which of the following is linked to the development of cervical cancer
Báo cáo khoa học: Calcium-induced activation and truncation of promatrix metalloproteinase-9 linked to the core protein of chondroitin sulfate proteoglycans pot
... the proMMP-9 with respect to its ability to autoactivate. The first example is the response to urea.During the purification of the complex, large amounts of urea was added to the preparation to ... the PG-core protein alters the ability of the gelatinase to autoactivate is the effect of calcium, which is astabilizer of proMMP-9 and other MMPs, but inducestruncation and activation of the ... the border between the stacking and the separating gel. Due to the high glycosylation of the proMMP-9/CSPGcomplex, the proteins migrate as if they initially are distributed to the edges of the...
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Báo cáo khoa học: Structure of Streptococcus agalactiae serine⁄threonine phosphatase The subdomain conformation is coupled to the binding of a third metal ion pptx
... (Ser155) in the monomer bound to the activesite (Fig. 3B). This feature might be related to the mechanism of the enzyme (see Discussion).DiscussionOverall structure The structure of SaSTP is very ... structure. The phosphate is bound indirectly to the metal ions viawater molecules and the Wn–P–O angle (146°) is rea-sonably close to optimal when the roughness of the analysis is taken into account.SaSTP ... bind directly to M3. Asn160 is, however, the closest flap domain resi-due to the M3 binding site. Because the M3 bindingsite is linked to the conformation of the flap, M3might also exist in eukaryotic...
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how the use of the diary form narrative is beneficial to the
... narrative. This was agood choice of how to write the novel since it was very beneficial to the plot of Dracula. Examples of how the diary form is beneficial to Dracula is seen in his writing and ... writing and book. One of the greatest benefits of the diarynarrative is that the reader is allowed see, and feel the emotional heartsand souls of the emotional characters. This is great because ... think forthemselves and they will not have to have the book, or someone in the book explain what they are reading to them. So in other words, if anewspaper is written in the book, the reader...
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Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
... from the mem-brane. By analyzing microsomes, we showed that the ectodomain is shedinto the lumen of vesicles, whereas the C-terminal half, which possesses the RING finger, is released to the cytoplasm. ... specificsignal to move into the nucleus either on its own or with the help of an adaptor protein that facilitates entry intoor retention in the nucleus – it is possible that the adap-tor protein is more ... form a complex with the nuclear adaptor Fe65 and the histone acetyltransferase Tip60 in order to target to the nucleus [61,62]. Other ICDs function exclusively in the cytoplasm. The adhesion protein...
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Tài liệu REPORT OF THE STAFFS OF THE CFTC AND SEC TO THE JOINT ADVISORY COMMITTEE ON EMERGING REGULATORY ISSUES doc
... in the E-Mini, the other with respect to individual stocks. LIQUIDITY CRISIS IN THE E-MINI The combined selling pressure from the Sell Algorithm, HFTs and other traders drove the price of the ... the increase is much more modest (Chart 3.B). These results are consistent with the hypothesis that relative to the liquidity of large-cap stocks, much more of the liquidity in ETFs is provided ... demonstrate the importance of data in today’s world of fully-automated trading strategies and systems. This is further complicated by the many 13 For stocks that are subject to the circuit...
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Tài liệu Báo cáo khoa học: Enlarging the gas access channel to the active site renders the regulatory hydrogenase HupUV of Rhodobacter capsulatus O2 sensitive without affecting its transductory activity docx
... In the case of the regulatory HupUV protein,our results favour the hypothesis of Volbeda et al.[25], which explains the O2resistance of RHs bylimited accessibility of the active site to ... to restore the regulation of HupSL synthesis. This implies that itwas able to transmit the information about the availab-ility of H2 to the histidine kinase, HupT. Indeed, weshowed that the ... growth[16,19]. These hydrogenases are the first element of amulticomponent system that regulates the synthesis of the energy -linked hydrogenase in response to H2; theirrole is to detect the availability...
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Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx
... treeswith the nt sequence of the open reading frame (ORF) of their cDNAs and the corresponding aa sequences, inTable 1. Summary of the purification of DNases I from the pancreases of three species of ... Ireduced their thermal stabilities to levels similar to those of amphibian enzymes. These findings led us to conclude thatthere are at least two mechanisms that might be involved inchanging the thermally ... in the initiation of human and rat SLE [12,40], the acquisition of thermally stable characteristics duringDNase I evolution may provide a clue to the etiology of SLE in humans and mice, which...
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Báo cáo khoa học: The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III s subunit ppt
... second half of the PolC N-terminuswould help to improve the results further. Therefore,we took only the fragment of the multiple sequencealignment covering the first half of the PolC N-termi-nus ... bacteria is carried out by the multicomponent protein machine, DNA polymeraseIII [1]. The actual DNA synthesis is performed by the catalytic a-subunit (PolIIIa), which belongs to the C-family of DNA ... functions for thesedomains. Taking into account the biological context,an obvious hypothesis is that either one or bothdomains mediate the interaction of PolC with the s-subunit. It is known that...
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JUDGMENTS OF THE COURT OF APPEAL OF NEW ZEALAND ON PROCEEDINGS TO REVIEW ASPECTS OF THE REPORT OF THE ROYAL COMMISSION OF INQUIRY INTO THE MOUNT EREBUS AIRCRAFT DISASTER potx
... judgment of the High Court in its civil jurisdiction. Plainly it is the exercise of a statutory power of decision. The jurisdiction of the New Zealand Courts to determine the validity of orders ... beyond argument, is that an order for costs made by a Commission under s. 11 of the Commissions of Inquiry Act is the exercise of a statutory power of decision within the meaning of the Judicature ... entitled to an order declaring that a decision made in the exercise of a statutory power of decision is unauthorized or otherwise invalid the Court may set aside the decision instead. The first...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... drug resistance is mediated by various mechanisms operating at varioussteps in the cytotoxic activity of the drug, from adecrease of drug accumulation in the cell to abrogation of apoptosis induced ... PI3K/Aktpathway is involved in PrPC-mediated MDR in gastric cancer. To test this hypothesis, the expression of Aktand PrPCwas examined by immunohistochemistry andconfocal microscope in human gastric cancer ... inhibition of the PI3K/Akt signalingpathway leads to inhibition of PrPC-induced cell drugresistance in gastric cancer cells.PI3K/Akt is involved in the activation of P-gp byPrPCin gastric cancer To...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy chỉ tiêu chất lượng 9 tr 25