tumor cell antigens and other markers
advances in cancer research
... Antigens I1 Tumor Cell Antigens and Other Markers 111 Various Laboratory Parameters 58 60 61 Chapter Pharmacology and Toxicity I IFN Effects in Animals-General ... prostaglandin and IFN in IFN-pretreated cells, while various other hormones were devoid of this activity (Zor et al., 1982) Other prostaglandin synthetase inhibitors, including indomethacin and aspirin, ... in direct anti -tumor cell therapy is that there are differences in drug response among cells of a parental tumor, between the parental tumor and its metastatic subpopulations, and among various...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... [249], Drosophila [250], Kc cells [251], Sf-9 cells and BII cells [252] QSARs (including classical and 3D QSARs) have been used extensively to investigate various in vivo and in vitro activities ... Two helices (H1 and H3) comprise an outer layer and are less coplanar in USP than in RXRa Three helices (H7, H10 and H11) form part of the outer layer, and four helices (H4, H5, H8 and H9) form ... BtEcR and TmEcR were similar, as anticipated by their sequence similarity In the PonA-bound HvEcR-LBD complex, the LBD is composed of 12 helices and three small b-strands, and possesses a long and...
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Báo cáo khoa học: Cloning of a rat gene encoding the histo-blood group A enzyme Tissue expression of the gene and of the A and B antigens potx
... submaxillary gland, the A antigen was expressed in the secretory cells and the B antigen in the duct cells The A and B antigens were only coexpressed in the pancreas acinar cells (Fig 5d) and in some ... hairy cells and on olfactory cells [37,38] In the present study, we noticed that with the exception of the pancreas and the skin, in rat organs, the A and B antigens never codistributed at the cellular ... both the A and B antigens were present, their cellular distribution differed For example, in the stomach, the A antigen was mainly present on cells of the neck area and on the parietal cells of...
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nuclear envelope dynamics in embryos and somatic cells
... editors and publishers believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and ... in Embryos and Somatic Cells, edited by Philippe Collas ©2002 Eurekah.com and Kluwer Academic/Plenum Publishers 2 Nuclear Envelope Dynamics in Embryos and Somatic Cells filaments and lamin-binding ... DYNAMICS IN EMBRYOS AND SOMATIC CELLS Molecular Biology Intelligence Unit 23 Landes Bioscience / Eurekah.com and Kluwer Academic / Plenum Publishers Copyright ©2002 Eurekah.com and Kluwer Academic/Plenum...
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báo cáo hóa học: " All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2" potx
... development of several tissues and organs [4], including the brain and the spinal cord [3,5] Retinoids are also present in the brain and spinal cord of adult rats and mice [6,7] and are involved in functions ... expression and increases PGE2 in SH-SY5Y human neuroblastoma cells Figure ATRA up-regulates COX-2 expression and increases PGE2 in SH-SY5Y human neuroblastoma cells (a,b) Expression of COX-1 and COX-2 ... activity and COX-2 mRNA expression significantly in another lung tumour-derived cell line [27] In other studies ATRA did not induce COX-2 in phorbol 12-myristate 13-acetate-dif- ferentiated U937 cells...
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Báo cáo hóa học: " Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma" potx
... histological subtype and then focus on clear cell RCC Fortyone samples were paraffin-embedded tissue fixed in Bouin's and 23 in formalin solution The majority of the tumours were of the clear cell RCC subtype: ... 46 were solid clear cell RCC and were cystic clear cell RCC DNA extraction Genomic DNA was extracted from tumour samples with ten µm sections of paraffin blocks loaded on standard slides focusing ... VHL gene in this study R and T are DNA from a commercially available reference and tumour tissue tested respectively Panels A, B and C correspond to different renal clear cell tumours fixed in formalin...
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Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection" doc
... HIV virions and exposed mucosal surfaces and that both the properties of the inoculum (cell free HIV virions and/ or cell associated infectivity in the form of HIV-infected cells) and the characteristics ... damage and repair in ex vivo tonsil organ culture and HIV infection of tonsil cells Epithelial damage and repair in ex vivo tonsil organ culture and HIV infection of tonsil cells Small randomly ... all T cell subsets), CD4 (helper T cells and macrophages; note the absence of any detectable CD4 expression on epithelial cells), CD8 (cytolytic T cells; Figure 2a–f, Table 1) Both CD4 and CD8...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... The ligand ephrinB1 is expressed by both endothelial cells and tumor cells EphA2 is required for VEGF-induced endothelial cell migration and angiogenesis [45, 46] Stimulation by EphB4 and reverse ... osteoblastic differentiation and bone homeostasis 265 Biological Functions Eph receptors and their ligands regulate cell- cell communication in a variety of tissues and cell types, resulting in a ... ephrinA and ephrinB ligands, and ephrinA5 which can 264 also bind to EphB2 [2, 3] Figure Domain structure of Eph receptors and ephrinA and ephrinB ligands Eph receptors have an extracellular...
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Báo cáo y học: "Phobic memory and somatic vulnerabilities in anorexia nervosa: a necessary unity" ppsx
... subunits in specific areas and how they are related to changes of cellular functions translated to the diverse clinical features of AN along its course and co-morbidities Somatic and cognitive aberrations: ... SK1 and SK2 are predominantly expressed in the nervous system, in cortical pyramidal cells; [37] the basal ganglia and limbic system; [26,38,39] dopaminergic (DA) midbrain neurons; [40] and supraoptic ... abnormalities of alveolar epithelial cells in the lung, mesenteric and pulmonary arteries, vascular smooth muscles, genitourinary and gastrointestinal smooth muscle cells Alkon [59] not only set out...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... in Fig 1, and has two distinct areas of staining for FDC and one large area of B cells encompassing both FDC regions Very few T cells could be seen within GC A and B, and no plasma cells could ... shown in Fig (e and f) appeared to be made up entirely of B cells because there was no positive staining for any of the other cell markers These were referred to as B -cell clusters C and D Repertoire ... mutated B cell clones represented as (a) and (b) The cellular components necessary for a GC response were present in both GC A and GC B (i.e B cells, FDCs capable of presenting antigen and T cells)...
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Báo cáo khoa học: "Probing the link between oestrogen receptors and oesophageal cancer" ppt
... growth factors, cytokines and enzymes and has been linked with hormone-independent growth, loss of cell- cell adhesion and angiogenesis Proliferation and apoptosis The mitogenic and growth-promoting ... of one ER dimer over another and their roles in many of oestrogen’s nonendocrine functions that likely contribute to disease onset and severity Phosphorylation and ligand-independent activation ... underlying ER and E2 interactions in oesophageal cancer are based on studies of other cancers in which ERs have been implicated and are briefly discussed below: Differential ERa and ERb expression and...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... unknown and other inflammatory cytokines stimulated by TLR activation, such as TNF-α and IL-6, may also play key roles Cellular debris and immune clearance A likely source of intracellular antigens ... include DNA in ICs and fit well with data showing that CpG DNA oligonucleotides can enter cells and stimulate TLR9 Other studies showed that singlestranded RNA stimulates TLR7 and TLR8 [18], suggesting ... phosphatidylserine and several other ligand-receptor pairs help phagocytes to recognize apoptotic cells and remove them from the circulation [40,43] through sequential tethering and engulfment Particularly...
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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf
... protein, DC-SIGN binds intercellular adhesion molecule (on endothelial cells) and intercellular adhesion molecule (on leukocytes), thereby regulating DC migration and T -cell interactions [13,14] ... thank Emily Lewis B.Sc and Jennifer Johnson B.Sc for obtaining patient blood samples; Taejah Vemuri, Marc Anderson and Amanda Bradke B.Sc for help with blood processing and cell culture; Emily Somers ... DC-SIGN, a dendritic cellspecific HIV-1-binding protein that enhances trans-infection of T cells Cell 2000, 100:587-597 Bajtay Z, Csomor E, Sandor N, Erdei A: Expression and role of Fc- and complement-receptors...
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Báo cáo y học: "NOD-like receptors and inflammation" pot
... mutants However, other studies have failed to corroborate the TLR2 story, with Kobayashi and colleagues [129] reporting similar responses to TLR ligands in wildtype and NOD2-/- cells, and indeed an ... of other NALP proteins, and its inflammasome assembles in response to both exogenous and endogenous PAMPs and DAMPs Activators of the NALP3 inflammasome include bacterial peptidoglycan; extracellular ... domain and a carboxyl-terminal LRR, and activation of this complex induces the combined activation of the TLR and NLR pathways The extracellular portion of flagellin is detected by TLR5, and the...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... John Wiley and Sons cells) as well as TLR ligands of microbial origin Similar to the microbial TLR ligands, endogenous TLR ligands have been found in the joints or serum of RA patients and their ... important for inducing the T -cell costimulatory molecules CD80 and CD86 This is particularly the case with TLR4, which achieves this via induction of IFNβ [11] B cells and T cells have also been shown ... of arthritis (right-hand side) Histological images of knee joints are shown, stained with hematoxylin and eosin Arrow indicates inflammatory cell influx and chondrocyte cell death Image taken...
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Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
... exists in both transmembrane and soluble isoforms and is critical for ligand binding and signal transduction through the receptor [27,28] Negative regulators of IFN and other proinflammatory cytokine ... TLR9 by DNA-associated autoantigens or TLR7 by RNA-associated autoantigens induces secretion of IFN-I by plasmacytoid dendritic cells (PDCs) and activates autoreactive B cells [3-12] Production ... directed against both RNA- and DNA-associated autoantigens TLR7 expression and activation by TLR7 agonists were completely abolished in IFNAR2-/ - B cells, demonstrating that B -cell activation through...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... cytokines or other stimulatory molecules, which trigger the adaptive immune system by activating B cells and T cells Janeway [4] and Poltorak et al [7] proposed a central concept in the understanding ... of MHC class II molecules and accessory molecules (B.7 antigens) on antigenpresenting cells and T -cell activation (see Fig 3) Further evidence for the role of TRAF6 and NF-κB-inducing kinase ... recognized ligands for TLR4 are presented in Table 2, and the known ligands for TLR2 are presented in Table Both TLR2 and TLR4 require the adapter protein MyD88 for signaling, and immunoprecipitation...
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Báo cáo y học: "A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion" pps
... randomly chosen fields were used for cell counts PI-stained cells (representing the total number of cells: alive + necrotic + apoptotic cells) were counted first, followed by TUNEL-positive cells ... whereas ERK1/2 exerts a cytoprotective effect and is involved in cell proliferation, transformation, and differentiation, p38 and JNK promote cell injury and apoptosis [4,7,11,37,38] Previous studies ... µg/kg) and beginning of reperfusion; and = DMSO administration Densitometry data presented is normalized to the intensity of actin bands *P < 0.01 versus groups 1–4, 8, and **P < 0.05 versus the other...
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Báo cáo khoa học: " Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis" ppt
... between host and infecting microorganism, including bacterial recognition, cell activation and transmigration, phagocytosis and destruction of the pathogen [3-6] Bacterial recognition and cellular ... authors read and approved the manuscript Acknowledgements The authors thank Leandro Martins and Camila Valentin for their help in the recruitment of patients, and Maria da Luz Fernandes and Maria ... added to each tube and centrifuged Supernatants were discarded and cells were resuspended in 0.3 ml PBS/1% sodium azide Event acquisition and analyses were performed using the CellQuest software...
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Báo cáo sinh học: " Developmental temperature and somatic excision rate of mariner transposable element in three natural populations of Drosophila simulans" pps
... co-migration of bands and degradation of high molecular weight bands may occur In this analysis 30, 22 and 21 isofemale lines were tested for Bordeaux, Loua and Agadir, respectively, and the ANC per ... modify the transcription and/ or the transposition rate of transposable elements (Strand and McDonald, 1985; Junakovic et al, 1986; lVIcDonald et al, 1987) On the other hand, populational factors, ... of hsp-70 was detected (see: Strand and McDonald, 1985; and references therein) Homologies of 50% were also observed with other sequences of heat shock promotors and with a 14-bp sequence of the...
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