total joint replacement and potential effects of bisphosphonates
Tài liệu NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP) pdf
Ngày tải lên :
13/02/2014, 10:20
... pregnancy and gestation Complete details of the study, including a description of reproductive effects in parents and offspring, are included in Section In the F1 offspring there were no effects ... Some evidence of no adverse effects Clear evidence of no adverse effects development and reproduction These studies reported that exposure of pregnant dams to relatively high doses of DIDP causes ... adverse effects Concern for adverse effects Some concern for adverse effects Developmental effects Reproductive effects Minimal concern for adverse effects Negligible concern for adverse effects...
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NTP-CERHR MONOGRAPH ON THE POTENTIAL HUMAN REPRODUCTIVE AND DEVELOPMENTAl EFFECTS OF BISPHENOL A pot
Ngày tải lên :
05/03/2014, 16:20
... than the developmental effects observed at “high” doses on survival and growth and the “low” dose effects on brain and behavior, mammary gland, prostate gland, and onset of puberty in females ... the incidence of a variety of other ovarian and uterine proliferative lesions and cysts were also reported Replication of these findings and further study of the linkage of early and late occurring ... confirm these findings and include longer periods of follow-up to understand the significance of the structural and cellular effects observed in fetuses and to clarify the relevance of prostate intraepithelial...
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Báo cáo y học: "Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke" docx
Ngày tải lên :
13/08/2014, 14:20
... (China) and was supported by the proposal of the Second Development of Pien Tze Huang of the National Ministry of Science and Technology Author details School of Biomedical Sciences, Faculty of Medicine, ... ischemia and stroke with and without hypertension in rats The mechanism of these effects was possibly related to prevention of cell death from apoptosis or ROS and oxidative damage of mitochondria ... hypertension) and in WKY (i.e ischemia without Zhang et al Chinese Medicine 2010, 5:35 http://www.cmjournal.org/content/5/1/35 Page of 14 Table (B) Score, time of onset of stroke, and time of death of the...
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Tài liệu The Economic and Social Effects of Financial Liberalization: A Primer for Developing Countries pptx
Ngày tải lên :
20/01/2014, 19:20
... #14-12 Cấu trúc tài (Q (Quản trò tài chính) ò ) – Trong đo: đó: EBIT (Earnings before interest and taxes) T : Ta es Taxes EBIT x (1- T)= Lợi nhuận sau thuế nợ vàø vốán cổå phầàn h ka : Chi phí ... dòng vốn p g ị g y g Các trung gian tài giảm chi phí giao dịch nào? Tạo kinh tế quy mơ (economies of scale) 2 Phát triển nghiệp vụ chun mơn làm giảm chi phí giao dịch (Puzzle 3) Copyright © 2000 ... Các nhà đầu tư khơng muốn mua chứng khốn xấu, thị trường khơng vân hành tốt g g Giải thích Puzzle and Puzzle Cũng giải thích Puzzle 6: Càng thơng tin bất cân xứng cho cơng ty hoạt động tốt vấn đề...
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Tài liệu Deteriorating Access to Women’s Health Services in Texas: Potential Effects of the Women’s Health Program Affiliate Rule doc
Ngày tải lên :
13/02/2014, 06:20
... expanded to 133% of the poverty line for nonelderly adults and there would also be a 5% standard deduction, leading to a net income limit of 138% of poverty 58 For example, Hawkins, J and Banda, ... in Texas were in need of contraceptive services and supplies, and of this population, 1.46 million were in need of publicly-funded services and supplies.14 About a third of women (32.5%, or 475,410 ... rates of unplanned pregnancies, low rates of breast and cervical cancer and other disease screening and high incidence of STIs The WHP policy changes would reduce access to screening services and...
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Tài liệu A Dissertation on the Medical Properties and Injurious Effects of the Habitual Use of Tobacco pptx
Ngày tải lên :
17/02/2014, 22:20
... variety of computers including obsolete, old, middle-aged and new computers It exists because of the efforts of hundreds of volunteers and donations from people in all walks of life Volunteers and ... moral character of men; that it often creates a thirst for spirituous liquors; that it allures to clubs, and grog-shops, and taverns, and thus helps to make idlers and spendthrifts; and finally, ... meeting of the Medical Society of the County of Oneida, on the 5th of March, 1830, a communication was received, signed by a number of highly respectable gentlemen from this and other counties of...
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Báo cáo khoa học: Alternative splicing: good and bad effects of translationally silent substitutions pdf
Ngày tải lên :
06/03/2014, 09:22
... splicing A variety of tools are available to us for this purpose and further investigation of these sequence variants will not only further our understanding of the splicing mechanism and improve clinical ... sites, most of them still lack experimental approaches directed at identifying the exact mechanism involved In spite of the well-known lack of reliability of in silico approaches, many of the synonymous ... (mouse–rat and human–dog) [10] This analysis showed a strong purifying selection at silent sites in a critical region of this gene [10], spanning the 3¢ end of exon 10 and the 5¢ end of exon 11...
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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
Ngày tải lên :
08/03/2014, 08:20
... field [26] The electrostatic potential energy was calculated with a distance-dependent dielectric screening of 4Ær and no cut-off was used Minimum-energy conformers of b- and a-amino acids were generated ... grid searches of b-amino acids were initially carried out at intervals of 30° for each torsion angle /, h, and w and were subsequently refined by varying /, w angles in intervals of 10° and setting ... shifts and random coil values, are commonly used to detect secondary structures in peptides and proteins [38] They are reported in Fig Stronger upfield shifts of Ha (Fig 3A) and downfield shifts of...
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The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra Costa, California pdf
Ngày tải lên :
14/03/2014, 17:20
... ii Abstract The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra ... University of California, Berkeley, for his advice and encouragement at every step of the way; Professor Elizabeth Deakin, Department of City & Regional Planning, Director of the University of California ... with survey design and thinking about the interaction of land use and transportation variables; Professor Paola Timiras, Department of Molecular & Cell Biology, University of California, Berkeley,...
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Youth Savings around the World - Youth Characteristics, Savings Performance, and Potential Effects docx
Ngày tải lên :
15/03/2014, 10:20
... accounted for 18% of HNB’s 2.2 million regular savings accounts, and the total volume of these accounts amounted to billion LKR (35.3 million USD), or 6% of the bank’s total volume of regular savings ... importance of saving and sound financial decision making • In Mexico, Caja Popular Mexicana, the country’s largest credit union, and its partners (World Council of Credit Unions, and California and ... programs, characteristics of youth savers, savings performance, and potential impacts of saving on youth development What We Know about Youth Saving Performance and Characteristics of Youth Savers This...
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Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc
Ngày tải lên :
16/03/2014, 06:20
... functional properties of the three domains of FlgCK, and lays the groundwork for study of the relationship between these functional properties and the structural interactions that potentially mediate ... essentially allowing only one of a set of interacting active sites to complete a catalytic cycle at a time Further understanding of catalysis and the interaction of active sites in these unique ... when MgADP, creatine and nitrate are bound to CKs This transition involves the movement of two flexible loops (residues 60–72 and 323–333 in both Torpedo and rabbit CyCKs) and ˚ at the N-terminus,...
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industry and the effects of climate in italy
Ngày tải lên :
21/03/2014, 22:04
... depositing at the feet of the chains of huge deposits of sand, gravel and clay There then followed a phase of general increased marine predominance, lasting a good part of the Miocene and all the Pliocene ... submersion of the margins of this major Tyrrhenian island The coastlineThe complexity of the peninsula's relief is echoed in the diversity of its coastal profile Along the low and sandy Adriatic ... with the exceptions of the bulge of the Po delta and of the two rocky promontories of the Conero and Gargano The Ionian and Tyrrhenian shores are very different, their extensive sandy curves, corresponding...
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PUBLIC ACCOUNTING FIRMS: Required Study on the Potential Effects of Mandatory Audit Firm Rotation doc
Ngày tải lên :
23/03/2014, 03:20
... to random samples of 282 of the 604 Tier firms and 237 of the 421 Tier firms We received responses from 74 of the 97 Tier firms, or 76.3 percent.7 Because of the more limited participation of ... percent, of their chief financial officers and 96, or 21.3 percent, of their audit committee chairs) and the foreign public companies (99, or 25.3 percent, of their chief financial officers and 63, ... competition-related effects of mandatory audit firm rotation, 54 percent of Tier firms believe mandatory audit firm rotation would decrease the number of firms willing and able to compete for audits of public...
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Báo cáo khoa học: Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is a-D-Gal-(1fi3)-a-D-GalNAc pot
Ngày tải lên :
23/03/2014, 13:20
... increments in t1 and spectral widths of 8000 Hz and 17 591 Hz in the 1H and 13C dimensions, respectively A total of 256 summed scans were collected with a relaxation delay of 1.3 s All 1H and 1H-13C ... addition of 10 lL 10% aqueous trifluoroacetic acid and immediately injected onto RP-HPLC and fractions collected were collected and analyzed with ESI and MALDI-MS Chemical reduction The native and ... protons of Thr10, Ala12 and Hyp13 interact with the A tx5a glycan protons Several NOEs are observed between the anomeric proton of GalNAc and the side-chain atoms of Thr10; Thr10b (strong NOE) and...
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Báo cáo khoa học: "Joint Syntactic and Semantic Parsing of Chinese" potx
Ngày tải lên :
23/03/2014, 16:20
... and Musillo, 2005) Yi and Palmer (2005) observed that the distributions of semantic labels could potentially interact with the distributions of syntactic labels and redefined the boundaries of ... (e.g., precision of 87.6 and recall of 65.8) There have been other efforts in NLP on joint learning with various degrees of success In particular, the recent shared tasks of CoNLL 2008 and 2009 (Surdeanu ... extraction and name entity recognition In addition, attempts on joint Chinese word segmentation and part -of- speech (POS) tagging (Ng and Low, 2004; Zhang and Clark, 2008) also illustrate the benefits of...
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Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf
Ngày tải lên :
29/03/2014, 00:20
... protein sequence with that of other species (Xenopus, Drosophila, mouse isoforms 1, 2, and 4, rat isoforms and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms 1, 2, 3, and 4) is shown in Fig ... applies to Artemia mitochondria, we tested the effect of ADP and ATP in the presence and absence of the ANT inhibitory ligand cATR, and of the F0F1ATP synthase inhibitor oligomycin The results ... well-characterized, inhibitors of ANT have also been reported [37] Mindful of (a) the well-established ligand profile of ANT, (b) the modulatory role of ANT in the mammalian PTP, and (c) the absence of a Ca2+-induced...
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Báo cáo khoa học: Prohibitin is expressed in pancreatic b-cells and protects against oxidative and proapoptotic effects of ethanol pdf
Ngày tải lên :
29/03/2014, 08:20
... proof of apoptosis, cleaved caspase-3 was determined in cell extracts by western blot (G) Representative blot of n = experiments showing 17 and 19 kDa caspase-3 cleavage bands and the levels of ... pancreatic b-cells The objective of the present study was to investigate the expression and antioxidant effects of PHB in pancreatic b-cells exposed to ethanol Effects of prohibitin in b-cells * 80 ... production of reactive oxygen species (ROS) and mitochondrial dysfunction [9,10] Increased ROS production is one of the earliest events in glucose intolerance and it may be a mechanism of pancreatic...
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Báo cáo hóa học: "Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-a 2b treatment" pptx
Ngày tải lên :
18/06/2014, 16:20
... understanding of the mechanism of action of IFN-a 2b may facilitate the development of treatment strategies to increase efficacy and reduce toxicity, ultimately leading to a better standard of care ... [25,26] The presence of Tregs in tumor-draining lymph nodes and tumors may serve as a basis of potential inhibition of host effector cell function Thus, depletion of Tregs or blockade of Treg function ... understanding of the mechanism of action may help to potentiate the clinical efficacy and reduce the toxicity [13] of IFN-a 2b/PegIFN-a 2b Numerous studies suggest that the mechanism of action of...
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