... in the design of the product, did not properly balance the risks to product users against the utility of the product tosociety.It is the reasonableness, or lack thereof, of the ... few of the areas where the law can have asignificant impact on engineers' discharge of their professional responsibilities. As part of the process of product design, the ... that the breach of duty by the defendant was the cause of the plaintiff's injury. The doctrine of negligence rests on the duty of every person to exercise due care in...
... late steps ofthe process. For example, early in the NER process, RPA assists TFIIH in the opening of the DNA helix around the damage site [36]. Further-more, in the presence ofthe XPA minimal ... sites.Taken together, these findings suggest that the struc-tural properties of DNA-damaged substrates, whetherintrinsic or the result of protein binding, function in the recruitment ofthe XPC–hHR23B ... sequentially at the site ofthe damage and constitute the pre-incisioncomplex. Endonuclease XPG and the XPF–ERCC1complex are responsible for the 3¢ and 5¢ DNA inci-sions, respectively. Binding of XPG...
... beenimplicated in all but one ofthe predicted reactions in the GPI pathway. The exception is the addition of the second mannose to the GPI core. We show here thatdepletion ofthe essential, multispanning ... Ybr004cp func-tions upstream of Smp3p. Together, these data furthersupport the conclusion that Ybr004cp functions in the yeast GPI assembly pathway.Sequence analysis ofthe Ybr004cp protein familyDatabase ... cells leads to the bio-chemical defects expected if addition ofthe second,a-1,6-linked mannose to GPI precursors is prevented.These defects are a block in the incorporation of [3H]inositol...
... mammalian-specific function of SMO (e.g. nucleartargeting ofthe mSMOl isoform). Inspection of the mSMOl modelled structure (Fig. 2) indicates that bothregions are located on the tip ofthe FAD-bindingdomain, ... islocalized on the tip ofthe FAD-binding domain, inclose spatial proximity to the protein region encodedby exon VIa ofthe mSMOl isoform. This observationhas led us to hypothesize that these two ... cytosolic. The only structuraldifference between the two isoforms is the presence of an extra protein domain in mSMO l, encoded by the exon VIa [10].Comparative analysis ofthe amino acid sequenceof...
... sites ofthe tetramer are indicated by the bound CoA molecules. The catalytic site ofthe yellow domain is marked by an arrowhead. (B) The binding mode of CoAto the thiolase monomer. The three ... contacts to the pantetheine moiety of CoA at the outer edge of the tunnel. Water molecules are also present in the pantetheine binding tunnel, both in the unliganded andliganded states [2,11]. There ... modes of these related compounds. The results show that both the CoA terminal SH group and the side chainSH group ofthe catalytic Cys89 are crucial for the correct positioning of substrate in the...
... representing the PSBD ofthe dihydrosuccinyltransferase chain of the 2-oxoglutarate dehydrogenase complex of E. coli [12]and ofthe dihydroacetyltransferase chain ofthe PDHcomplex of B. stearothermophilus ... 119–171) ofthe B. stearothermophilusE2p polypeptide chain with the dimer of a proteindomain (E3int) representing the interface domain (resi-dues 343–470) of B. stearothermophilus E3. The use of the ... (seeabove) are probably due to the use of uniformly15N-labelled PSBD and the inclusion of additional resi-dues in the construct at the N-terminus ofthe domain.In particular, the absence of residues...
... properties ofthe FeFe protein (Eur. J. Biochem. 269) 1655Comparison ofthe turnover signals from enzyme-reduced states ofthe MoFe protein and the FeFe protein The characteristic EPR signal ofthe ... identical with the controlspectrum in the absence of Rc1Mo.Furthermore,withtheexception ofthe classical S ¼ 3/2 signal ofthe MoFeprotein a t l ower temperatures (< 12 K), no other signalwas ... assignment of these novel EPR signals toeither the cofactor or the P-cluster has proven elusive due to the fact that both of these metal clusters present in the Fe-only n itrogenase are d iamagnetic...
... translocation ofthe internally sequence of PreS1 domain onto the viral surface [62, 63]. This supports the hypothesis that the low pH in the endosome may induce the conformation change of HBV surface ... follows [10]. The assembled HBV virion and sub-viral particles are transported to the Golgi for further modification of its glycans in the surface proteins, and then are secreted out ofthe host ... target, further confirmed the role of LHBs in the HBV attachment [23]. Recently, the attachment site of LHBs was functionally narrowed down to the amino acids 21–47 of preS1 by employing synthetic...
... role in the regulation of proliferation, migration, and differ-entiation ofthe epithelial cells [2,12,18,19]. Following the surgical treatment of adult periodontitis, the epithelial regeneration ... gingivitis grade of 0 or 1. Thanks to the bacteriostatic properties ofthe tested polymer, a more effective control ofthe surgical wound no bacterial contamina-tion ofthe surgical site ... largely responsible for the consistency ofthe active component that can act as a barrier to the spread of any bacteria penetrating the tissues including those ofthe periodontium. It is conceivable...
... clearer and more precise, limiting the chances ofthe provision being misinterpreted. The participants, therefore, are clearly aware ofthe circumstances of their rights and obligations. The ... that the function of a text is the application or use which the text has in the particular context of situation” (p.36). There are two componentsof a text’s function: the ideational and the ... Significance ofthe study The results of this study will help test the quality ofthe English translation of the Law on Investment 2005 of Vietnam under the model developed by the German linguist...
... and there are many other examples around the world. In short, rainwater harvesting has been proven to be successful in many parts ofthe world. In any buildings in the urban areas, there are ... despite the numerous sources of atmospheric pollution, in most parts ofthe world, especially in rural and island locations, levels of contamination of rainfall are generally low. Contaminations are ... and the development can become sustainable in terms of water resources. Another added benefit of rainwater harvesting is the potential reduction in flood peaks. If rain that fell on the roof...
... recommended that the outer harder and shiny part ofthe palm fronds be used for the fabrication of PFCBB. 4. Other factors like water absorption ofthe PFCBB be conducted to determine its other properties ... Fabrication of Palm frond cement-bonded blocks Testing of compressive strength of PFCBB using The Universal Testing Machine 1 THE 28TH CONFERENCE OF THE FEDERATION OF ENGINEERING ... 3,000 hectares per year. Palms are usually pruned every 15 days and the pruned fronds are usually used for “kalakat” and sometimes are burned or left in plantations to rot. The use of chipped...
... withstand the impact of the salt in sea water. 3than 37°C in April, the hottest month. The division ofthe season in the north more clearly than in the southern, where the only exception ofthe ... and are mined from the rivers, according to data [8] of dust, mud, clay of these sand all most are permitted. Also present in all Viet nam, there are many basic materials, building stone, the ... to nail macadam and concrete. The distribution of reserve of macadam are not equally, in northern Vietnam, Central Vietnam, mainly along the borders of Laos, there is little madacam in South...