatggatctgc-3¢; ... delineates a channel that could be the pathway for the release of the aglycone in the glyco-sylation step and the entrance of the water moleculeinvolved in the hydrolysis of the covalent intermediate[17]....
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... soy arabinogalactan consists of 57%D-galactose and 38%L-arabinose. Methylation analysisdemonstrated that a substantial amount of the L-arabinoseresidues (14%) in soy arabinogalactan is ... canbe substituted with a) 1-,3-linkedL-arabinofuranose chains.Type I arabinogalactan is degraded by b-1,4-endogalacta-nase and b-galactosidase. b-1,4-Endogalactanases cleavewithin the galactan ... thank Simon Flitter for the identification and isolationof the galA containing phage clones and Matthew Illsley for the analysis of a- L-1,5-arabinofuranosidase activity in the endogalactanasepreparation.REFERENCES1....
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The Carbon and Global Warming Potential Impacts of Organic Farming: Does It Have a Significant Role in an Energy Constrained World? pptx
... Finally, reducing transport offers some additional, if smaller, potential for E and GHG gains (and again data for the Canadian food system is lacking) and a significant body of literature has ... to average approximately 80 and 90%, respectively of that in conventional dairy farming. Thomassen et al. [60] in the Netherlands conducted a detailed ‗cradle-to-farm-gate‘ LCA analysis, including ... those of the stakeholders involved in the survey, namely the Organic Agriculture Centre of Canada, the Organic Value Chain Roundtable and Agriculture and Agri-Food Canada. References and Notes...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... 5¢-ATCTGATAACACAGCCCACTCAAGTAT-3¢; C46 6A( sense) 5¢-GATAAAGCACCCGCTATCACAGACTGG-3¢; C46 6A( antisense)5¢-CCAGTCTGTGATAGCGGGTGCTTTATCTG-3¢;C49 1A( sense) 5¢-GCAGAGAGCAAAGCCTATTTGATAACAG-3¢ and C491(antisense) 5¢-TGTTATCAAATAGGCTTTGCTCTCTG-3¢.PCRs ... result in a conformational change within the receptor chain enabling the activating interaction with the LIFR. Another explanation is that of an intermolecularbond between gp130C458Ac and the LIFR. ... FNIII domains of gp130 are therefore assumed tobe arranged in such a way that the C-terminal parts of the membrane-proximal domain D6 are positioned in closevicinity to each other. In analogy,...
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Báo cáo Y học: The a1b1 contact of human hemoglobin plays a key role in stabilizing the bound dioxygen Further evidence from the iron valency hybrids potx
... resistance against the acidic autoxidation in a manner of contacting with the a chain, no matter which valency state t he latter partner is in, the ferrous or the ferric. These new ®ndings have led ... a1 b2anda2b1 contacts undergo the principal changesassociated with the cooperative oxygen binding, so thatthese are named the sliding contacts. At the a1 b1anda2b2interfaces, on the other hand, negligible ... Thesewere taken as an indication that the He2proton is stabilizedagainst solvent water exchange by a hydrogen bond between the distal His and the O2ligand in both a and b chains. At the same t...
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Natural botanical products have a long history in the world and are featured in using a complex
... treatment groups. They were fed intragastrically (i.g.) daily for 14 and 28 days. Tumor areas were measured every 7 days using a caliper, and the tumor area was calculated according to the ... expressed as the number of apoptotic cells per field. Statistical analysis Statistical significance between the treatment groups was analyzed using a two-way statistical analysis of variance (ANOVA), ... Research, and the Gastrointestinal Pharmacology Section of International Union of Pharmacology. He serves on the editorial board of several journals such as European Journal of Pharmacology, Journal...
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Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
... IgG, Santa Cruz Biotech, CA). The assay was developed using a stabilized HRP substrate. All samples were analyzed in the linear range of the ELISA using over-expressed human Vgf as a standard. ... Acad Sci USA 2006; 103(39): 14584-14589. 16. Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, Gonzalez LJ, Shioda S, Takao T, Nakazato M, Minamino N. Peptidomic ... and the recombinant virus was packaged by infecting the PacI linearized recombinant viral DNA into human embryonic kidney (HEK)-293 cells (Clontech, CA). The resulting recom-binant virus was...
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