... the possible role of IFN-β in immune-mediated diseases such as MS and RA This antiangiogenic capacity of IFN-β may also be of relevance for the treatmentof RA The importance of angiogenesis in ... polyarthritis of the wrists and hand joints after weeks of IFN-β treatment for MS [62] Eight months after the IFN-β treatment ended, symptoms of arthritis subsided, with resolution of the synovitis ... subcutaneous injections of placebo or one of three doses of recombinant human IL-1 receptor antagonist After months, the patients who received the highest dose of the active treatment exhibited significant...
... site of infection), and the potential of inhibiting the migration of cells that are able to produce an array of proinflammatory cytokines at the site of inflammation The identification of the ... effects oftreatment aimed at blocking cell migration to the site of inflammation It is likely that we will also see the development of other forms of molecular imaging to assist in selection of therapeutic ... number of cells, especially in the number of macrophages and CCR1+ cells after treatment (Fig 1) Because only cells capable of expressing CCR1 were affected, the results confirmed the specificity of...
... Observation during the treatmentof AIA rats At 13 days after arthritis induction, the ankle size of most of the AIA rats reached a plateau (data not shown) At this time, the hind legs of the affected ... patterns of certain enzymes have been used to enhance the tissue specificity of these delivery systems [11,25,33] The application of these drug delivery systems to improve the current treatmentof ... release of drugs in the treatmentof RA and related forms of inflammatory arthritis Competing interests DW and SCM are inventors named in a patent application partially related to the content of this...
... encouraged a possible use of these cells to modulate autoimmune responses and in the treatmentof autoimmue diseases [12,13] To date, the experience of MSCs in the treatmentof RA is limited to a ... erosion of cartilage and subchondral bone, and = loss of joint integrity and ankylosis Each joint was scored separately by two individuals unaware of the treatment protocol To trace the migration of ... China 5Department of Rheumatology, The Affiliated Hospital of Nantong University, 20 Xi Si Road, Nantong, 226001, PR China 6Laboratory of Oncology, Affiliated Hospital of Academy of Military Medical...
... the first day oftreatment *Statistically significant difference SEM, standard error of the mean 125 pg/ml of IL-1β together with various concentrations of IFN-β before measurement of luciferase ... Evaluation of arthritis activity Mice were inspected daily for signs of arthritis by an independent observer who was not aware of the treatment Swelling was quantified by measuring the thickness of the ... swelling (mean ± SEM) of the first arthritic paw was monitored during the course of disease using calipers On day after the start of the treatment, differences between all treatment groups and...
... on the first day oftreatment (baseline), prior to administration of masitinib and then again after 4, and 12 weeks oftreatment Secondary endpoints included the 12week analysis of disease activity ... reintroduction oftreatment Analysis of AEs with respect to the dose of their occurrence (data not shown) showed that no clear dose-toxicity relationships exist, with the exception of oedema The number of ... mechanism of action of masitinib, the results of this study help to further establish the critical role of MCs in the pathogenesis of active RA More specifically, this study supports the viability of...
... the peripheral blood cells of approximately 50% of anti-TNF treatment- naive RA patients [13] This analysis was based on the measurement of the expression of a set of 34 type I IFN response genes ... the gene expression profiles of peripheral blood cells of RA patients with those of healthy controls and found that a subgroup of RA patients has an increased expression of type I IFN response ... (d) after treatmenttreatment Interestingly, the patients who showed an increase in type I IFN response gene expression levels after month oftreatment had a poor clinical response to treatment...
... I is Professor of Clinical Psychology in the Department of Psychology at the University of Montreal Fearing Others The Nature and Treatmentof Social Phobia Ariel Stravynski University of Montreal ... disruptive social anxiety are features of the lives of many thousands of people But exactly what is social phobia? What causes it? What is its nature and what kinds of treatments can improve it? Using ... and ways of testing them 81 5.3 Reliability: agreeing about the entity of social phobia 86 5.4 Predictors of response to treatment 95 5.5 Social phobia in the family 99 5.6 Association of social...
... by insufficient treatmentof AF or, on the contrary, is caused by adverse effects of the treatment, however, is too realistic to be ignored All we have stated about the treatmentof AF in MICU ... 80% of patients with AF convert to SR within 24 hours The use of β-blockers before the start of AF and the absence of diabetes and left ventricular hypertrophy were independent predictors of conversion ... disease and other nosocomial complications Can treatmentof atrial fibrillation improve survival? There are few data on the effect oftreatmentof AF on mortality in ICU patients A meta-analysis...
... Antipsychotics [29] Initiation ofTreatment First Year ofTreatment Duration ofTreatment • Baseline fasting glucose level • Fasting glucose level every 3–4 months • Observe for signs of hyperglycemia • ... of our patients develop renal disease, psychiatrists must be aware of the effects of psychotropics on the kidneys, as well the effects of decreased renal functioning on the pharmacokinetics of ... bioavailability of free, active highly protein-bound drugs Accumulation of active hydroxylated metabolites of carbamazepine may lead to symptoms of drug toxicity despite therapeutic drug levels [70] Of all...
... mind, in the presence of adherent scars, after having infiltrated the whole area with a solution of Lidocaine 0.5% and Epinephrine 1:200,000 very close to one of the two edges of the scar, a small ... that brings great improvement to the treatmentof depressed scars AUTHORS' CONTRIBUTIONS FI: participated in the surgical treatment and in the follow-up of this patient MT: drafted the manuscript ... literature FMA: participated in the surgical treatment and in the follow-up of this patient MM: participated in the design of this case study and in the follow-up of this patient ADI: revised the literature...
... Position of Occlusion Begnning of the CCA Begnning of the CCA Begnning of the ICA Left cavernous sinus part of the ICA, right beginning of the ICA Begnning of the ICA Symptom Other aeurysms SAH PCA SAH ... sclerosis of the CCA PCA VA→ECA→IC A Present case 2010 69/F Arterio- Begnning SAH sclerosis of the ICA No No Year Age/ Cause gender 41/F aortitis 63/M Position of Occlusion Begnning of the CCA ... arteries The angiograph of the vertebral artery showed no delay in the blood flow of anterior circulation The saccular aneurysm with a diameter of 3.2 mm was observed at the apex of the basilar artery...
... Different methods of decompressive craniectomy in the treatmentof TBI Different methods of decompressive craniectomy have been developed for, or applied to, decompression of the brain at risk ... most authors.11, 26 The temporary removal of a piece of skull followed by loose closure of the dura and skin layers presumably allows for expansion of the edematous brain into a durotomy “bag” ... comes down to the floor of the middle cranial fossa, at the root of the zygoma; this ensures adequate lateral decompression of the temporal lobe, allowing it to “fall out” of its usual calvarial...
... indication of techniques for the treatmentof this kind of surgical complication Spontaneous healing of to mm openings can occur, while untreated larger defects are connected with the pathogenesis of ... attention for the presence of sporadic intraoral drainage in posterior left maxilla The discomfort was of a few years duration and had its origin following an endodontic treatmentof tooth 2.6 provided ... characteristics of OAC/OAF; the apexes of tooth 26 were in extremely close approximation to the maxillary sinus, and an area of periapical rarefaction was evident (Fig 1) After the failure of the endodontic...
... restraints of the surgery RESULTS A total of 174 people (77 women, 97 men; mean age 64, range 22-89) were included Length of follow-up was at least years with a maximum of years Location of facet ... the treatmentof low back syndrome Pain 1977;3:257-63 Savitz MH Percutaneous radiofrequency rhizotomy of the lumbar facets: ten years' experience Mt Sinai J Med 1991;58:177-8 Schaerer JP Radiofrequency ... elsewhere as treatment prior to considering the endoscopic option The facet injections in these 72 patients gave 50 to 100% relief of their pain in 86% of the patients with a median relief period of months...
... objectives adaptation and the development of new forms oftreatment are necessary This team is composed of the lymphologist or professional trained in the treatmentof lymphedema, psychologists, nutritionists, ... was developed for the treatmentof the lower extremities by producing dorsoflexion of the foot and allows treatment sessions of hours or more daily with losses of as much as 20 cm in circumference ... research of lymphedema with excellent results attending the necessities of patients from distant localities This option of simple and feasible treatment can change the lives of millions of people...
... adhered to the dosing schedule less than 75% of the time Method of assigning patients to treatment groups Patients were assigned to treatment groups (order of treatments) using computer-generated randomization ... ingredients Use of concomitant prohibited medication (narcotics, oral NSAIDs, topical NSAIDs) within four weeks of randomization Use of acetaminophen or ibuprofen within days of randomization ... thus compromising the quality of life of millions of Americans In addition, OA costs the North American economy approximately $60 billion per year Current treatmentof OA includes exercise, heat/cold...
... efficient treatment option even for deep wound infections The most important advantages of this system are an increased localised blood flow, the reduction of tissue bacterial counts, elimination of ... the transport of cellular and humoral components of the immune system to the infected area is facilitated, which leads to a significant reduction of the bacterial count The efficacy of the V.A.C ... reduction, the V.A.C.-system is not often used in the treatmentof prosthesis – related infections Currently, there exist only four reports about the use of the V.A.C – system in the infection...
... total dose of antibiotics should not exceed 10% of the weight of the cement in order to avoid fracture of the cement spacer [27] The implantation of an ALC spacer shortens the duration of systemic ... time of reimplantation and allow delivery of the antibiotics of choice according to sensitivities [23,36] The disadvantage of a static spacer is that it does not allow physiological motion of the ... substantial impairment of patients’ normal daily activities during the prolonged course oftreatment Another drawback of the static spacer is bone loss attributed to migration of the block spacer...
... of soft-tissue shortening and provision of sufficient infection therapy is the usage of temporary, antibiotic-loaded cement spacers [5, 7, 14, 24] Although their indication in the treatmentof ... the diagnosis of an osteomyelitis of the femoral head Table 1: Patients’ data, surgical procedures, and causative organisms at the site of hip spacer implantation in the treatmentof coxitis and ... Fig 2: Evaluation of the hip joint function by the Merle d’ Aubigne score at the site of spacer implantation in the treatmentof proximal femur infections Fig 3: Evaluation of the hip joint function...