understanding the binding entry and trafficking patterns of aav particles in the cell
Residence, habitat use, and movement patterns of atlantic tripletail in the ossabaw sound estuary, georgia
... outside of the sound or (2) remained within the sound but out of range of the receiver array Furthermore, flooding and the loss of core receivers (e.g., COS [channel outer sound] and CIS [channel inner ... N M Garber, and K M Larsen 1997 Potential of spines and fin rays for estimating the age of Tripletail, Lobotes surinamensis, from the northern Gulf of Mexico Proceedings of the Gulf and Caribbean ... assessment of the temporal patterns of residency within the study area Individual residence (IR) of each fish was calculated by dividing the number of days the individual was detected (days of detection...
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a study on structural and semantic patterns of wh-questions in english = nghiên cứu về mô hình cấu trúc và ngữ nghĩa của câu hỏi có từ hỏi trong tiếng anh
... When the wh-element acts as the subject of the question, there is no change in the order of the sentence element The wh-element stands at the beginning of the question In such tenses as the simple ... question There are two common forms In the first the suggested action is given in the –ing form In the second the action is given in the plain form of the verb E.g How about ? (How about inviting the ... of operator, non-inversion failure and the omissions of "do" in questions about main verbs and the omission of "are there" From the result of the survey, the author can assume the causes of the...
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A Study on Structural and Semantic patterns of Wh-questions in English
... of operator, non-inversion failure and the omissions of "do" in questions about main verbs and the omission of "are there" From the result of the survey, the author can assume the causes of the ... of Whquestions in English Then he would like to investigate the kinds of mistakes in using whquestions the students in Kinh Mon High School often make Basing on the findings, the author can make ... functions and the use of English operators in certain setting by regarding to the context of utterance First, the tenses of the sentences and their auxiliaries should be clearly defined Then show the...
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Báo cáo sinh học: "Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" docx
... results in phosphorylation of p70S6 and 4E-BP1 mTORC2 consists of mTOR and the rapamycin-insensitive companion of mTOR (Rictor), and causes Akt phosphorylation Akt promotes protein synthesis and cell ... of cells treated with LY294002, rapamycin or the combination is calculated as a percent of the viability of the untreated (control) cells Activity of the dual PI3K-mTOR inhibitor NVP-BEZ235 in ... exposure in tumor tissue [49] It inhibits both mTORC1 and mTORC2, resulting in enhanced inhibition of p-Akt compared to either LY294002 or rapamycin, or the combination of LY294002 and rapamycin,...
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báo cáo hóa học:" Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" pot
... results in phosphorylation of p70S6 and 4E-BP1 mTORC2 consists of mTOR and the rapamycin-insensitive companion of mTOR (Rictor), and causes Akt phosphorylation Akt promotes protein synthesis and cell ... of cells treated with LY294002, rapamycin or the combination is calculated as a percent of the viability of the untreated (control) cells Activity of the dual PI3K-mTOR inhibitor NVP-BEZ235 in ... exposure in tumor tissue [49] It inhibits both mTORC1 and mTORC2, resulting in enhanced inhibition of p-Akt compared to either LY294002 or rapamycin, or the combination of LY294002 and rapamycin,...
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Separation and collective phenomena of colloidal particles in brownian ratchets
... by the interaction with the molecules of the surrounding fluid Since the full time dependence of these interactions cannot be resolved experimentally, the resulting motion of the suspended particles ... part contains the ratchet mechanism and is set to the temperature T1 while the other part contains the paddles and is kept at T2 This difference in the temperatures breaks the balance of the probabilities ... molecules, they are dependent on the temperature T of the fluid This is because the average velocity of the molecules and hence the strength of the collisions depend on the temperature Furthermore, the...
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Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx
... RPAP The size of the interaction surface between ˚ the peptide and the non binding bottom of the Fab is 173 A2 which corresponds to about 36% of the interaction of the full peptide with the binding ... different flexibility in the N-terminal and the C-terminal parts of the molecule due to interactions with the protein This is in full agreement with the STD determination of the binding epitope that ... (cf Figures 6,7 and 9) The overall agreement between the contacts obtained from docking the trNOE derived structure into the binding cavity of SM3 and the binding epitope obtained from STD NMR...
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Tài liệu Báo cáo Y học: Mutations in the docking site for cytochrome c on the Paracoccus heme aa3 oxidase Electron entry and kinetic phases of the reaction pptx
... here for the bacterial enzyme by stripping subunits III and IV off the native complex, and by further destroying a large part of the acidic lobe(s) of the docking site of subunit II in the TM1 ... considerably, also in the context of the above subunit criterion Binding of Fv to the subunit II epitope has a profound effect on the transition As outlined in Table 3, this cannot be explained by the purification ... that the observed effects indeed relate to the early phases of electron entry Using the cyanide-inhibited enzyme, the reaction sequence is limited to the transfer of the first two electrons reaching...
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Báo cáo khoa học: Characterization of HbpR binding by site-directed mutagenesis of its DNA-binding site and by deletion of the effector domain pot
... identify critical motifs in the binding site for HbpR and to examine the necessity of the sensing A-domain of HbpR for DNA binding The role of individual nucleotides and nucleotide motifs was ... impaired in binding of the R13 region Both of these patterns contributed to the loss of binding contacts of mutant 72 Construction of a DA HbpR derivative In order to study whether the A-domain was ... important in forming the oligomeric structure and for DNA binding, by cloning an hbpR gene devoid of the A-domain, purifying this protein, and analyzing its DNA -binding characteristics and its...
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Báo cáo khoa học: Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes ppt
... grooves in which the RNA and DNA backbones of RNA ⁄ DNA hybrids bind A phosphate -binding pocket and DNA -binding channel located in the DNA -binding groove are responsible for the specificity of RNase ... the phosphate binding pocket and DNA -binding channel in the DNA -binding groove are also indicated 1488 these proteins recognize the substrate in a similar mechanism (Fig 5) In fact, the mutational ... RNases H in the location of a domain involved in substrate binding For example, Tko-RNase HII and Bst-RNase HIII have a substrate -binding domain at the C- and N-termini, respectively Both proteins...
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báo cáo khoa học: " Patterns of sequence polymorphism in the fleshless berry locus in cultivated and wild Vitis vinifera accessions" pdf
... fragments at the top of chromosome 18 in the cultivated and the wild compartment of Vitis vinifera and details of the shared and specific insertions/deletions (INDELs) and segregating SNP sites in wild ... trait in relation to both yield (table grapes) and quality (wine grapes) Indeed, the flavor in wine results from the ratio of skin to flesh, the former being the source of most aromatic and tannins ... from the flb region in wild and cultivated grapevines Venn diagram showing the distribution of the 554 non-redundant SNPs found in the 948 kb region at the top of chromosome 18 in the sets of wild...
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Báo cáo y học: "Distinct patterns of SSR distribution in the Arabidopsis thaliana and rice genomes" pptx
... comparing the amino acid runs, while both plants contain many runs of glycine and proline (accounting for either the second or third highest amounts), they differ in what amino acid occurs in the ... that tri- and hexanucleotide repeats are the most common in the coding regions of eukaryotes [27,28] The rather similar distribution of SSRs of period to 10 in the coding regions of the two genomes ... approximately 80% of all the SSRs found in various regions and the genomes (Figure and 7) For both species, the distribution of SSRs in the 5'UTRs and exons show patterns distinct from the other genic...
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The long term performance and survival patterns of canadian IPOs
... benchmark and matching firms based on the book-to-market ratio and market capitalization, the mixed results require further investigation in the robustness of selecting benchmarks and the impact of ... identifying, if any, the individual IPO characteristics that explain the long-term abnormal return of Canadian IPOs; (4) investigating certain characteristics of the survival patterns to explain the ... capitalizations increased the probability of delisting from stock exchange, and decreased the probability of being acquired rather than going bankrupt and thereby influenced the overall performance...
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Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"
... (CLDN1-NLS), there is increased expression of claudin-1 in the nucleus, but there are still large amounts of claudin-1 in the cytoplasm as well B) All of the claudin-1 in the nucleus can be shuttled into ... that increasing the levels of CLDN-1 increases the invasion of melanoma cells (4) To determine if the increase in claudin-1 needs to be cytoplasmic and not nuclear to affect the ability of melanoma ... exclusion of claudin-1 from the nucleus (Figure 1B) This implies that active PKC may exist in the nucleus of melanoma cells, and the presence of active PKC isoforms in the nuclei of many cell types...
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Tài liệu Báo cáo khoa học: Bioinformatics of the glycoside hydrolase family 57 and identification of catalytic residues in amylopullulanase from Thermococcus hydrothermalis doc
... that in the future further subfamilies will be identified, owing to the appearance of new members or by subdivision of the existing subfamilies Indeed, there are several GH-57 candidates in the ... domain (SLD2), a threonine-rich region and a putative transmembrane domain [22] Interestingly, the 3D structure of a protein domain, which is clearly homologous to SLD1 and -2 of Q9Y8I8_THEHY, ... the C-terminus of the first b-strand of the catalytic (b/a)7-barrel [16] Interestingly, the three shortest GH-57 members, which include the P furiosus a-galactosidase (Q9HHB5_PYRFU), exhibit the...
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Tài liệu Báo cáo khoa học: Molecular characterization, phylogenetic relationships, and developmental expression patterns of prion genes in zebrafish (Danio rerio) doc
... last finding should be of interest because in terms of function, the fish intestine is highly regionalized both in the larva and in the adult [38] The posterior segment of the fish intestine is the ... [41,42], and in epithelial cells lining the digestive tract lumen [43,44] Considering the importance of the intestinal barrier in the process of oral prion infection, this finding might help clarify the ... distributed within the CNS 509 Expression of prion genes in the developing zebrafish and in specific areas outside the CNS of the developing zebrafish The prp1 and prp2-expressing sites in the developing fish...
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Driving and parking patterns of European car drivers --- a mobility survey pptx
... by retaining only the following types of letter: the letter of invitation to take part in the survey (day – Section only) the letter of invitation to begin keeping the travel diary the reminder ... collecting a number of different items (e.g the share of individuals making more trips per day, the share of individuals parking on kerbside and so forth) describing the driving habits of the individuals ... were NOT included in the final sample, while the other responses obtained in the pilot phase were included to reach the total number of 600 cases in each country If the estimate of the completion...
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Patterns of drug resistance in pulmonary tuberculosis cases in the Izmir district, Turkey pdf
... quadruple resistance instead of notifying the incidence of plain resistance rates, in the new and the previously treated cases in the Izmir district METHODS Setting The study was carried out by ... born at East and South-East of Turkey (the regions, which obtained the lowest living standards of country) and had moved to the West Sixty-three (23.8%) cases had left the hospital of their own ... between one of the seven chest clinics and the microbiology laboratory Izmir Chest Diseases and Chest Surgery Training Hospital the sole tertiary referral hospital of the Izmir district and Western...
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báo cáo sinh học:" Burnout and training satisfaction of medical residents in Greece: will the European Work Time Directive make a difference?" pot
... supervisors' interest towards their training, on the merit of their CME activities, on the responsibilities and time given to them for patient care and on the overall quality of training in their clinic ... assisted in the development of the draft of the manuscript; CL supervised the project and contributed to the draft of the manuscript All authors read and approved the final manuscript Page 10 of 11 ... reforms of residency training in combination with novel patterns of care management, stress reduction programs and other systemic interventions Competing interests The authors declare that they...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25