vascular disrupting action of electrochemotherapy mode of action and therapeutic implications
báo cáo khoa học: " Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center" pptx
Ngày tải lên :
10/08/2014, 10:20
... sex, primary tumor, date of initial diagnosis of primary cancer, date of radiographic diagnosis of BMs, number and location of BMs, neurologic symptoms, presence/absence of extracranial disease, ... patients, the lack of technical resources may influence the therapeutic decision of the treating physician In fact, in clinical practice, the treatment of BMs is often planned on the basis of the resources ... according to type of treatment and therapeutic resources of the treating center Journal of Experimental & Clinical Cancer Research 2011 30:10 Submit your next manuscript to BioMed Central and take full...
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Báo cáo y học: "Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications" pps
Ngày tải lên :
10/08/2014, 21:23
... synergistic effects of ATO and MEK inhibition, as well as ATO and FLT3 inhibition, on FLT3-ITD cells [101] The combination of ATO and AG1296, an FLT3 inhibitor, profoundly inhibited the growth and induced ... phosphorylation of FOXO3a leading to suppression of its function, thereby promoting the survival and proliferation of AML cells [54] FLT3-ITD is also known to inhibit the expression and function of several ... function of C/EBPa through phosphorylation of the N-terminal serine 21 of this protein by activation of ERK [56] Following this aberrant phosphorylation of C/EBPa, the differentiation of FLT3-ITD...
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Báo cáo y học: "Impact of rhinitis on airway inflammation: biological and therapeutic implications" ppsx
Ngày tải lên :
12/08/2014, 18:20
... relationship between rhinitis and asthma and its therapeutic implications [27], highlighting the concept of ‘one airway one disease’ The link between upper respiratory disease and asthma is also evident ... e Allergiche) and the Italian Ministry of University and Scientific and Technological Research 19 Durham SR: Effect of intranasal corticosteroid treatment on asthma in children and adults Allergy ... in children, where allergic inflammation and viral infections seem to interact The bronchodilator action of H1 receptor antagonists per se is weak and of negligible clinical relevance The effect...
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Báo cáo y học: "The molecular basis of lung cancer: molecular abnormalities and therapeutic implications" potx
Ngày tải lên :
12/08/2014, 18:21
... progressive accumulation of mutations, loss of apoptotic control and regulation of cell proliferation, and the appearance of aneusomy are associated with worsening dysplasia phenotypes and may reflect ... subclasses of adenocarcinomas Selected genes allow the discrimination between primary lung cancer and metastasis of extrapulmonary sites [90] Studies of expression profiles of adenocarcinomas of the ... Tissue microarrays (TMAs) of lung cancer Tissue microarrays (TMAs) of lung cancer TMAs are comprised of core biopsies of 0.6 mm in diameter of different tumors and of uninvolved lung from the...
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Báo cáo y học: " Changes in health-related quality of life and clinical implications in Chinese patients with chronic cough" pot
Ngày tải lên :
13/08/2014, 08:20
... review of the manuscript, YW, XL and HL took part in the collection of cases and review of the manuscript, ZQ was in charge of design and coordination of the program, review and correction of the ... charge of collection of cases and writing the manuscript, LY was in charge of collection, process, and Page of (page number not for citation purposes) Cough 2009, 5:7 statistical analysis of data and ... assessments of chronic cough, as a precise and quantitative measurement, could be applied in monitoring of cough severity, evaluation of treatment efficacy and verification of new therapeutic...
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stenersen - chemical pesticides - mode of action and toxicology (crc, 2004)
Ngày tải lên :
03/04/2014, 12:11
... pesticides: Mode of action and toxicology Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of ... inhibit synthesis of amino acids 81 5.2.1 The mode of action of glyphosate 81 5.2.2 Degradation of glyphosate 83 5.2.3 Selectivity 84 5.2.4 Mode of action of glufosinate ... Motivation The mode of action of pesticides is extremely fascinating because the subject covers so many fields of biology and chemistry and has many practical implications All disciplines of biology...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 2 pptx
Ngày tải lên :
11/08/2014, 12:21
... Stenersen 2.2.2 Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of the reactants This ... and resistant flies and a mixture (50:50) of susceptible and resistant flies (a) Doses and responses on linear scales (b) Doses on log scale and responses on probit scale LD50), will be large and ... between dose or concentration of the toxicant and the severity of the symptoms is fundamental in toxicology By using the law of mass action, we get the following equilibrium and mathematical expression:...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 3 pps
Ngày tải lên :
11/08/2014, 12:21
... butachlor, and several others) and a group of fungicides referred to as phenylamides (metalaxyl, ofurace, and oxadixyl) They have similar structure and mode of action: O C CH2R’’ N R R’ R is often ... inhibiting the formation of the microtubules Although the mode of action of the two types of compounds is different, the net result will be the same: impairment of cell division Binding of guanosine triphosphate ... fluoroglycofen-ethyl COCH3 NO2 O COCH2COCH2CH3 CF3 O OCH2CH3 NO2 Cl oxyfluorfen Bifenox, fluoroglycofen-ethyl, HC-252, lactofen, and oxyfluorfen have analogous structures and modes of action The...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 4 ppt
Ngày tải lên :
11/08/2014, 12:21
... in cessation of feeding of Lepidoptera larvae and paralysis of the gut that retards the passage of food and allows the spores to germinate The larvae suffer a general paralysis and die Bt israelensis-treated ... from beach deserts and tundra, and may multiply in cadavers of insects and other animals Insecticidal activity does not correlate with the origin of the isolate, and many of them not seem to ... proteins, and their function and versatility for insect control have yet to be elucidated 4.1 The mechanism of action of δ-endotoxins As mentioned, the δ-endotoxin (Cry protein) that makes up most of...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 5 docx
Ngày tải lên :
11/08/2014, 12:21
... a buffer of pH 7.6 at 37˚C and have the unit min–1 G Schrader (1951, 1963) also synthesized a lot of other derivatives of parathion Parathion-methyl is of similar toxicity and mode of action but ... glutamate and ammonia, and the first common enzyme in the biosynthesis of the branched-chain amino acids 5.2.1 The mode of action of glyphosate The amino acids tryptophan, phenylalanine, and tyrosine ... integrated pest control programs Three series of compounds with this type of mode of action have been found, exemplified by polyoxin B, diflubenzuron, and buprofezin Diflubenzuron belongs to the group...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 6 ppsx
Ngày tải lên :
11/08/2014, 12:21
... axon and is then transmitted to the receiving cell at the synapse are not extremely complicated, and some knowledge about this mechanism is of importance in understanding the mode of action of ... amphibians, and others may have their modes of action by binding to one of the sites It is also important to know that cross-resistance between all the DDT analogues and the pyrethroids often occurs ... Stenersen of the synthetic analogues took off in the 1960s when M Elliott and his colleagues at Rothamstead Experimental Station, U.K., began an extensive study of the mechanisms of action and the...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 8 pptx
Ngày tải lên :
11/08/2014, 12:21
... A and B are constants) They measured the vapor densities of p,p-DDT on sand at 20, 30, and 40˚C and found them to be 2.9, 13.6, and 60.2 ng/l Furthermore, Spencer and Cliath found that DDE and ... an exposure of mg of dieldrin/kg of body weight/day and xenobiotics However, the enormous number of species, the high frequency of mutations per unit time in reproductive cells, and the high ... complicated and involves binding of the substrate to the enzyme, oxidation of Fe+++ to Fe++, change of the valence electrons of Fe++ from low-spin to high-spin orbital, binding of oxygen to iron, and...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 9 pdf
Ngày tải lên :
11/08/2014, 12:21
... to make resistant strains by breeding pairs of insects separately Some of the offspring were used for resistance testing, and the brothers and sisters of insects with low susceptibility were taken ... G.D., and Devonshire, A.L 1998 Pest Sci., 54, 319–320 The cotton bollworm, Helicoverpa armigera, in Australia is of great economic importance and is cross-resistant to parathion-methyl and profenofos, ... N NHCH(CH3)2 conjugate of atrazine and glutathione The data in Table 9.4 are extracted from data of Plaisance and Gronwald (1999) and show the difference in the activity of glutathione transferase...
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Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway
Ngày tải lên :
11/09/2015, 09:08
... docked models of UDP interacting with the binding residues of H orenii SPS Ten docked models of ADP interacting with the binding residues of H orenii SPS Superimposition of one docked-UDP ligand and ... actual UDP ligand Superimposition of one docked-ADP ligand and the actual ADP ligand Superimposition of the catalytic regions of the open SPS-F6P complex (cyan) and the closed SPS-S6PUDP model (magenta) ... filtration profile of FRK Crystal of SeMet FRK 3.4 Sample diffraction pattern of SeMet FRK crystal 81 3.5 Crystal structure of HoFRK 85 3.6 Structure based sequence alignment of HoFRK 90 3.7 Stereo...
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Tài liệu BIOCHEMICAL TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects doc
Ngày tải lên :
17/02/2014, 05:20
... tens of thousands of individual primary scientific papers and reviews describing the isolation, structural characterization, pharmacological effects and biochemical targets of thousands of plant-derived ... chemistry of living things) This biochemical review provides a detailed background for understanding the nature and function of the targets of plant defensive metabolites and proteins The remainder of ... K+-ATPase and Naf, K f -ATPase H Voltage-gated Na+ channel Ligand- and voltage-gated K+ channels + Voltage- and ligand-gated Ca2+channels and ~ a /Ca2+ antiporter CFTR, voltage-gated C channels and...
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Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor: Implications for Policy Action and Intervention Measures pot
Ngày tải lên :
15/03/2014, 16:20
... Impact of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures | Annex A Range of levels of small particles (PM10 ) and carbon ... Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures • Cancer of the Nasopharynx and Larynx Several ... Impact of Household Energy and Indoor Air Pollution on the Health of the Poor Implications for Policy Action and Intervention Measures 2.3 Summary of Evidence Table summarises the nature and extent...
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Base Working Paper on Strategy and Action Plan for Ensuring Safety of Milk and Milk Products ppt
Ngày tải lên :
24/03/2014, 04:20
... Exports and imports of milk and milk products Problems in export and import of milk and milk products Objective 3: Current enforcement procedures and Prevention of Food Adulteration (PFA) Act and ... manufactured, and their quality, by the registered units Bureau of Indian Standards The Bureau of Indian Standards (BIS) has formulated and revised standards and guidelines for various dairy products and ... purpose of having, in addition to mandatory PFA food standards, separate BIS and Agmark standards for milk products, enforced by BIS and Directorate of Marketing and Inspection, Department of Agriculture...
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NATIONAL ACTION PLAN for CHILD INJURY PREVENTION: An Agenda to Prevent Injuries and Promote the Safety of Children and Adolescents in the United States pptx
Ngày tải lên :
30/03/2014, 03:20
... risk and protective factors, and, on the basis of this information, developing, implementing, and evaluating interventions, and promoting widespread adoption of evidence-based practices and policies ... gaps, and to spark action across the nation that will result in measurable reductions in death and disability, and diminish the financial and emotional burden of childhood injuries in families and ... to the acquisition and use of skills Education and training in injury prevention can benefit children and families, health care providers, public safety officials, and other professionals such...
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- examples of sentences with action and linking verbs
- examples of action and linking verbs
- what are some examples of action and linking verbs
- origin metabolism action and mode of action
- quality consortia—freedom of action and dependence
- problems determine potential causes of problems and identify corrective action s