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Báo cáo khoa học: Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin potx
... detailedmap of the epitopes for the mAbs, where 45M1 recog-nizes an epitope located in the N-terminal region of the C-terminal cysteine-rich part of MUC5AC, pre-sumably in the last CysD domain of the ... epitopes locatedin the MUC5AC C-terminal cysteine-rich part.Further localization of the epitopes of 45M1,2-12 M1 and 166M1In order to further locate the epitopes of the hithertounmapped 45M1, ... representation of full-length human MUC5AC with its domains. The C-terminal region of the protein is expanded,and its domains and GDPH-cleavage site are indicated. In the lower part of the figure, the mapped...
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Economic Impact of the Abolition of the Milk Quota Regime – Regional Analysis of the Milk Production in the EU – doc
... average, with +35.5% in the EU-10 and +13.8 in the EU-15. This excess supply makes the net trade position of the EU-27 stronger towards the Rest of the World. Within the EU there is a quite heterogeneous ... Impact of the Abolition of the Milk Quota Regime – Regional Analysis of the Milk Production in the EU" (AGRI-2007-0444). The project aimed at a thorough policy impact analysis of the EU ... through either the transfer of an entire farm, the leasing or purchase of quota, or the allocation of quota from a national reserve. The transfer of milk quota may take place via a variety of administrative...
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Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf
... between the projection of the tilt of the z axis on the xÂ,y plane (dened direction of tilt of z and the x axis), and j % a + c denes the location of the rhombic (x, y) axes. The orientation of the ... at position E7 as the source of the H-bond to ligand on the basis of apartial sequence, which had indicated a Tyr on the distalE-helix. The similarity in the 1HNMRspectraofthethree globin ... ligand.Comparison of the strengths of dipolar interactions insolution with the alternate crystal structures of methemo-globin establish that the solution structure of wild-type Hbmore closely resembles the...
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Báo cáo khoa học: Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides pptx
... residue of the primary sequence; the second series consists of a progressivetruncation of the C-terminal domain of PufX (Fig. 1)obtained by the introduction of stop codons in the genesequence of ... demonstrated the role of PufX in the orientation of the RC inside the LH1Fig. 4. Isolation of the PMCs on a sucrose gradient. The final detergentextracts from the ICM were loaded on the top of a 10–40% ... PufXD2)7neither affects the photo-synthetic capability of the bacteria nor the efficiency of exchange of the ubiq uinol molecules between th e RC and the bc1, a s judged from the reduction kinetics of...
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Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
... which the N-terminus of the OTR is replaced with the corresponding sequence of the V1aR [10]. The role of the N-terminus has beenaddressed recently by alanine-scanning mutagenesis of the N-terminus ... of the V1aR. The V1aR is illustrated as sevena-helical transmembrane domains traversing the lipid bilayer. The enlarged circle shows the amino acid sequence of the distal N-terminus of the ... mutation of Arg46 had the dualeffect of (a) decreasing agonist affinity and (b) promoting the agonist-induced active conformation due to the loss of astabilizing constraint on the ground state of the...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
... evaluation of the effect of singlepoint mutations on the solution structure of monomericderivatives, we analysed the 2D NMR spectra of the different variants of mBS. Figure 3 shows the expandedregions ... whereas in the case of L28Q and P19A/L28Qvariants the yield of dimer was significantly lower, 50%. The recombinant dimers were obtained predominantly intheir nonswapped forms; the extent of exchange ... the structural properties of the monomeric forms of P19A-BS-RNase, L28Q-BS-RNase and P19A/L28Q-BS-RNase variants with those of the parent protein, andinvestigated the exchange kinetics of the...
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Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
... copies of the N protein, respectively. (C) The RNA binding efficiency of N protein is represented as a percentage of bound RNA (i.e. the percentage of bound RNA = 100%)percentage of free probe). The ... as 100 · (arbitrary unit of each band in individual lane divided by the unit of the unbound RNA detected in the absence of the N protein). The results are representative of four independent experiments. ... phosphorylation.Effect of RS motif phosphorylation onoligomerization of the N proteinTo better understand the effect of RS motif phosphor-ylation on the biological function of the N protein, weFig. 3. The translation...
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Báo cáo khoa học: Structure of the exceptionally large nonrepetitive carbohydrate backbone of the lipopolysaccharide of Pectinatus frisingensis strain VTT E-82164 doc
... compared with 7a (Table 1) because of the b-effect of the acetylation. Acetylation of 7b was confirmed byESI MS data, which gave the expected mass of 3221.4 Da. The spectra of oligosaccharide 6 were ... the L-isomer instead of the D-isomer resulted in the disappearance of the contactbetween protons U6 and P4.To determine the absolute configurations of the mono-saccharides, LPS (300 mg) was ... position 2. The substitution positions of all the other monosaccharideswere confirmed by GC-MS data of the methylated productsto be as presented in Scheme 1.Deamination of the products of complete...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc
... [28]. Aggregation of the NR1FAD/NADPH domain was much less extensive in the absence of cofactor reduction.Stopped-flow kinetic studiesReduction of the FAD/NADPH domain of NR1 was investigated ... stabilization of the FMN semiqui-none, consistent with (a) a need to transfer electrons from the FAD/NADPH domain to the FMN domain, and (b) the thermodynamic properties of the FMN domain in CPR ... from the NR1-FAD/NADPH domain as the His-tag was ineffi-ciently cleaved from this domain. The presence of the His-tag on the FAD/NADPH domain had no apparent effecton catalytic activity.The...
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Báo cáo khoa học: Structure of the O-polysaccharide fromProteus myxofaciens Classification of the bacterium into a newProteusO-serogroup pptx
... the Dconfiguration (the b effect on C3 of L-GlcAwouldbeclosetozero[27]).On the basis of the data obtained, it was concluded that the repeating unit of the O-polysaccharide of P. myxofac-iens has the following ... LPS)[5,6]. The serological specificity of the bacteria is definedby the structure of the O-specific polysaccharide chain(O-antigen) of the lipopolysaccharide. On the basis of the O-antigens, the strains ... demonstrated the modes of glycosylation of the monosaccharides. The linkage positions were confirmed and the sequence of the monosaccharides was determined using a 2D ROESYexperiment, which revealed the...
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AUDIT OF THE CONTROL SYSTEM GOVERNING THE PRODUCTION, PROCESSING, DISTRIBUTION AND IMPORTS OF ORGANIC PRODUCTS potx
... reports and transmit them to the Commission, within six months of the end of the year to which the reports relate.’ REPLY OF THE COMMISSION60Special Report No 9/2012 – Audit of the control system ... is the responsibility of the competent authority of the Member State to verify the competence of the control body to issue a certificate of inspection, and in particu-lar the evidence that the ... 6 The Commission agrees with the recommendation of the Court. The main challenge of the system of import authoris ations is to ensure that the competent authorities of the 27 Member States adopt...
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Báo cáo khoa học: Expression and characterization of soluble forms of the extracellular domains of the b, c and e subunits of the human muscle acetylcholine receptor pot
... closely related to the a7subunit of the neuronal AChR (24% identity of aminoacids) than each of the muscle AChR subunits (22%on average) necessitates the solution of the structure of the mammalian ... studied.Our aim was to obtain satisfactory amounts of the ECDs of the non-a sub-units of human muscle AChR for use as starting material for the determin-ation of the 3D structure of the receptor ... of the b, c and e ECDsAs (a) the presence of the HIS tail on the constructsgreatly facilitates purification, (b) its negative effect on the yield of c1–128 was considerably counteracted bythe...
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LORD NEUBERGER OF ABBOTSBURY, MASTER OF THE ROLLS JUSTICE IN A TIME OF ECONOMIC CRISIS AND IN THE AGE OF THE INTERNET ppt
... buildings owe their design to the necessities of parties, witnesses and their lawyers attending court for hearings, and, behind the scenes, the needs of the judges and of the back offices, which ... performed. And, apart from the defence of the realm, there is no duty as important as maintaining the rule of law; and just as every fundamental aspect of the defence of the realm must be real ... Parliament, the executive, and, of course, the justice system. 10. Reform of the justice system, to our courts and the legal profession, like reform of the law, must clearly be consistent with the...
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Review of the Literature Regarding Critical Information Needs of the American Public
... identify the broadest possible range of potentially useful analytical approaches going forward. At the same time, however, this review remains tightly focused on the issues of the diversity of communities’ ... in the U.S. devoted to education, but there is no substantiation of this figure, and most of the blogs discuss are professional or academic blogs. There is an extended discussion of nonprofit ... outlining the historical context of health and media studies, the authors describe major individual-level theoretical frameworks applicable in the area: social cognitive theory, the theory of reasoned...
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