use of biomarkers to assess drug drug interactions
Báo cáo y học: "Current Status of Methods to Assess Cancer Drug Resistance"
... research teams started to develop laboratory tests in order to predict tumor reaction to cytostatic drugs [5] They used fresh cancer tissue and examined the effect of the drugs on tumor cell growth ... isolation of cells, incubation of cells with drugs and assessment of cell survival are the same Usually a range of drug doses is applied in order to find a dose-response relationship Drug concentrations ... should not be confused: drug resistance is considered as highly predictable, which is not the case with drug sensitivity Results of sensitive drugs obtained by the net effect of drug action on cancer...
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THE USE OF DERIVATIVES TO MANAGE INTEREST RATE RISK IN COMMERCIAL BANKS docx
... basis risk to exist, the equation used to determine the number of put options to buy to hedge interest rate risk becomes: Np DA kDL A/ D B br (19) Where br is a measure of the volatility of interest ... manager thus wants to adopt a put option position to generate profits that just offset the loss in net worth due to an interest rate shock position If P is the total change in the value of a put option ... could issue long-term notes with a maturity equal or close to that of the mortgages The proceeds of the sales of the notes can be used to pay of the CDs and reduce the duration gap Alternatively the...
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Promoting the Use of End-to-End Congestion Control in the Internet pptx
... can be of use to the end user [Var96] This can occur when web users abort partiallycompleted TCP transfers because of delays in the network and then re-request the same data This form of fragmentationbased ... as a whole to include incentives for applications to use end -to- end congestion control In the current architecture, there are no concrete incentives for individual users to use end -to- end congestion ... in times of congestion, could also be used on aggregates of flows This use of aggregation is most likely to be attractive for routers in the interior of the network with a high degree of statistical...
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use of coatings to improve
... slip from the top to the bottom of the vertical specimen or fall off the specimen While substantial parts of the foam sometimes fell off, the base of the foam layer remained attached to the plywood ... the property of a material to withstand fire or give protection from it Fire resistance of elements of buildings is characterized by the ability to confine a fire or to continue to perform a ... is needed to determine performance of coatings on loadbearing assemblies To obtain actual in -use performance, details of the total construction must be considered Unprotected portions of the construction...
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Báo cáo y học: "Validation of actigraphy to assess circadian organization and sleep quality in patients with advanced lung cancer" potx
... scale of (denoting perfect health) to (dead) In this investigation, patients were restricted to scores of 0, (fully active but symptomatic), and (capable of selfcare and able to carry out work of ... presence of COPD Its severity was graded according to the Spirometric Classification of COPD severity, by reference to percent of predicted forced expiratory volume in one second (FEV1) Thirty to 50% ... actigraph, worn on the non-dominant wrist, was used to record a patient’s level and pattern of gross motor activity (Mini Motionlogger Basic model, Ambulatory Monitoring, Inc, AMI) Internal motion sensors...
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Báo cáo y học: "Clinical use of biomarkers of survival in pulmonary fibrosis" pot
... loss of integrity of the epithelial barrier caused by lung injury and of an increased mass of type II cells due to hyperplasia [12] Three studies tried to validate the use of these serum markers ... different forms of ILD A baseline FVC, a change of FVC of more than 10%, and a decrement of more than 25 m in MWD are predictors of survival Measurements of FVC and MWD are clinically easy to do, results ... validated the use of SP-A and D in a population of 142 IPF patients as a predictor of survival They used a Cox’s proportional hazards model and found that an elevated concentration of SP-D (and...
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TRANSGENIC USE OF SMAD7 TO SUPPRESS TGFβ SIGNALING DURING MOUSE DEVELOPMENT
... with a set of distinct co-receptors, adding to the signaling complexity Activation of these serine/threonine kinase receptors leads to signal propagation by phosphorylation of Receptor- Sma- And ... by the Faculty of Indiana University, in partial fulfillment of the requirements for the degree of Doctor of Philosophy Simon J Conway, Ph.D., Chair Maureen A Harrington, Ph.D Doctoral Committee ... [28] With respect to receptors for TGFβ family factors, TGFβ type II receptor (Tgbfr2) and TGFβ type I receptor (Alk5) inactivation in the neural crest caused extensive craniofacial defects, such...
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a vietnamese-english cross-cultural study on the use of responding to english greetings = nghiên cứu giao văn hóa anh - việt trong việc sử dụng lời đáp lại các lời chào của tiếng anh
... name or surname The use of title and full name is not found in the responses, perhaps, because the respondents found them too formal to use In fact, the English prefers to use title and last name ... sensitive to potential as well as actual meaning because pragmatics refers to the meaning implied in individual words and the order of words to consider how we use utterances when we talk To be more ... the use of the only term “you’ in English The use of one term, furthermore, is not given a firm consideration of formality The term “d ” (aunt) for example, can be very formal as it is used to...
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The use of songs to improve listening skills for students at ITC Foreign Language Centre in Haiphong = Sử dụng bài hát nhằm cải thiện kỹ năng nghe cho sinh viên.PDF
... listening To stimulate discussion of attitudes and feelings To encourage creativity and use of imagination To provide a relaxed classroom atmosphere To bring variety and fun to learning ... According to Eken (1996), songs can be used: To present a topic, a language point, lexis, etc To practice a language point, lexis, etc To focus on common learner errors in more direct way To ... skill to be learned and tested CLT emphasizes the use of extensive listening to material taken from “authentic” L1 situations where learners are expected to select the language they need to use...
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The use of songs to improve listening skills for students at ITC Foreign Language Centre in Haiphong = Sử dụng bài hát nhằm cải thiện kỹ năng nghe cho sinh viên20150227.PDF
... factor to the success of a listening lesson Secondly, most of the students realized the fact that English songs were not only a tool to help them relax but it could be used a powerful tool to ... 1999) To sum up, songs not only play an important part in our life but are a useful tool to learn in a foreign language classroom So teachers of foreign language should make use of them to make ... listening To stimulate discussion of attitudes and feelings To encourage creativity and use of imagination To provide a relaxed classroom atmosphere To bring variety and fun to learning...
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A vietnamese –english cross-cultural study on the use of responding to english greetings
... important role of responding to greetings, the author has chosen to study Vietnamese and English cross-cultural communication in term of responding to greetings with the expectation of finding out ... non-verbal factors in real-life communication is fully conscious, the study focuses on the verbal aspects of the act of replying a greeting only - The study is confined only to strategies of replying ... properly and used more effectively However, in reality, Vietnamese learners of English often make mistakes in communicating with English speakers This is mostly caused by the effect of Vietnamese...
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the use of pictures to engage young learners in speaking activities at new oriental english school
... learners need to be familiar with a varieties of topics and need to practice listening comprehension to topic nominations of native speakers, need to practice introducing new topics into their conversations; ... trailer, they have to name the cartoon and main characters Discuss the orders of the pictures, and then try to retell the story Finally, they have to present their story in front of the class Let’s ... 1) To what extent does the use of pictures help learners with their speaking skill? 2) What are the learners’ attitudes towards the use of pictures in speaking activities? 1.4 Significance of...
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báo cáo khoa học: " Designing an experimental HIV/HCV intervention to promote the safe re-use of drug preparation materials by injection drug users in Puerto Rico" potx
... utilization of shooting galleries [5], joint drug purchase and injection of shared drugs [6], and re -use of injection equipment [7] At present, IDUs are unable to access adequate numbers of new syringes ... equipment) referred to as La Criolla (Figure 1b) permits IDUs to pull up a measurable amount of water to add to drug powder, an alternative to producing water drops using the flip-top bottle This ... Estimating numbers of injecting drug users in metropolitan areas for structural analyses of community vulnerability and for assessing relative degrees of service provision for injecting drug users J Urban...
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Báo cáo y học: " Cystitis due to the use of ketamine as a recreational drug: a case report" pot
... benefited from cessation of ketamine use In one case the addition of pentosane polysulphate appeared to provide some symptomatic relief In our case cystoscopy showed only mild signs of inflammation and ... Erythematous patches Erythematous patches Unknown In three patients, similar to patient Unknown Yes Unknown Yes Unknown Yes Age Sex Ketamine use Duration of symptoms Urine cultures Bladder wall Cystoscopy ... Vercillino C, Tonetti F: Ketamine: a new look to an old drug Minerva Anestesiol 2003, 69:468-471 Dillon P, Copeland J, Jansen K: Patterns of use and harm associated with non-medical ketamine use Drug...
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
... years ago, prior to the development of modern laboratory techniques to determine pathways of drug metabolism Furthermore, there are no published studies of possible drug- drug interactions between ... mg of lopinavir with 50 mg of ritonavir) twice-daily Lopinavir / ritonavir (Kaletra ™) – tablets (200 mg of lopinavir with 50 mg of ritonavir) + 300 mg of ritonavir twice-daily Lopinavir/ritonavir ... months of treatment among patients with advanced HIV disease 8, Predicting Drug Interactions Involving Rifamycins Knowledge of the mechanisms of drug interactions can help predict the likelihood of...
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R INTE S OF MEDIC REPORTING ADVERSE DRUG REACTIONS DEFINITIONS OF TERMS AND CRITERIA FOR THEIR USE ppt
... irrespective of the terminology used Meetings of working groups were organized to process lists of selected terms The groups consisted of representatives of drug regulators (from drug safety units); ... symptoms, and laboratory findings It is also important to give the evolutionary history of the reaction in relation to administration of the drug and final outcome Validation of reports of cutaneous ... Fixed drug eruption Preamble The term fixed drug eruption is preferred to fixed drug reaction The term drug eruption (drug rash) should not be used as a synonym of fixed drug eruption or fixed drug...
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Báo cáo lâm nghiệp: "SHORT COMMUNICATION The use of cotyledon proteins to assess the genetic diversity in sweet holm oak" potx
... SDS-PAGE of glutelins from cotyledons of holm oak Fig 1B Diagrammatic representation of each zone evaluated, zone C (upper), zone D (medium) and zone E (lower) The aim of the present study was to evaluate ... frequencies of each band are shown in Table 1 The classification of Marshall and Brown (1975) was used to assess the distribution of alleles in different populations In general, the bands presented ... important to set up appropriate management strategies, mainly in reforestation In this respect, this method of analyzing cotyledon storage proteins (glutelins) could be considered an additional tool to...
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Báo cáo y học: "QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy" pdf
... was used to test the effect of treatments on QTc (within subject factor: time of ECG examination, between subject factor: therapy group) Fisher Exact Test was used to compared the number of patients ... the end of electrical ventricular activity Prolongation of this interval is considered a marker of the arrhythmogenic potential of a drug specifically linked to an increased risk of torsade de ... Department of Psychiatry of San Matteo Hospital in Pavia The study was approved by local Ethics Review Committee We chosed to recruit only women because of their higher risk of developing drug related...
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Delivery of chemotherapeutic agents using drug-loaded irradiated tumor cells to treat murine ovarian tumors doc
... injected into the peritoneum of each mouse to obtain peritoneal cells Peritoneal cells (1 × 106 /mouse) were then analyzed by flow cytometry Characterization of tumor cell death by drug- treated ... addition, intraperitoneal mode of delivery of irradiated tumor cells loaded with drug would potentially have less systemic toxicity compared to intravenous drug delivery The irradiation of drug- loaded ... the intracellular uptake of the drug and the eventual death of the tumor cells We also found that drugloaded tumor cells were capable of transferring the drug to other non -drug- loaded tumor cells...
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Báo cáo y học: "Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation" docx
... to MMF and rapamycin Discussion Thrombotic thrombocytopenic purpura- haemolytic uraemic syndrome is an inclusive term describing diverse symptoms of multiple etiologies with common features of ... renal 8% Liver & 2% Heart -Lungs 96% of the cases occurred within year In the majority of renal cases and all non-renal transplants HUS was attributed to the use of cyclosporin Only patients developed ... from emphysema As to whether there is a relationship between emphysema/a-1 antitrypsin deficiency and the development of HUS in a background of tacrolimus toxicity remains to be seen In conclusion...
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