tràn khí màng phổi vùng trước bên tạo dấu hiệu góc sườn hoành sâu deep sulcus sign
Báo cáo y học: "Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults" pot
Ngày tải lên :
12/08/2014, 18:20
... his eldest brother commentary Genomic DNA from other family members was then examined by PCR designed to detect the normal or the mutated allele separately (Fig 1E) The patient’s mother was confirmed...
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Báo cáo y học: "X-linked agammaglobulinemia diagnosed late in life: case report and review of the literature." pps
Ngày tải lên :
13/08/2014, 13:22
... activation is key to the activation of NF-κB and subsequent signaling needed for cell survival Without sufficient Btk protein, these pro-survival signals are not made and the pre-B cells undergo immature ... hemizygous point mutation in our patient may inhibit the signaling needed for recruitment of Btk to the cell membrane where it functions to transduce signals from the B cell receptor (BCR) of pre-B cells ... reference ranges measure This was deemed appropriate since he was hypogammaglobulinemic, demonstrated significantly impaired functional responses to pneumococcal serotypes, had a history of severe sinopulmonary...
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báo cáo hóa học:" AIDS-associated Kaposi’s sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa" pdf
Ngày tải lên :
20/06/2014, 08:20
... Observatory, Cape Town, South Africa Authors’ contributions KC was responsible for the overall design, analysis and writing of the paper GM and GVC wrote the first draft of the study protocol GM, ... Highly active antiretroviral therapy in AIDS-associated Kaposi’s sarcoma: implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi’s sarcoma J Clin Oncol...
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Báo cáo sinh học: "Mycobacterium avium subsp. paratuberculosis linked to Crohn''''s Disease and Paratuberculosis" pot
Ngày tải lên :
08/08/2014, 19:20
... Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime."...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
Ngày tải lên :
25/10/2013, 05:20
... mitogen-activated protein kinase (MAPK)-signaling members, extracellular kinase signal-regulated kinases (ERK1 and ERK2), stressactivated protein kinase (p38), and extracellular signal-regulated ERK kinase ... statistically significant association This means that digitalis had no effect on long-term death rates, significantly decreased the need for hospitalization for worsening heart failure, and significantly ... (Kresty et al., 2008) PAC pretreatment significantly inhibited the viability and proliferation of SEG-1 cells in a time- and dose-dependent manner Moreover, PAC significantly inhibited acid-induced...
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TIỂU LUẬN CHẨN ĐOÁN AUJESZKY’S DISEASE VIRUS (ADV) BẰNG KỸ THUẬT NUÔI CẤY TẾ BÀO
Ngày tải lên :
21/01/2014, 13:47
... Protein tegument quan trọng trình xâm nhập nhân lên virus, xâm nhập màng bao bọc màng nhân màng thể golgi • Vỏ envelope virus màng phospholipids lớp bao gồm 10 glycoprotein (gB, gC, gD, gE, gH, ... bọc (envelope) • Bộ gen ADV bao gồm vùng đơn vị (two unique regions), đơn vị dài (unique long UL), đơn (unique vị ngắn shot US), cặp sườn trình tự lặp lại, bên (an internal one-IRS), phía cuối ... (Photos Copyright FAO 1997) Ở bò chủ yếu biểu thể: • Thể kích thích: đặc trưng ngứa nhiều vùng hay nhiều vùng vùng da đầu, ngực, đùi • Thể bại liệt: vật suy nhược, chướng bụng, táo bón, bại liệt,...
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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
Ngày tải lên :
14/02/2014, 17:20
... shown that the resetting index varies significantly with the magnitude of the mechanical perturbation and with the tremor amplitude (Britton et al., 1992) No significant difference was found in ... electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher Wiley also publishes its ... electronic formats Some content that appears in print may not be available in electronic books Designations used by companies to distinguish their products are often claimed as trademarks All brand...
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Tài liệu Parkinson’s Disease and Related Disorders docx
Ngày tải lên :
14/02/2014, 17:20
... which he demonstrates that deep brain stimulation results in even better outcome of motor function than regular medication For this reason, he advocated earlier use of deep brain stimulation in ... of the classical signs of tremor, rigidity and akinesia varies with respect to disability – its presence and progress; hence the need to quantify this interaction of physical signs and functional ... reinforcement signal is provided by the midbrain dopaminergic (the critic) projections to the striatum, i.e., to the actor networks of the basal ganglia The dopamine-reinforcement signal represents...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
Ngày tải lên :
14/02/2014, 18:20
... first signs of dementia are mild, then these signs worsen at a steady pace For known and unknown reasons, irreversible What Is Dementia? Figure 1.1 A researcher tests an elderly man for signs ... Alzheimer’s Disease and Other Dementias Ten Warning Signs of Alzheimer’s Disease The Alzheimer’s Association has come up with a list of 10 warning signs of Alzheimer’s disease that may help people ... help people more easily recognize the condition These warning signs are meant to serve as a guide for people to recognize common signs of Alzheimer’s disease Some of these symptoms may be present...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
Ngày tải lên :
15/02/2014, 01:20
... was significantly different in at least one of the four groups considered (Fig 2) Two groups of spots showing remarkable changes in the isoform pattern in the four conditions were easily assigned ... a-synuclein significantly affected the levels of four proteins [stathmin 1, glutathione S-transferase 4912 d Not applicable (GST)p, Ran binding protein and C1q binding protein], related to cell signaling, ... B Fig Enriched protein networks (A) Proteins that displayed significant changes after dopamine treatment (B) Proteins that displayed significant changes as a consequence of a-synuclein overexpression...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
Ngày tải lên :
16/02/2014, 09:20
... designed from which Ab was released by furin-like enzymes on the cell surface BRI is a transmembrane protein that is involved in amyloid deposition in British familial dementia The fusion design ... were mistakenly identified as amyloid-like fibrils in these mice [27] Fusion proteins, in which the signal peptide and C-terminal fragment (C99) of wild-type APP were joined and expressed under the ... pyroglutamyl modification [7] The biochemical processes generating all these Ab species and their significance to AD pathogenesis are only partially understood Early-onset AD can also arise as a...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
Ngày tải lên :
18/02/2014, 13:20
... understanding of the structure of both the Ab monomer and its various assemblies could help in the design of new therapeutic strategies targeted at preventing the formation or ameliorating the activity ... recombinant Ab peptides that would allow isotope labeling and the generation of Ab peptides with design or disease-associated amino acid substitutions Production and purification of recombinant Ab ... of the gel band (data not shown) The PCR protocol used to generate Ab(M1–40) and Ab(M1–42) was designed to facilitate incorporation of familial mutants by exchange of only the middle primer We...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx
Ngày tải lên :
18/02/2014, 14:20
... and significantly increased 1-methy-4-phenylpyridinium and rotenone-induced cytotoxicity [40] Furthermore, it has been reported very recently that germline deletion of the PINK1 gene in mice significantly ... various functions, notably in resistance to oxidative stress [11], but also transcription, cell signalling, apoptosis [27,28] and aggregation of a-synuclein [29] The protein may also act as a ... possible that PINK1 could exhibit an extramitochondrial role, interacting with Parkin, DJ-1 and other signalling molecules in the cytosol, which in turn regulate mitochondrial function Given that mitochondria...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
Ngày tải lên :
18/02/2014, 14:20
... Patients usually present neuropathic arthropathy, recurrent ulceration of the lower extremities, signs of radicular sensory deficiency in both the upper and the lower extremities without any motor ... uptake [47] and that the presence of palmitic acid increases the de novo synthesis of ceramide significantly [48] However, known pathogenic mutations in SNCA are likely gain-of-function mutations, ... mitochondria Hum Mol Genet 12, 321–327 Hannun YA & Obeid LM (2008) Principles of bioactive lipid signalling: lessons from sphingolipids Nat Rev 9, 139–150 Morgan NV, Westaway SK, Morton JE, Gregory...
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Tài liệu PARKINSON’S DISEASE pptx
Ngày tải lên :
19/02/2014, 04:20
... (see Chapter 8) * Symptoms are what the patient complains of; signs are what the doctor finds on examination Parkinson’s has both signs and symptoms that are typical of the disease We discuss ... the brain which contains dopamine cells), deep within the brain The large cerebral hemispheres enclose and cover the substantia nigra as well as other deep midbrain structures 8 / INTRODUCTION ... fundamental cause or causes And progress of the dis- 24 / INTRODUCTION ease varies significantly among people with the same signs and symptoms, and perhaps the same diagnosis, and we don’t know why Here...
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Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study docx
Ngày tải lên :
05/03/2014, 12:20
... those with concurrent intestinal or systemic infection were excluded from the study Protocol Design The study was a 6-month open-label pilot evaluation of the efficacy of LGG at a dose of 1010 ... Statistical Analysis Quantitative variables are described as medians with ranges in parentheses The significance of changes was evaluated us- ing analysis of variance (ANOVA) for parametric variables ... with metronidazole did not inhibit intestinal colonization with LGG (Fig 1) The patients showed significant improvement in Crohn’s disease activity, when measured by PCDAI scores (P )20.0 סweek...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
Ngày tải lên :
05/03/2014, 21:20
... better than the group without that variable A significant time effect would indicate a change in a factor score over the total duration of follow-up A significant interaction effect would indicate ... was not statistically significant among those with more than 10 years of education ( ϭ Ϫ1.5, P ϭ 0.6), but the number of subjects was small Memory performance still declined significantly over time ... values which represent associations between a factor score and variables included in the model A significant group effect would indicate a difference between two groups at the baseline or at any...
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Hirschsprung´s Disease and Allied Disorders pptx
Ngày tải lên :
05/03/2014, 22:21
... 2.6 Genes Involved in ENS Development 2.6.1 RET/GDNF/GFRα1 Signaling System 2.6.2 Endothelin Signaling Pathway 2.6.3 SOX10 ... deleted, interfere with ENS development (Table 2.2) [7, 42–44] 2.6.1 RET/GDNF/GFRα1 Signaling System This signaling pathway is of importance for subpopulations of both peripheral and central ... [47–49] In vivo the absence of GDNF/GFRα1-mediated signaling leads to the failure of ENS development, whereas the absence of NTN/GFRα2-mediated signaling leads to more subtle abnormalities in ENS...
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PARKINSON''''S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN potx
Ngày tải lên :
05/03/2014, 23:20
... or absent deep tendon reflexes The deep tendon reflexes are decreased in proportion to the weakness in myopathy or neuromuscular junction defects (e.g., myasthenia gravis) • A Babinski sign, with ... Chaddock sign is elicited by scratching the lateral side of the foot from back to front with a slightly sharp object (the same used to test for the Babinski sign) A positive Chaddock sign is also ... slowed, and eye movement falls short of target (hypometric) d • Meyerson’s sign a Traditional cardinal signs: rigidity, b Limb signs typically asymmetrical c bradykinesia, resting tremor, and imbalance...
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