virus host systems detection and isolation
Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway
... docked-UDP ligand and the actual UDP ligand Superimposition of one docked-ADP ligand and the actual ADP ligand Superimposition of the catalytic regions of the open SPS-F6P complex (cyan) and the closed ... Material and Methods 3.2.1 Cloning, expression and purification 3.2.2 Crystallization 3.2.3 Data collection, structure solution and refinement 3.2.4 Structure solution and refinement Results and Discussion ... structure solution and refinement 2.2.7 Structure solution and refinement 2.2.8 F6P-SPS and S6P-SPS complexes 2.2.9 Bioinformatics analyses 2.2.10 Protein Data Bank accession code Results and Discussion...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance (7) The vascular and ... Popliteal and pedal pulses were absent bilaterally with poor capillary refill The left foot was red and inflamed up to and including the medial malleolus The lateral aspect of the great toe and second ... abnormalities and diseases such as type diabetes mellitus, obesity and the metabolic syndrome (30) In these conditions there is an elevation of both glucose and free fatty acid levels in the blood and...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... monochromator, and Glan-Thompson polarizers using quartz cuvettes with continuous stirring of the suspension, bandwidths of nm for excitation and nm for emission, and excitation and emission wavelengths ... potential and volume homeostasis of mitochondria Cell 91, 627–637 27 Haugland RP (1996) Handbook of Fluorescent Probes and Research Chemicals, 6th edn Molecular Probes, Inc, Eugene, OR 28 Chandra ... between cytosolic Ca2+, VtA3, and (A) H2O2 production and (B) cell viability F solani spores were preincubated with different concentrations of Bapta-AM for 40 as indicated and then incubated with...
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Báo cáo y học: "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel." ppt
... pre-treatment of mice with LA (12.5 and 25 mg/kg, i.p) significantly reduced the volume (μL) of the edema in the 2nd (31 and 41%), rd (30 and 50%) and 4th (23 and 27%) hours after administration ... of the inflammatory process, and by prostaglandin and bradykinin in later stages On the other hand, paw edema induced by dextran although also mediated by histamine and serotonin does not involve ... Authors’ contributions DL and EL: carried out most of the in vivo experiments MB, HV and AS: isolation and determination of the chemical structure of LA LL, AL, VA and GS: responsible for all...
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Báo cáo y học: "The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study" pdf
... metabolites TFV-DP and FTC-TP [30]; and (2) DEC or DEC-like complex formation by TFV-terminated DNA and HIV-1 RT in the presence of the FTC-TP or EFV, and by FTC-MP-terminated DNA and HIV-1 RT in ... FTC-TP, and EFV-facilitated DEC formation and the data fittings are illustrated in Fig Data were fitted by nonlinear regression to simple ligand binding equation: y = (Bmax × [ligand])/(Kd + [ligand]) ... complexes with HIV-1 RT and TFV- or FTC-MP-terminated DNA Results Two- and three-drug combinations of TFV, FTC, and EFV showed synergistic anti-HIV activity in cell culture TFV, FTC, and EFV were tested...
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Discovery and mechanism of action study of anti viral compounds for dengue virus
... (e.g dengue virus, West Nile virus, and yellow fever virus) , hepacivirus (hepatitis C virus) and pestivirus (e.g bovine viral diarrhea virus) , as shown in figure The detailed taxonomy and classification ... dengue virus in host cell Reprinted from Host Cell Cell Host & Microbe, 5(4), Fernandez-Garcia M-D, Mazzon M, Jacobs M, and Amara, A., Pathogenesis of Flavivirus Infections: Using and Abusing the Host ... (Aedes borne Flaviviruses), Purple (Culex borne Flaviviruses), Blue (Tick borne Flaviviruses), Orange (No known vector Flaviviruses), Green (Pestiviruses), Cyan (Hepaciviruses) and Black (unassigned...
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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques
... FLT3 (wild-type and mutant) SU5416 Sugen FLT3 (wild-type and mutant) KIT, FMS and PDGFR SU11248 Sugen FLT3 (wild-type and mutant) KIT, FMS and PDGFR MLN518 Millenium FLT3 (wild-type and mutant) KIT ... and mutant) KIT PDGFR PKC412 Novartis L-000021649 Merck and FLT3 (wild-type and mutant) PKC, VEGFR and PDGFR FLT3 (wild-type and mutant) and VEGFR Responses of patients: 5% blasts in bone marrow ... genes such as RAS, FLT3, and c-KIT as well as loss of function mutations have been frequently implicated in AML progression, survival and drug resistance (Gilliland and Tallman, 2002) Figure...
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The mechanism of action of sprouty2 characterization of the interaction between sprouty2 and PKCdelta
... guidance and understanding throughout my PhD candidature My thanks also extend to my PhD supervisory committee members, A/Prof Cao Xinmin and A/Prof Low Boon Chuan, for their suggestions and advice ... the GG lab, past and present, for having created a friendly and interesting environment to work in, especially Dr Ben McCaw, for his training and patience early in my candidature and Judy Saw for ... his constant support and encouragement I would like to express my appreciation to Hanping, Ellen and Yen Li for their concern I am also grateful to my nephew and niece, Calvin and Casie, for providing...
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Tài liệu BIOCHEMICAL TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects doc
... K+-ATPase and Naf, K f -ATPase H Voltage-gated Na+ channel Ligand- and voltage-gated K+ channels + Voltage- and ligand-gated Ca2+channels and ~ a /Ca2+ antiporter CFTR, voltage-gated C channels and ... thousands of individual primary scientific papers and reviews describing the isolation, structural characterization, pharmacological effects and biochemical targets of thousands of plant-derived and ... tea, cotton and preservative spices), African subjugation (slavery, cocoa, rubber and timber) and temperate colonization (grain, cotton, timber and herbivore production) Notwithstanding the European...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... 0.1 U ACS and 50–100 lL diluted medium All components were added with the exception of MDH and citrate synthase and the resulting absorbance at 340 nm was measured (A1) MDH was added and the absorbance ... conditions Carbon and energy sources were: 50 mM glucose; 50 mM glucose and 100 mM sodium propionate; 50 mM glucose, 100 mM sodium acetate, and 100 mM sodium propionate; 100 mM sodium acetate and 100 mM ... ground to a fine powder in a mortar and suspended in 10 mL 2% HClO4 and mL 0.1% trifluoroacetic acid The suspension was sonicated three times for each at 70% full power and 60% pulses (Branson 250 sonifier;...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... MPO, LPO and their intermediates The absorption spectrum of MPO is characterized by an intense Soret peak at kmax ¼ 430 nm and weaker bands at 570, 620 and 690 nm, whereas at 370 nm and 496 nm, ... rapidly inactivates LPO and generates Cpd III (with bands at 424, 550 and 588 nm) (Table 2) In contrast to MPO, LPO Cpd III spectral pattern is clearly distinct from that of Cpd II and can be easily ... (430, 572 and 625 nm bands) correspond to the real Cpd II? In such a case, the optical features of Cpd I isomer have to be defined The second hypothesis assigns the 455 and 625 nm bands to this...
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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc
... disprove these hypotheses MATERIALS AND METHODS Kinetics of the systems shown in Schemes 1–3 were simulated with the help of the ordinary differential equations systems They were numerically integrated ... TFPI (k XaÀVIIaÀTF ;TFPI and a k TFPIÀXaÀVIIaÀTF ), association of Xa–TFPI and VIIa–TF, d which results in the intermediate inhibitory complex formation (k XaÀTFPI;VIIaÀTF and k TFPIÀXaÀVIIaÀTF ... concentration was nM Factor X and TFPI were present at their mean plasma concentrations, 170 nM and 2.4 nM, respectively Experiments in the absence of inhibitor revealed rapid and nearly complete activation...
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Báo cáo khoa học: Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils ppt
... pH 5.5, and sonicated for prior to imaging; and (C) stored in Tris ⁄ HCl buffer, pH 7.4 All three samples were analyzed in parallel by thioflavine T-fluorescence microscopy (left panels) and by ... of experimental procedures used for extraction and purification of PrPSc involved sonication, treatment with detergents and, sometimes, freezing and thawing [49–51] All of these steps cause severe ... 230 and 162–230 were found to maintain high seeding activity in vitro despite cleavage of the N-terminal and central regions [53,55] Consistent with these studies, the rPrP regions 159–174 and...
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stenersen - chemical pesticides - mode of action and toxicology (crc, 2004)
... physiology, and neurophysiology Breidbach, O and Kutsch, W 1995 The Nervous Systems of Invertebrates: An Evolutionary and Comparative Approach Birkhäuser Verlag, Basel, Switzerland 448 pp Levitan, I.K and ... and resistant flies and a mixture (50:50) of susceptible and resistant flies (a) Doses and responses on linear scales (b) Doses on log scale and responses on probit scale LD50), will be large and ... names, and trade names Pesticides are chemicals specifically developed and produced for use in the control of agricultural and public health pests, to increase production of food and fiber, and to...
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báo cáo khoa học: "Mechanism of action of lenalidomide in hematological malignancies" pptx
... thrombosis, and sedation, more potent and safer analogues were developed by Celgene Lenalidomide is one such analogue which has been extensively tested and proven to be more potent than thalidomide and ... stimulates T cell proliferation and increases IFN-γ and IL-2 production Lenalidomide is 100–1000 times more potent in stimulating T cell proliferation and IFN-γ and IL-2 production than thalidomide ... structures of thalidomide, lenalidomide and pomalChemical structures of thalidomide, lenalidomide and pomalidomide T cell regulation of host- tumor immune interactions, and diminished NK cell activity...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 2 pptx
... and resistant flies and a mixture (50:50) of susceptible and resistant flies (a) Doses and responses on linear scales (b) Doses on log scale and responses on probit scale LD50), will be large and ... here is the relative response of two substances A and B, given together in doses a and b, while pa and pb are the expected relative responses when a and b are given separately In cases where there ... example, we can use Parathion oil® and Bladan® and suggest that they have LD50 values of 12 and 10 mg/kg, respectively A dose consisting of mg/kg of Parathion oil and mg/kg of Bladan will then kill...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 3 pps
... Tetrapyrrol and protoporphyrin accumulate, act as photosensitizers, and cause photooxidation and necrosis They are contact herbicides and are more active in strong sunlight 3.3 General SH reagents and ... (dinitroorthocreosol [DNOC], dinoterb, and dinoseb) and other phenols such as pentachlorophenol and ioxynil DNOC is a biocide useful against mites, insects, weeds, and fungi The mammalian toxicity ... of them and give a very brief outline of the photosynthetic process Textbooks of cell biology, biochemistry, and plant physiology (e.g., Alberts et al., 2002; Nelson and Cox, 2000; Taitz and Zaiger,...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 4 ppt
... etc.) and the individual proteins are called Cry1A1, Cry3B3, etc Other older classification and designation systems, not based on amino acid sequence, are still in use The δ-endotoxins and the ... habitats such as soil, mushroom compost, and stored products Bt may be present in samples from beach deserts and tundra, and may multiply in cadavers of insects and other animals Insecticidal activity ... feeding of Lepidoptera larvae and paralysis of the gut that retards the passage of food and allows the spores to germinate The larvae suffer a general paralysis and die Bt israelensis-treated...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 5 docx
... values are 13 and 3.6 mg/kg, respectively, and the dermal values are 21 and 6.8 mg/kg, respectively For mouse, guinea pig, rabbit, cat, dog, and horse, the LD50 values are between and 50 mg/kg ... ubiquinone, and vitamin K, which are essential substances for plants and other life-forms The cofactor tetrahydrofolate is required for biosynthesis of the amino acids glycine, methionine, and serine, and ... the phloem and xylem and is metabolized in the plants to glufosinate It is almost nontoxic to aquatic animals, has a very low toxicity to mammals, and is regarded as nonmutagenic and nonteratogenic...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu