west nile virus eruptions in summer 2010 what is the possible linkage with climate change
Báo cáo y học: " The natural history of West Nile virus infection presenting with West Nile virus meningoencephalitis in a man with a prolonged illness: a case report" doc
... resonance imaging (MRI) scans were obtained which correlated with the clinical course of the disease, hence supporting the use of brain MRI in rendering a preliminary diagnosis and following the progression ... that the brain MRI findings (bilateral edema and hyperintensity of the basal ganglia and thalami) were helpful in this clinical setting to establish a preliminary diagnosis of WNND Further, since ... resonance imaging; TB: tuberculosis; WNND: West Nile virus neuroinvasive disease; WNV: West Nile virus Acknowledgements This material is the result of work supported with resources and use of the facilities...
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Effects of serial passaging on west nile virus (sarafend) in a mouse model
... encephalitis and St Louis encephalitis Tissue damage is seen in the meninges contributing to meningitis, in the brain parenchyma contributing to encephalitis, and in the spinal cord contributing to ... Both the breed of mice and strain of virus play an important role in defining the pathogenicity and prognosis of the infection This is clear from the different virus strains used to infect Swiss ... long with terminal knobs of two nanometers in diameter (Schlesinger, 1980) There are three domains within the E protein Little is known of Domain I Domain II is suggested to be important during virus...
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Đề tài:what qualities and skill are needs for the manage people in a company? what is the importance of good human resources?
... 3.Accommodate to the person you are talking to • 4.Take into account that you can be wrong • 5.Leave the space for others to think • 6.Timing is the key • 7 .What you send is what you get • 8 .What kind of ... practices 7)Information processing and thinking capacity • The power of your brain is incalculably large The manager have an enormous potential for creativity, innovation and invention They knowing how ... cope with people This is your daily bread The way you communicate with others can be a key to either your success or failure • 1.Respect the person you talk to • 2.Listen, listen, listen and then...
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Báo cáo sinh học: " The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World" pdf
... in its scope, the results indicate that WNV strain IS- 98-ST1 is suitable as viral model for West Nile encephalitis in the Old World The Israeli strain IS- 98-ST1 that caused the epizootic in Israel ... viral infection and the possible cells that could be involved in such a passage remain elusive The dissemination of foci of infection within the brain that is observed in our study is compatible with ... previous report[15] indicating that WNV replicates locally in draining lymph nodes in mice inoculated subcutaneously, then in the spleen and in multiple sites in the CNS, although the sites of extraneural...
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Báo cáo hóa học: " In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity" ppt
... reducing the FBS concentration from 10% to 1% Since lowering the FBS concentration reduces the essential growth factors in the media, we supplemented the media with insulin and transferrin and changed ... (SK-N-SH), the natural target of WNV in the brain Furthermore, we infected Sedeficient Vero cells with WNV and compared the WNV replication kinetics, cytopathogenicity and virus- induced apoptosis with ... immune responses associated with inadequate dietary Se results in increased disease severity following infections with HIV, influenza virus and Coxsackie virus [2,3] In HIV- infected patients, low...
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Báo cáo y học: " First serological evidence of West Nile virus in human rural populations of Gabon" pdf
... [23] In conclusion, this first serological survey of West Nile virus in Gabonese human populations shows widespread circulation of this virus Further investigations are needed to determine the ... pathology, and clinical manifestations of West Nile virus disease Emerg Infect Dis 2005, 11:1174-1179 Murgue B, Zeller H, Deubel V: The ecology and epidemiology of West Nile virus in Africa, Europe ... 55% In countries with no reported clinical cases or WNV isolation, WNV-specific IgG prevalence rates ranged from 0.9% in Kenya in 1987 [17] to 6.6% in Cameroon in 2000 [6] and 27.9% in Ghana in...
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Báo cáo y học: "A VLP-based vaccine targeting domain III of the West Nile virus E protein protects from lethal infection in mice" pptx
... Vaccine Domain III of the WNV E protein was engineered to comprise a hexahistidine tag and a cysteine-containing linker at its C-terminus (DIII-C) Upon expression in E coli the protein formed insoluble ... Collins PD, Jones JE, Campbell GL: The epidemic of West Nile virus in the United States, 2002 Vector Borne Zoonotic Dis 2004, 4:61-70 Gubler DJ: The continuing spread of West Nile virus in the western ... tri(2-carboxyethyl)phosphine-hydrochloride Under these mildly reducing conditions the cysteine residue contained in the linker is reduced, while the internal disulfide bridge of DIII-C remains intact The reduced...
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Báo cáo khoa học: "Recombination in West Nile Virus: minimal contribution to genomic diversity" ppt
... of the aligned genomes, we analyzed portions of the MSA containing: the complete NS5 coding region, the NS5 coding region lacking the recombinant region, or only the region within the NS5 coding ... some role in the generation of WNV diversity in these, or other replicating lineages Previous studies attempting to detect recombination in West Nile virus used only the envelope coding region ... both viruses within the local environment until they eventually infected the same host and the recombination event occurred It is also impossible with the present amount of information to determine...
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Báo cáo khoa học: "Diversification of West Nile virus in a subtropical region" pptx
... residues with two nonpolar ones, perhaps leading to a change in the positioning of the neighboring histidines Such a repositioning of these histidines could alter the conformation of the envelope, ... also interested in determining whether or not our isolates contained a previously reported mutation in the envelope region encoding for an amino acid substitution characteristic of the WN02 strain ... analysis of the NS3/NS4A sequences along with the corresponding sequences from several other strains obtained from GenBank showed that our isolates from Florida in 2005 grouped together, with the...
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Báo cáo khoa học: "Diversification of West Nile virus in a subtropical region" potx
... residues with two nonpolar ones, perhaps leading to a change in the positioning of the neighboring histidines Such a repositioning of these histidines could alter the conformation of the envelope, ... also interested in determining whether or not our isolates contained a previously reported mutation in the envelope region encoding for an amino acid substitution characteristic of the WN02 strain ... analysis of the NS3/NS4A sequences along with the corresponding sequences from several other strains obtained from GenBank showed that our isolates from Florida in 2005 grouped together, with the...
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The involvement of cellular components in west nile virus replication cycle
... WEST NILE VIRUS BINDING AND PENETRATION INTO CELLS 4.4 EFFECTS OF INTEGRIN LIGANDS ON WEST NILE VIRUS ENTRY INTO CELLS 4.5 130 136 GENE SILENCING OF HUMAN β3 INTEGRIN SUBUNITS INHIBITS WEST NILE ... 151 MURINE POLYCLONAL ANTIBODY TO RECOMBINANT WEST NILE VIRUS- DIII NEUTRALIZED WEST NILE VIRUS 4.13 150 154 RECOMBINANT WEST NILE VIRUS E DIII BINDS TO αVβ3 INTEGRIN AND PREVENTS WEST NILE VIRUS ... Valley encephalitis virus) Damages are seen in the meninges contributing to meningitis, the brain parenchyma contributing to encephalitis and the spinal cord contributing to myelitis In the recent...
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Báo cáo khoa học: NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B–NS3 protease ppt
... binding of to the substrate-binding site, demonstrated changes in cross-peak positions for residues lining the substrate-binding site, without discussing the complete resonance assignment In the ... observed in the crystal structures of the complex with peptidic inhibitors [4–6], in which the C-terminal b-hairpin of NS2B is positioned near the substrate-binding site rather than far away as in the ... we only studied the binding of the nonsymmetric and more soluble compound using intermolecular NOEs In the : complex with the protease, the proton resonances of the phthalazine ring of were too...
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Norwalk virus, west nile virus, hanta virus
... eggs is harvested, centrifuged and filtered Virus is inactivated with formalin Purified inactivated virus from each strain is combined and packaged into doses How are vaccines made? The influenza ... -Achieved by co-infection of a single cell with these viruses How does this happen? Virus shed in bird feces gets into pigs drinking water Humans handle and/or cough on the pig = New virus: segments ... -Achieved by co-infection of a single cell with these viruses How does this happen? Virus shed in bird feces gets into pigs drinking water Humans handle and/or cough on the pig = New virus: segments...
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Báo cáo sinh học: " Peptide inhibitors of dengue virus and West Nile virus infectivity" pot
... HIV infections, immune responses against DENV and other flaviviruses are capable of clearing the viruses in individuals that survive the initial infection By reducing the viral load during the ini- ... corresponding increase in WNV inhibition with an IC50 in the 10 µM range (C) Increasing concentrations of peptide DN59 also produce a corresponding increase in DNV inhibition with an IC50 in the 10 ... 2:49 The prototypic viral envelope fusion protein, the hemagglutinin of influenza virus, contains short alpha helical domains in the trimeric virion configuration In response to receptor binding...
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Báo cáo sinh học: " Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA" ppt
... WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage II WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage ... to confirm the precise mechanism WNV polyprotein translation and RNA replication within hours of infection [45] Treatment of cells with the protein chain elongation inhibitor puromycin confirmed ... flavivirus-induced membrane reorganization in RNAi resistance, and determine whether this mechanism is a common feature of other positive strand enveloped RNA viruses Such information may inform the...
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báo cáo hóa học:" Peptide inhibitors of dengue virus and West Nile virus infectivity" doc
... HIV infections, immune responses against DENV and other flaviviruses are capable of clearing the viruses in individuals that survive the initial infection By reducing the viral load during the ini- ... corresponding increase in WNV inhibition with an IC50 in the 10 µM range (C) Increasing concentrations of peptide DN59 also produce a corresponding increase in DNV inhibition with an IC50 in the 10 ... 2:49 The prototypic viral envelope fusion protein, the hemagglutinin of influenza virus, contains short alpha helical domains in the trimeric virion configuration In response to receptor binding...
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báo cáo hóa học:" Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA" pptx
... WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage II WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage I WNV Lineage ... to confirm the precise mechanism WNV polyprotein translation and RNA replication within hours of infection [45] Treatment of cells with the protein chain elongation inhibitor puromycin confirmed ... flavivirus-induced membrane reorganization in RNAi resistance, and determine whether this mechanism is a common feature of other positive strand enveloped RNA viruses Such information may inform the...
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Báo cáo y học: "Ocular Manifestations of West Nile Virus Infection" doc
... multifocal chorioretinitis can help establish an early diagnosis of the disease while serologic testing is pending Therefore, an ocular examination, including ophthalmoscopy and FA in selected cases, ... al Chorioretinal involvement in patients with West Nile virus infection Ophthalmology 2004;111:2065-70 Garg S, Jampol LM Systemic and intraocular manifestations of West Nile virus infection Surv ... of the routine evaluation of patients with clinically suspected WNV infection References Hayes EB, Gubler DJ West Nile virus: epidemiology and clinical features of an emerging epidemic in the...
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