what is the history of the mcintosh apple the fruit not the computer
Báo cáo khoa học: Structure of the complex of a yeast glucoamylase with acarbose reveals the presence of a raw starch binding site on the catalytic domain doc
... [16]. The active site is at the narrower end of the barrel asmapped by the presence of ligands (Tris in Glu1.1 oracarbose in the Glu-A structure).Accuracy of modelsAs expected, the accuracy of ... confirms that the deviation of torsion angles from ideal geometry of these two residues is an intrinsic feature of the struc-ture. In Glu1.1 there is another residue, Ser305 in the generously ... and discussionDescription of the structuresThere is one molecule in the asymmetric unit of bothstructures composed of a single domain consisting of 14 helices, 12 of them forming an (a ⁄ a6)...
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routledge history of philosophy vol v british philosophy and the age of enlightenment - stuart brown
... developed is the main concern of this History. In speaking of what is now regarded as philosophy’, we may have given the impression that there now exists a single view of what philosophy is. This is ... Context (1994). He is the author of numerous articles on the history of seventeenth century philosophy. M.A.Stewart is Professor of the History of Philosophy at the University of Lancaster. Hehas ... The history of philosophy, as its name implies, represents a union of two very differentdisciplines, each of which imposes severe constraints upon the other. As an exercise in the history of...
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Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"
... below the 0.70 for Bc1 in all groups. The relevance of this finding is that it was the result of the first sub-group analysis for these biomarkers. Bc1 should therefore be studied in terms of ... subjects, the comparison of the benign and control groups did not yield a statistically significant difference. None of the proteomics reach reasonable AUC values for the discrimination of the BC. ... products. These approaches, however, have poor sensitivities and specificities since none of them alone is useful for the majority of the BC and none of them is specific for cancer or breast tissues....
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A STUDY ON THE USE OF PEER TEACHING IN ESP CLASSES AT THE COLLEGE OF SCIENCE, VIETNAM NATIONAL UNIVERSITY HANOI
... translate the materials in their specific fields written in English. The biggest difficulty for the teachers of ESP here is that they do not have enough knowledge of the specific field that they ... review of higher education research on teaching and learning: The best answer to the question of what is the most effective method of teaching is that it depends on the goal, the student, the ... design of the study. The second part, the main part, of the study is divided into three chapters. Chapter 1 deals with the review of the literature relevant to the study. Chapter 2 covers the...
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Tài liệu Guidelines for the appointment of General Practitioners with Special Interests in the Delivery of Clinical Services pdf
... supervisor/s to confirm the satisfactoryfulfilment of the required training experience and the acquisition of the competencies enumerated in this document and others thought necessary by the employing ... level 1 services. Therefore an initial role of a GPwSI service maybe to support this further.Further activities of the GPwSI service depend on the needs of the Primary CareOrganisation (PCO) and ... The number of sessions should be sufficient to ensure that the GPwSI is able to meet the competencies of the service requirements, the skillbeing assessed and the level of expertise required....
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
... sensitivity analysis of the chicken Ig-b locus has not been finished because of the technical difficulty of this type of assay, there may beno difference in the range and extent of general sensi-tivity ... acetylation of H3 and H4histones, and the remaining DHSs in the deleted cellswere examined to determine the roles of these DHSson the transcription of Ig-b gene and on the mainten-ance of the active ... the Na channel gene and in the first intron of the Ig-bgene. Furthermore, the acetylation status of H3 andH4 histones was examined [15]. In the present study,10 DT40-specific DHSs found in the...
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Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis doc
... concentration of the inhibitor, A is locked to 0%, B to 100%, C is the IC50value and D is the slope of the curve. The IC50value is the concentration x, where y ẳ 50%.Kmwas measured using the HPLC ... aggregation of the protein. This is further confirmed by the existence of a natural variant of CPU, where T347 is subsitutedby an I. Although accentuating the hydrophobiccharacter of the protein ... WT CPU andthereby decreasing the observed Kmin comparison toWT CPU. This hypothesis is supported by the use of a newly developed continuous coupled enzyme assayinstead of the discontinuous...
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Báo cáo khoa học: The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides pot
... hese gels, as the ODN h ybridizes to the center of the input target RNA. The asterisk indicates the input targetRNA; the arrow indicates the digested product bands. The amount of digested product ... investigate the nature of the differences inresponse t o a ntisense ODNs we analyzed the RNase H levelsin the cell lines, as RNase H is claimed to be a keycomponent in the mechanism of inhibition of ... expression is presumed to result indegradation of the target mRNA via RNase H activity. The efđcacy of a particular ODN can therefore b est be a ddressedby Northern blot analysis of the target...
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Bringing the Hidden Giants to the Footlight: the Role of Savings and Retail Banks in Increasing the Level of Access to Financial Services docx
... loan is decided on the basis of the borrower’s investment need and their ability to repay. The amount of the first loan does not exceed US$ 750 and the borrowers can apply for a second loan of ... analysis of the creditworthiness and the repayment capacity of their clients, a domain where they have a high level of expertise, while savings banks could make use of their front and back of ce ... physical banking infrastructure is essential to collect the often small amounts of savings, and maintain them at the disposal of the client on a permanent basis. It requires skilled staff,...
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Surfing the waves of globalization - Asia and financial lobalization in the context of the trilemma
... TIỂU LUẬN TÀI CHÍNH QUỐC TẾ ĐỀ TÀI: SURFING THE WAVES OF GLOBALIZATION: ASIA AND FINANCIAL LOBALIZATION IN THE CONTEXT OF THE TRILEMMA + GVHD : Ts Nguyễn Khắc Quốc Bảo + Nhóm ... cho nền kinh tế đóng theo đuổi chính sách tỷ giá cố định. Vì vậy, đối với các nước có nền kinh tế đóng có mức độ nắm giữ IR cao ( cao hơn ngưỡng 15-16% GDP), tốt cho việc theo đuổi chính sách ... trung vào việc theo đuổi tỷ giá hoái đoái cố định. Đối với nền kinh tế này thì biên động đầu tư ít quan trọng nhưng nó làm quan trọng hơn mức độ nắm giữ IR cao. Thật là quan trong khi theo đuổi...
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Báo cáo khóa học: The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex pptx
... form.These d ata suggest that chaperone a ctivity is not aprerequisite for protection of t ranslation by small hsps afterheat shock [35]. The ubiquitin-proteasome pathway is a nother mech-anism ... investigation into the regulation of protein synthesis in mammalian cells, we have investigated the e ffects of inhibition of the p roteasome o n the localiza-tion and integrity of eIF4G in C2C12 ... [50,51].Results The proteasome inhibitor, MG132, promotesan inhibition of protein synthesis without the cleavage of eIF4GI or eIF4GIIIn a number of different cell types, inhibition of the 26Sproteasome...
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Báo cáo khoa học: Analysis of the effect of potato carboxypeptidase inhibitor pro-sequence on the folding of the mature protein pot
... large dispersion of resonances at the low or high fields. In the 0–1 p.p.m. region there are not a significant number of potential shifted methyl protons,and the dispersion of resonances is also ... by the presence of external thiols in the foldingmixture [18]. While the addition of Cys accelerates the second stage of disulfide reshuffling of scrambled forms tonative PCI, the addition of ... Similarly, the pro-region of the guanylylcyclase activating peptide (GCAPII) contributes signifi-cantly to the correct disulfide-coupled folding of the matureprotein and the dimerization of the molecule...
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Báo cáo Y học: The presence of phosphate at a catalytic site suppresses the formation of the MgADP-inhibited form of F1-ATPase potx
... course of the ¯uorescence quenching on addition of MgATP in the presence of various concentrations of Pi is shown in Fig. 3B.Although the ®nal magnitude of the ¯uorescence quenchingby the addition ... Pi[18]. Here weexamined the effects of Pion the formation of the MgADP-inhibited f orm o f the a(W463F)3b(Y341W)3c subcomplex. The extent of ADP inhibition of the a(W463F)3b(Y341W)3c ... is at the c phosphate of ATP, and does not interfere with ADP binding. The other is that Pibinds to a site o ther than any of the catalytic sites.In the ®rst case, it is possible that Pibinding...
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the neuroscience of social interaction decoding imitating and influencing the actions of others mar 2004
... reaching when there is no reason tobelieve an object is hidden from sight fails to activate the F5 cells. Thus F5and STS cells code the sight of actions on the basis of what is currently vis-ible ... it. This leads to a fundamental problem. What we see is a series of configurations of the person in space, but what we have to do is to issue aseries of motor commands. How can we translate what ... into what weneed to do? The discovery of mirror neurons demonstrated that a mechanismfor translation is present in the primate brain and is automatically elicitedwhen viewing the actions of others....
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báo cáo hóa học:" The influence of the level of physical activity and human development in the quality of life in survivors of stroke" potx
... smaller is the numerator and therefore the worse the situation o fdevelopment. Conversely, the closer the observed value is to the maximum value, the better the situation interms of development. The ... Brazil, andthat the HDI Table is based on the territorial division in2000, year of completion of the last census, with 5,507cities. The periods of interest for this study, on the other hand, correspond ... definedthrough the observation of t he world tendencies interms of i ndicators for the long term, allowing periodiccomparisons of the indexes obtained.It is noteworthy that there are 27 states...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25