viruses signaling events and modulation of the innate host response syed mohammad moin anindita kar roy and shahid jameel

Báo cáo y học: "Bench-to-bedside review: Biotrauma and modulation of the innate immune response" pps

Ngày tải lên : 12/08/2014, 20:21

... body of evidence in support of the theory that mechanical ventilation may sensitize the innate immune system and that, in turn, the innate immune system may sensitize the lungs to the effects of ... clinical trial of protective ventilation strategy Further evidence is required to determine whether the soluble Fas ligand actually originated in the lungs Irrespective of the source, these findings ... mg/kg) and did not result in overt ALI before initiation of the ventilation protocol; and the mechanical ventilation protocol used levels of Vt that did not lead to disruption of the epithelial...

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Báo cáo y học: " Characterization of the innate immune response to chronic aspiration in a novel rodent model" ppsx

Ngày tải lên : 12/08/2014, 15:21

... to the macrophage in the right lung is shown as a function of time In the inset, the ratio of macrophages in the left to the macrophages in the right lung is shown for all rats, regardless of the ... accordance with the Guide for the Care and Use of Laboratory Animals prepared by the National Academy of Sciences and published by the National Institutes of Health Protocols were approved by the Duke ... lung of rats receiving gastric fluid in their left lung, the left lung of rats receiving normal saline in their left lung, the right lung of rats receiving gastric fluid in their left lung, and the...

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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt

Ngày tải lên : 06/03/2014, 09:22

... markers are indicated on the left of Spatzle-C108 (Fig 8A) Analysis of tryptic peptides ¨ from these bands by MS ⁄ MS and mascot software identiﬁed them as attacin-1, lysozyme, and cecropinA ⁄ B (Table ... comparison of the genomic and cDNA sequences Analysis of the amino acid sequences deduced 158 from the cDNA, including prediction of signal peptide and glycosylation sites, was carried out in the expasy ... to B mori Spatzle-1 [23] We performed ¨ 3¢-RACE and 5¢-RACE to obtain the missing ends of the cDNA, and then used primers encompassing the start and stop codons, with larval fat body cDNA as template,...

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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

Ngày tải lên : 08/03/2014, 09:20

... particular, the four-stranded b sheet formed by the aminoacid residues at the N- and C-termini of PR contribute close to 75% of the total Gibbs energy [15] The importance of this four-stranded b ... dimer (residues 1–5 and 95–99) Additional interactions include a complex salt bridge between D29 and R87 of one subunit and R8 of the other subunit Thermodynamic analyses of the dimeric PR molecule ... interactions in the dimer include interactions between the catalytic triad residues (D25-G27), I50 and G51 at the tip of the ﬂaps, and the antiparallel b sheet formed by the four termini in the dimer...

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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf

Ngày tải lên : 22/03/2014, 21:20

... capacity and also modulating the catalytic properties of the enzyme [19] To extend the information about the role of the noncatalytic SBD regions and their effect on the C-terminal CD, we further ... showing a lack of interaction for the individual SBDs and also in the absence of the D(316–344) and D(495–535) regions of the D2 and D3 domains, respectively Kinetic parameters of co-puriﬁed recombinant ... that the N-terminal region of SSIII can interact with SSI [13] The possible regulatory role of this protein makes this isoform a potential target for the manipulation of the level and quality of...

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Báo cáo khoa học: " Cisplatin chemotherapy (without erythropoietin) and risk of life-threatening thromboembolic events in carcinoma of the uterine cervix: the tip of the iceberg? A review of the literature" docx

Ngày tải lên : 09/08/2014, 10:20

... toxicity and graded from to on the RTOG scale (Table 1) However, these trials often not specify the incidence and severity of treatment related cardiovascular (thrombotic) toxicities In fact, of the ... Four of these 48 patients developed grade 4–5 TE [9] Of these events, there were grade toxicities and grade toxicity This is consistent with our unpublished institutional experience with grade and ... cases of severe thrombotic events out of the 1424 patients described in Table In addition to the increase of thromboses as a result of malignancy, a review of chemotherapy associated vascular...

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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx

Ngày tải lên : 12/08/2014, 19:21

... the exoskeleton of the crab immediately jeopardizes the integrity of the internal milieu of the organism Not only is there a real threat of loss of internal contents of the crab to the external ... integument of the animal, and it seals off the injured area from the remainder of the crab’s open circulatory system The animal will often clot off and sacrifice an entire extremity (they have ... disadvantageous to the host, with consumption of clotting factors and widespread deposition of fibrin clots throughout the microcirculation [2,19–21] The actions of the human coagulation system and the innate...

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Báo cáo y học: "Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway" pot

Ngày tải lên : 13/08/2014, 06:20

... stimuli [11-13] However, in spite of the relevance of these reservoir cells in the control of viral persistence, the mechanisms responsible of apoptosis resistance of persistently-infected cells ... independent of the magnitude of viral replication Apoptosis resistance is independent of the magnitude of viral replication A) Jurkat and J1.1 cells were incubated in the presence or absence of 1000 ... experiments of apoptosis by Hoechst and APOBrDU DOC and GAR were responsible of experiments using Western blot analysis, and contributed to writing of the manuscript MB, RL and MS performed and interpreted...

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Báo cáo y học: " Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection" docx

Ngày tải lên : 13/08/2014, 20:22

... [7] The aim of the study was to identify if the early statuses of the innate and adaptive immune systems of septic patients differ in relation to the underlying type of infection stimulating the ... located either in the cell membrane or inside the cytoplasm of blood monocytes and tissue macrophages Endotoxins of the cell wall of Gram-negative bacteria and peptidoglycan of the cell wall of Gram-positive ... endotoxemia and in patients with melioidosis and bacteremia [22] Increase of the absolute counts of NK cells was a profound change of sepsis due to CAP The rate of apoptosis of NK cells and of NKT...

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Báo cáo sinh học: "∆RR vaccination protects from KA-induced seizures and neuronal loss through ICP10PK-mediated modulation of the neuronal-microglial axis" docx

Ngày tải lên : 14/08/2014, 19:22

... out the experiments, participated in the design of the study and the drafting of this manuscript LA designed the vectors, conceived the experiments and drafted the manuscript Both authors read and ... contributes to the neuroprotective activity of the CM from ∆RR-infected EOC2 and E0C20 cells To examine the effect of IL-10 on the neuroprotective capacity of the CM from ∆RR-infected EOC2 and EOC20 ... strain and are growth-compromised in the CNS, (ii) the two viruses have no genetic differences other than the mutated ICP10 protein, as evidenced by the study of revertant viruses, (iii) the PK-deleted...

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modulation of the structure and dynamics of acyl-acyl carrier protein by fatty acids of different length

Ngày tải lên : 14/11/2014, 10:21

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Tài liệu Báo cáo khoa học: Modulation of the enzymatic efﬁciency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site pptx

Ngày tải lên : 18/02/2014, 17:20

... intricate network of interactions that involve other amino acids and the prosthetic group, contributing to the correct positioning of FAD and the substrate NADP+ [12] The other tyrosine (Y308 ... and phenol as the tyrosine R group This system has been used previously to analyze the geometry of the tyrosine stacked on the si-face of the ﬂavin in FNRs [12] The single point energies of the ... conﬁrmed by DNA sequencing The design of the mutants was intended to preserve the amino acid character and to modify only the relative volume of their R groups The expression of the FNR mutants as soluble...

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Báo cáo khóa học: Collectins Players of the innate immune system docx

Ngày tải lên : 07/03/2014, 15:20

... carbohydrate ligands on the microbial surface [83] on the one hand, and on the degree of oligomerization of the collectin [66], on the other Clustering of glycoproteins or glycolipids on the surface of microorganisms ... that the acquisition of oligosaccharides antigenetically identical to those of the host helps the virus to escape the collectin-based immune defenses of the host organism, and is thus one of the ... because viruses make use of the host cell machinery for the synthesis, folding and transport of proteins to the site of Ó FEBS 2004 virus assembly at the cell surface This machinery includes the...

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Báo cáo khoa học: Copper-containing nitrite reductase fromPseudomonas chlororaphis DSM 50135 Evidence for modulation of the rate of intramolecular electron transfer through nitrite binding to the type 2 copper center pot

Ngày tải lên : 07/03/2014, 15:20

... 0.6 and Na2B2O7, 0.1 The optical density, the concentrations of nitrate [17] and nitrite [18], the pO2 and the pH of the medium were monitored, and the composition of the gaseous phase in the ... catalytic center of the enzyme These modications may be attributed to either the presence of the substrate and/ or a product in the vicinity of the T2Cu active center rather than to disruption of this ... the applicability of the Nicholson and Shain theory to the present system, and the variation of the pseudo-rst order rate constant with CuNir concentrations (between and lM) yielded a value of...

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Báo cáo khoa học: Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide pot

Ngày tải lên : 08/03/2014, 08:20

... v/v/v/v), and (c) chloroform/methanol/acetic acid (65 : 2.5 : 4, v/v/v) The ﬁrst solvent system was developed through the plate, the second reached cm from the bottom of the plate, whereas the third ... with iodine vapor, and the bands of 1-O-acylCer and nonesteriﬁed fatty acids were scraped from the plates to quantitate the radioactivity incorporated by liquid scintillation The bands corresponding ... tested the effect of C2-Cer on Etn plasmalogen levels The concentration range of C2-Cer was chosen on the basis of previous evidence [26,27] A concentration of 50 lM was the lowest capable of decreasing...

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Báo cáo Y học: Irregular spiking in free calcium concentration in single, human platelets Regulation by modulation of the inositol trisphosphate receptors ppt

Ngày tải lên : 17/03/2014, 17:20

... (a-c); and from a region of interest of an adjacent platelet (r) (initial value of each trace, F/Fo ¼ 1) Insert shows expanded part of curves a–c (B) Selection of regions of interest of the platelets ... at the right physiological sites during hemostasis and at atherosclerotic sites during thrombosis ACKNOWLEDGEMENTS We acknowledge grants from the Netherlands Heart Foundation and the Netherlands ... primarily independently of InsP3 receptors (U73122), and regardless of the type of stores used by these agonists, the spiking process was always irregular in amplitude and frequency and occurred with...

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Báo cáo khoa học: Modulation of the Arabidopsis KAT1 channel by an activator of protein kinase C in Xenopus laevis oocytes potx

Ngày tải lên : 22/03/2014, 21:21

... 641 Phosphorylation and dephosphorylation events are critical for the modulation of the activity of the guard cell-expressed K+ uptake channel KAT1 Nevertheless, information on the kinase-mediated ... the addition of lM PMA to the bath solution A black bar indicates the addition and removal of PMA (B) Changes in the current at –150 mV in response to lM PMA PMA was added immediately after the ... depolarization of the membrane This activates anion efﬂux channels and inhibits inward K+ uptake channels [6] to reduce the turgor pressure of the cells The involvement of KAT1 in these regulatory...

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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf

Ngày tải lên : 23/03/2014, 07:20

... levels of AEA (A) and activity of FAAH (B) and NAPE-PLD (C) in the ischemic striatum and cortex of rats subjected to h of MCAo, with or without h of reperfusion Sham rats were exposed to the same ... a consequence of focal brain ischemia, CB1 and TRPV1 receptor binding in cortices and striata did not change following h of MCAo, either in the absence or in the presence of h of reperfusion ... esters and ethers of long-chain polyunsaturated fatty acids that are synthesized on demand Anandamide (arachidonoylethanolamide) (AEA) was the ﬁrst member of this family to be discovered [1], and...

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Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt

Ngày tải lên : 18/06/2014, 16:20

... 7, day 14 and day 28 by counting the number of foot faults in the left and right forelimbs The sum of foot faults (SOFFF) in the forelimbs is defined as the number of faults of right and left ... http://www.axon.com) The stimulating electrode and the reference electrode were placed in the median nerve of the muscles between the ulner and radical bone, and the pre-frontal scalp of the midline, ... forelimbs, whereas the differentiation of forelimb foot faults (DOFFF) is the difference between the number of faults for the right and left forelimbs SOFFF and DOFFF were used as an index of motor deficit...

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Báo cáo lâm nghiệp: " A comparison of the photosynthetic radiation response of Scots pine shoots in direct and diffuse radiation" pot

Ngày tải lên : 09/08/2014, 04:20

... unit of intercepted radiation and the difference between the respective rates of photosynthesis result from differences in the distribution of radiation over the shoot In Fig 2A, the photosynthetic ... photosynthetic units are assumed to be uniformly distributed within the needle and the transmission of radiation was assumed to be an exponential function of the Measured rates of photosynthesis of ... be the major component causing variation in the photosynthetic response (Smolander et al., 1987) Thus, much of the variation in photosynthesis caused by Our results showed a tween the rates of...

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