what is its role in drug discovery
Báo cáo y học: "What is the role of surfactant and inhaled nitric oxide in lung transplantation" pps
... considered This interesting approach was successful in the experimental setting of acute lung injury and needs to be verified in clinical indications other than lung transplantation Competing interests ... the hypothesis that this combination prevents intrapulmonary shunt more effectively than does either intervention alone, and that it reduces inactivation of surfactant substitutes In summary, ... improved surfactant function in an ischaemia/reperfusion model in minipigs by preventing plasma leakage [11] A further improvement in graft function and better maintenance of the small aggregate/large...
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Báo cáo y học: " Recombinant human activated protein C in acute lung injury: what is the role of bronchial circulation" docx
... determine the effects of rhAPC in an ovine model when the bronchial artery is tied off to clear its mechanism in ALI Competing interests The authors declare that they have no competing interests ... special feature, a single bronchial artery, and a single lymphatic draining of the lung A 10-fold increase in bronchial blood flow could be shown within 20 minutes of smoke inhalation These same ... of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344:699-709 Levi M, van der Poll T: Recombinant human activated protein C: current insights into its mechanism of action...
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Báo cáo y học: "Clinical review: What is the role for autopsy in the ICU" doc
... this are many First, pathologists are experiencing an increasing workload Secondly, since infectious diseases are rising, pathologists fear the risk of infection [10] Finally, autopsies now contribute ... already known infections This finding emphasises the difficulty of diagnosing unexpected or new pathogens in patients with existing infections Pulmonary embolism remains one of the major missed diagnoses ... 2009 in uenza A H1N1 infection are located in the lungs, identifying three distinct histological patterns Ongoing aberrant immune responses in lung specimens could be identified in patients dying...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... very-KIND-MAP2 interaction v-KIND KIND2 KIND2-1 KIND2-2 KIND2-3 KIND2-4 KIND2-5 A 620 521 555 488 589 EGFP EGFP-KIND2-1 EGFP-KIND2-2 EGFP-KIND2-3 EGFP-KIND2-4 EGFP-KIND2-5 EGFP-KIND2 EGFP-KIND1 ... v-KIND KIND2 domain contain the MAP2-binding core site (A) Division of the KIND2 domain (456–620) into five subregions: KIND2-1 (amino acids 456–487), KIND2-2 (amino acids 456–521), KIND2-3 (amino ... deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 domain (B) KIND2 domain anchors v-KIND to dendrites Flag-tagged v-KIND, DKIND1, DKIND2, DKIND1 + 2, DRasN, DGEF, KIND1 or KIND2 together with...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... the mechanisms of this regulation On the basis of the above findings, our research provides new insights into the role of exon in the regulation of apoptosis and invasion in liver cell lines FEBS ... levels is not considered to be the mechanism underlying its effects in cancer cell apoptosis and invasion [21] In this article, we provide evidence of an additional occludin variant deleted in exon ... occludin in apoptosis and invasion A C B D E F Fig Identification of a human occludin splice variant in liver cell lines (A) Occludin protein expression was examined with an antibody to the N-terminus...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... histidines in the C-terminal, another histidine is present at position 18, and given the folded state of the protein it is possible that this residue could play a role in copper binding No His ... C-terminus (box in Fig 1) at sites: 92, 75, 66 and 58 As histidine residues are central to copper binding in many proteins they probably form part of the copper binding sites in this protein Although ... were consistently increased in brain tissue from CSTB-deficient mice encode proteins involved in responding to neuronal damage [21], i.e., genes which code for increased proteolysis, apoptosis and...
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Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx
... in the AUH gene This indicated that AUH, in addition to its RNA binding function, must play an important role in leucine catabolism AUH was overproduced in E coli and characterized by measuring ... suggesting that this enzyme had another function in cellular metabolism Indeed, AUH had enoyl-CoA hydratase activity, which was described as an additional intrinsic function of the protein Its role ... biosynthesis exists [8] Interestingly, certain patients with Smith–Lemli–Opitz syndrome also show abnormally increased plasma levels of this compound, further challenging our understanding of 3-methylglutaconic...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... Km (Michaelis constant) and Vmax (maximum velocity) values were determined by incubating the diluted recombinant proteins in the standard reaction mixture in the presence of increasing concentrations ... determined using a PPi hydrolysis assay in a standard reaction mixture containing mM Mg2+, 100 mM Tris/HCl, pH 7.5 and mM PPi The recombinant protein showed a specific activity of 937 lmol PiÆmin)1Æmg)1 ... Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR Infect...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... may play a role in promoting proliferation and preventing apoptosis [8] dMASK mediates receptor tyrosine kinase (RTK) signaling, independent of MAP kinase (MAPK) by either functioning downstream ... St Louis, MO) for days and cultured in RPMI containing 10% FBS, 1% penicillin– streptomycin and interleukin-2 growth factor Monocytes were isolated using CD14 beads and differentiated into macrophages ... Cancer Institute, Shanghai, China Smith RK, Carroll PM, Allard JD & Simon MA (2000) MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... mLámin)1 The following gradients were used: incubations containing arbutin or salicin as substrate; 100% C initial, increasing D to 20% (10 min), 50% (15 min), 100% (5 min), held at 100% (5 min); ... GlcRha, rutinoside (1,6-linked rhamnoglucoside) Class Compound Flavonols Quercetin-3-Glc (isoquercitrin) Quercetin-3-GlcRha (rutin) Quercetin-4¢-GlA Kaempferol-3-Glc Isorhamnetin-3-Glc Naringenin-7-GlcRha ... CBG in metabolic tissues such as the intestine, liver, kidney and spleen indicate that CBG is exposed to orally ingested xenobiotic glycosides The broad speci®city of the CBG distinguishes this...
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Solar and Space Physics and Its Role in Space Exploration doc
... Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in the ... with new missions The senior review process15 is one mechanism for determining the value of extending an individual mission The science during an extended mission is typically cutting-edge and ... of the initial mission development cost Prime mission funding is provided under the mission budget, while extended mission funding is competed through periodic review of all ongoing missions...
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Interest Rate Policy in Egypt - Its Role in Stabilization and Adjustment pdf
... discounted A Interest Rate and Business Investment The first step in examining how higher interestrates may influence business investmentdecisions and performances is the understandingof firms' ... deficit IV THE ROLE OF INTERI T RATES IN THE ADJUSTHKUT PROG*MM Among the multitude of reasons arguing for interest rate reform in Egypt it is its role in facilitatingthe country's ongoing process ... succeed in getting public enterpriseson the same footing as private enterprises in the financing of their investment program, the yields on the alternative financing sources will be equalized This...
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The Causal Effect of Education on Health: What is the Role of Health Behaviors? pot
... measured by smoking, drinking, exercising and the body mass index – contribute to explaining the gradient We find that the effects of education on smoking, drinking, exercising and eating a proper ... published in this series may include views on policy, but the institute itself takes no institutional policy positions The Institute for the Study of Labor (IZA) in Bonn is a local and virtual international ... health There is also evidence that health behaviors - measured by smoking, drinking, exercising and the body mass index - contribute to explaining the gradient The size of this contribution is larger...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... Only this latter construct directs the production of a fusion protein bearing an N-terminal extension of 20 residues including a His6-tag At a later stage, a point mutation was introduced in the ... alanine reported in [24] In yeast, human, and Arabidopsis, it has been shown that the N-terminal part of PEX14 is responsible for the interaction with PEX5 [16,31,32] This N-terminal domain of ... organisms is followed by a stretch of hydrophobic amino acids that is presumably involved in the protein’s anchoring to the membrane Also in PEX14 of T brucei a series of hydrophobic residues is...
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Advanced Computer-Assisted Techniques in Drug Discoveryedited by Han van de Waterbeemd.Methods pot
... of computers in molecular design and in the lead discovery process The present series “Methods and Principles in Medicinal Chemistry” compiles the progress made in medicinal chemistry and illustrates ... computer-assisted molecular design (CAMD) In Fig a schematic representation of the main building blocks used in computerassisted methods in medicinal chemistry is given The core is formed by ... Tetrachloro-dibenzo-p-dioxins Trichloro-dibenzo-p-dioxins 2.1.1 Introduction The role of computational simulations of molecular mechanisms in understanding biological processes is emphasized in this sentence by Weinstein...
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Báo cáo y học: "ignal 3 and its role in autoimmunity" pot
... Available online http://arthritis-research.com/content/6/1/26 known roles in tissue inflammation, and damage in innate immunity Besides its capacity to drive the production ... development of inflammatory arthritis [14-16] This highlights the critical role of IL-1ra in the constitutive maintenance of peripheral tolerance, and in counterbalancing the proinflammatory effects ... Wiekowski M, Lira SA, Gorman D, Kastelein DA, Sedgwick JD: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 2003, 421:744-748 Nakae...
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Báo cáo y học: "Circadian rhythm and its role in malignancy" docx
... loss during intestinal tumorigenesis may, in part, act through upregulation of b-catenin, increasing intestinal b-catenin signaling and cell proliferation Also, increase in small-intestinal mucosa ... oscillators A major finding in the field of circadian rhythms in recent years is that the SCN is not the only circadian clock in the organism Indeed, most tissues including extra-SCN brain regions and ... excision repair has been investigated in mice Nucleotide excision repair is found to display prominent circadian oscillations in mouse brain reaching at its maximum in the afternoon/early evening...
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Báo cáo y học: " Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively" docx
... as insulin resistant) [16] Exclusion criteria were a history of infectious chronic diseases including hepatitis B and C, neoplastic and/or haematological diseases, autoimmune and storage diseases, ... more absolute risk because SAAT volume is greater than VAT [19]; jjjj) in adults, visceral fat is directly associated with liver inflammation and fibrosis independently of insulin resistance and ... 18.0 5.2 8.9 6.1 Visceral adipose tissue (VAT); subcutaneous abdominal adipose tissue (SAAT); spleen longitudinal diameter (SLD); alanine aminotransferase (ALT); insulin resistance (IR); [black...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... this cytokine owing to inherited defects might further contribute to the pathophysiology of asthma Optimal signaling by IL-4 (reviewed in [23]) involves its interaction with receptors consisting ... apoptosis by IL-4 might be mediated partly by the ability of this cytokine to maintain levels of the survival-promoting protein Bcl-2 in T cells [11] Apoptosis of T lymphocytes can be induced ... treatment of rheumatoid arthritis in adults and children Clinical studies with rhuIL-4R (Nuvance™) The promising results in preclinical studies led to preliminary investigations in which rhuIL-4R proved...
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Báo cáo y học: " Beyond the first 25 years: The International AIDS Society and its role in the global response to AIDS" pps
... IAS is also increasingly involved in the development and delivery of a range of education and training programmes designed to help individuals working in HIV advance professionally, from administering ... Providing education and training opportunities for its membership is important for any professional society, and the IAS is looking at ways to strategically expand its role in this area in order ... currently in development, will ensure the IAS is an effective advocate for its membership, bringing its voice and influence on key policy issues, in collaboration with other stakeholders engaged in...
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