tryptophan hydroxylase pet 1 and lim homeobox transcription factor 1β

Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx

Ngày tải lên : 07/03/2014, 12:20

... HO -1 expression, including heat shock transcription factor -1 (HSF -1) , hypoxia-inducible factor -1 (HIF -1) and NF-E2-related factor (Nrf2) The PI3K ⁄ Akt pathway has been implicated in HSF -1 regulation ... including kidney [10 ], liver [11 ], heart [12 ] and small bowel [13 ], by virtue of the products of the reaction it catalyzes [14 ] Bilirubin is known to be a powerful antioxidant [15 ,16 ], and HO-derived ... phospho-GSK3a ⁄ b (ser 21 ⁄ 9) (pGSK3a ⁄ b), phospho-ERK1 ⁄ ERK2 MAPK (Thr202 ⁄ Tyr204) (E10) monoclonal (p-ERK1 ⁄ 2), ERK1 ⁄ ERK2 MAPK (total-ERK1 ⁄ 2), phospho-p38 MAPK (Thr180 ⁄ Tyr182) (28B10) monoclonal...

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Báo cáo y học: "Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura" ppsx

Ngày tải lên : 14/08/2014, 14:21

... 3L 4, 612 ,8 91 4, 614 ,005 1, 115 CG13 716 -16 1 CG13 715 +16 81 11 11 10 10 6.6 51 PCE 810 8 2L 14 ,403,7 71 14,404,937 1, 167 CG15284 -43 01 BG:DS06238.4 +2346 10 13 11 6.5 6.5 52 PCE 810 9 3R 7,9 41, 6 01 7,942,426 ... 826 CG 313 61 +17 775 CG4702 +11 512 10 11 12 53 PCE 811 0 2L 8,804 ,16 6 8,805,336 1, 1 71 CG9468 -30684 SoxN -12 519 10 13 11 6.5 54 PCE 811 1 3L 8, 612 ,337 8, 613 , 016 680 CG6486 + 410 4 h - 216 52 12 13 6.5 ... - 319 6 18 11 6.3 70 PCE 812 8 3R 27, 713 ,3 81 27, 715 ,087 1, 707 heph +3 517 1 heph +3 517 1 10 17 10 6.3 6.3 PCE 813 0 3R 12 ,383,752 12 ,385,269 1, 518 CG14889 +18 58 CG14889 +18 58 11 14 PCE 813 1 3R 21, 329, 716 ...

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algorithms for representation and discovery of transcription factor binding sites

Ngày tải lên : 13/11/2014, 09:10

... of TG C 19 G 18 16 15 14 13 12 10 TA CT T 17 C CCC G C CAG A T ATA C T A C G TG A T T G G A T GTCGA C C TA 11 A T A bits 5′ CTGTATA 19 LexA Binding Sites 3′ weblogo.berkeley.edu Figure 1. 1: Sequence ... process left 35 transcription factors and 410 binding sites, with an average of 11 .7 ± 8.5 sites per transcription factor 2.2.2 Approaches for representing and searching for transcription factor binding ... problem (e.g., [Staden 19 84, Schneider et al 19 86, Berg and von Hippel 19 87, Day and McMorris 19 92, Gelfand 19 95, Stormo 2000]) Traditionally, a particular transcription factor s preference for...

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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf

Ngày tải lên : 18/02/2014, 16:20

... (0.04) (0 .19 ) (0.09) 19 83 2493 14 86 18 85 10 30 16 30 13 45 10 38 19 60 805 514 (406) (13 74) (780) ( 710 ) ( 613 ) (809) (740) (542) (10 47) (752) (277) 19 64 15 61 1008 15 96 905 12 97 11 42 468 14 03 276 206 ... ¨ 13 14 15 16 17 18 19 20 21 22 23 24 25 26 nuclear 1H 13 C correlation spectroscopy J Am Chem Soc 11 0, 7557–7558 Kay LE, Torchia DA & Bax A (19 89) Backbone dynamics of proteins as studied by 15 N ... (0.029) (0.020) (0. 017 ) (0. 014 ) (0.024) (0. 010 ) (0.065) (0.052) 0.008 0.008 0. 011 0.008 0. 014 0. 010 0.008 0.027 0.030 (0.0 01) (0.0 01) (0.005) (0.002) (0.006) (0.003) (0.0 01) (0. 013 ) (0.006) Tyr25...

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Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf

Ngày tải lên : 15/03/2014, 00:20

... 1 4, T 211 , TTF -1 sites at )358 ⁄ )355 and )353 ⁄ )350; lanes and 6, mutated T 211 ; lanes 7 10 , T 212 , TTF -1 sites at )709 ⁄ )706 and )700 ⁄ )697; lanes 11 and 12 , mutated T 212 Lanes 1, 5, and 11 , ... T2 41 T238 T84 T242 T239 T254 Consensus GATA Muc5b TTF -1 ( )11 2 ⁄ )10 9) TTF -1 ()358 ⁄ )355; )353 ⁄ )350) Mutated T 211 TTF -1 ()709 ⁄ )706; )700 ⁄ )697) Mutated T 212 TTF -1 ()325 ⁄ )322) GATA ( )11 43 ... sites at )709 ⁄ )706 and )700 ⁄ )697 The probes T 213 , T238 and T242 contain one predicted site at )11 2 ⁄ )10 9, )325 ⁄ )322 and ) 417 ⁄ ) 414 , respectively Incubation of T 211 and T 212 radiolabeled probes...

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Báo cáo khoa học: Transcriptional activity and Sp 1⁄3 transcription factor binding to the P1 promoter sequences of the human AbH-J-J locus docx

Ngày tải lên : 23/03/2014, 07:20

... et al 12 13 14 15 16 17 12 fold molar excess of competitor 12 25 12 25 Sp1/3 Sp3 Sp1/3 * Sp3 * 23 24 25 26 er r Sp 1m e 31 32 33 34 35 fold 25 50 25 molar excess of competitor 50 25 50 10 0 10 0 ... Junctate, an inositol 1, 4,5-triphosphate receptor associated protein, is present in rodent sperm and binds 12 13 14 15 16 17 18 19 20 21 22 23 TRPC2 and TRPC5 but not TRPC1 channels Dev Biol 286, ... 21 er 20 Km Em e er H/ 19 D/ Im – 18 H/Imer er Probe Competitor Sp1 mer r Competitor Probe B r 10 0 fold molar excess of competitor A Sp1/3 Sp3 C fold 50 50 10 0 molar excess of competitor 50 10 0...

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Báo cáo khoa học: Transcription factor speciﬁcity protein 1 (SP1) and activating protein 2a (AP-2a) regulate expression of human KCTD10 gene by binding to proximal region of promoter pot

Ngày tải lên : 30/03/2014, 02:20

... patch in transcription factor Sp1 contacts the dTAFII 110 component of the Drosophila SP1 and AP-2a regulate KCTD10 16 17 18 19 20 21 22 23 24 25 26 27 28 TFIID complex and mediates transcriptional ... (2009) 11 14 11 24 ª 2009 Hunan Normal University Journal compilation ª 2009 FEBS 11 15 SP1 and AP-2a regulate KCTD10 R Liu et al A B Fig Genomic structure of human and mouse KCTD10 genes, and the ... AP-2 FEBS Journal 276 (2009) 11 14 11 24 ª 2009 Hunan Normal University Journal compilation ª 2009 FEBS 11 19 SP1 and AP-2a regulate KCTD10 R Liu et al Fig Effects of Sp1 and AP-2a expression level...

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Báo cáo khoa học: Synergistic co-operation of signal transducer and activator of transcription 5B with activator protein 1 in angiotensin II-induced angiotensinogen gene activation in vascular smooth muscle cells potx

Ngày tải lên : 30/03/2014, 02:20

... STAT5B and activator protein (AP -1) Previous studies indicate that transcription activation by STATs requires activated AP -1 [11 13 ] AP -1 is a complex composed of the Fos and Jun proteins [14 16 ] ... compilation ª 2009 FEBS No antibody Input 17 23 STAT5B and AP -1 interaction in AGT gene activation A M Han et al +1 AP -1 STAT5 tataaa –282~–277 17 2~ 16 3 TATA AP -1 – 419 ~– 412 B Relative luciferase activity ... (2009) 17 20 17 28 ª 2009 The Authors Journal compilation ª 2009 FEBS 17 21 STAT5B and AP -1 interaction in AGT gene activation A Ang II 12 M Han et al inhibition of STAT5B phosphorylation (Fig 1C and...

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Báo cáo khoa học: The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene pot

Ngày tải lên : 30/03/2014, 09:20

... primers including a SalI site: 19 55A, 19 02A, 18 89A, 18 77A, 18 70A, 18 62A, 18 51A, 18 43A, 18 32A, 18 21A, 18 10A, 18 01A and 17 90A The common sense primer was 16 76ST and included and EcoRI site The same series ... to 18 10 (end points at 18 01 and 18 10 not shown) 14 38 Unlike the effects on PS1 transcription (Fig 6A), further deletions with end points at amino acids 18 10, 18 18, 18 30, 839, 18 51 and 18 61 did ... 219 A: 19 9A: CHD3 subclones 37-1S: 37-1A: 37-9S: 37-9A 37-8S: 16 76S: CHD3 inserts in pCMV-Tag2 16 76ST: 2000AT: 2000AX: N-terminal deletions 17 41S: 18 00S: 18 10S: 18 18S: 18 30S: 18 39S: 18 51S: 18 61S:...

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Báo cáo y học: "Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)" ppt

Ngày tải lên : 09/08/2014, 07:20

... October 2002 References 10 11 12 13 14 15 16 17 Cush JJ, Lipsky PE: Cellular basis for rheumatoid inflammation Clin Orthop 19 91, 265:9-22 Gay S, Gay RE, Koopman WJ: Molecular and cellular mechanisms ... histological sections and U Griechen for technical assistance This work was supported by the Deutsche Forschungsgemeinschaft (Br 13 72/5 -1, Wi 11 02/8 -1 to Wi 11 02/8-3, and SFB405/B17), and the Interdisciplinary ... CD40 on fibroblasts induces CD54 (ICAM -1) and CD106 (VCAM -1) up-regulation and IL-6 production and proliferation J Leukoc Biol 19 95, 58:209- 216 Page 13 of 13 (page number not for citation purposes)...

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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx

Ngày tải lên : 12/08/2014, 19:21

... enhancement and constructive purposes References 10 11 12 13 14 15 16 17 18 19 D’Angio CT, Finkelstein JN: Oxygen regulation of gene expression: a study in opposites Mol Genet Metab 2000, 71: 3 71- 380 ... signaling transcription factors in the alveolar epithelium Cell Signal 2002, 14 :799- 810 Semenza GL: HIF -1 and mechanisms of hypoxia sensing Curr Opin Cell Biol 20 01, 13 :16 7 -17 1 Semenza GL: HIF -1 and ... Rutkowski K, Metzen E, Fandrey J, Jelkmann W: β Interleukin -1 and tumor necrosis factor- alpha stimulate DNA binding of hypoxia-inducible factor -1 Blood 19 99, 94 :15 611 567 El Awad B, Kreft B,...

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Báo cáo y học: " The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription" potx

Ngày tải lên : 13/08/2014, 06:20

... Sanità, Italy to MG References 10 11 12 13 14 15 16 17 Polo SE, Almouzni G: Chromatin assembly: a basic recipe with various flavours Curr Opin Genet Dev 2006, 16 (2) :10 4 -11 1 Li B, Carey M, Workman JL: ... Virol 19 98, 72(9): 715 4- 715 9 Zhou Q, Chen D, Pierstorff E, Luo K: Transcription elongation factor P-TEFb mediates Tat activation of HIV -1 transcription at multiple stages EMBO J 19 98, 17 (13 ):36 81- 36 91 ... release during transcription: NAP1 forms a complex with H2A and H2B and facilitates a 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 topologically dependent release of H3 and H4 from...

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Tài liệu Báo cáo khoa học: Hsp105b upregulates hsp70 gene expression through signal transducer and activator of transcription-3 pdf

Ngày tải lên : 18/02/2014, 06:20

... Furthermore, Hsp105b (1 698), Hsp105b (1 677) and Hsp105b (1 662) induced approximately 60% of the luciferase activity as compared with the control However, Hsp105b (1 6 41) , Hsp105b (1 5 91) , and Hsp105b (1 564), ... cells However, Hsp105b (1 6 41) , Hsp105b (1 5 91) , and Hsp105b(D642– 698), which failed to activate the hsp70 promoter, also localized to the nucleus and cytoplasm Interestingly, Hsp105b (1 564) localized ... heat shock response and beyond FASEB J 15 , 11 81 11 31 18 Baler R, Dahl G & Voellmy R (19 93) Activation of human heat shock genes is accompanied by oligomerization, modiﬁcation, and rapid translocation...

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Tài liệu Báo cáo khoa học: Efﬁcient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf

Ngày tải lên : 18/02/2014, 08:20

... treated with IFN-c (Fig 6C, lane 3) IRF1 200 2000 10 0 10 00 0 IFN-γ (10 0 ng·mL 1) + IFN-γ (10 0 ng·mL 1) + Western blotting B IFN-γ (ng·mL 1) 20 10 0 200 P-STAT1 STAT1 P-STAT3 STAT3 Discussion – – Pull-down ... (%) C IRF1 DAPI Merge 40 20 10 + IFN-γ (ng·mL 1) ODN 0 + Control B 70 60 50 40 30 20 10 Stattic (µM) 0 + + 0 10 0 200 10 0 200 10 0 200 0 0 + + Dead cells (%) Fig Transcriptional activity and subcellular ... single-stranded oligonucleotides that inhibit signal transducer and activator of transcription induce apoptosis in vitro and in vivo in prostate cancer cell lines Mol Cancer Ther 3, 11 83 11 91 Tomita...

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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc

Ngày tải lên : 19/02/2014, 06:20

... 20, 10 3 11 1 17 Meisenhelder J, Suh PG, Rhee SG & Hunter T (19 89) Phospholipase C-c is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro Cell 57, 11 09 11 22 18 ... Oncogene 17 , 13 1 14 1 15 Geier A, Beery R, Haimsohn M, Hemi R, Malik Z & Karasik A (19 94) Epidermal growth factor, phorbol esters, and aurintricarboxylic acid are survival factors for MDA-2 31 cells ... 3, 323–330 11 Xia Z, Dickens M, Raingeaud J, Davis RJ & Greenberg ME (19 95) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 270, 13 26 13 31 12 Kulik G & Weber MJ (19 98) Akt-dependent...

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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc

Ngày tải lên : 19/02/2014, 07:20

... Elk -1, SAP-1a, MHox(K-2), Fli -1 o Egr-B, SAP-1b, BRIP1, pRB, p130, DP -1, DP-2, E2F -1, E2F-2, E2F-3, p107, E2F-4, E2F-5, E2F-6, HDAC3, HDAC1, HDAC2, YAF2, ADA3, BRCA1, WT1, 53BP1, PML-3, MTA1-L1, ... Osteosarcoma [ 71] Hepatocyte apoptosis and foetal death [72] Proliferative disease [73] Proliferative disease [74] Proliferative disease [75] 27 23 18 18 15 17 .3 18 .5 20.2 27 .1 14 14 13 12 6.6 4 .1 10.5 ... Yeast ER model Proteome Internet 230 8 51 3.70 0 .17 4.50 )0 .18 230 8 51 3.70 0. 015 4 .15 )0.005 18 70 4488 2.40 0.07 6. 81 )0 .15 10 10 0 38 380 3.80 0.24 3.70 )0 .19 N total number of nodes, l total number...

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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf

Ngày tải lên : 19/02/2014, 16:20

... by the transcription factor, Egr -1, via the cis-regulatory element of the cyclin D1 promoter located between )11 2 and )10 5 bp [13 ] We decided to investigate the effect of PUFAs on the Egr -1- binding ... bp human cyclin D1 promoter ()973 to +29 bp), the full-length (Wt Egr -1) or the mutated (mutEgr -1) ( )13 7 to )99 bp) cyclin D1 promoter, or the 697-bp human Egr -1 (pGLE), and 10 0 ng of pSV-bgal ... skin and were cultured in DMEM supplemented with 10 % (v/v) fetal bovine serum, mM glutamine, 10 0 unitsÆmL )1 of penicillin and 10 0 lgÆmL )1 of streptomycin SMC were subcultured every days, and experiments...

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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc

Ngày tải lên : 19/02/2014, 17:20

... such as IL -1 [ 21] , and TNF-a [ 21] can also induce ESE -1, and ESE -1 target genes with regard to inﬂammation so far identiﬁed by us include iNOS, COX-2 and potentially MMP -1 and MMP -13 (X Gu, F ... COX-2 is activated Several transcription factor families have been shown to be involved in this process such as C ⁄ EBP [5,9 ,10 ,26], NF-jB [7 ,10 ,11 ], NFAT [6 ,10 ] and Ets [16 ,18 ,27] We now report the ... Ets -1 [14 ,15 ], PEA3 [16 18 ] and Pu .1 [19 ] The multiple activation modalities observed across the different studies as well as the similarity of the recognition sites of the NFAT and Ets factors...

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Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx

Ngày tải lên : 06/03/2014, 00:21

... Journal 278 (2 011 ) 17 79 17 89 ª 2 011 The Authors Journal compilation ª 2 011 FEBS 17 81 Interaction of TnrA with GlnK and GS A Kayumov et al Fig BIAcore analysis of GlnK–TnrA complex formation and ATP ... proteins (wild-type and truncated versions), GlnK-ST and GS-ST FEBS Journal 278 (2 011 ) 17 79 17 89 ª 2 011 The Authors Journal compilation ª 2 011 FEBS 17 87 Interaction of TnrA with GlnK and GS A Kayumov ... 2-oxoglutarate [12 ] Other nucleotides, such as ADP, AMP, and GTP, at concentrations of FEBS Journal 278 (2 011 ) 17 79 17 89 ª 2 011 The Authors Journal compilation ª 2 011 FEBS A Kayumov et al 1 3 mm had...

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Báo cáo Y học: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line pptx

Ngày tải lên : 08/03/2014, 16:20

... 415 2– 415 8 10 Nakata, H & Fujisawa, H (19 82) Puriﬁcation and properties of tryptophan 5-monooxygenase from rat brain-stem Eur J Biochem 12 2, 41 47 11 Cash, C.D., Vayer, P., Mandel, P & Maitre, M (19 85) ... P & Maitre, M (19 91) Tryptophan hydroxylase synthesis is induced by 3¢,5¢-cyclic adenosine monophosphate during circadian rhythm in the rat pineal gland J Neurochem 57, 15 16 15 21 36 Ichiyama, ... 245, 16 99 17 09 Ichiyama, A., Hasegawa, H., Tohyama, C., Dohmoto, C & Kataoka, T (19 76) Some properties of bovine pineal tryptophan hydroxylase Adv Exp Med Biol 74, 10 3 11 7 Hosoda, S (19 75) Further...

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