toxicity management of renal cell cancer patients on targeted therapies
Báo cáo sinh học: "Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" docx
Ngày tải lên :
18/06/2014, 22:20
... common mutations are of p110a (PIK3CA) and loss of the tumor suppressor PTEN Amplification of PIK3CA and Akt are occasionally observed in epithelial cancers [15] Recently, high expression of the ... activation is tumor Page of 10 specific [21] Activation of mTOR can also up-regulate HIF gene expression, which, in patients with VHL mutations, can magnify HIF accumulation and expression of HIF-inducible ... stimulatory only The functional roles of the subunits, in conjunction with our findings of stronger co-expression of the p110a subunit and mTOR, suggest that pharmacological co-targeting of p110a...
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báo cáo hóa học:" Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" pot
Ngày tải lên :
20/06/2014, 04:20
... common mutations are of p110a (PIK3CA) and loss of the tumor suppressor PTEN Amplification of PIK3CA and Akt are occasionally observed in epithelial cancers [15] Recently, high expression of the ... activation is tumor Page of 10 specific [21] Activation of mTOR can also up-regulate HIF gene expression, which, in patients with VHL mutations, can magnify HIF accumulation and expression of HIF-inducible ... stimulatory only The functional roles of the subunits, in conjunction with our findings of stronger co-expression of the p110a subunit and mTOR, suggest that pharmacological co-targeting of p110a...
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báo cáo khoa học: "Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma" pptx
Ngày tải lên :
10/08/2014, 22:20
... http://www.jhoonline.org/content/1/1/14 Figure arginase inhibitor nor-NOHA on cell proliferation Effect of3 Effect of arginase inhibitor nor-NOHA on cell proliferation (A) Proliferation of CL-2, CL-19 ... and IFNα for RCC, only 10–20% of the patients respond [46] This lack of response may be caused by the markedly impaired T -cell function associated with a decreased expression of the CD3ζ receptor ... effect of L-arginine deprivation on the expression of CD3ζ, mRCC cell lines (600,000 cells/well) were cultured in six-well plates with mL of complete media for 24 hours × 105 Jurkat T-cells (ATCC,...
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Tài liệu THE MANAGEMENT OF SICKLE CELL DISEASE ppt
Ngày tải lên :
21/02/2014, 12:20
... incidence of sickle cell disease (SCD) but the extent to which informed self-interest decisions are made B ASIC C ONTENT FOR A LL S ESSIONS ■ Purpose and goal of the session ■ How sickle cell conditions ... NTRODUCTION This edition of The Management of Sickle Cell Disease (SCD) is organized into four parts: Diagnosis and Counseling, Health Maintenance, Treatment of Acute and Chronic Complications, and ... information for patients and health care providers The Sickle Cell Information Center http://www.emory.edu/PEDS/SICKLE A broad range of information for the public and professionals National Organization...
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Management of Sickle Cell Disease in Children doc
Ngày tải lên :
05/03/2014, 12:20
... ECG Continuous monitoring for patients whose underlying condition predisposes them to respiratory depression As ordered No No CPG 21-1 Management of Sickle Cell Disease in Children Page 15 of 15 ... history and physical Monitor vital signs, oxygen saturation, clinical state and response to treatment based on severity of clinical condition Conduct the following investigations: • CBC, reticulocyte ... history and physical Monitor vital signs, oxygen saturation, clinical state and response to treatment based on severity of clinical condition Conduct the following investigations: • CBC, reticulocyte...
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báo cáo hóa học: " Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008" pot
Ngày tải lên :
18/06/2014, 19:20
... understanding of cancer patients' experiences? A study of patients with lung cancer Qual Life Res 2003, 12:157-166 Montazeri A: Health-related quality of life in breast cancer patients: a bibliographic of ... Abbreviations: EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire; ESAS: Edmonton Symptom Assessment System; HDS: Hamilton Depression Scale; ... and Treatment of Cancer Quality of Life Core Questionnaire; EORTC QLQ-H&N35: EORTC Head and Neck Cancer specific Quality of Life Questionnaire; FACT-G: Functional Assessment of Cancer Therapy-General...
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báo cáo khoa học: "The management of advanced oral cancer in a Jehovah''''s Witness using the Ultracision Harmonic Scalpel" docx
Ngày tải lên :
09/08/2014, 02:21
... reused once taken out of circulation On discussion with our patient cell scavenging was also ruled out as it involves the reinfusion of blood which has left the circulation We decided on a strategy ... oral cancer requiring neck dissection and free flap transfer without use of blood transfusion[15] Skoner et al’s presentation of JWs with head and neck cancers requiring free flap reconstructions ... We also used controlled hypotension with a mean arterial pressure of 65 mmHg maintained with an opiate infusion Similarly, the use of controlled hypotension is only recommended in patients known...
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Báo cáo khoa học: "Renal cell cancer without a renal primary" pptx
Ngày tải lên :
09/08/2014, 03:21
... SS: Contemporary epidemiology of renal cell cancer Cancer J 2008, 14(5):288-301 Pascual D, Borque A: Epidemiology of kidney cancer Adv Urol 2008, 782381 Motzer RJ, Bander NH, Nanus DM: Renal- cell ... al.: Renal cell cancer without a renal primary World Journal of Surgical Oncology 2010 8:18 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission ... indication of treatment for metastatic lesions of renal adenocarcinoma J Urol 1982, 128(5):916-8 Ninan S, Jain PK, Paul A, Menon KV: Synchronous pancreatic metastases from asymptomatic renal cell...
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Báo cáo khoa học: "Leptomeningeal carcinomatosis from renal cell cancer: treatment attempt with radiation and sunitinib (case report)" pptx
Ngày tải lên :
09/08/2014, 03:21
... after admission Survival was 11 years from nephrectomy, 35 months from initial diagnosis of brain and lung metastases, and months from NM and bone metastases Conclusions NM from renal cell carcinoma ... antiangiogenic agents have become a mainstay of treatment in the general population of patients with metastatic renal cell carcinoma and occasional responses of brain metastases to these drugs have ... 6397) J Clin Oncol 2005, 23:8870-8876 Page of 12 Koutras AK, Krikelis D, Alexandrou N, Starakis I, Kalofonos HP: Brain metastasis in renal cell cancer responding to sunitinib Anticancer Res 2007,...
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Báo cáo khoa học: "Haemostatics in surgery and our experience in the enucleoresection of renal cell carcinoma" ppt
Ngày tải lên :
09/08/2014, 03:21
... 8% of papillary and 2% of chromophobe RCC (Group vs 2; p > 0.05) All margins of resection were negative At a mean follow-up of 15 months (6-37 months) no recurrence was observed Among all patients, ... approved by the Ethics Committee of our hospital Consent was obtained from all patients after full explanation of the procedure Patients were randomly assigned to one of the two haemostatic approaches: ... vector for prevention of recurrence of prostate cancer following RP [41] To our knowledge this is the first study which compare the use of a HA and of the ISC in the enucleoresection of RCC The recent...
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Báo cáo khoa học: "Constitutive gene expression profile segregates toxicity in locally advanced breast cancer patients treated with high-dose hyperfractionated radical radiotherapy" pot
Ngày tải lên :
09/08/2014, 09:22
... regulation of endothelial cell proliferation, oxidation reduction and cellular respiration were constitutively modulated (p < 0.05) [see Additional file 6] The same strategy was followed for late toxicity ... approval of the version to be published Page of (page number not for citation purposes) Radiation Oncology 2009, 4:17 Additional file Functional Classification Acute toxicity, Gy The table contains ... squamous cell carcinoma of the head and neck BMC Cancer 2006, 6:28 Johansson S, Svensson H, Denekamp J: Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer...
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Báo cáo y học: "Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis" docx
Ngày tải lên :
09/08/2014, 14:22
... preservation of renal function during the 12 months of therapy compared with controls [41] On the other hand, in a cohort of patients with chronic kidney disease treated with allopurinol, discontinuation ... discontinuation of allopurinol led to a significant acceleration of the rate of loss of kidney function [42] The above studies highlight the role of UA as an independent predictor of renal dysfunction ... with renal dysfunction in patients with RA In this study, we focus on the potential association of UA with renal dysfunction in patients with RA and investigate whether such an association is...
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Báo cáo y học: "Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study" pdf
Ngày tải lên :
09/08/2014, 14:22
... levels of highavidity anti-dsDNA antibodies and markers of renal disease, including an assessment of whether the patients entered renal remission Materials and methods Sixteen patients with new-onset ... Clinics at University Page of (page number not for citation purposes) College London and St Thomas' hospitals (London) All of the patients fulfilled the American College of Rheumatology revised ... No Manson et al Introduction Lupus nephritis (LN) occurs in 40% to 60% of patients with systemic lupus erythematosus (SLE) [1] Koffler and colleagues [2] first demonstrated deposition of autoantibodies...
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Báo cáo y học: "Hazards of tube thoracostomy in patients on a ventilator" doc
Ngày tải lên :
10/08/2014, 09:21
... parenchyma Conclusion Previously the risks of ICD insertion in patients on mechanical ventilation has been described [5] however we presented the above case due to frequent referral of patients on mechanical ... ventilation to us with harmful complications of tube thoracostomy Prior to ICD insertion in a patient on mechanical ventilation, the PEEP must be turned off and the ventilator must be disconnected ... thoracic surgery a large bore ICD with conventional insertion technique is favourable The royal college of surgeons has introduced S-DOPS (direct observation of procedural skills in surgery) via...
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báo cáo khoa học: "Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports" pptx
Ngày tải lên :
10/08/2014, 23:20
... metastasis as an initial presentation of renal cell carcinoma Med Oncol 2010 35 Azam F, Abubakerr M, Gollins S: Tongue metastasis as an initial presentation of renal cell carcinoma: a case report ... five years) Out of these, 17 cases were metastasis of RCC of clear cell type Six of these cases were diagnosed as primary ovarian clear cell cancer, while renal primary was diagnosed only after extensive ... resonance imaging (MRI)) [30-33] Tongue and tonsils The tongue is a frequent target for RCC metastasis although isolated spread to the floor of the mouth is rare Lesions in the tongue or floor of...
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Báo cáo y học: "Atypical presentation of renal cell carcinoma: a case report" doc
Ngày tải lên :
11/08/2014, 10:22
... picture of renal ultrasound This is a1 This is a picture of renal ultrasound It shows echo-dense area in the renal area, suggestive of a renal tumour Renal Cell Carcinoma in the form of hoarseness ... metastasis of which only five cases have been reported [3,4] Renal cell carcinoma represents a heterogenous group of tumors, the most common of which is clear cell adenocarcinoma RCC accounts for 3% of ... instead of the pathologic stage to determine the risk of recurrence [8] Conclusion Renal cell carcinoma presents with various clinical features Atypical presentations of RCC should be considered...
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Báo cáo y học: " The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports" pot
Ngày tải lên :
11/08/2014, 12:20
... 0.18 Transfusion of unit of red blood cell 5.2 0.24 Sequestrectomy tibia, transfusion of units of red blood cells Debridement tibia, transfusion of units of red blood cells In addition to classical ... Transfusion of units of red blood cells 5.0 0.24 Start dialysis, transfusion of units of red blood cells 6.9 0.31 5.6 0.27 5.5 0.26 4.6 0.22 Sequestrectomy femur, transfusion of unit of red blood cell ... of red blood cell 3.7 0.18 Transfusion of units of red blood cells 5.3 0.25 Debridement humerus, transfusion of unit of red blood cell 4.4 0.21 General anaesthesia to insertion of central venous...
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báo cáo khoa học: " Epigenetics of renal cell carcinoma: the path towards new diagnostics and therapeutics" pps
Ngày tải lên :
11/08/2014, 12:20
... initiation, resulting in the clonal evolution of a population of cells at risk of obtaining further genetic or epigenetic lesions [27,28] In inherited cancer syndromes such as von HippelLindau disease ... 20% of RCC cases [35,42,44,55] WNT pathway regulators Dysregulation of the WNT/β-catenin pathway is common in a variety of cancers, and oncogenic activation of this pathway drives the expression ... and that loss of these genes correlated with transcriptional deregulation [81,98] The interplay between erroneous histone modification and aberrant DNA methylation in the evolution of RCC merits...
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Báo cáo y học: " Tongue metastasis as an initial presentation of renal cell carcinoma: a case report and literature review" pps
Ngày tải lên :
11/08/2014, 21:22
... Authors' contributions FA assisted in the conception and design of the paper, and also helped in the acquisition, review and interpretation of the data MA contributed towards data collection and ... tongue Base of tongue Middle third of dorsum BOT Anterior right lateral Lung None Lung Lung Brain None Lung Lung Not mentioned Lung, liver Lung, bone Lung, brain Lung, bone, lymph nodes None Brain ... 70/M 59/M 82/F 68/M Not mentioned Right BOT Tip of tongue Anterior right lateral Not mentioned None Brain Lungs, bone BOT, base of tongue Nephrectomy may be justified in patients with metastatic...
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Báo cáo y học: " Oral cavity metastasis of renal cell carcinoma: A case report" pdf
Ngày tải lên :
11/08/2014, 21:22
... tumor ulceration of secondarycarcinoma ;cell infiltrationmucosal epithelium noted Renal cell Renal cell carcinoma; ulceration of mucosal epithelium noted secondary to tumor cell infiltration Figure ... Early trials have shown a prolongation of progression-free survival with the use of these targeted molecular therapies in cytokine-refractory patients [12] Conclusion RCC has been shown to metastasize ... that of the primary renal lesion in terms of morphology and histology The risk of bleeding after fine needle aspiration biopsy of RCC in the kidney is well documented, with up to 90% of patients...
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