total 522 molecular descriptors selected 100 descriptors are highlighted machine learning classification studies were performed using either total 522 descriptors or the selected 100 descriptors
Roles and relationship of gasotransmitters hydrogen sulfide nitric oxide in myocardial infarction
Ngày tải lên :
14/09/2015, 08:45
... associated with the mitochondrial respiratory electron transport Sulfite is oxidized by sulfite oxidase to form sulfate, the major endproduct of H2S metabolism Sulfate, either in the free form or conjugated ... Metabolism of H2S In the body, majority of the H2S is metabolized either by oxidation in the mitochondria, methylation in the cytosol or is scavenged by methemoglobin, metallo- or disulfidecontaining ... Leukocytes are the key cellular mediators of the inflammatory process Exogenous NO donors were reported to limit leukocyte interaction and adherence to vessel walls On the contrary, inhibitors of...
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Báo cáo y học: "Myocardial post-conditioning with DanshenGegen decoction protects against isoproterenolinduced myocardial injury via a PKCε/mKATPmediated pathway in rats" pptx
Ngày tải lên :
13/08/2014, 14:20
... × g for 30 min, the mitochondrial pellets were collected The supernatants were saved for the preparation of cytosolic fractions The mitochondrial pellets Page of 10 were then washed with the same ... production were quantified according to the area under /or above the curve Effects of DG post-treatment on ISO-induced changes were expressed in percentage (%) of protection in relation to the corresponding ... Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China Authors’ contributions KMK designed the experiments SMW, PYC and HYL performed the pharmacological experiments LZ and ZZ performed the...
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Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx
Ngày tải lên :
23/03/2014, 03:20
... variants of the enzyme, then the efficient protein digestion in these crustacea can be better explained, as well as their ecological success Some studies are available on decapod trypsins at the molecular ... mostly focused on the nucleotide sequence [2,3] There are no previous reports on the trypsin sequence for any spiny lobster species Since the discovery of trypsin, a plethora of studies has been ... of the superficial loops are boxed and indicated according to Fodor et al.’s [8] nomenclature The numbers start at the first residue of proteins between these clones were nonstandard PCR errors...
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Báo cáo khoa học: Biosynthesis of D-arabinose in mycobacteria – a novel bacterial pathway with implications for antimycobacterial therapy pdf
Ngày tải lên :
30/03/2014, 04:20
... addition, the early work reported the presence of d-arabinose in the Azorhizobium Nod factor glycolipids in the pyranose rather than furanose form [55], and convincing evidence for the presence ... with the utilization of the arabinose donor by inhibiting either arabinosyltransferase activity or the formation of an arabinose acceptor in mycobacteria [32,33] (Scheme 1, Fig 2) Studies of the ... minor role in the synthesis of the vital arabinans in mycobacteria Formation of 5-phosphoribosyl-a-1-pyrophosphate The second step in the biosynthesis of decaprenylphospho-arabinose (Fig 2) is the...
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Báo cáo hóa học: " Research Article Robust Linear MIMO in the Downlink: A Worst-Case Optimization with Ellipsoidal Uncertainty " pptx
Ngày tải lên :
21/06/2014, 22:20
... describe this T in the next subsection Theorem The optimal power control for the original beamforming problem (11) with fixed transmit beamforming vectors is given by the solution to the following ... 0.05 are assumed The vertices indicate the minimum transmit power (or SNR) needed for each scheme As we can see, the region for the lower bounding approach is the smallest while the region for the ... to the power control The main result is based on S-procedure and given in Theorem as follows where wm denotes a fixed unit-norm transmit beamforming vector and the transmit beamforming vectors are...
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Báo cáo y học: " Aripiprazole Augmentation in the Treatment of Military-Related PTSD with Major Depression: a retrospective chart review" docx
Ngày tải lên :
11/08/2014, 15:22
... PTSD for more than 10 years, with comorbid major depression in the severe range, the observation that the majority of patients had improved scores for both PTSD and depression severity is noteworthy ... efficacy variables Analysis The LOCF data for each visit included the data recorded at that visit or carried forward from the last visit For the primary outcome, the Wilcoxon signed rank test ... t4) over the course of treatment The total PCL-M and the total BDI were the primary efficacy variables; the total PCL-M re-experiencing, avoidance/numbing, and hyperarousal subscale scores served...
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Báo cáo y học: "The ‘off-hour’ effect in trauma care: a possible quality indicator with appealing characteristic" pps
Ngày tải lên :
13/08/2014, 23:20
... from the trauma scene to the definitive hospital are crucial [29] Further, these processes are also likely to be affected by the time of the day The processes of care would be fully mirrored if the ... majority of the processes of care are not supported by evidence Subsequently, the respective QIs are also not supported The ensuing attempts to validate these QIs (i.e the assessment of their relationship ... program Moreover, the re-calculation of the QI at a later time could assess the efficacy of the abovementioned interventions On the other hand, the absence of the ‘off-hour’ effect could be a sort...
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Tài liệu Báo cáo khoa học: The plasminogen activator inhibitor 2 transcript is destabilized via a multi-component 3¢ UTR localized adenylate and uridylate-rich instability element in an analogous manner to cytokines and oncogenes pdf
Ngày tải lên :
16/02/2014, 09:20
... the destabilizing activity of the core ARE II sequence, the ARE IV and ARE I elements also appear to buffer effects of mutations in the core ARE II nonameric sequence, thereby retaining the AREs ... domains have been identified either 5¢ or 3¢ to the core domains in class I and II AREs [28,29,33] (Fig 9); moreover, placing the c-fos auxiliary domain either 5¢ or 3¢ to the core domain resulted in ... REMSA analyses were performed to determine the role of the ARE II and ARE IV sites in the binding of proteins to the ‘extended ARE Binding of cytoplasmic proteins to the ‘extended ARE probe was...
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Báo cáo y học: "Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis" ppt
Ngày tải lên :
09/08/2014, 06:22
... in the design of the study and performed the statistical analysis MKP participated in the isolation of the cells CHY drafted the manuscript SHP participated in the molecular biology and in the ... NF-κB binding The lower panel shows an immunoblot for IκB-α and actin at the same time Authors' contributions KWK performed the cellular immune response studies and participated in the immunoassays ... evaluate the potential of direct cytotoxic effect of inhibitors on cells After incubation for 24 hours, the cells were harvested and the percentage cell viability was calculated with the formula 100...
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Báo cáo y học: " Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study" doc
Ngày tải lên :
09/08/2014, 23:20
... 2% apparent minor allele frequency with the identity of the minor alleles corresponding to the M10C1 sequence In other words, the mixing was performed to make fixed differences between the two ... of 94°C for 45 s, 60°C for 30 s, and 72°C for 3.5 minutes for 30 cycles For site 8,992, the thermal profile was 94° C for 45 s, 55°C for 30 s, and 72°C for minutes also for 30 cycles For both ... differences between these individuals, this procedure was expected to yield a 2% apparent minor allele frequency with the identity of the minor allele corresponding to the M10C1’s sequence For the mixing...
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báo cáo khoa học: " Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer" pdf
Ngày tải lên :
10/08/2014, 10:20
... of their respective histoscores On the other hand, Immunohistochemical reactions for CD34 antigen were observed independently by two investigators using microscope The two most vascularized areas ... Fullerton, CA, USA) for 30 min, correcting the instrument using fluorescent microspheres (laser wavelength, 488 nm) and calibrating using the blank control, 1000 cells were counted and the percentage ... staining The percentages of positive tumor cells of different intensities (percentage of the surface area covered) were calculated as the number of cells with each intensity score divided by the total...
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Báo cáo y học: " Prompt improvement of a pressure ulcer by the administration of high viscosity semi-solid nutrition via a nasogastric tube in a man with tuberculosis: a case report" pdf
Ngày tải lên :
11/08/2014, 14:21
... grant-in-aid from the Osaka Tuberculosis Foundation The authors are grateful to Ms Reiko Hayashi for her linguistic help Authors’ contributions TN, KH, YO and YM performed the assessment of the nutrition ... the pressure ulcer that had existed for a long time disappeared in months As for amelioration of the pressure ulcer, the favorable effects of debridement and the antibacterial effect of anti-tuberculosis ... participated in the assessment of the patient’s clinical data MS supervised the treatment of tuberculosis and revised the manuscript for important intellectual content All authors read and approved the final...
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Báo cáo y học: " CD39+ Regulatory T cells suppress generation and differentiation of Th17 cells in human malignant pleural effusion via a LAP-dependent mechanism" pps
Ngày tải lên :
12/08/2014, 13:22
... numbers of CD39+Tregs were added into the cultures To demonstrate that LAP was responsible for the inhibitive effects of CD39+Tregs, blocking experiments were performed by mixing the MPE with 500 ... CD39+Tregs from MPE or blood As shown in Figure 6C, addition of the anti-LAP mAb to the cultures markedly reverted the inhibitory effect exerted by CD39 + Tregs Therefore, the above results indicate ... experiments The purified naïve CD4+ T cells were stimulated with plate-bound anti-CD3 and soluble anti-CD28 mAbs in the presence of the indicated cytokines, either alone or in various combinations for...
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a study on the prosodic features in responses via english and the equivalent expressions in vietnamese = nghiên cứu đặc điểm ngôn điệu trong sự phản hồi thông qua tiếng anh và sự thể hiện tương đương trong tiếng việ
Ngày tải lên :
02/03/2015, 14:22
... a word or syllable with more than the surrounding words or syllables A stress word or syllable is produced by using more air from the lung'' 20 Rhythm, on the other hand, is ''creating by the ... principle of morality are the two requirements in tradition Therefore, the position of the teachers is always put on the first place The content of the proverb is also the opinion about behavior in relationship ... fall are always low 23 Therefore, with these few marks we can show all the features of the glide-down They are mostly used in definite statement or an assurance 1.4.2.2 The first rising tune The...
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A study on the prosodic features in responses via English and the equivalent expressions in Vietnamese
Ngày tải lên :
10/08/2015, 19:48
... One more reason for choosing responses as the topic of the study is that response is a factor in communication that helps speakers or hearers go on the conversation, depending on the way they ... part, the rationale which explains the reasons for choosing this topic, the aims of the study which illustrates typical goals, the scope of the study which narrows down the research scale and the ... speakers in reaching their aims in communication For example, speakers may raise their tone at the end of the utterance in asking instead of using question words as in: ''While the teacher is teaching,...
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Oxidative stress regulates DTNBPI dysbindin 1 expression and degradation via a pest sequence in it s c terminus
Ngày tải lên :
01/10/2015, 17:27
... declare that the thesis is my original work and it has been written by me in its entirety I have duly acknowledged all the sources of information which have been used in the thesis This thesis ... which are more debilitating than the positive features of the disorder (Milev et al., 2005; Kurtz, 2006; Tabares-Seisdedos et al., 2008) None of the attempts to develop effective treatments for these ... environmental factors may add to the risk for the onset of schizophrenia (Tsuang, 2000; Sullivan, 2005; van Os et al., 2008) Studies have highlighted that the former could have a larger impact than the latter...
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Báo cáo khoa học: "What do we know about medication errors made via a CPOE system versus those made via handwritten orders"
Ngày tải lên :
25/10/2012, 10:39
... virtues is their ability to reduce errors that seldom reach patients (which neither negates their many valuable contributions nor precludes their extraordinary promise) Delineating the purview ... us to address the multifaceted reality of error cause, error type, error certainty, error severity and, indeed, the ability to determine that an error occurred Moreover, because error reduction ... of CPOE systems are actually studies of CPOE and DSS, the waters get even more muddied Shulman et al posit a direct link between the most serious medication errors and the use of their CPOE system...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
Ngày tải lên :
25/10/2012, 11:04
... critical for morphological or forensic investigations and for neurosurgeons performing pterional or supraorbital craniotomy because of the proximity of the sinus to the orbit and the anterior skull ... 28,29] and if there is persistence of a metopic suture, the frontal sinuses are small or absent [8-10] The form of the face and forehead in the presence of a metopic suture conforms to the evolutionary ... was the opposite of the case in women In addition, the authors also reported that a greater frequency of unilateral agenesis of the sinus occurs among females In contrast with the study performed...
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Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
Ngày tải lên :
03/11/2012, 10:52
... horn areas from six L3-L5 tissue sections of the spinal cord of each mouse All SMI-32 immunoreactive neurons were counted from within the ventral horn below a lateral line across the spinal cord ... Zenon Alexa Fluor 594 (mouse IgG labeling kit; Molecular Probes Inc.) at 25°C for h Furthermore, the sections were treated with the monoclonal antibody against Vgf (rat monoclonal, 1 :100 dilution; ... epitope) immunoreactive spinal cord motorneurons, 10 serial coronal sections (12 μm thick) were cut 350 μm apart through the lumbar (L3 to L5) spinal cord of each animal The sections were mounted...
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Reading Comprehension Success in 20 mins a day
Ngày tải lên :
18/03/2013, 01:45
... down, what the main topics are, and the order in which they are covered Notice key words and ideas that are boldfaced, bulleted, boxed, or otherwise highlighted Skimming through the text beforehand ... did the narrator enjoy it when his father drank too many “horns,” or drafts of liquor? a The father spoke brilliantly at those times b The boy was then allowed to as he pleased c These were the ... about the owner c more praise for agreeing to watch the animals d greater detail on the animals’ cute behavior 26 The author uses the word children to describe his or her pets because a the author...
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