... polymorphism was associated with an increased risk of coronary heart disease [9,22] whereas others failed to demonstrate this association [23-25]. Furthermore, a recent meta-analysis study ... Medical Sciences ISSN 1449-1907 www.medsci.org 2004 1(3):181-192 â2004 Ivyspring International Publisher. All rights reserved Elevated plasma homocysteine is positively associatedwith age independent ... Coagul Fibrinolysis. 2002;13(3):271-5. 53. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C >T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002;288(16):2023-31....
... chronic gastritis and ulcer(normal group), 50 with IM including adenoma (highrisk group), 40 with EGC (EGC group), 45 with AGC with- out distant metastasis (AGC group), and 42 with meta-static ... gastriccarcinogenesis. Serum HMGB1 levels were significantly associatedwith depth of invasion, lymphnode metastasis, tumor size, and poor prognosis (p < 0.05). However, HMGB1 levels were not associated with ... meas-urement of HMGB1 activity in tissues is clinically impor-tant, this method of biomarker analysis is somewhatlimited because the measurement of biomarker activity intissue requires invasive techniques...
... Multivariate analysis of factors associatedwith ICU LOS Table 2 demonstrates that hypoglycemia—minimum BG < 50 mg/dL as well as minimum BG 50–69 mg/dL is independently associatedwith prolonged ... of the patients with hypoglycemia in the NL cohort had an episode within the first 48 hours of ICU admission. Figure 5 displays the strong association between the number of episodes of hypoglycemia ... associatedwith mortality on univariate analysis and therefore was not entered into the multivariate model. Mortality is defined throughout as hospital, not ICU, mortality. Statistical analysis was...
... variable inlogistic regression models, one unit of increased BMI(1 kg/m2) was associatedwith a 3.1% increase in AHR risk(CI 1.01–1.05; p , .005) in all subjects. For men, this riskwas 3.4% ... a 25 kg weight gain was associated with a 2.5-fold increase in the risk for diagnosisof asthma compared with no significant weight gain.11In across-sectional analysis of 18,000 children aged ... the two. Our study estab-lished obesity as a risk factor for new diagnosis of asthma,the risk increasing with higher levels of obesity. Thesefindings should be the basis for future controlledinvestigations...
... medialis at the patellofemoral joint is alsosupported by electromyography studies, which demonstratedthat delayed activation of vastus medialis relative to vastus lat-eralis isassociatedwith ... results in a pain-free population without clinical knee oste-oarthritis suggest that increased cross-sectional area of vas-tus medialis, whichisassociatedwith participation in vigorousphysical ... study is unknown. Thus, the aim ofthis study was to examine the determinants of vastus medialisand lateralis cross-sectional areas and whether vastus media-lis cross-sectional area is associated...
... Research Divisions. We also thank Dr Olle Olerup for providing us with HLA typing kits, Miss Diab Diab for technical assistance with HLA typ-ing, and Mr Ben de Jong for technical assistance with serum ... Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's ... study and is respon-sible for the Blood Bank in Umeå.HS assisted in the statistical analyses and discussions.AcknowledgementsWe gratefully acknowledge the technical assistance of Mrs Lisbeth...
... univariateanalysis (P > 0.05) and Cox's multivariate analysis.Table 1: Distribution of 50 patients with cutaneous melanoma in terms of primary diagnosis and location of tumor and first metastasisPrimary ... mechanism through which bcl-2inhibits apoptosis is not fully understood [19]. In thepresence of bcl-2 overexpression, the ability of the cell toremove genetic and cell damage through apoptosis is ... metastases and one for disease in the axilla, all with palliative intent.ImmunohistochemistrySections of paraffin-embedded metastasis specimens wereinitially stained with hematoxylin-eosin...
... -168A>G polymorphism has convinc-ingly been associatedwith MHC2TA gene expression, it is unclear whether the polymorphism itself is functional orwhether it is in linkage disequilibrium with one or ... Revisions requested: 6 Apr 2006 Revisions received: 8 May 2006 Accepted: 17 May 2006 Published: 15 Jun 2006Arthritis Research & Therapy 2006, 8:R97 (doi:10.1186/ar1974)This article is online ... purposes)Vol 8 No 4Research articleThe MHC2TA -168A>G gene polymorphism is not associatedwith rheumatoid arthritis in Austrian patientsBabak Yazdani-Biuki1, Kerstin Brickmann1, Klaus...
... Comparison of risk factors for vascular disease inthe carotid artery and aorta in women with systemic lupuserythematosus. Arthritis Rheum 2004, 50:151-159.35. Vitali C, Bencivelli W, Isenberg ... analysis.As a consequence of the low number of opportunistic infec-tions since lupus onset in our patients, a further analysis of var-iables associatedwith the occurrence of opportunisticinfections ... inother studies in patients with SLE [1,30] is confirmed by ourstudy, which shows a third of the infections in patients with SLE to be major infections for which hospital admission wasrequired. Furthermore,...
... Revisions requested: 27 Feb 2007 Revisions received: 16 Apr 2007 Accepted: 18 Apr 2007 Published: 18 Apr 2007Arthritis Research & Therapy 2007, 9:R40 (doi:10.1186/ar2179)This article is ... because IFIH1 is a highly IFNβ-inducible protein that is thought important in mediating IFNβeffects such as growth inhibition and apoptosis [23]. Immuno-histochemical analysis has shown IFNβ ... distribution. All geneexpression analysis was performed using GraphPad PrismVersion 4 (GraphPad Software, San Diego, CA, USA).ResultsIFIH1 A946T is not associatedwith RA susceptibility or severityAllele...
... LLI.The most probable explanation for this finding is that, despiteopinion found in textbooks, no association actually exists. Thisreasoning is consistent with the near absence of data support-ing ... 11cases with ipsilateral longer leg, and 17 cases with bilateralGTPS) and in 163 subjects without GTPS; therefore, 13.7%of subjects with GTPS had a LLI compared with 14.1% ofthose without ... 2007 Revisions received: 12 Apr 2008 Accepted: 29 May 2008 Published: 29 May 2008Arthritis Research & Therapy 2008, 10:R62 (doi:10.1186/ar2433)This article is online at: http://arthritis-research.com/content/10/3/R62â...
... medialis at the patellofemoral joint is alsosupported by electromyography studies, which demonstratedthat delayed activation of vastus medialis relative to vastus lat-eralis isassociatedwith ... inmultivariate analysis. BMI was positively associatedwith vas-tus medialis cross-sectional area in multivariate analysis, with a similar trend observed with vastus lateralis. Participation invigorous ... results in a pain-free population without clinical knee oste-oarthritis suggest that increased cross-sectional area of vas-tus medialis, whichisassociatedwith participation in vigorousphysical...
... competing interests.AcknowledgementsThis work is supported by an Arthritis Research Campaign Clinical Fel-lowship grant (grant number 18848 to TET) and an Arthritis ResearchCampaign infrastructure ... Foundation Trust, Department ofRheumatology). HJ is supported by an Arthritis Research CampaignEducational Research Fellowship Grant (grant number 17883). VFP is supported by a PhD scholarship from the ... associates with a reduced prevalence of the meta-bolic syndrome in rheumatoid arthritis patients over the ageof 60: more than just an anti-inflammatory effect? A cross-sectional study. Arthritis Res...
... quasispecies variants was 15%. In this cohort,only patients with major L76V positive population wereincluded. Minor wildtype variants were not detected atthis position.Phenotypic resistance ... 3.6HIVGradePhenotypeResistantIntermediateSensitiveResistantIntermediateSensitiveFigure 1 Resensitizing effects of the L76V mutation are visible in phenotype results: Phenotypic resistance analysis before ... therapy was noticeable associated with an additional establishment of t he protease gene muta-tion at position L90 M which resulted in resistanceagainst all available PIs [17]. Six of eight patients...