unbiased forward genetics and systems biology approaches to understanding how gene environment interactions work to predict susceptibility and outcomes of infections
Báo cáo khoa học: Metabolomics, modelling and machine learning in systems biology – towards an understanding of the languages of cells potx
Ngày tải lên :
07/03/2014, 12:20
... are perceived (to make the message) This leads to a profoundly different view of the signicance of networks in systems biology, and one that allows one a much better understanding of signalling ... modelling and machine learning systems The cycle of knowledge B Basic bottom-up-driven Systems Biology pipeline C Fig Some of the iterative elements of systems biology (A) Science can be said to advance ... Most of these have yet to be identied chemically The history of biomedicine as perceived via the awards of the Nobel Committee indicates the importance to our understanding of the subject of both...
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Báo cáo hóa học: " A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana" pdf
Ngày tải lên :
21/06/2014, 03:20
... (a) Histogram of the system with activation of v2 by Hex, weak feedback inhibition of SP on v5 and strong feedback inhibition of Hex on v4; (b) histogram of the system with activation of v2 by ... activity and of the synthesis of SP, as well as the activation of the synthesis of Scr by the Hex Steady states in such strongly regulated systems are prone to instability, leading to effects ... Histogram of the system without instances of activation or feedback inhibition; (b) histogram of the system with activation of v2 by Hex without feedback inhibition; and (c) histogram of the system...
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Investigation of the regulatory roles of micrornas by systems biology approaches
Ngày tải lên :
10/09/2015, 15:52
... labour-intensive and inefficient The biology society urges the revolution of methodologies and in recent years have seen more and more research activities in the field of systems biology 1.1 Systems Biology Systems ... in systems biology is how to obtain an accurate and predictable computational model for the biomolecular networks under study Therefore, to enhance the reliability, we propose two approaches to ... activity levels of thousands of genes simultaneously Thus, it is possible to identify inter-relationships between groups of genes and analyse dynamic interactions among these genes As we can...
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A systems biology approach to elucidating the frequency decoding mechanism governing differential mammalian gonadotropin subunit gene expression
Ngày tải lên :
11/09/2015, 09:11
... of LH (the “LH surge”) In males, androgens produced by the Leydig cells of the testes in response to LH, induce spermatogonial cell formation and spermatogenesis in the Sertoli cells [4] LH and ... contribute to an understanding of the downstream effects of GnRH on the subunit genes [9, 16] Such studies began to demonstrate the role of calcium, protein kinase C (PKC) and the mitogen-activated ... the receptor and MAPKs, and could even include elements of chromatin re-modeling [16, 32, 35] 1.1.4 Understanding gonadotropin-subunit gene expression through the use of model cell-lines To facilitate...
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Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx
Ngày tải lên :
16/03/2014, 19:20
... thought to be the epitome of genetic determinism, can be modified by environmental factors, has focused new attention on the crucial area of gene environment interactions While understanding gene ... (2004) Genetic and environmental factors in the pathogenesis of Huntington’s disease Neurogenetics 5, 9–17 14 Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, ... number of Venezuelan kindreds and rigorous assessment of symptom onset, has also implicated environmental factors in modulating the age of onset in clinical HD [55] However, the nature of these environmental...
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Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
Ngày tải lên :
09/08/2014, 10:23
... threefold elevated odds of developing RA in the presence of both factors Kallberg and colleagues [38] recently explored potential geneenvironment and gene- gene interactions in RA susceptibility, combining ... epitope hypothesis An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis Arthritis Rheum 1987, 30:1205-13 Thomson W, Harrison B, Ollier B, Wiles N, Payton ... L, Alfredsson L: Gene- gene and gene- environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis Am J Hum Genet 2007, 80:867-875 Hernandez-Avila M, Liang...
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Báo cáo y học: " A model of gene-gene and gene-environment interactions and its implications for targeting environmental " doc
Ngày tải lên :
13/08/2014, 16:21
... assumptions This model of gene- gene and gene- environment interactions is then used to implement a 'top-down' approach to quantifying the utility of genetic 'prediction and prevention' Method ... of the 'equal environments' assumption and of gene- environment interactions have previously been recognised [17,18]; however, less attention has been paid to the potential role of gene- gene interactions ... cancer); (ii) the complexity of gene- gene and gene- environment interactions and/ or lack of knowledge of environmental factors (for example, schizophrenia) Targeting environmental/lifestyle interventions...
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Báo cáo y học: " Searching for an ideal hemodynamic marker to predict short-term outcome in cardiogenic shock" ppsx
Ngày tải lên :
13/08/2014, 20:21
... shock complicating acute myocardial infarction: predictors of death GUSTO Investigators Global Utilization of Streptokinase and Tissue-Plasminogen Activator for Occluded Coronary Arteries Am Heart ... are important to consider in the setting of CS, particularly those parameters integrating generation of cardiac energy with spreading of blood flow, such as the CPI Since it was shown that almost ... almost one-half of nonsurvivors of CS die with a normal CI, this finding changed the paradigm of CS recently from being only a cardiac problem into a disease of the entire circulatory system [9,10]...
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The use of a frailty index to predict adverse health outcomes (falls, fractures, hospitalization, medication use, comorbid conditions) in people with intellectual disabilities
Ngày tải lên :
25/08/2016, 23:25
... V., Maltoni, B., & Ravaglia, G (2012) A comparison of frailty indexes for prediction of adverse health outcomes in an elderly cohort Archives of Gerontology and Geriatrics, 54(1), 16–20 Fulton, ... than found in the general population The frailty index is not suitable as a tool to predict admission to general hospitals and falls in this group The low explained variance of the models implies ... status of older people with ID using formal care in the Netherlands All clients of the care organizations aged 50 years and over were invited to participate (N = 2322) Those capable of understanding...
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Báo cáo y học: "The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics" ppt
Ngày tải lên :
09/08/2014, 22:24
... used two types of networks: protein-protein interactions and gene regulatory [21] (genetic interaction and phosphorylome [22] had too few nodes to determine significance) All topological statistics ... molecule descriptor sensitivities to disparate types of systems- wide and transcription factor features to features of those their target genes Further, we showed that this type of integration ... binding genes as the total number of white balls(x) and non-binding genes as black balls (n) The total number of differentially expressed genes (ER+ vs ER-) represents the sample withdrawn and x of...
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báo cáo khoa học: " An archived activation tagged population of Arabidopsis thaliana to facilitate forward genetics approaches" potx
Ngày tải lên :
12/08/2014, 03:21
... of tools to elucidate the function of the inferred genes is required in order to exploit the potential wealth of information provided by the annotated genome sequence Large scale random mutagenesis ... wealth of information to our understanding of the flavonoid pathway and trichome development The SK population already has proven its value by yielding new phenotypes and genes previously unknown to ... second to activation of an adjacent microRNA resulting in enhanced seed carotenoid levels (Wei et al, submitted) To fully realise the potential of this genetic resource, a number of forward genetic...
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Báo cáo y học: " Review and application of group theory to molecular systems biology" ppsx
Ngày tải lên :
13/08/2014, 16:20
... oscillators, and logic gates Engineers have constructed random and non-random networks of these components and discovered not only that the network is capable of memory storage in the form of Page ... space of the network dynamics We showed a simple case of a C6 network and its phase space network We envision that the molecular network of a cell is actually a complex network of hypercycles and ... http://www.tbiomed.com/content/8/1/21 Page of 29 groupoids are useful in describing networks, and thus transcriptome and interactome networks The Genetic Code In this section we review some work describing the genetic code...
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Approaches to the design of model predictive controllers for linear, piecewise linear and nonlinear systems
Ngày tải lên :
11/09/2015, 14:29
... determined off-line For constrained PWLBD systems, two approaches are proposed under the time optimal control (TOC) and MPC frameworks Both approaches result in the polytopal domains of attraction ... interior of Ω cl(Ω) closure of Ω |Ω| cardinality of Ω NATIONAL UNIVERSITY OF SINGAPORE SINGAPORE LIST OF SYMBOLS xiii Area(Ω) size of Ω Vol(Ω) hypervolume of Ω In1 (Ω) inner polytopal approximation of ... neural networks and the condition of the accuracy of the approximation is given 1.3 Objectives and Scope of the Thesis This thesis attempts to improve and characterize several issues of MPC control...
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Slide an investigation into some approaches to vocabulary teaching and learning and the application of games in teaching and learning vocabulary at pre – intermediate level at foreign language center – haiphong university
Ngày tải lên :
29/01/2014, 14:36
... teaching and learning 1.3 Approaches to language teaching and their relevance to vocabulary 1.4 Recent research about teaching and learning second language vocabulary 1.5 Advantages of the use of games ... teaching and learning 1.3 Approaches to language teaching and their relevance to vocabulary 1.4 Recent research about teaching and learning second language vocabulary 1.5 Advantages of the use ... 1972, p.111) Rationale Aims of the study Scope of the study Methods of the study Design of the study Research questions: What is the present situation of teaching and learning vocabulary at Pre...
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Tài liệu Báo cáo khoa học: Applications and trends in systems biology in biochemistry docx
Ngày tải lên :
14/02/2014, 14:20
... using the keyword systems biology actually reflect applications of systems biology approaches to biological systems resulting in new biological insights However, on the other hand, and by restricting ... increased understanding of complex mechanisms, there are also very applied examples of research benefitting from systems biology Thus, systems biology has been used for the prediction of drug targets ... analysis Stoich FBA FBA FBA ss, sim, FBA, sens, fit Analysis Stoich Stoich Stoich Stoich ODE + Stoich Model EXCEL MATLAB, SIMPHENY, MATLAB GLPK, TOOL RESEARCH BIOLOGY SYSTEMS GAMS MATLAB COBRA Software...
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Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc
Ngày tải lên :
14/02/2014, 22:20
... numerical software matlab (Version 7.6.0.324, R2008a) with the software packages systems biology toolbox2 and the sbpd Extension Package as described in [34] Both matlab and systems biology toolbox2 ... ¨ However, the complex interactions of metabolic pathways precludes the generation of a full picture of cold acclimation through assembly of reaction details In the present study, a systems biology ... accessions by a factor of $ 1.5 during the first day of cold exposure (Fig 3F) Cold-induced changes in net carbon uptake and sink export To obtain a quantitative measure of how exposure to °C influenced...
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Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf
Ngày tải lên :
19/02/2014, 12:20
... than in the case of ligand binding, because the requirements for catalysis are more precise and less well understood This is the basis of early ÔgeneticÕ approaches to understanding the functional ... Cochran and coworkers have examined the effect of cross-strand pairs in b-sheets by displaying variants of the B1 domain of IgG-binding protein G on filamentous phage [62] Baker and coworkers ... to understand what makes proteins ÔtickÕ and to engineer proteins with native-like properties In this review we discuss combinatorial approaches toward understanding protein structure and stability...
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Continuing Challenges and Potential for Collaborative Approaches to Education Reform pot
Ngày tải lên :
06/03/2014, 01:22
... the original CERI and the following CERI 2, the role RAND played, and the purpose of the research and the general approach RAND took to examine CERI Finally, it outlines the rest of this monograph ... appended to the common protocol to ensure that we covered site-specific issues In addition to the protocols, we had a list specific to each of the documents and evidence to be collected To the ... dedicated to improving the lives of underserved minorities and proposed work with other CBOs to build a teacher pipeline to provide high-quality teachers to hard-tostaff schools • DC VOICE in Washington,...
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Đề tài " Classical and modular approaches to exponential Diophantine equations I. Fibonacci and Lucas perfect powers " pdf
Ngày tải lên :
06/03/2014, 08:21
... reduces to a Thue equation, and we may apply the results of Bugeaud and Gy˝ry [10] to get an upper bound for x and y o However, it is of much interest to rework the proof of Bugeaud and Gy˝ry ... Fk = U p and Lk = V p for some positive integers U and V The proofs of both Lemmas 5.1 and 5.2 make use of Frey curves and levellowering Here and elsewhere where we make use of these tools, we ... /K1 )| Proof This is Proposition 4.9 of [38] 9.2 Proof of Proposition 9.2 We now turn our attention to the proof of Proposition 9.2 and so to equation (17) Lemma 3.1 reduces the problem to solving...
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