upregulation of foxm1 transcription factor
Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... Activation of STAT1 induces the transcription factor, T-box expressed in T cells (T-bet), which is a master regulator of Th1 differentiation [11] T-bet potentiates the expression of IFN-c, which, ... protein domains important in the functioning of these transcription factors T-bet (also known as Tbox-21) belongs to the T-box family of genes, consisting of over 20 members characterized in mammals ... activity [39] Foxp3 belongs to the fork-head box (FOX) family of proteins [42], a family of transcription factors that are both transcriptional repressors and activators It contains at least...
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Báo cáo khoa học: Phosphorylation-dependent binding of human transcription factor MOK2 to lamin A⁄C pot
... Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A ⁄ C Biol Cell 100, 51–61 Dhanasekaran DN, Kashef K, Lee CM, Xu H & Reddy EP (2007) Scaffold proteins of ... function of JIP proteins has been previously proposed for two other transcription factors, c-Myc and Max [11] Interestingly, the region of JLP that binds Myc is similar to the region of JSAP1 ... & Lee WH (1992) Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F Mol Cell Biol 12, 5620–5631...
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Báo cáo khoa học: Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic b-cells ppt
... activation of the JNK pathway [15,23] In the current study, we planned to determine whether either of the other two MAP kinases, ERK and p38 kinase, and activation of their target transcription factors, ... kinases, JNK and p38 [26] Activation of MAPK-mediated signaling pathways could result in phosphorylation of several protein targets, including activating transcription factor (ATF2) This protein regulates ... played by MAPK in the regulation of transcription factor activities and gene expression, we sought here to investigate whether hA treatment might increase the activity of ERK1 ⁄ or p38 kinase, and...
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Báo cáo khoa học: Identification and characterization of four novel peptide motifs that recognize distinct regions of the transcription factor CP2 doc
... disease Repression of HIV-1 LTR transcription by CP2 is accomplished via the binding of CP2 to another transcription factor, Yin-Yang1 (YY1), and the resultant recruitment of histone deacetylase ... Identification of CP2-binding peptide motifs Numerous data point to the transcriptional activation of a range of genes by CP2, leading to functional diversity of CP2 in various species ... Erythroid-specific gene activation [49] Transcription factor IIE, a subunit (TFIIE a) [50] casein kinase II-a (CKII-a), ETS-1 and the a subunit of transcription factor IIE (TFIIE-a) (Table 2) REST...
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Báo cáo khoa học: Nucleocytoplasmic shuttling of STAT transcription factors Thomas Meyer and Uwe Vinkemeier doc
... shuttling of STAT transcription factors (Eur J Biochem 271) 4607 Fig STATs at the cell membrane A schematic representation of the events leading to the tyrosine phosphorylation (activation) of STATs ... sequences of other STATs are listed: D, Drosophila; h, human Ó FEBS 2004 Continuous nucleocytoplasmic cycling of STATs Loss -of- function mutations of the STAT1 dsNLS block nuclear entry of tyrosine-phosphorylated ... overwhelming majority of examples of protein nucleocytoplasmic shuttling belong to this active mode of translocation STAT proteins have also been demonstrated to utilize components of this Ran-dependent...
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Báo cáo y học: " Regulatory interdependence of myeloid transcription factors revealed by Matrix RNAi analysis" docx
... Suzuki M: Identification of DNA regions and a set of transcriptional regulatory factors involved in transcriptional regulation of several human liver-enriched transcription factor genes Nucleic Acids ... deviation; siRNA: small interfering RNA; TF: transcription factor; TFBS: transcription factor binding site; TRN: transcriptional regulatory network; TSS: transcription start site Authors' contributions ... Out of these, 654 were activating edges (that is, knockdown of one TF led to a decrease of expression of another) and 222 were repressing edges (that is, knockdown of one TF led to an increase of...
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báo cáo khoa học: " Identification and expression analysis of WRKY transcription factor genes in canola (Brassica napus L.) in response to fungal pathogens and hormone treatments" ppt
... result of pathogen challenge in canola [2-5] Plant defense responses include the transcriptional control of expression of stress-responsive genes [6-9], including a number of transcription factors ... Identification of 46 WRKY transcription factor genes in B napus Although the complete sequence of the B napus genome has not yet been determined, the number of publicly available ESTs was 593,895 as of May ... coat development gene of Arabidopsis, encodes a WRKY transcription factor Plant Cell 2002, 14(6):1359-1375 Lagace M, Matton DP: Characterization of a WRKY transcription factor expressed in late...
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Báo cáo y học: "Understanding the roles of the transcription factors nuclear κ α factor-κB and hypoxia-inducible factor-1α in lung injury" pptx
... transcription factors in the regulation of oxidant-mediated κ lung injury: role for nuclear factor- κB Crit Care 2002, 6:481490 10 11 12 13 Haddad JJ: Basic science review: Redox and oxygen-sensitive transcription ... normoxia The accumulation of the α-subunits allows for αβ heterodimer formation and translocation into the nucleus during hypoxia This process leads to selective upregulation of genes whose products ... Hypoxia-inducible factor- 1α: role in hypoxaemia-initiated lung injury The master regulatory element of hypoxic conditions and adapting oxidative stresses to gene expression is HIF-1α [8–10] HIF-1 consists of...
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Báo cáo y học: " Number of active transcription factor binding sites is essential for the Hes7 oscillator" pptx
... that a single bound dimer represses the transcription of Hes7 completely Then the response function is the long-term relative frequency of occupation of one of the binding sites in dependence on ... increase of the strength of the switch Regression of the Hill plot gives a Hill coefficient equal to 2.6 (Fig 2B dotted line) Thus, an increase in the number of binding sites or in the affinity of ... binding of Hes7 dimers to the regulatory region of Hes7 Because no experimental data from transcriptional analysis of Hes7 were available, we assumed that one bound Hes7 dimer can repress transcription...
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Báo cáo y học: " Prediction of synergistic transcription factors by function conservation" ppsx
... Database of Transcriptional Start Sites; EEL, enhancer element locator; GO, Gene Ontology; LOD, log odds ratio; PWM, position weight matrices; TF, transcription factor; TFBS, transcription factor ... via transcriptional regulation of groups of genes with similar functions The roles of a particular TF in cellular processes can, therefore, be deduced from the known physiological functions of ... determined by the integration of multiple signal-activated and tissue-restricted transcription factors Cell 2000, 103:63-74 Garten Y, Kaplan S, Pilpel Y: Extraction of transcription regulatory signals...
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Báo cáo y học: "Alternative splicing of mouse transcription factors affects their DNA-binding domain architecture and is tissue specific" pot
... cell Expression of a given gene is dependent on the interactions of different transcription factors and their cofactors with the regulatory regions of that gene These transcription factors are in ... interactions of transcription factors with their cofactors Such changes have been observed experimentally to alter specificity or binding strength or to switch between activator and repressor isoforms of ... has three different isoforms with entirely different DNA-binding domains, which are all transcription activators On the other hand, isoforms of the human transcription factor AML1 function both...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... of a new AP-2 transcription factor, AP-2 epsilon Dev Dyn 231, 128–135 Garcia MA, Campillos M, Ogueta S, Valdivieso F & Vazquez J (2000) Identification of amino acid residues of transcription factor ... Characterization of the activation domains of AP-2 family transcription factors J Biol Chem 275, 29701–29708 10 Williams T & Tjian R (1991) Analysis of the DNAbinding and activation properties of the human transcription ... failure of chondrocyte progenitor cells to differentiate into hypertrophic chondrocytes [56] Two members of the Runx family of transcription factors, Runx2 and Runx3, are positive regulators of chondrocyte...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... potential regulators that affect transcriptional activities of ERF ⁄ AP2 proteins in higher plants Results BPM proteins assemble with members of the ERF ⁄ AP2 transcription factor family Because it has ... what kind of interactions are mediated by the MATH domain in plants In this article, we show that the MATH domain of BPM proteins is used to assemble with members of the ethylene response factor ... and petioles of rosette leaves (Fig 4C) proBPM4:GUS showed GUS staining very similar to that of proBPM3:GUS in the stipules, the central veins of rosette leaves and in the anthers of differentiated...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... point of support, needed for the hinging of the C-terminal part of helix III This relative rigidity of residue 50 is also relevant to biological function, and has been long recognized as one of ... emerge Backbone dynamics of the rat TTF-1 homeodomain under physiological conditions, when the HD is part of a much larger transcription factor, and determine the extent of the conformational changes ... Tell G, Leonardi A, Di Lauro R & Viglino P (1996) Analysis of the solution structure of the homeodomain of rat thyroid transcription factor by 1H-NMR spectroscopy and restrained molecular mechanics...
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Tài liệu Báo cáo khoa học: Seed-based systematic discovery of specific transcription factor target genes pptx
... in the case of transcription factors that target different genes depending on the splice form of the transcription factor Interestingly, however, in our analysis, the performance of the method ... cross-validation of the seed distribution method for six different transcription factors By means of a jackknife method, the recovery position of the gene left out in the rank was calculated for each transcription ... method relies on the assumption that the transcription factor of interest shows some biological activity in the data If, for example, the transcription factor of interest is completely shut down in...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of transcription factors ppt
... proteins are transcriptional factors In this review, we focus on the role of transcriptional factors on the pathology of rheumatoid arthritis (RA) Nuclear factor- jB The nuclear factor- jB (NF-jB) ... roles in RA Other transcription factors Other transcription factors implicated in the pathogenesis of RA are the signal transducer and activator of transcription (STAT) family of proteins, interferon ... Activator protein-1 The activator protein-1 (AP-1) transcription factor is composed of members of the Fos, Jun and activating transcription factor families of proteins While the Fos proteins (Fos, FosB,...
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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
... the 5¢-end of the bcl-X gene [30] Because MAP kinase has been shown to regulate the transcription of c-Fos, a member of the Fos family, AP1 may be implicated in the transcription of bcl-XL induced ... connected with the activation of the MAP kinase cascade includes the phosphorylation of Bcl-2 family members, the transcriptional upregulation of Bcl-XL, and its translational upregulation [19,21] We ... signaling in the inhibition of apoptosis of a variety of cells through the increased phosphorylation of Bad and caspase or through the transcriptional activation of NF-jB [33–35,51] Surprisingly,...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... 2005 FEBS C Rodriguez-Caso et al Human transcription factor network topology Table Description and functionality of transcriptions factor hubs Transcription factor (TF), degree (k), betweenness ... number of TFs is associated with higher control of gene regulation [24] Interestingly, such an increase is based on the use of the same structural types of proteins Human transcription factors ... 2005 FEBS C Rodriguez-Caso et al Human transcription factor network topology Table Topological parameters of some real networks: Human ´ transcription factor network (HTFN); Erdos-Renyi (ER)...
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Tài liệu Báo cáo khoa học: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation ppt
... BMAL1 (50 ng of each) Transfection of 0.1 ng of the DEC1 expression vector did not significantly decrease the transcriptional activity of CLOCK/BMAL1 (Fig 1B) Transfection of ng of the expression ... Fig 1C, transfection of 10 ng of FLAG-DEC1 expression vector and 50 ng of FLAG-BMAL1 expression vector resulted in adequate levels of expression The transcriptional activity of FLAG-BMAL1, and ... of CLOCK/BMAL1-induced transcription in the presence of full-length DEC1 As DEC1 lacking the basic region interfered with full-length DEC1 for the transcriptional suppression in the absence of...
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
... important site for transcription factors as the mutation of the CRE site within the COX-2 promoter or the expression of a dominant negative mutant of CREB reduces inducibility of the COX-2 promoter ... studies as well as the similarity of the recognition sites of the NFAT and Ets factors led us to investigate the potential involvement of the epithelial specific Ets factor (ESE-1 ⁄ ESX ⁄ ELF3 ⁄ ERT ... stimulation of human monocytic THP1 cells leads to an induction of ESE-1 mRNA expression within h of exposure, reaching a peak at h and leveling off after 24 h [12] To investigate the level of ESE-1...
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