... behavior of real-life financial intermediaries When information asymmetries are not the driving force behind intermediation activity and their elimination is not the commercial motive for financial ... tries to reflect on the merits of the present theory of financial intermediation, on what it does and doesnot explain from both a practical and a theoretical point of view The theory is impressive ... savers and to investors/entrepreneurs But as far as the authors of this essay are aware, it does not, or not yet, provide a satisfactory answer to the question of why real-life financial institutions...
... believe your spouse is not reporting all of his or her income, or You not want to be responsible for any taxes due if your spouse doesnot have enough tax withheld or doesnot pay enough estimated ... Form 8822 to notify the IRS of your new address Note An ITIN is for tax use only It doesnot entitle you to social P.O box Enter your P.O box number only if your post office doesnot deliver mail ... divorce was not final (an interlocutory decree), you are considered married and cannot use the single filing status You were widowed before January 1, 2012, and did not remarry in 2012 You not claim...
... was not sufficient to judge a firm’s audit capabilities For example, some noted that part of the inspection results were not published, inspection reports were not always timely, and PCAOB did not ... report doesnot include the responses of the largest firms, or firms with four or fewer audit clients unless otherwise noted Also, data for smaller firms refer to survey respondents only and cannot ... participants we spoke to did not express such concerns Further Concentration Could Adversely Affect Audit Fees and Limit Choices Although the current level of concentration doesnot appear to be having...
... indicates that expression of fiber type specific MLC isoforms is not affected by PV deficiency, in line with previous findings that a lack of PV doesnot change the myosin heavy chain pattern [16] Also, two ... method) from three individual mice from each genotype Direct images were obtained from Phosphoimager (B) Quantitative analysis of four to nine mice per genotype, and samples, were quantified from three ... mice per genotype) In addition, CaN activity was doubled in extracts from PV– ⁄ – TA compared with WT: 212 ± 43% vs 100 ± 27%, respectively (mean ± SEM; P < 0.05, n ¼ animals per genotype) Moreover,...
... Deaths, 1957-2007 per 100,000 births pregnancy, which can lead to death if not treated promptly Legal abortion does nothing to solve the underlying problem of poor medical care in the developing ... medical care, not abortion, is the solution to the problem of maternal mortality in the developing world A Defense of Human Life (New York: Doubleday, 2008); and Maureen L Condic, WhenDoes Human ... Question of Justice (New York: Routledge, 2011) 17 This doesnot include medical procedures that are necessary to prevent the death of the mother but not intend the death of the child 18 A research team...
... [17,23,26] Furthermore, pre-SufIHA was not processed in a tatC minus background during the chase period (Fig 4B, lanes 21–25), confirming that the HA-tag doesnot change targeting pathway specificity ... Tat signal peptide [36] might prevent rerouting via the Sec pathway even when TF is absent Second, deletion of tig doesnot affect the export of SufI which proceeds in vivo with the slow kinetics ... On the other hand, when IMVs were added during synthesis of nascent Tat proteins, crosslinking to the Tat translocase was not observed irrespective of the presence of TF (data not shown) Also,...
... physiological fluctuations or changes in this ratio not alter the computed body composition (25) In summary, vigorous endurance training doesnot increase total energy expenditure in older persons ... probably a slight underestimate because it (Lotus, Cambridge, MA) or Statplan (The Futures Group, doesnot include warm-up activity or the residual energy expen- Washington, DC) software packages ... new finding is that operative during the remainder of the day The present endurance training doesnot enhance free-living total enresults show that the energy expended in physical activergy expenditure...
... and cannot compensate for its loss Decreased NMNAT1 activity in heterozygous null mice, however, doesnot affect the rate of Wallerian degeneration, suggesting that endogenous NMNAT1 doesnot have ... in transgenic mice [22] and does so only weakly in Drosophila [20] In dorsal root ganglia cultures, NMNAT1 confers protection when locally transduced into axons or when highly overexpressed [18,23] ... mediated by the activity of sirtuin family member Sir2p [8] Another member of this family, SIRT1, also regulates circadian rhythm in mammals [9] Notably, nicotinamide phosphoribosyltransferase (NAMPT),...
... or polygonal shape in the presence of serum When serum is removed, they stop proliferating and differentiate, acquiring a neuron-like morphology, and, when serum is re-added, a rapid shortening ... because major MAPs are not expressed in these cells However, neurites elongate at the same rate as those of normal neurons in culture Results Cytoskeletal proteins As noted in the Introduction, ... microtubules [41] Immunofluorescence images of CAD cells using an antibody against total tubulin (which doesnot discriminate different states of tubulin tyrosination) showed a bright, typical microtubule...
... lobulation of granulopiesis [27] Although LBR was not detectable in liver microsomes, it cannot be excluded that in vivo LBR supports cholesterol biosynthesis when present in the ER Alternatively, the ... outbred strains Offspring were genotyped by PCR, which produced the expected 230 and 388 bp fragments from wild-type and disrupted allele, respectively (Fig 2B,C) Genotyping was confirmed by Southern ... biosynthetic precursors, including C29D8,14, were not detectable by GC-MS analysis of microsomal sterols, indicating that C29D8,14 intermediate was not accumulated in Tm7sf2() ⁄ )) mice FEBS Journal...
... studies indicated that RAP and antibody 2189 ⁄ 90 against LA-1 of LpR not compete (data not shown), suggesting that RAP doesnot bind LA-1 On the basis of the presence of an important acidic residue ... LDLR(1–251)LpR(302–850) was not able to bind HDLp Moreover, as was previously found for ligand binding to LpR and LDLR [14], for binding to the hybrid receptors the ligands are not interchangeable (data not shown) ... size of the antibody and not from competition for the same binding site No competition was observed between RAP and the antibody (data not shown), suggesting that LA-1 is not involved in the binding...
... Parliament in the matter did not elude the Court’s supervision Prenatal Medical Tests Vo v France (no 53924/00) 08.07.2004 (Grand Chamber) Owing to a mix-up with another patient with the same ... gametes) A genetic condition, affecting around one in every 2,500 girls, in which the sufferer doesnot have the usual pair of two X chromosomes They are also usually shorter than average and infertile ... contradictory information and had not received objective medical counselling; and, the fact that access to abortion was a subject of heated debate in Poland did not absolve the medical staff from...
... structure unfolds prior to the unfolding of a-helix and the formation of aggregates Note that the formation of aggregates cannot be fully excluded in the temperature range 25–60 °C because a small population ... also structurally similar However, despite the sequence homology, both FTIR Thermal stability doesnot correlate with carbohydrate content Glycoproteins can be found in most organisms, including ... correlation between secondary structure and stability (data not shown) suggests that the conformational variability amongst the FUs is not a determining factor for the differences in their stabilities...
... Open Access Insertion of the human sodium iodide symporter to facilitate deep tissue imaging doesnot alter oncolytic or replication capability of a novel vaccinia virus Dana Haddad1,2†, Nanhai ... facilitated imaging of virus replication in tumors via 124I-PET Conclusion: Insertion of the hNIS gene doesnot hinder replication or oncolytic capability of GLV-1h153, rendering this novel virus a promising ... tumors were easily detected, whereas GLV-1h68- and PBS-injected tumors could not be visualized and therefore were not significantly above background (Figure 6) Discussion Oncolytic viral therapy...
... glycoproteins during latency) did not proceed to the production of detectable infectious virus in immune-deficient mice The results suggest that viral reactivation doesnot occur spontaneously and ... appear to imply that mouse neural tissue containing latent HSV-1 (e.g., the trigeminal ganglion) doesnot support periodic episodic viral reactivation Although spontaneous molecular viral reactivation ... reactivation has been reported [8], the results presented here suggest that this molecular reactivation doesnot proceed to the production of detectable infectious virus It may be that there are nonimmunological...
... the small sample size, we chose the nonparametric methods because the validity of this approach doesnot depend crucially on normality assumption We set the significance level at p < 0.05 If a main ... in time when we performed the H-reflex measurements and background soleus EMG amplitude during powered walking (epoch 5: 1.33 ± 0.26, epoch 6: 1.62 ± 0.60, epoch 8: 1.11 ± 0.67) were not significantly ... results when using catch trials (i.e., turning off the exoskeleton assistance unexpectedly) [57] to assess the presence of negative aftereffects, a benchmark of motor adaptation [58] Our findings not...
... contracts to develop and implement it However, this system doesnot directly cover the major portion of Air Force assets, and the Air Force doesnot expect it to be operational before 1994 With the ... adjustments could not be explained by Air Force officials The inventory systems not provide reliable data to support either the quantities or the values of inventories on hand There is not an accounting ... unauditable The Air Force doesnot have financial systems that produce reliable financial data A number of large dollar items-aircraft and accounts payable, for example-are not included in its accounting...