... over the coming years There is a general sense that the best is yet to come out of phage research Conclusion We anticipate that the pages of Virology Journal will reflect the excitement ofthe ... in all divisions of life The large numbers of phylogenetic variants of biologically interesting proteins and nucleic acids that one can derive from sequenced phage genomes are treasure troves for ... 64:69-114 Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical...
... over the coming years There is a general sense that the best is yet to come out of phage research Conclusion We anticipate that the pages of Virology Journal will reflect the excitement ofthe ... in all divisions of life The large numbers of phylogenetic variants of biologically interesting proteins and nucleic acids that one can derive from sequenced phage genomes are treasure troves for ... 64:69-114 Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical...
... Sheldon Teperman ofthe Jacobi Medical Center, New York, were part ofthe hospital’s disaster committee and offer some straight-talking criticism ofthe city’s reaction [7] The lack of communication ... assistance in the creation of this 10-part review series This article, and the series it is part of, is dedicated to the first responders – fire, police and medical personnel – who attended the ... because the Internet has disseminated sophisticated information about bioterrorism, comprehensive guidelines on managing all kinds of outbreaks, from anthrax to smallpox, are needed Finally, in the...
... the key link among all these changes isthe structural readjustment ofthesame key proteins Conclusion The cornerstone ofthe hypothesis of native aggregation isthe generation in proteins of ... ofthe resting state of cell (as well as of its individual parts) isof great importance for understanding the mechanisms of activation Here we return again to the issue ofthe structure ofthe ... reminiscent of denaturation of isolated proteins; therefore, Nasonov called his theory explaining the cell response reaction the denaturational theory of excitation and damage According to this theory,...
... that have the form of (31) or (32) is excluded from the viewpoint of a necessary condition forthe identity to exist in y(T) Thus we obtain the following theorem Theorem For a given T, the following ... proposed algorithm is applied to the system ofthe form (3) obtained for each inputcombination of ξi It is remarked that depending on the choice ofthe kind of control inputs, there exist several cases ... holds irrespective ofthevalueof u(1), similarly forthe case of x2 (0) = Therefore, we see that system (10) is not 2-output-controllable In thesame way, we see that system (10) is not T-output-controllable...
... where q isthe output, xi isthe level of input I, α i isthe output elasticity of input I, A is a constant, and where N isthe number of inputs The Cobb-Douglas production function isthe most ... Ph.D The University of Texas at Austin, 2002 Supervisors: Andrew B Whinston & Anitesh Barua This dissertation consists of three essays that address the issue ofthe business valueof Information ... available for most ofthe companies in the dataset, this study first uses the number of employees as a proxy forthe labor input The total labor cost can be thought of as a product ofthe number of...
... observed in this investigation (Fig 5B) The ER isthe site of synthesis ofall secretory proteins and resident proteins ofthe membrane system, and any perturbation that compromises the proteinfolding ... folding, the ER is responsible for lipid synthesis In particular, excess availability of FFAs, as isthe case in the present experimental model, leads to increased formation of TAGs, which are either ... TAG synthesis It is suggested that the creation of a pool of oversaturated lipid intermediates makes these molecules inaccessible to the enzymes of TAG synthesis, whereas a certain degree of unsaturation...
... framework; the latter is described below The family of distributions used forthe forecast error isthe normal family with precision τ 12 In this case the likelihood for an observation is L(yit ... will be thesame as that from any other identical vector of θs This holds forthe case when all θ’s are identical and not equal to one Another issue is that the surface ofthe likelihood is very ... matrix forthe LVTS using the normalized BCL vectors for each bank This approach is based on the premise that money flows out of a bank in the proportions given by the BCLs the bank has with the other...
... preferentially the phosphorylation ofthe p46 isoform of JNK, whereas sorbitol treatment induced phosphorylation of both the p46 and p55 isoforms To confirm functional activation ofthe JNK signaling ... system, as the presence ofthe SV40 large T antigen in these cells enhances their resistance to apoptosis Apoptosis is a tightly regulated mechanism forthe disposal of damaged cells and to remove ... similarity beyond the conserved active-site signature motif HCX5R Although they use 2464 thesame catalytic mechanism as the classical PTPs, the catalytic cleft of DSPs is shallower, which allows accommodation...
... M/F at the as1-Cas locus Therefore, analysis of their transcripts could have been rather difficult because ofthe occurrence of at least nine different forms of messenger arising from the F allele ... 23 in the 9th exon ofthe A allele, which is deleted in the F allele, is mutated to T in the M allele, giving rise to a Ser fi Leu substitution Analysis ofthe intronic flanking sequences The flanking ... haplotype formulae strongly suggest that the allele that provided the 3¢ part ofthe recombinant allele (M) isthe A allele (Fig 10) In contrast, one can wonder whether the donor allele ofthe 5¢...
... with cloud services The apothegm is ‘Own the base and rent the peak’ Conclusion The customer’s overall cloud health starts with an assessment ofvalueThe assessment ofvalueof cloud services ... Services (AMS) This is yet another approach businesses should use when assessing cloud value AMS isthe paradigm where a predefined level of demand is managed internally and the remainder augmented ... An example ofthe disruptive consumption rates is shown in the chart below This chart presents the forecasted market growth-rate for cloud services (Forrester, 2011 http://www.zdnet.com/blog/btl/cloud-computing-market-241-billion-in-2020/47702;...
... levels of soluble APP remaining constant irrespective ofthe presence or absence of BACE1 The levels of APPsa increased to account forthe loss of APPsb (soluble C-terminally truncated b-cleaved form ... (Table 1), whereas the absence of this band in the APP KO extract confirms the specificity of this band as a true APPs species (Fig 1C) The levels of this APPsa band were dramatically increased in ... expression, mirroring the modifications ofthe levels of FLAPLP1 in the NaCl ⁄ Tris-T fraction An attractive explanation forthe presence of FLAPLP1 in NaCl ⁄ Tris homogenates is its secretion via...
... family isoforms is not understood – especially in the context of their intracellular localization as described forallclass III members [4,5,8,9,28] This raises the question of whether these transporters ... resolve some of these discrepancies in order to (a) identify the subcellular localization of GLUT8 in testis, (b) elucidate the role of APs in GLUT8 sorting, and (c) understand the role ofthe EXXXLL ... localization ofthe endogenous GLUT8 in testis, the nature of its sorting, and the interaction of its Nterminal dileucine motif with the various AP subunits The [DE]XXXL[LI] signal of GLUT8 has...
... annual 0.32% of GDP Given the importance of mobile in the economy ofthe Philippines, this would account for 6.9% ofall GDP growth forthe economy during the past decade, , according to the Broadband ... date, the Commission has published a number of high-level policy reports, as well as a number of best practices and case studies This report is published by the Commission on the occasion ofthe ... vision document or broader Information Society strategy (this was often the case for earlier policy objectives set out between 2000 and 2007) The advantage of these broad plans is that they often...
... consideration in further investigations ofthe role of this cytokine as an LPS mediator The present PEC culture also showed the advantage of using mixed-cell cultures forthe investigation of LPS mediators ... experiments is shown combination of these cytokines forthe production of IFN-c, similarly to NO production The responses, ofthe HeN culture, were not suppressed by anti-CD14 Ig (data not shown) These ... mediator of LPS in NO production A synergistic effect of exogenous IFN-c + LPS on the induction of LPS mediators in macrophage cultures is well known The effect is, however, influenced profoundly by the...
... in the transcriptional regulation of WD gene Previous studies report that MREa is also the most crucial MRE for transcription ofthe MT gene and that there is a relationship between the distance ... addition, the concurrent decrease in the level of Ku-70 from 0.5 to 12 h after transfection of Ku-80 IR gene is consistent with previous report that the stability of Ku-70 is compromised by the absence ... proposed that the WD protein acts as a copperspecific pump that mediates the export of copper from the cytosol, similar to the P-type ATPase [14] On the basis ofthe fact that MREs mediate the transcriptional...
... specicity ofthe substrate) [26] Consequently, substitution of Val371 to isoleucine might prevent the full development ofthe active conformation This hypothesis is further conrmed by the results of ... in this position most likely causes some degree of structural change; this is especially true in the case ofthe introduction of an isoleucine, a b-branched amino acid that is not exible In the ... where V120 isthe velocity of S-2366 hydrolysis at 120 and FXIT isthe total concentration of either wild-type or mutant zymogen FXI present in the activation solution The validity of this approach...
... activity ofthe kb ofthe 5¢-flanking region was dramatically decreased by the deletion of GC-box3, the GC-rich Fig Alignment ofthe 5¢-nucleotide sequences ofthe human, rat and mouse NOX4 genes The ... with the anti-Sp1 shRNA-expression plasmid (Fig 7B) These results highlight the pivotal role of Sp3 in the transcription ofthe NOX4 gene Discussion The major lines of evidence provided by this ... [11], but there seem to be species differences in the transcriptional regulation of NOX enzymes, as found for NOX1 [12,13] This led us to undertake an investigation ofthe molecular basis ofthe constitutive...