... Permalloy StructuresInducedby a Local Current Fig 2.14: Variation of domain patterns with size in 50 nm thick Permalloy structuresby Fischer et al [18] The different magnetic domain structuresof ... Magnetic Domain Study of Micron- and Nano-sized Permalloy StructuresInducedby a Local Current objective of case is to study the uniformity of the magnetic field produced by the current along ... were obtained by the technique of field induced switching presented in section 2.2.1 Though the 14 Magnetic Domain Study of Micron- and Nano-sized Permalloy StructuresInducedby a Local Current...
... progression of this chain of events by the use of two blockers of mRNA synthesis: Actinomycin, an overall inhibitor of RNA synthesis, and F11R-siRNA, a specific inhibitor of the synthesis of F11R-mRNA ... critical role of F11R in the initiation of atherogenesis This study demonstrates that inhibition by specific siRNA of the de-novo biosynthesis of F11R, induced in endothelial cells by inflammatory ... concentrations of cytokines in comparison to levels of F11R mRNA measured in the absence of cytokines Since the inhibition of the activity of NFB by parthenolide did not block the increase in the level of...
... is usually modeled by the theory of Bradley and Harper, which explains the surface instability by curvature-dependent energy dispersion, a process that happens by the removal of atoms similar as ... Review E (Statistical, Nonlinear, and Soft Matter Physics) 2006, 74:050103 15 Bradley RM, James MEH: Theory of ripple topography inducedby ion bombardment Journal of Vacuum Science & Technology A: ... relatively high energy of ion beam over 10 keV, which is more likely to promote the preferential sputtering and high mobility of the diffusing atoms Ripple structure inducedby diffusion-driven...
... increase of body hair and muscle mass of the preExtensive increase of body hair and muscle mass of the premenopausal patient Page of (page number not for citation purposes) World Journal of Surgical ... Metabolism of testosterone by virilizing Krukenberg tumor of the ovary Ances at al (18) A case of Krukenberg tumor with virilization aspects Sani et al (22) Approach to the mechanism of androgen ... World Journal of Surgical Oncology 2008, 6:19 median survival of patients ranges between to 14 months [4,5] Diagnosis is usually accomplished by CT scan or ultrasound [5] The literature...
... chronic disease characterized by accumulation of genetic modifications such as mutation of p53 within the host genome [296-299] Approximately half of the solid tumors inducedby BLV in cattle contain ... characterized by the presence of an aminoterminal zinc finger and by a leucine-rich activation domain located between residues 157 and 197 [188,194] Deletion of the activation domain or substitutions of ... to the presence of a E-to-K mutation at codon 303 of the Tax protein [83,184,186] In cell culture, transfection of provirus 395 yields reduced levels of Tax activity (~ 10 % of wild-type) although...
... reactions, phlebitis inducedby intravenous infusion of antineoplastic agents reduces the completion of chemotherapy The causative factors of phlebitis include the pH and osmotic pressure of the solution, ... part of the vein in all animals and in the distal part of the vein in of the animals Edema (Grades 1-3) was found in the proximal part of the vein in of the animals and in the distal part of the ... phlebitis caused by VNR, so we tried to clarify the difference in the effect of DEX administration before VNR or after VNR Effect of PSL on DXR -induced phlebitis A 1.4 mg/mL solution of DXR was infused...
... proteins as a result of its structural similarity to nucleotide cofactors Specifically-bound proteins are then normally eluted by the application of either an amount of cofactor or by increasing the ... co-ordination of the two distinct functions of TorD with the folding of TorA and possible interactions of both proteins with the MGD biosynthetic apparatus [12] The concentration of GTP in the cytoplasm of ... therefore be limited by the intrinsic rate of GTP hydrolysis, by the action of a GAP, or by interaction with a cognate target GTPases governed by these factors are often referred to as ‘clocks’, ‘switches...
... Enzymatic regulation of human TK1 Impact of enzyme concentration on the oligomerization of hTK1 Fig Effect of orthophosphate and di- and tri-polyphosphates on oligomerization of native hTK1 hTK1 ... 15625 Li CL, Lu CY, Ke PY & Chang ZF (2004) Perturbation of ATP -induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation ... Discussion Identification of the group inducing tetramerization of human TK1 Human TK1 has 234 amino acids and a subunit size of 25.5 kDa [18] Several reports have shown by gel filtration that native...
... stress-activated MAPK (SAPK), represents a group of MAPKs that are activated by treatment of cells with cytokines or by exposure of cells to a variety of stresses [19–21] JNK activity has been implicated ... inhibition of ERK1 ⁄ MAPK and ⁄ or PtdIns3K ⁄ Akt growth ⁄ survival signaling cascades leads to apoptosis of cancer cells However, there are no studies addressing the role of JNK in apoptosis inducedby ... initiation of stress -induced apoptosis [29,30] To examine whether JNK might be activated by AG1478, we treated PC-9 cells with AG1478 for various periods (Fig 2A) Activation of JNK was measured by performing...
... stimulate some of its activities because of better substrate availability is not yet known The partial restoration of proteasome activities by Hsps contrasts with the lack of effect inducedby NAC Hence, ... inhibition of proteasome activities generated by httEx1-polyQ expression does appear to be a consequence of the oxidative stress inducedby this mutant protein The effects inducedby Hsps in ... cytotoxicity was inducedby EGFP expression The mitochondrial depolarization mediated by httEx1-103Q-EGFP expression was more drastic and was roughly similar to that inducedby a 15 incubation of control...
... transcription of c-Fos, a member of the Fos family, AP1 may be implicated in the transcription of bcl-XL inducedby EGF We then studied the effects of EGF on AP1 DNA binding in TMK-1 cells The results of ... by Dr K Shuai (University of Role of AP1 in EGF-mediated cell protection California, Los Angeles) TMK-1 cells were cotransfected with 8.5 lg of TAM67 and 1.5 lg of pBabePuro by using the Lipofectamine ... ADR -induced apoptosis by suppressing caspase activity via stabilization of the mitochondria membrane The protective action resulted from the activation of a MAP kinase-dependent pathway, thereby...
... transition of CRPW85A on binding of cAMP The effect of different concentrations of cAMP on the uorescence intensity of Trp13 is shown in Fig 2B When 200 lM cAMP was added to the solution of CRPW85A, ... the mobility of helix A of the protein As Trp13 is located in the vicinity of the activation region AR2 of the protein [1], which is responsible for the activation of the second class of E coli ... decreases by about A to 18.7 A on binding of cAMP to the anti-cAMP-binding sites of the protein The distance between the sulfur atom of Cys178 and the C9C10 bond of the indole ring of Trp85,...
... production, but additions of both LPS and IFN induced detectably high levels of NO in VSMC As shown in Fig 2A, approximately 20 lM of NO was produced by 10 lgÆmL)1 of LPS and 100 UÆmL)1 of IFN Under these ... amount of iNOS protein inducedby LPS/IFN (Fig 2B), as well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of ... induction Effects of a-T and its derivatives on the enhancement by TS of LPS/IFN -induced NO production We compared the effects of a-T and its derivatives TA and TN with that of TS on LPS/IFN -induced NO...
... demonstrating a dose-responsive effect of hA on activation of p38 kinase In parallel experiments, we studied the effects of inhibition of ERK1 ⁄ and p38 kinase on hA -induced caspase-3 activation and ... phosphorylation of ATF-2 in response to hA treatment is catalyzed mainly by p38 kinase We examined protein expression and phosphorylation of ATF-2 by p38 kinase during hA-evoked b-cell 3782 Fig Effects of ... activation of ATF-2 is correlated with induction of apoptosis and the ability of hA to form b-sheet-containing aggregates In contrast, we found that levels of nonphosphorylated ATF-2 were unaffected by...
... matrix of globular protein by diffusion, which is facilitated by small-amplitude uctuations in the protein structure [25,26] The process of quenching the uorescence of Trp residues in protein by ... contributions of the uorescence of the red and blue components from the solute quenching experiments by using the fractional contributions of the short and long lifetimes of the Trp13 residue obtained by ... values of the average Trp13 lifetime instead of the values of lifetimes of the resolved components Binding of cAMP to anticAMP-binding sites leads to signicant changes in the uorescing properties of...
... analysis of the complexes of Hsp273D with thermally denatured actin The complexes were obtained by heating of F-actin (0.5 mgÆmL)1) to 75 °C at a constant rate of C°Æmin)1 in the presence of 0.1 ... phosphorylation of Hsp27 by MAPKAP2 kinase [12], and this phosphorylation is inducedby different stimuli and stress conditions [19,23,24] Phosphorylation (or mutations) induces dissociation of large ... heating, thermal unfolding of F-actin is accompanied by formation of stable, soluble complexes of Hsp27-3D with denatured actin that contain roughly equal quantities of denatured actin and Hsp27-3D...
... in the cell [38,39] Of interest was the periodic pattern of induction of RhoB gene transcription by TGFb As shown in Fig 1B, TGFb induced RhoB gene expression 2.6-fold at h of treatment in HepG2 ... activation of Rho protein activity, and specifically that of RhoA, by TGFb [23,24], We have shown recently that overexpression of Smad7, a known and potent inhibitor of the TGFb signaling pathway and of ... translocation of Smad2 and Smad3 during the smooth muscle cell differentiation inducedby TGFb, indicating that RhoA is a modulator of Smad activation [24] Moreover, by studying the signaling properties of...
... Biochem 269) Fig Effects of CsA and BKA on the release of cytochrome c from mitochondria inducedby Ca2+ and by valinomycin During the measurement of respiration, aliquots of a mitochondrial suspension ... ordinary PT of inner mitochondrial membrane like that inducedby Ca2+ Ó FEBS 2002 Cytochrome c release inducedby valinomycin (Eur J Biochem 269) 5227 Fig Transmission electron micrographs of mitochondria ... c Ó FEBS 2002 Cytochrome c release inducedby valinomycin (Eur J Biochem 269) 5229 released by valinomycin was larger than that inducedby Ca2+ As the amount of the latter accorded well with the...
... patients to (j) Release induced with nDer p 1; (h) release inducedby rpro-Der p Concentration of the allergen ranged from 0.1 ngámL)1 to 10 lgámL)1 Histamine release inducedby rpro-Der p was signi®cantly ... pH 5.5, for h in a ®nal volume of 20 lL Incubation was ended by the addition of reducing sample buffer Samples were analyzed by autoradiography after separation by SDS/PAGE on Excel gel (8±18%) ... basis of differences in post-translational processing The lack of induction of maturation of rpro-Der p after dialysis to pH 4.0 observed in our study contrasts with observations reported by Yasuhara...