transporter xenobiotic interactions an important aspect of drug development studies
Báo cáo khoa học: Purification and characterization of zebrafish hatching enzyme – an evolutionary aspect of the mechanism of egg envelope digestion pot
... for (lane 2), 10 (lane 3) and 40 (lane 4) Numbers on the right show the molecular masses of the major bands 5938 39 kDa band disappeared, and only two bands with the same mobility as the 43 and ... 1) were incubated with either ZHE1 (lane 2), MHCE (lanes 3–5) or MLCE (lanes 6–8) After incubation for 10 (lanes 2, and 6), 40 (lanes and 7) and 120 (lanes and 8), each digest was separated by ... DNA of Teleostei, Osteoglossomorpha first branched off from an ancestor, followed by Elopomorpha, and then branched paraphyletically to Otocephala and Euteleostei [11–14] The cDNA cloning analysis...
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Skills-based health education including life skills: An important component of a Child-Friendly/Health-Promoting School potx
... infections, drug and alcohol abuse, violence and injury, early and unintended pregnancy, and infection with HIV and other sexually transmitted infections threaten the health and lives of children and ... content of the programme focuses on a range of health and social issues relevant to children and young people, including personal health and hygiene, growth and development, nutrition, alcohol and drugs, ... and negotiation are important aspects of skills-based health education and life skills Building these types of interactions into activities, with opportunities to practise the skills, is an important...
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Báo cáo lâm nghiệp: "An economic aspect of conversion of Scots pine (Pinus sylvestris L.) stands in the Polish Lowland" docx
... 500 Fig Relation between mean timber values of pine stands and mean timber values of oak stands at consecutive 10-year age intervals Pine pine stands Oakstands oak stands 2,000 0О A – -500 – -1,000 ... increment rate of the mean value of pine stands from unsuitable sites is initially greater than that of oak stands but these relationships get reversed at older age – The mean value of pine stands from ... 108,000 stands taking up the area of over 344,500 ha, of which the (m3/ha) (m3/ha) Pine 400 area of single-species pine stands was 92,800 and that of mixed stands in which pine was a dominant species...
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Báo cáo y học: "Neurocysticercosis as an important differential of seizures in pregnancy: two case reports" pdf
... Neurocysticercosis as an important differential of seizures in pregnancy: two case reports Journal of Medical Case Reports 2011 5:206 Submit your next manuscript to BioMed Central and take full advantage of: • ... Journal of Medical Case Reports 2011, 5:206 http://www.jmedicalcasereports.com/content/5/1/206 Page of cases [2] During pregnancy, treatment of neurocysticercosis consists of anti-convulsant therapy ... Editor-in-Chief of this journal Author details Department of Obstetrics and Gynecology, Pandit Bhagwat Dayal Sharma, Post Graduate Institute of Medical Sciences, Rohtak (124001), Haryana, India Department of...
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báo cáo khoa học: " AtMRP6/AtABCC6, an ATP-Binding Cassette transporter gene expressed during early steps of seedling development and up-regulated by cadmium in Arabidopsis thaliana" doc
... yeast and mammalian cell studies and performed the cloning of the cDNA AV contributed in the design of the study NL carried out with SG the molecular analysis of transgenic plants and the transient ... requires an ABC transporter Science 2004, 306:702-704 Deeley RG, Westlake C, Cole SP: Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins ... the second half of the protein exhibits only transmembrane helixes whereas transmembrane spans are usually found HMMTop_V2 (very well-known and suitable for the analysis of ABC transporters) as...
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Báo cáo khoa học: "Clinical review: Tokyo – protecting the health care worker during a chemical mass casualty event: an important issue of continuing relevance" ppt
... personnel should cordon off the site of the incident in cooperation with the police, and should decontaminate victims because this is an essential and The use of PPE is as important as decontamination ... Decontamination Manual (the official report of the Task Force on the advanced procedures of fire righters by the Japanese National Fire Defense Agency, 2004) cartridge; for instance, such devices ... Notwithstanding, it is important to remember that level B PPE carries inherent dangers for the wearer One potential disadvantage is that the time taken to put on the equipment can be considerable, and...
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One leg balance is an important predictor of injurious falls in older persons
... sensitive to significant changes; and (3) most importantly, reflected position changes and gait maneuvers used during normal daily activities The geriatric assessment was repeated annually to assess ... interventions on the less than 25%) of the total population who are at greater risk of injury Why one-leg balance was a more important predictor of injurious falls in our study than some of the other factors ... sex, and other important variables in the logistic regression model Age was also significantly associated with the risk of incurring an injurious fall The sensitivity of abnormal one-leg balance...
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Is money the most important aspect of a job
... Again, I would state my objection to the issue after analyzing the three reasons The money a person earns is not the most important aspect of a job ...
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Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
... creation of a new class of drugs for cancer therapy B1-021P Localization and trafcking of prostate specic membrane antigen (PSMA) and its variant form PSM P Mlcochova1,2, C Barinka1, P Sacha1,2 and ... possible aminoacids that can be participant in the active site and the sub sites of interaction The total understanding of these interactions can be a important tool for drug design against bacterial ... oxidative damage and its modications by antioxidants Therefore, the aim of the present work was to investigate the molecular mechanisms of antioxidant and prooxidant activities of quercetin toward...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... engaged in the development or acquisition of drugs and biologics for CBW defense It also recommends organizational changes in the Office of the Secretary of iii iv The Acquisition of Drugs and Biologics ... decentralized, and fragmented organizational system for drug and vaccine development This required us to understand the relation of different DoD organizations to CBW drug and biologics development and ... body; and any information on toxic effects found in animal studies All the important details of the design, conduct, and proposed analysis of the clinical trial are provided in an IND and in...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... transformants were analyzed for b-1,4-endogalactanase production using azo-galactan Transformant NW290::pIM3982.77 was selected as the highest b-1,4-endogalactanase producing transformant and was ... small amount of a-L-1,3-arabinofuranosidase was responsible for the disappearance of Fig HPAEC analysis of the hydrolysis of arabinogalactans by GALA Three different arabinogalactans were used: ... arabinogalactan consists of 86% D-galactose and 6.6% L-arabinose, while soy arabinogalactan consists of 57% D-galactose and 38% L-arabinose Methylation analysis demonstrated that a substantial amount of...
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Tài liệu Báo cáo khoa học: The molecular surface of proteolytic enzymes has an important role in stability of the enzymatic activity in extraordinary environments pptx
... resistance of ALP I to anionic surfactants The unfolding caused by surfactants occurred in a moderate manner in comparison with denaturation by high alkalinity, and the structural change of the ... higher than that of the wild-type ALP I, 70.2 °C, and almost the same as that of wild-type Sendai, 73.6 °C Stability of mutant Sendai in alkaline conditions The substitutions of Asp266Asn and Tyr269Ala ... 60% of the original activity after h, and 30% after h The D266NALP I showed 40 and 20% of the original activity after h and h of incubation, respectively The stability of Y269A/A271T/Q272R- and...
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
... side effect profiles of antituberculosis drugs and antiretroviral drugs, immune reconstitution inflammatory syndrome, and drug- drug interactions The key interactions, and the focus of this document, ... months of treatment among patients with advanced HIV disease 8, Predicting Drug Interactions Involving Rifamycins Knowledge of the mechanisms of drug interactions can help predict the likelihood of ... zidovudine 10 and raltegravir Rifampin and Antiretroviral Therapy The most important drug- drug interactions in the treatment of HIV-related tuberculosis are those between rifampin and the NNRTIs,...
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Báo cáo khoa học: "Generating Templates of Entity Summaries with an Entity-Aspect Model and Pattern Mining" potx
... patterns in terms of f1 measure compared with two baseline methods, and it can also achieve reasonably good quality of aspect clusters in terms of purity Compared with standard LDA and K-means sentence ... at aspect clusters, ideally we want to compute the precision and recall of our patterns, that is, the percentage of our sentence patterns that are meaningful, and the percentage of true meaningful ... the given category We can then treat the set of meaningful sentence patterns found by the human judge this way as the ground truth, and precision and recall of each method can be computed If our...
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Báo cáo khoa học: "FACTORING RECURSION AND DEPENDENCIES: AN ASPECT OF TREE ADJOINING GRAMMARS (TAG) AND A COMPARISON OF SOME FORMAL PROPERTIES OF TAGS, GPSGS, PLGS, AND LPGS " pot
... languages 1,2,3,4,5, and In TABLE I give some idea of the degree of freedom The language in in TABLE I is the extreme case where the a's, b's,and c's can he any order, as long as the number of ... of a's =the number of b's=the number of c'S GPSG~and TAG's cannot g e n e r a t e t h i s language (although f o r TAG's a proof is not in hand yet), LFG's can generate this language TAG's (or ... n ~ 0}, w is a string of a's and b's such that (1) the number of a's = the number of b's and (2) for any initial substrlng o f w, t h e n u m b e r of a's ~ t h e number of b ' s } -r S A ~z"...
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