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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"

Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"

Ngày tải lên : 26/10/2012, 10:04
... models with a deletion of this gene develop disorders that resemble the symptoms of subjects with a deleted allele in the 5’-untranslated region of NPRA. We previously iso- lated a missense ... levels. Thus, it is possible that the plasma BNP level is not an accurate reflection of the function of the NPPB gene. In the present study, the overall distribution of the VNTR genotype and the ... School of Medicine, Tokyo, Ja- pan 3. Division of General Medicine, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan Correspondence to: Tomohiro Nakayama M.D., Division of...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc

Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc

Ngày tải lên : 16/02/2014, 15:20
... control of gene expression. As each step of the RNA metabolism is tightly regulated, the regulation of mRNA export, stability and transla- tion rate is essential for the control of the expression of ... and reflect the capacity of TIAR to be associated with polysomes. Although the association of DDX21 with TIAR relies on RNA intermediate, DDX5, hnRNP M and ASF ⁄ SF2 are associated with TIAR by protein– protein ... family of RNA-binding-proteins. It is a shuttling protein [5] involved in multiple aspects of RNA metabolism. In the nucleus, this protein acts as a regulator of the alternative splicing of diverse...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx

Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx

Ngày tải lên : 19/02/2014, 05:20
... cultured human cells. Discussion We have shown that the selective knockdown of HO-2 expression with each of two different siRNAs is consis- tently associated with increased expression of HO-1 mRNA and ... influence the expression of HO-1. The dominant expression of HO-2 protein, in comparison with the low expression of HO-1 protein, in H146 small cell lung cancer cells is of particular interest ... It is the MARE site that is bound by Nrf2, a transcription activator, or Bach1, a transcription repressor, each of which functions as a heterodimer with a member of the Maf family [46]. Bach1 is...
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Tài liệu Báo cáo khoa học: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum ppt

Tài liệu Báo cáo khoa học: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum ppt

Ngày tải lên : 19/02/2014, 17:20
... A short variant of about 1700 nucleotides is abundantly present in brain. Lower amounts of this variant and also of a longer isoform of about 2200 nucleotides were ubiquitiously expressed with lowest ... pressure on this sequence and supporting the hypothesis that this part of the mRNA is translated. Eleven exons encode the ORF of human Hu-K4 (Fig. 4A, exon 5–15). The analysis of more than 100 GenBank ... protein colocalizing with protein disulfide isomerase, a marker of the endoplasmic reticulum. Glycosylation of Hu-K4 as shown by treatment with peptide N-glycosidase F or tunicamycin indicates that Hu-K4 has a type...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx

Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx

Ngày tải lên : 05/03/2014, 23:20
... as MB, is capable of inducing mitochondrial proton leak in the spleen and liver of injected mice. Moreover, it is of importance to note that the maximum in vivo effect of MDP and some of its ... infections, potentiation of anti-tumour activity of macrophages, manipulation of cytokine release and restoration of haematopoiesis [18–20]. The parent molecule of this family is muramyl dipeptide (MDP), which ... effects with those of the parent molecule MDP. The results reported establish the safety of MB, the absence of undesirable effects on the central nervous system, and the lack of induction of inflammatory...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf

Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf

Ngày tải lên : 08/03/2014, 08:20
... absence of differentially glycosylated forms of GC-C. It is possible that the reappearance of the 145 kDa form following removal of ST peptide was a consequence of further glycosylation of the ER -associated ... The absence of GC-C desensitization (which is correlated with removal of the 145 kDa form of GC-C from cells) in HEK293-GC-C cells could be due to lack of a cellular factor that is present in T84 ... all derived from different types of colonic carcinomas. T84 cells are derived from lung metastasis of a patient with colonic carcinoma and exhibit many charac- teristics of polarized epithelial...
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Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx

Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx

Ngày tải lên : 08/03/2014, 10:20
... of only one isomer. Molecular modelling data ( not shown) suggested t hat this isomer is 2-E with trans orientation of N 1 to C5 as 2- Z would be s terically hindered b y interaction of one of ... stereoisomerism). The lower-đeld 1 H NMR signal of 3 belonged to the N-methyl group at N 2 in the E isomer and t he higher-đeld signal t o that in t he Z isomer, in which N 1 is in trans and cis ... careful NMR spectroscopic analysis was used to elucidate the structure of N-methylated derivatives of legionaminic acid. Comparison of the 1 H N MR spectra of the OPS of pool III from all three investigated...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx

Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx

Ngày tải lên : 17/03/2014, 11:20
... possibly through suppression of upstream targets of ERK. Thus, one of the functions of bikunin is the regulation of uPA synthesis and uPA binding by modulat- ing uPAR. It is most likely that the PMA-induced ... reported that bikunin expression is associated with a less malignant phenotype [24]. There is evidence that bikunin significantly prevented pulmonary metastasis of mouse Lewis lung carcinoma 3LL cells ... twice with similar results. Ó FEBS 2002 Suppression of uPAR by bikunin (Eur. J. Biochem. 269) 3951 Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream...
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Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf

Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf

Ngày tải lên : 23/03/2014, 09:20
... FEBS His15 and His66 seem to contribute to the differential interaction of Lqh3 with channel receptors of various origin. In total, the bioactive surface of Lqh3 is composed of two distinct ... 6B). Discussion Insight into the molecular basis of preferential interac- tions of scorpion a-toxins with insect or mammalian Na v s was thus far obtained mainly from mutagenesis and comparison of ... 3). Whereas substitutions of His15, His36 and His43 did not reduce Lqh3 sensitiv- ity to pH, substitutions of His66 had a clear impact with the utmost decrease obtained with H66R (Table 3). Unexpectedly,...
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Báo cáo khoa học: "WHAT A TYPE OF INTERACTION IS IT TOBE HT" potx

Báo cáo khoa học: "WHAT A TYPE OF INTERACTION IS IT TOBE HT" potx

Ngày tải lên : 24/03/2014, 01:21
... impacts on this aspect of the exchange of talk. It is one reason for wondering whether retention of ordinary conversation as the target of this enterprise is appro- priate. For some of the contemplated ... "interactionality" is the sequential organiza- tion of the talk; that is, the construction of units of participation with specific respect to the details of what has preceded, and thereby ... matters right. This is a major safe- guard of "intersubjectivity," a retention of a sense that the "sa~ thing" is being understood as what is being spoken of. The requirements...
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Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf

Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf

Ngày tải lên : 29/03/2014, 00:20
... alignment of the Artemia ANT p rotein sequence with that of other species (Xenopus, Drosophila, mouse isoforms 1, 2, and 4, rat isoforms 1 and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms ... compared with the known structure of bovine ANT. Comparison of the predicted three-dimensional structure of Artemia ANT with that of bovine ANT The structure of bovine ANT (isoform 1) is known (structure: ... mitochondria isolated from embryos of A. francis- cana. It is of note that, in the presence of oligomycin and ADP, addition of Ca 2+ failed to induce an increase in light scattering (Fig. 2A), consistent...
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