... which seek to bring together such knowledge and experience in one volume These publications have often been devoted tothe livestock of certain countries or regions They seek to bring to light ... While Antonius' suggestion regarding the possible evolution of the fat-tailed type of sheep of the Syrian steppe may be correct, the evidence available is insufficient to prove it From the viewpoint ... mutton typeThe improved Awassi of Israel is larger and more refined than the unimproved type and the characteristics of the respiratory type of milch sheep are more pronounced than are the mutton...
... dimension of the cube 234 c Toothbrush is to toothpaste as butter knife is to butter This relationship shows function The toothbrush is used to apply the toothpaste to teeth; the knife is used to apply ... sewing.” But this is not the same relationship as the one above the line The oak and the cotton are both materials used to make the table and the shirt 245.d The words above the line show a continuum: ... rodent The other three choices are not rodents 243 a In the relationship above the line, the saw and the nails are tools a carpenter uses In the relationship below the line, the stethoscope and thermometer...
... (SCID-I and BipolarSpectrum evaluation) is to be applied to all participants by the same investigator (RNC) Primary outcomes The main outcome is to determine the prevalence of bipolarspectrum ... companies involved in the area of bipolar and depressive disorders (Servier, Bristol Myers Squibb, Solvay Pharma, Abbott, Astra Zêneca, Pfizer, and Roche) JA has served on the advisory board ... recruited from the Eating Disorder Unit of the Institute of Psychiatry of the Clinicas Hospital of the University of São Paulo, School of Medicine, are to take part in the study TheBipolar Spectrum...
... during the relaxation phase Thus, the effect of mitochondria on [Ca2+]i is very similar tothe role of PV (i.e to promote an increase in the initial rate of [Ca2+]i decay) The up-regulation of mitochondria ... unchanged [16] The increased mitochondrial volume in PV– ⁄ – EDL [6] prompted us to analyze, in detail, mitochondrial alterations and to investigate the presence of additional putative compensation ... be sufficient to induce the transcription of genes encoding mitochondrial proteins To test this hypothesis, we determined the mRNA levels for COX I, COX Vb and F1-ATPase b The levels of F1-ATPase...
... have revealed the importance of the arginine residue in the transmembrane domain of the immunoglobulin receptor However, the cytoplasmic domain of these FcRs is not essential for binding tothe ... recognition of the receptor by the snake venom This illustrates the dual mechanism of the complex, with one subunit, namely GPVI, responsible for binding tothe ligand, and the other subunit, the FcR ... K562 cells The absence of activation does not appear to be due tothetype of collagen used in this study as the same observation was made with bovine collagen types I V (D Tulasne & Jarvis, unpublished)...
... dithionite, i.e is the fastest of the three redox processes involved in the catalysis (cf [14]) The gz value and hyperne coupling constant of thespectrum of the turnover form of the T2Cu center ... S-6, reveals that the deviation of the Sd(Met150) atom from the axial position of the NNS plane formed by two Nd(His95 and His145) atoms and one Sb(Cys136) atom causes the different colors in the ... studies seem to indicate that cytochrome c551 could be the physiological electron donor tothe aforementioned Nir [11] The electrons donated by the donor tothe T1Cu center are transferred tothe catalytic...
... related to ability to bind tothe IGF1R Previously we have expressed a recombinant form of the human IGF1R by fusing the cDNA encoding the receptor ectodomain (residues 1±944) tothe cDNA of the ... improve ¯exibility and access tothe receptor Having established the relative binding af®nities of IGF-I, IGF-II and the 14 analogues for rhIGF1R, we related these to their abilities to prevent ... af®nity than their binding to IGF receptors IGFBPs thereby in¯uence the availability of IGF to bind to IGF receptors [12] Over the past 14 years, a large number of IGF analogues have been designed...
... showing that the H57Q mutation did not abolish the NADP+ oxidation activity of FprA The previous studies summarized above only gave a qualitative evidence of the ability of FprA to catalyze the production ... NADP derivative bearing an oxygen atom bound tothe nicotinamide ring Previously, the same NADP+ modification was observed by MS analysis of the whole reaction mixture [4] However, even though ... with the transferred electron couple being transiently stored on the enzyme prosthetic group Thus, experimental evidence points tothe involvement of FAD in the mechanism of NADPO formation The...
... stretches or the deleted sequences in the basic stretches, respectively, at the N-terminus of the protein (B) Plasmids expressing the native GFP (a), GFP fused tothe entire nPTB (b), the 60amino-acid ... GST–NLD-I fusion protein The GST fusions with SV40 tag NLS (GST–NLS) and an inverse version of Tag NLS (GST–NLSinv) served as positive and negative controls, respectively, for the importin a binding ... in the 30-amino-acid spacer sequence In the present work, we have characterized the NLD domain present in the neural counterpart of hnRNPI/PTB and investigated whether the hnRNPI/PTB import involves...
... more than the half of the items of the scale were available ("half item rule”); the score of the scale was the sum of the item scores further normalized to range from to 100, with higher values ... socio-demographic variables, those related to health status and those related tothe SF-36 questionnaire were tested as predictor variables The variables related tothe SF-36 were the number of items of the ... tothe item analyzed) and the eight subscale scores, including the score for the scale to which the missing item belongs calculated without the missing item All the variables tested, except the...
... activators of Stat 1-induced resistance to HSV-1 in vivo However, further studies are necessary to determine if chemokines and pro-inflammatory cytokines are also important contributors to Stat ... resistance to HSV-1 However, the fact that peripheral WBCs of NOD scid mice lack detectable NK cell cytotoxic activity in vitro does not prove that NOD scid mice are devoid of NK cell function in vivo ... (evident by day p.i.) and a reduced duration of survival CyP impairs the immune response of normal mice to HSV-1 [31] This study provides the first evidence that CyP can also be used to blunt the...
... activators of Stat 1-induced resistance to HSV-1 in vivo However, further studies are necessary to determine if chemokines and pro-inflammatory cytokines are also important contributors to Stat ... resistance to HSV-1 However, the fact that peripheral WBCs of NOD scid mice lack detectable NK cell cytotoxic activity in vitro does not prove that NOD scid mice are devoid of NK cell function in vivo ... (evident by day p.i.) and a reduced duration of survival CyP impairs the immune response of normal mice to HSV-1 [31] This study provides the first evidence that CyP can also be used to blunt the...
... adherence tothe postcapillary endothelium by ALP in vivo The results show the number of leukocytes adherent tothe endothelium of postcapillary synovial venules (expressed as cells per mm2 endothelial ... upregulation on endothelial cells On the basis of the above experimental evidence for the capacity of ALP to block leukocyte interaction with cytokineactivated endothelium tothe same extent as ... http://arthritis-research.com/content/8/4/R95 preceded the addition of the isolated granulocytes, to ensure that the cellular interaction took place after the removal of the cytokine and the ALP from the medium Additional experiments...
... implies they have to be distinguished from the secretory cargo To this end, they must possess specific ER localization determinants to prevent their exit from the ER, and/or to interact with receptors ... bear at their C-terminal end a H/ KDEL tetrapeptide that ensure their retrieval from the Golgi apparatus tothe ER when they escape to this organelle [3,5,9]via the binding to a receptor named ... AB, CSJD, CR, LF and VG have been involved in drafting the manuscript or revising it critically for important intellectual content GV has given final approval of the version to be published All...
... are rather resistant to HIV-1 infection, these cells bear HIV-1 in vivo and piggyback the virus into tissues and through the blood brain barrier into the central nervous system [5,6] With their ... differentiation into macrophages, and according tothe stimulation received, macrophages become permissive to HIV-1, and albeit remaining more restrictive tothe virus than other cell types, become overtly ... infected The virus takes hold of these cells and uses them to spread to neighboring T cells, to support a low persistent level of virus production, as well as to influence the cytokines secreted by these...
... provided by the patients or their first-degree relatives for patients unable to consent The study protocol was approved by the Ethics Committees of the hospitals of the participating centers Every ... for any sample Another ml aliquot was given tothe courier service mentioned above for transportation; it was returned tothe central laboratory after seven hours The aliquot was then processed ... stimulated by their agonists they produce proinflammatory cytokines [15] When monocytes of the septic host are stimulated ex vivo they fail to produce a similar amount of cytokines as monocytes of the...