whats at the other side of a black hole
Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
Ngày tải lên :
16/03/2014, 13:20
... DosH as a template
and using the following respective 5Â-sense primers: 5Â-gatga
gtcgggagACCcagctggagaaaaaag-3Â,5Â-gatgagtcgggagTTTcag
ctggagaaaaaag-3Â,5Â-ggacccgttttgcgACCtcgaaagtgagc-3Â,
and ... decreased the rate of auto-oxidation [5],
whereas Ala and Asn substitutions at Asp40, an
amino-acid residue that interacts via two water mole-
cules with the proximal ligand His77, markedly
increased ... mutations,
although the effects of the Leu99 and Leu115 muta-
tions were modest compared with those of Met95
mutations.
It seems likely that potential data based on our data
and that of others have accuracies of...
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Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx
Ngày tải lên :
20/02/2014, 23:20
... the catalytic activities in the reductive
acetylationassaymeasuredwiththefreelipoyldomainas
substrate (Table 1) and that the PDH complex activity was
measured with pyruvate at a concentration of ... assays, the E1aS283C and E1aF26 6A mutants
behaved essentially the same as wild-type E1. In the DCPIP
assay, the E1aY28 1A and E1aR28 2A mutants displayed a
catalytic activity about twice that of ... (Fig. 3). The reaction mixture with E1 was incubated
for exactly 10 min at the relevant temperature and the
catalytic activity at that temperature was then determined.
The inactivation temperatures...
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Tài liệu The Proof is in the Pudding - A Look at the Changing Nature of Mathematical Proof doc
Ngày tải lên :
21/02/2014, 09:20
... will
ever find a counterexample, nor ever gainsay that particular mathematical
fact.
It should not be thought that the generation of mathematical proofs is
mechanical. Far from it. A mathematician discovers ... solidity of mathematics (see also Section 0.9). But mathematics
is applied in a variety of ways, in a vast panorama of disciplines. And the
applications are many and varied. Other disciplines often ... clear that mathematicians will have difficulty escaping from the Kan-
tian fold. Even a Platonist must concede that mathematics is only accessible
through the human mind, and thus all mathematics...
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Báo cáo khoa học: Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center? Supporting amino acid residues at the active site of penicillin G acylase pptx
Ngày tải lên :
16/03/2014, 01:20
... investi-
gation of Perakyla et al. on the catalytic reaction of
AGA, however, predicts that, energetically, the highest
point in the acylation step is the nucleophilic attack on
the carbonyl carbon of ... deriva-
tive. These structures are mimics of the stationary
points along the reaction pathway; they depict the
changes in the spatial structure of the active site during
catalysis. Phenylacetic acid ... titration
of active site. Bioorg Khim 3, 547–553.
25 Yamagami C, Takao N, Tanaka M, Horisaka K, Asada
S & Fujita T (1984) A quantitative structure–activity
study of anticonvulsant phenylacetanilides....
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Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"
Ngày tải lên :
26/10/2012, 09:39
... expression of Cx40 and Cx43
were elevated in the neointimal area at the early stage of atherosclerosis. The mRNA and
protein expression of Cx43 were significantly down-regulated by losartan treatment ... losartan group (panel C). In panel A, the elastic lamina was clear and intact; endothelia and smooth muscle
cells (arrow) arranged regularly. In panel B, the elastic lamina was incomplete and ...
Abstract
Aim: to investigate effects of Losartan on expression of connexin 40 and 43 (Cx40 and
Cx43), in arteries at the early stage of atherosclerosis in a rabbit model. Methods: A total of...
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The Marketing Strategy of a multinational join stock company.doc
Ngày tải lên :
27/10/2012, 16:51
... distribution of ideas, goods, and services to create exchanges that satisfy individual
and organizational goals”
2
.
The writer of the book The Silk Road to International
Marketing” had another ... The Marketing Strategy of a multinational join stock company
multinational join stock company has a certain advantage: a multinational join stock
company has always kept its prices as competitive ...
without any product changing. Although it retains the scale economics on the
manufacturing side the firm sacrifices potential saving on the communication way .
another strategy is dual adaptation....
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INTRODUCTION - The Hidden Side of Everything
Ngày tải lên :
17/10/2013, 18:20
... real-estate agents—use their infor-
mational advantage to serve their own agenda. However, they can be
beat at their own game. And in the face of the Internet, their informa-
tional advantage ... control or a strong economy or new police strategies
that finally blunted the American crime wave. It was, among other
factors, the reality that the pool of potential criminals had dramati-
cally ... himself. That is, Candidate A today is likely to
be similar to Candidate A two or four years hence. The same could be
said for Candidate B. If only Candidate A ran against Candidate B in
two consecutive...
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Meeting the Business Side of Google
Ngày tải lên :
24/10/2013, 08:20
... is a search engine dedicated to displaying printed catalogs
and linking to their sites. It’s available only to companies that publish such
catalogs. Froogle is available to any business that ... largest publishers, manufacturers,
and e-tailers. As with eBay, small and large participants enjoy the same
benefits.
The Three Goals of Every Webmaster
Innumerable business plans operate side ... (participants controlled their costs and tracked
their returns). In time, the advantages of eBay’s system got the attention of
midsize brick-and-mortar stores, which now operate eBay outlets as...
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LECTURE SLIDES ON NONLINEAR PROGRAMMING BASED ON LECTURES GIVEN AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MASS DIMITRI P. BERTSEKAS
Ngày tải lên :
26/10/2013, 17:15
... Duality
ã Organization
COMPUTATION PROBLEM
ã Iterative descent
ã Approximation
ã Role of convergence analysis
ã Role of rate of convergence analysis
ã Using an existing package to solve a nonlinear
programming ... Sensitivity
Duality
ã Computation by iterative algorithms
Iterative descent
− Approximation methods
− Dual and primal-dual methods
LOCAL AND GLOBAL MINIMA
f(x)
x
Strict Local
Minimum
Local Minima Strict ... x
k
, the method ob-
tains x
k+1
as the minimum
of a quadratic approxima-
tion of f based on a sec-
ond order Taylor expansion
around x
k
.
CONVERGENCE RATE OF PURE FORM
ã Consider solution of...
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Tài liệu Issues Involved When Updating the Primary Key of a Parent Row pptx
Ngày tải lên :
24/12/2013, 01:17
... in the child DataTable. This is the default.
None Indicates that no action takes place.
SetDefault Indicates that the DataColumn values in the child DataTable are to be set
to the value in the ... stored in a DataTable named ordersDT.
ã
The customersDT and ordersDT DataTable objects are related to each other using
the following DataRelation:
ã
DataRelation customersOrdersDataRel =
ã ... you change the DataColumn in
the parent DataTable on which the ForeignKeyConstraint was created, then the same
change is also made in any corresponding DataRow objects in the child DataTable....
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