tumors of unknown primary
báo cáo khoa học: " Classification of unknown primary tumors with a data-driven method based on a large microarray reference database" ppsx
... ‘type’ of cancer is known as a cancer of unknown primary (CUP) and represents a condition requiring specific clinical attention The origin of the metastasis needs to be identified as primary ... capable of identifying the tissue of origin of CUP samples with 89% accuracy when excluding the most uncertain 30% of the samples If we, like some of the previously published Page 10 of 12 studies ... program to that of the cancer of origin This is reflected in the ability to identify the origin of metastases with reference data on primary tumors, but it is also visible at the level of individual...
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Chapter 095. Carcinoma of Unknown Primary (Part 2) pps
... small number of patients; primary tumors were identified in ~21–30% The diagnostic contribution of PET to the evaluation of noncervical CUP is controversial PET or PET-CT helps to detect primary tumor ... adenopathy MRI of the breast is a recognized follow-up modality in patients with suspected occult primary breast carcinoma (following negative mammography and sonography findings) The results of these ... tumor in 20–35% of patients PET-CT can be helpful for patients who are candidates for surgical intervention for solitary metastatic disease because the presence of disease outside the primary site...
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Chapter 095. Carcinoma of Unknown Primary (Part 3) pdf
... thyroid cancer, respectively, are the most specific of the current marker panel However, these cancers rarely present as CUP, so the yield of these tests may be low Fig 95-1 delineates a simple ... comprehensive algorithm may improve the diagnostic accuracy but can make the process complex With the use of immunohistochemical markers, electron microscopic analysis, which is timeconsuming and expensive, ... CK20) markers used in CUP Table 95-2 Additional Immunohistochemical Stains Useful in the Diagnosis of CUP Tissue Marker Estrogen and progesterone receptors Breast cancer BRST-1 Breast cancer Gross...
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Chapter 095. Carcinoma of Unknown Primary (Part 4) ppt
... the role of molecular studies in CUP Carcinoma of Unknown Primary: Treatment General Considerations The treatment of CUP continues to evolve, albeit slowly The median survival duration of most ... profiles Typically, a training set of gene profiles from known cancers (preferably from metastatic sites) are used to train the software The program can then be used to predict the origin of ... chemotherapy is the primary treatment modality in most cases, but the careful integration of surgery, radiation therapy, and even periods of observation are important in the overall management of this condition...
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Chapter 095. Carcinoma of Unknown Primary (Part 5) ppsx
... ovarian primary tumor identified on transvaginal sonography or laparotomy Studies suggest that ovarian cancer and PPSC, which are both of mullerian origin, have similar gene expression profiles ... evidence of prostate cancer in these patients Those with elevated levels are candidates for hormonal therapy for prostate cancer, although it is important to rule out other primary tumors (lung ... squamous cell CUP emission tomography; RT, CT, computed radiation; C, chemotherapy Treatment of Favorable Subsets of CUP Women with Isolated Axillary Adenopathy Women with isolated axillary adenopathy...
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Chapter 095. Carcinoma of Unknown Primary (Part 6) pps
... biology of unknown primary tumors Semin Oncol 20:238, 1993 [PMID: 8503019] Bugat R et al: Summary of the standards, options and recommendations for the management of patients with carcinoma of unknown ... etoposide in the treatment of carcinoma of unknown primary site Semin Oncol 24(6 Suppl 19):S19, 1997 Kende AI et al: Expression of cytokeratins and 20 in carcinomas of the gastrointestinal tract ... of unknown primary site Br J Cancer 89(Suppl 1):S59, 2003 Culine S et al: Cisplatin in combination with either gemcitabine or irinotecan in carcinomas of unknown primary site: Results of a randomized...
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Chapter 095. Carcinoma of Unknown Primary (Part 1) pdf
... procedures may affect the choice of therapy and the patient's survival and quality of life The reason tumors present as CUP remains unclear One hypothesis is that the primary tumor either regresses ... imaging techniques and the emergence of targeted therapies that have been shown to be effective in several cancers, oncologists must decide on the extent of workup that is warranted Specifically, ... hemogram, chest x-ray, CT scan of the abdomen and pelvis, mammography in women, and prostate-specific antigen (PSA) test in men With the increasing availability of additional sophisticated imaging...
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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... multitude of methods for introducing glial-type neoplasms into the rodent CNS, which histologically mimic human primary tumors, these methods can be described as belonging to one of two groups: 1) Tumors ... via suppression of the PI3-kinase signaling pathway [53] Loss of function mutations of PTEN have been observed in approximately 50% of de novo GBM patients [54] One significance of this observation ... (EGF-R) EGF-R is a member of the ErbB tyrosine kinase receptor family that is mutated or overexpressed in a variety of human tumors, including approximately 30-50% of primary glioblastoma multiforme...
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Báo cáo khoa học: "Primary carcinoid tumors of the liver" ppsx
... heterogenous depicting a ofof the left lobe of the liver solid mass in the Ultrasound 6.3 the abdomen; Ultrasound of the abdomen latUltrasound of the abdomen; Ultrasound of the abdomen depicting ... alternative options available for non-resectable tumors and severe symptoms The risk of recurrence of primary hepatic carcinoid tumors after resection remains unknown Competing interests Despite the classic ... without primary hepatic recurrence has not been reported Conclusion Carcinoid tumors involving the liver are common, but primary hepatic carcinoid tumors are rare Classification as a primary...
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báo cáo khoa học: "Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature" ppt
... neuroendocrine carcinomas of unknown primary site 17 years after the initial diagnosis of the synchronous described malignancies Neuroendocrine tumors from an unknown primary site are uncommon; ... review of different studies evoking Figure Photomicrograph of the histopathological analysis of the liver metastases showing the aspect of a neuroendocrine carcinoma Mesmoudi et al Journal of Medical ... control of both tumors might exclude the hypothesis of skin metastases from the cervical carcinoma Furthermore, both tumors were diagnosed at the same time suggesting a synchronous association of...
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Báo cáo khoa học: Semi-nested PCR analysis of unknown tags on serial analysis of gene expression potx
... course of our research on the SAGE data of the human spermatozoa, we became aware that other methods [rapid reverse transcription–PCR analysis of unknown SAGE tags (RAST-PCR) [15], generation of ... serve as a primary library of spermatozoa cDNAs to be used for further studies Amplification of primary library The full-length cDNAs in spermatozoa were amplified by PCR with the use of Takara ... analysis of gene expression: rapid RT-PCR analysis of unknown SAGE tags Nucleic Acids Res 27, e17 Chen JJ, Rowley JD & Wang SM (2000) Generation of longer cDNA fragments from serial analysis of gene...
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TUMORS OF THE PARANASAL SINUSES: APPROACHES TO DIAGNOSTIC IMAGING potx
... Nir Harish, HMS III Radiologic Menu of Tests CT: Modality of choice MRI: Complementary X-Ray Nir Harish, HMS III Radiologic Menu of Tests: CT CT: Modality of Choice #1 for both inflammatory and ... Nasal cavity Paranasal sinuses: 3% of HNC Salivary glands Nir Harish, HMS III Agenda Meet the patient: Mr R Common signs/symptoms of sinus disease Radiological Menu of Tests Normal anatomy Differential ... swelling and secretions Radiation exposure Nir Harish, HMS III Radiologic Menu of Tests: MRI MRI: Complementary Assessment of soft tissue infiltration, esp intracranial Multiplanar capability, esp sagittal...
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Báo cáo khoa học: "Analysis of Unknown Words through Morphological Decomposition" potx
... and often produce a large number of possible analyses Out of the test set of 200 words, based on a lexicon consisting of around 3500 morphemes (including the ** entries), the average number of ... would be offset by a speed penalty T h e rules m a k e use of sets of characters Anything is a set consisting of all surface characters, BCDFGKPSTW and HJLMNqRVXYZ are sets consisting of those ... morphological analysis of words into morphemes based on user-defined rules The basic system does not offer analysis of words containing unknown morphemes, nor does it provide a rank ordering of the output...
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Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx
... distance of 2.0 A The position of the ring structure of PG should be 70–80% accurate based on the prediction accuracy of ‘sievgene’ Although it is difficult to predict the position of side chains of ... fluorescence quenching curves of AKR1B1 and its mutants are shown in Fig 3D The Kd value of the K77L mutant of AKR1B1 was similar to that of the wildtype enzyme (0.3 lm) and the values of the D43N, D43E, ... higher than that of the wild-type AKR1B1 However, the Kd value of the Y48F ⁄ H110F double mutant of AKR1B3 was similar to that of the wild-type enzyme (5.7 lm) and the values of the Y48F and H110F...
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Heroes of Unknown Seas and Savage Lands ppt
... thousands upon thousands of years of penance in the form of a fish Every Christmas Eve he came to the shore at the ruins of a small chapel that stood in one of the bays of the South of Galway, and inquired, ... LIII Heroes of Unknown Seas and Savage Lands By J W BUEL Author of "The Beautiful Story," "The Story of Man," "The Living World," "Russia and Siberia," etc A RECORD OF THE FINDING OF ALL LANDS ... force of a head wind, profanely swore that he would persist in his course in spite of the decrees of Providence Undeterred by the remonstrances of his crew, he laughed at their fears, made some of...
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Risk of second primary cancer in men with breast cancer docx
... comparison of the incidence of second primary tumors among study patients (observed) with the incidence of the same tumors in the general population of California males (expected) Calculation of the ... The unit of analysis in our study was person/days at risk in order to maximize use of fractions of years if applicable Person-years of observation were calculated two months from the date of breast ... number of second cancers followed a Poisson distribution Results The characteristics of men diagnosed with first primary breast cancer are shown in Table The cohort contained a total of 1,926 men of...
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Symptoms of Unknown Origin A Medical Odyssey pptx
... case of heat injury would be brought before general courts martial and punished if found guilty of neglect of his troops The definition of neglect was merely the occurrence of a single case of heat ... about the nature of disease, about doctor-patient relationships, and about principles of caring for patients who came to me with symptoms of unknown origin I have changed the names of the patients ... application of them is a cause of much of the public’s present dissatisfaction with medical care It was only by an accumulation of confounding clinical experiences, described in the early chapters of...
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Báo cáo khoa học: "Guessing Parts-of-Speech of Unknown Words Using Global Information" ppt
... distribution of the parts -of- speech of all occurrences of the unknown words in a document which have the same lexical form We suppose that such partsof-speech have correlation, and the part -of- speech of ... distribution of the part -of- speech of the kth occurrence of the unknown words given a set of local contexts w, and is calculated as an expected value over the distribution of the unknown words ... the POS tag of the kth occurrence of the unknown words, let wk denote the local context (e.g the lexical forms and the POS tags of the surrounding words) of the kth occurrence of the unknown words,...
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