tumors of unknown primary site
báo cáo khoa học: "Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature" ppt
... neuroendocrine carcinomas of unknown primary site 17 years after the initial diagnosis of the synchronous described malignancies Neuroendocrine tumors from an unknown primary site are uncommon; they ... carcinoma from an unknown primary site: A case report and review of the literature Journal of Medical Case Reports 2011 5:462 Authors’ contributions MM was involved in the analysis of the data and ... review of different studies evoking Figure Photomicrograph of the histopathological analysis of the liver metastases showing the aspect of a neuroendocrine carcinoma Mesmoudi et al Journal of Medical...
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báo cáo khoa học: " Classification of unknown primary tumors with a data-driven method based on a large microarray reference database" ppsx
... ‘type’ of cancer is known as a cancer of unknown primary (CUP) and represents a condition requiring specific clinical attention The origin of the metastasis needs to be identified as primary ... capable of identifying the tissue of origin of CUP samples with 89% accuracy when excluding the most uncertain 30% of the samples If we, like some of the previously published Page 10 of 12 studies ... program to that of the cancer of origin This is reflected in the ability to identify the origin of metastases with reference data on primary tumors, but it is also visible at the level of individual...
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Chapter 095. Carcinoma of Unknown Primary (Part 2) pps
... small number of patients; primary tumors were identified in ~21–30% The diagnostic contribution of PET to the evaluation of noncervical CUP is controversial PET or PET-CT helps to detect primary tumor ... 20–35% of patients PET-CT can be helpful for patients who are candidates for surgical intervention for solitary metastatic disease because the presence of disease outside the primary site will ... adenopathy MRI of the breast is a recognized follow-up modality in patients with suspected occult primary breast carcinoma (following negative mammography and sonography findings) The results of these...
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Chapter 095. Carcinoma of Unknown Primary (Part 3) pdf
... thyroid cancer, respectively, are the most specific of the current marker panel However, these cancers rarely present as CUP, so the yield of these tests may be low Fig 95-1 delineates a simple ... comprehensive algorithm may improve the diagnostic accuracy but can make the process complex With the use of immunohistochemical markers, electron microscopic analysis, which is timeconsuming and expensive, ... CK20) markers used in CUP Table 95-2 Additional Immunohistochemical Stains Useful in the Diagnosis of CUP Tissue Marker Estrogen and progesterone receptors Breast cancer BRST-1 Breast cancer Gross...
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Chapter 095. Carcinoma of Unknown Primary (Part 4) ppt
... profiles Typically, a training set of gene profiles from known cancers (preferably from metastatic sites) are used to train the software The program can then be used to predict the origin of ... the role of molecular studies in CUP Carcinoma of Unknown Primary: Treatment General Considerations The treatment of CUP continues to evolve, albeit slowly The median survival duration of most ... cancers and their metastasis However, because, by definition, the primary tumor site is not identifiable in CUP, validation of site prediction in this setting can be challenging, and any predictions...
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Chapter 095. Carcinoma of Unknown Primary (Part 5) ppsx
... ovarian primary tumor identified on transvaginal sonography or laparotomy Studies suggest that ovarian cancer and PPSC, which are both of mullerian origin, have similar gene expression profiles ... evidence of prostate cancer in these patients Those with elevated levels are candidates for hormonal therapy for prostate cancer, although it is important to rule out other primary tumors (lung ... squamous cell CUP emission tomography; RT, CT, computed radiation; C, chemotherapy Treatment of Favorable Subsets of CUP Women with Isolated Axillary Adenopathy Women with isolated axillary adenopathy...
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Chapter 095. Carcinoma of Unknown Primary (Part 6) pps
... biology of unknown primary tumors Semin Oncol 20:238, 1993 [PMID: 8503019] Bugat R et al: Summary of the standards, options and recommendations for the management of patients with carcinoma of unknown ... of unknown primary site Br J Cancer 89(Suppl 1):S59, 2003 Culine S et al: Cisplatin in combination with either gemcitabine or irinotecan in carcinomas of unknown primary site: Results of a randomized ... etoposide in the treatment of carcinoma of unknown primary site Semin Oncol 24(6 Suppl 19):S19, 1997 Kende AI et al: Expression of cytokeratins and 20 in carcinomas of the gastrointestinal tract...
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Chapter 095. Carcinoma of Unknown Primary (Part 1) pdf
... procedures may affect the choice of therapy and the patient's survival and quality of life The reason tumors present as CUP remains unclear One hypothesis is that the primary tumor either regresses ... Role of Serum Tumor Markers and Cytogenetics Most tumor markers, including CEA, CA-125, CA 19-9, and CA 15-3, when elevated, are nonspecific and not helpful in determining the primary tumor site ... hemogram, chest x-ray, CT scan of the abdomen and pelvis, mammography in women, and prostate-specific antigen (PSA) test in men With the increasing availability of additional sophisticated imaging...
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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... multitude of methods for introducing glial-type neoplasms into the rodent CNS, which histologically mimic human primary tumors, these methods can be described as belonging to one of two groups: 1) Tumors ... via suppression of the PI3-kinase signaling pathway [53] Loss of function mutations of PTEN have been observed in approximately 50% of de novo GBM patients [54] One significance of this observation ... (EGF-R) EGF-R is a member of the ErbB tyrosine kinase receptor family that is mutated or overexpressed in a variety of human tumors, including approximately 30-50% of primary glioblastoma multiforme...
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Báo cáo khoa học: "Primary carcinoid tumors of the liver" ppsx
... heterogenous depicting a ofof the left lobe of the liver solid mass in the Ultrasound 6.3 the abdomen; Ultrasound of the abdomen latUltrasound of the abdomen; Ultrasound of the abdomen depicting ... alternative options available for non-resectable tumors and severe symptoms The risk of recurrence of primary hepatic carcinoid tumors after resection remains unknown Competing interests Despite the classic ... present in primary hepatic carcinoid tumors, with only two reported cases [4,5] Page of (page number not for citation purposes) World Journal of Surgical Oncology 2008, 6:91 Imaging studies of any...
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Tài liệu Báo cáo khoa học: Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis docx
... Fig Schematic view of the active site of ACE2 and tACE Binding interactions of the inhibitor (A) MLN-4760 at the active site of ACE2 and (B) lisinopril at the active site of tACE Hydrogen bonds ... inhibitor This study provides the first investigation of the importance of key active -site residues of ACE2 through site- directed mutagenesis, with the aim of providing practical evidence for their role ... result of replacing this single residue could not have 3517 Critical active -site residues of ACE2 been predicted simply by analysis of the active -site structure Further to this, the role of His505...
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Tài liệu Báo cáo Y học: Identification of syntaxin-1A sites of phosphorylation by casein kinase I and casein kinase II ppt
... potential PKA sites are present within the primary structure of munc18 according to the Ó FEBS 2002 Phosphorylation of syntaxin-1A by CKI and CKII (Eur J Biochem 269) 911 Fig Phosphorylation of syntaxin-1A ... The mass spectrometry of radioactive peptides showed the presence of a doubly charged phosphopeptide of mass 974.0 and a singly charged phosphopeptide of mass 1946.3 both of which correspond only ... on phosphopeptides from each of the constructs Because the site of phosphorylation by CKII was close to the N-terminus of syntaxin-1A, automated Edman degradation of the syntaxin (1–265) which...
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Báo cáo khoa học: Analysis of DNA-binding sites on Mhr1, a yeast mitochondrial ATP-independent homologous pairing protein potx
... DNA-binding activity of Mhr1 in the absence of Mg2+, because the DNAbinding activities of other HP proteins are often increased by the addition of Mg2+ in vitro [31,32] In the presence of 10 mm EDTA, ... changes of Mhr1 after ssDNA binding (A) Schematic representation of the positions of the Trp residues in Mhr1 (B) Emission spectra of wild-type Mhr1 (0.5 lM) with varying concentrations of the ... ssDNA (µM) 1441 DNA-binding sites of Mhr1 T Masuda et al protein; Fig 1C) These results imply that the environment of some of the Trp residues changed after the binding of Mhr1 to the 74-mer ssDNA...
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Báo cáo khoa học: Semi-nested PCR analysis of unknown tags on serial analysis of gene expression potx
... NlaIII (CATG) sites were found between the site of the no tag D tag and a poly(dA) among the cDNA of the gene (Hs 436980) The blast results of another 11 sequences in the GenBank sequences of the products ... course of our research on the SAGE data of the human spermatozoa, we became aware that other methods [rapid reverse transcription–PCR analysis of unknown SAGE tags (RAST-PCR) [15], generation of ... serve as a primary library of spermatozoa cDNAs to be used for further studies Amplification of primary library The full-length cDNAs in spermatozoa were amplified by PCR with the use of Takara...
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Báo cáo khoa học: Identification of tyrosine-phosphorylation sites in the nuclear membrane protein emerin pot
... comparison of tyrosine-phosphorylated proteins Table Phosphorylation sites of mouse and of human emerin Phosphorylation site Number of phosphorylated residues Peptide sequence Residues S-72 or Y-75 ... FEBS A Schlosser et al Tyrosine-phosphorylation of emerin Fig Identification of emerin and of tyrosine-phosphorylation sites (A) MS ⁄ MS spectrum of the mouse-emerin peptide DYNDD-pY-YEESYLTTK ... in-gel digestion to identify human emerin phosphorylation sites in HeLa cells This led to the identification of tyrosine phosphorylation sites of mouse and human emerin Results To identify tyrosine-phosphorylated...
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TUMORS OF THE PARANASAL SINUSES: APPROACHES TO DIAGNOSTIC IMAGING potx
... Nir Harish, HMS III Radiologic Menu of Tests CT: Modality of choice MRI: Complementary X-Ray Nir Harish, HMS III Radiologic Menu of Tests: CT CT: Modality of Choice #1 for both inflammatory and ... Nasal cavity Paranasal sinuses: 3% of HNC Salivary glands Nir Harish, HMS III Agenda Meet the patient: Mr R Common signs/symptoms of sinus disease Radiological Menu of Tests Normal anatomy Differential ... swelling and secretions Radiation exposure Nir Harish, HMS III Radiologic Menu of Tests: MRI MRI: Complementary Assessment of soft tissue infiltration, esp intracranial Multiplanar capability, esp sagittal...
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Báo cáo khoa học: Structure and function of N-acetylglucosamine kinase Identification of two active site cysteines pptx
... determination of the Km of GlcNAc, different concentrations of GlcNAc were used in the presence of 10 mM ATP For determination of the Km of ATP, different concentrations of ATP were used in the presence of ... ATP-binding subdomains, indicating a common structure of the ATPbinding sites of the two enzymes Interestingly, five of the six cysteines of GlcNAc kinase had an equivalent cysteine in glucokinase, ... feature of the active site of enzymes with phosphate binding sites [27] In GlcNAc kinase these cysteines seem to be C131 and C143 Their counterparts in glucokinase are C233 and C252 Mutations of these...
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Báo cáo khoa học: "Analysis of Unknown Words through Morphological Decomposition" potx
... and often produce a large number of possible analyses Out of the test set of 200 words, based on a lexicon consisting of around 3500 morphemes (including the ** entries), the average number of ... would be offset by a speed penalty T h e rules m a k e use of sets of characters Anything is a set consisting of all surface characters, BCDFGKPSTW and HJLMNqRVXYZ are sets consisting of those ... morphological analysis of words into morphemes based on user-defined rules The basic system does not offer analysis of words containing unknown morphemes, nor does it provide a rank ordering of the output...
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Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx
... distance of 2.0 A The position of the ring structure of PG should be 70–80% accurate based on the prediction accuracy of ‘sievgene’ Although it is difficult to predict the position of side chains of ... fluorescence quenching curves of AKR1B1 and its mutants are shown in Fig 3D The Kd value of the K77L mutant of AKR1B1 was similar to that of the wildtype enzyme (0.3 lm) and the values of the D43N, D43E, ... higher than that of the wild-type AKR1B1 However, the Kd value of the Y48F ⁄ H110F double mutant of AKR1B3 was similar to that of the wild-type enzyme (5.7 lm) and the values of the Y48F and H110F...
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