vaccine induced autoimmunity in the dog
Tài liệu Báo cáo khoa học: The calcium-induced switch in the troponin complex probed by fluorescent mutants of troponin I doc
... sensitive to Ca2+ binding to the two classes of sites, and the authors interpreted the high affinity sites being in the C-domain and the low affinity in the N-domain of TnC Nevertheless an absolute ... Also, the N-domain was linked to the first part of the bimodal Ca2+ titration curves of the binary complexes Together, these could be evidence that the high affinity sites are in the N-domain when ... and in particular site II modifies the first part of the signal This indicates that the high affinity Ca2+ signal is related to the N-domain Further, the disruption of the sites in the C-domain affects...
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báo cáo hóa học: " Lipopolysaccharide induced inflammation in the perivascular space in lungs" docx
... migration of inflammatory cells into the PVS in LPS -induced lung inflammation Therefore, we conducted this study to define the kinetics of neutrophils and monocytes/macrophages into PVS in lungs ... run in the opposite direction to the central draining lymph nodes While the PVS is increased in various models of lung inflammation, anti-inflammatory agents such as anti-IL-9 agent reduce the ... leukocytes showed a gradual increase in the LPS groups beginning hrs after the challenge reaching significance after 36 hours In contrast, the neutrophil numbers in the PVS showed an abrupt and...
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báo cáo hóa học:" Mechanically-induced osteogenesis in the cortical bone of pre- to peripubertal stage and peri- to postpubertal stage mice" ppt
... endocortical expansion in the postpubertal stage [8,10], but the effects of loading and estrogen may be independent of each other [11] The aim of this study is to further examine the relationship between ... Again, this growth pattern would serve to increase the ability of the bone to resist bending forces in exercised mice relative to controls because there is more bone mass further from the bending ... apposition in postpubertal females The results presented here experimentally confirm this finding in mice, but fluorochrome labels also indicate that, despite a net increase in the size of the medullary...
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Báo cáo khoa học: "Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat" pdf
... ethanol -induced toxicity in a mouse model [1] In this study, the herbal extract mixture and yogurt also showed protective and therapeutic effects for the ethanol -induced toxicity in a rat model The ... and fixed in 10% buffered formalin for 24 h, processed in an alcohol-xylene series, embedded in paraffin wax, and sectioned at µm The sections were stained with hematoxylin and eosin The sections ... bilirubin similar to the results of the commercial drug On the other hand, the ALT levels in the herbal extract mixture and yogurt treatment group showed a further decrease when compared to the...
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Báo cáo khoa học: " Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex" doc
... levels in the rat forebrain cortex The results in Fig show the bilateral nitrite levels (nM/ mg proteins) in the rat forebrain cortex homogenates at h (A) and 30 d (B) after the treatments At the ... production in the rat forebrain cortex The results in Fig show the bilateral ∙O2 levels (μM red NBT/min/mg proteins) in the rat forebrain cortex homogenates at h (A) and 30 d (B) after the treatments ... AlCl3 injection, Reduced glutathione contents in the rat forebrain cortex The results in Fig show the bilateral GSH contents (nM GSH/mg proteins) in the forebrain cortex homogenates at Fig The...
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Báo cáo y học: "A web tool for finding gene candidates associated with experimentally induced arthritis in the rat" docx
... QTLs in rat were obtained from the RatMap database [7] These data were originally collected from experimentally induced inflammatory arthritis in rat strains susceptible to the following inducing ... polymorphism within the first intron of the gene encoding interferon-γ [12] IL22 (interleukin-22), CGC points 14.1, CGC ranking 2, manual rating IL22 was selected by the keywords 'inflam', 'T cell', ... 1), CGC points 219.7, CGC ranking 1, manual rating The very high point that NFKB1 obtained from the keyword query was in part due to the word 'arthritis' appearing in the corresponding OMIM text...
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Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot
... chemokines in RA synoviocytes, especially in the presence of TNF-α, highlighting its role in neutrophil recruitment into the joint [49] Furthermore, IL-17 induces the production of GCP-2 in a ... as the percentage of swelling (i.e 100 × the difference between the increase of thickness of the left and the right ears, divided by the thickness of the right ear) at the indicated time points ... PBS in the right ear DTH response was calculated as the percentage swelling (the difference between the increase of thickness of the left ear and the right ear, divided by the thickness of the...
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Báo cáo sinh học: " Chromosomal localization and activity of nucleolar organizer regions in the dog" pot
... made the development of the physical mapping of the canine genome possible The objective of the present study was the chromosomal localization of NORs in the dog karyotype and the analysis of their ... terminal part of the q arms of chromosome pairs: and 17 The third chromosome pair, also bearing NORs in the terminal part of the q arm, belongs to a group of small autosomes not yet included in the ... included in the canine standard karyotype The banding pattern of this chromosome is shown in figure 1A In the male karyotype, a NOR occurred also in the terminal part of the long arm of the Y chromosome...
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Báo cáo y học: "Treatment of hypertriglyceridemia and HIV: fenofibrate-induced changes in the expression of chemokine genes in circulating leukocytes" ppsx
... similar effect in the contiguous endothelial cells, which, in combination with the CCR2 decreased expression, could be beneficial with respect to the risk of atherosclerosis considering their well ... documented role in the local accumulation of monocytes [8,9] However, fenofibrate had an intriguing effect in SDF-1 expression neutralizing the significant decrease in its expression observed in untreated ... be useful in the attempt to decrease the risk of atherosclerosis and may act as modulators of systemic inflammation and the associated vascular response However, further studies in other type...
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Báo cáo y học: " Unaltered TNF-α production by macrophages and monocytes in diet-induced obesity in the rat" ppsx
... described within the adipose tissue are intrinsic to the macrophages, or whether these defects result from the interaction with the local microenvironment in the adipose tissue If intrinsic macrophage ... between the interior and the exterior, such as the mucosa of the lungs or the gastrointestinal tract Notably, increasing evidence suggests that macrophages also play an important role in the development ... neuroendocrine changes in the brain as well as in the periphery, involving mediators such as neuropeptide Y (NPY) and leptin [1] Additionally, there have been several reports demonstrating that...
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báo cáo khoa học: " Cold- and light-induced changes in the transcriptome of wheat leading to phase transition from vegetative to reproductive growth" pot
... much higher in the crown tissue of the two winter varieties than in Paragon and increased across the time course There was also an increase in transcript abundance in leaf tissue of the winter varieties, ... of TaAGL42 increased, principally in leaf tissue, in the winter varieties and showed no response in Paragon If these two MADS-box genes are involved in cold induced phase transition, their profiles ... distinguished by the intrinsic rate at which they tend to pass from floral induction to heading This tendency is referred to as earliness per se [3] In Arabidopsis, the genetic factors underpinning...
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Báo cáo y học: " Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice" pdf
... value in streamlining future research [45,46] Our negative findings may aid in focusing future basic investigations into the relationship of lung carcinogenesis with inflammation in pertinent ... (to TSB) The study sponsors had no involvement in the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript ... determining the impact of experimental -induced allergic airway inflammation on chemical -induced lung carcinogenesis in mice We hypothesized that either acute or chronic allergic airway inflammation...
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Báo cáo khoa học: " Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum." ppt
... prednisolone, indicate that the fever and other clinical signs in these dogs were immunemediated This is further supported by that none of the patients during the past years since the study was ... separated into groups based on clinical signs (Table 1) One group showed only fever, while the others who showed muscle pain and muscle and joint-pain, respectively Dogs included in the latter ... methods Dogs The material consisted of 20 dogs of 13 different breeds All dogs were brought to the clinic within days after they became ill They were submitted to general clinical examinations,...
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Báo cáo y học: " Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse" potx
... sensitive to acutely administered corticosterone acting on OCT3 These data provide new insights into the mechanisms involved in 5-HT -induced bronchoconstriction, including novel information about non-genomic, ... response following cholinergic stimulation, as shown in this and in an earlier study [11] These data clearly indicate that the release of epithelial ACh is not involved in the 5-HT -induced bronchoconstrictor ... sensitive to acutely administered corticosterone acting on OCT3 These data provide new insights into the mechanisms involved in 5-HT -induced bronchoconstriction, including novel information about non-genomic,...
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Báo cáo y học: "Heparin-induced thrombocytopenia in the ICU: an overview" pps
... directly inhibit thrombin Lepirudin, argatroban und bivalirudin are available for use in patients with HIT • Lepirudin: Lepirudin is a recombinant hirudin (found in the saliva of the medicinal leech, ... thrombin inhibitor therapy for the management of heparin -induced thrombocytopenia (HIT)–bridging the River Coumarin Thromb Haemost 2008, 99:2–3 51 Warkentin TE: Should vitamin K be administered ... antagonist therapy is contraindicated in patients with HIT because of the increased risk of thrombosis in the presence of thrombocytopenia In these patients, vitamin K antagonist therapy may induce...
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Assessment of testis development during induced spermatogenesis in the european eel anguilla anguilla
... development than the GSI, which remains low Both the SMI and GSI increase during the developing phase However, the SMI continued to increase as the males initiated sperm production, whereas the GSI reached ... Maryland) as shown in Figure The tissue type at each intersection of the grid lines (i.e., each point) was categorized by using the cell type present in the upper right corner of the intersection as ... longitudinal section; arrows indicate photography points: p = proximal, c = central, d = distal) The thumb at the top of the photo indicates scale The in uence of sectioning angle in relation to the...
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Molecular analysis of maternal diabetes induced changes in the developing neural tube
... TGF-ß l TGF-ß l III III E F TNF-α III G Fig 17 TNF-α G III H Lectin TGF-ß1 A B C Lectin TNF-α III D Fig 18 TGF-ß1+Lectin TNF-α+Lectin III III E F tm III htms III htm A Fig 19 B 50 Mean Cell numbers/mm ... IL-1ß C TGFß 173bp D 370bp iNOS Fig 21 folds of induction 7.5 6.5 5.5 4.5 3.5 2.5 1.5 0.5 Diabetic CP-treated CP-treated diabetic TNF- α Fig 22 Normal ** ** IL-1β TGF-β1 iNOS ... in e A III LV E B dc dc e vtw vtw E C vt dt D Fig Thickness of Ventral Telencephalon Wall (µm) 300 250 * 200 150 100 50 Fig Control Diabetic vt dt vt vt A B Fig % of BrdU-cells in Ventral...
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Báo cáo y học: "Placenta Percreta-Induced Uterine Rupture Diagnosed By Laparoscopy in the First Trimester"
... day The final pathological examination revealed that the chorionic villi had invaded the entire myometrium up to the serosa, confirming the diagnosis of placenta percreta (Fig 3) The length of the ... Ultrasound examination showing intrauterine pregnancy at 14 weeks gestation Placenta percreta -induced uterine rupture in the first trimester in our patient may be attributed to the previous dilatation ... occur during delivery, the affected site is the lower uterine segment; however, in cases of uterine rupture during the first trimester, the site commonly affected is the fundus, as noted in our...
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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... TAG synthesis was initially hindered following stearate administration and was completely interrupted at longer incubation periods Interestingly, the interruption of TAG synthesis preceded the appearance ... activating transcription factor (ATF4) and of CCAAT ⁄ enhancer-binding protein homologous protein (CHOP) proteins downstream of eIF2a were observed (Fig 4A), indicating the initiation of ER stress -induced ... supporting the notion that it constitutes the initiating event in the process of lipotoxicity Stearate has to be activated in order to be toxic The first enzyme involved in metabolism of FFAs after their...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s ... heterogeneity in the efficacy of the BCG vaccine reported in the individual studies Using a model that included the geographic latitude of the study site and the data validity score as covariates, they ... associated with the use of the vaccine in these persons In the United States, the use of BCG vaccination is rarely indicated BCG vaccination is not recommended for inclusion in immunization or...
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