tools for vaccine design prediction and validation of highly immunogenic and conserved class ii epitopes and developmentof epitope driven vaccines
Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
Ngày tải lên :
10/09/2015, 09:02
... 83 6.3.1 Base and ensemble model performances for SJS/TEN study 83 6.3.2 Base and ensemble model performances for TdP study 84 iii 6.3.3 Base and ensemble model performances for serious psychiatric ... reliable ADMET predictions vii List of Tables Table 1.1 Recent QSAR studies of ADR and Toxicity Prediction Table 3.1 Performances of best base models from external 5-fold cross validation for SJS/TEN ... 6.3 Performances of best base models and best ensemble models for serious psychiatric ADR study 86 Table 7.1 Performance profile of SVM models on testing and validation set for AM...
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Antigenic diversity of dengue virus implications for vaccine design
Ngày tải lên :
11/09/2015, 14:20
... http://www.imtech.res.in/raghava/hladr4pred/ http:/ /tools. immuneepitope.org /tools/ matrix/iedb_input?matrixClass =II - HLA Class I, single allele HLA Class I, promiscuous epitopes HLA Class I, promiscuous epitopes, prediction of mutated ... 31 and the number of epitopes associated with each HLA allele Table 2.6 An overview of bioinformatics prediction servers for mapping 37 putative T-cell epitopes Table 3.1 Number of collected and ... the scope of this thesis, include the assessment of immunological relevance of the identified and validated conserved T-cell epitopes and assessment of their suitability for vaccine formulation...
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Development and application of bioinformatics tools for discovery disease markers and disease targeting antibodies
Ngày tải lên :
12/09/2015, 08:20
... five-fold cross validation 164 Performance evaluation of SVM prediction system of antibody-antigen pairs 165 VIII List of figures LIST OF FIGURES Figure 1-1 Figure 1-2 Procedure of microarray ... Microarray database containing tens of millions of expression profiles Information and microarray expression data for genes involved in mitosis and meiosis, gamete formation and germ line development across ... sets of genes (one or two genes) that formed accurate classifier (140-142) For example, Slonim et al reported that the classifier consisting of one gene (HOXA9) outperformed all of other classifiers...
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Development of multivariate curve resolution and associated system identification tools for IR emission, chiroptical, and far infrared and far raman spectroscopies
Ngày tải lên :
12/09/2015, 08:20
... simply impossible without all of them ii TABLE OF CONTENTS Page ACKNOWLEDGEMENTS i TABLE OF CONTENTS iii SUMMARY xi NOMENCLATURE xiv LIST OF FIGURES xviii LIST OF TABLES xxv Introduction 1.1 ... emission spectra of (1) the empty cell; (2) chloroform; (3) ~ (5) DMAD in chloroform; (6) ~ (8) CP, DMAD and reaction in the solution 76 Figure 3.27 10 right singular vectors of VT Matrix for consolidated ... component spectra (●) and experiment design (○) Profiles for (a) Rh4(CO)12 and (b) Rh4(CO)11 PPh3 101 Figure 4.6 UV-Vis reaction spectra of the ligand substitution reaction of Rh4(CO)12 with (S)-BINAP...
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Báo cáo khoa học: Emerging tools for real-time label-free detection of interactions on functional protein microarrays ppt
Ngày tải lên :
23/03/2014, 15:21
... magnitude of the change in the local index of refraction caused by binding is a function of the mass and conformation of both the query molecule and the immobilized protein, the number of query ... conventional SPR in the areas of sensitivity, smaller quantity of protein needed for analysis, and the potential for very large arrays The potential for small sample volume and large arrays can be ... collections of genes in expression-ready format A novel approach involving in situ expression of protein from immobilized cDNAs avoids the need for purification and allows for rapid production of proteins...
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báo cáo hóa học:" Research Article HIFSuite: Tools for HDL Code Conversion and Manipulation" ppt
Ngày tải lên :
21/06/2014, 11:20
... manipulation tools We define a semantics for HIF that aims at supporting the representation of RTL designs for the main important and used HDLs (i.e., VHDL, Verilog, and SystemC) and the representation of ... number of code lines of the RTL and TLM sides of the transactors Finally, column Transactor shows the total number of code lines of the transactor implementations For each design, few minutes of ... Fummi, and G Pravadelli, “A methodology for abstracting RTL designs into TL descriptions,” in Proceedings of the 4th ACM and IEEE International Conference on Formal Methods and Models for Co-Design...
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Computational Methods for Protein Structure Prediction and Modeling Volume 1: Basic Characterization pot
Ngày tải lên :
27/06/2014, 10:20
... methods for prediction of secondary structure and topology of membrane proteins, as well as prediction of their tertiary structure A list of useful resources for membrane protein structure prediction ... backbone and protein cores Yet, the conformation of side chains and loops may carry very important information for understanding the function of proteins There are mainly two classes of computational ... efficiency of folding simulation and ab initio methods for protein structure prediction 1.2.3.2 Reduced Models of Proteins and Their Applications Reduced models of proteins are necessary for easy and...
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Tools for Project Management, Workshops and Consulting pdf
Ngày tải lên :
29/06/2014, 08:20
... Elisabeth and Erwin Andler, for their love, trust, support and never-ending faith in me Tools for Project Management, Workshops and Consulting A must-have compendium of essential tools and techniques ... as the ‘Andler best-pratice list of tools , a TOP 10 list of the most preferred tools and an overview of project management planning and scoping tools have been added There are 23 new tools in ... evaluate and receive feedback 45 Problem solving approach and application Example of a ‘shopping list’ of tools for a workshop Problem solving process steps: Categories of tools: Tools and techniques:...
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the xp files windows hidden tools for secure sharing communication and collaboration
Ngày tải lên :
06/07/2014, 15:33
... Tara Davis for laying out the pages Linda Medoff for proofreading the book Jack Lewis for creating the index Introduction XP offers a great set of tools for communicating, collaborating, and sharing ... covered in the book and the communications tools most suited to them XP: Built to Take Advantage of the Internet -and of You Microsoft designed and built Windows XP to take advantage of the Internet ... fully understand the range of communications tools that XP offers, know the advantages and disadvantages of each communications tool, and use them to the max to communicate effectively and securely...
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Learn Xcode Tools for Mac OS X and iPhone Development potx
Ngày tải lên :
01/08/2014, 13:20
... Developer Tools into the core tools, companion tools and features, and supporting utilities This broadly reflects the importance of the tools in terms of the amount of use you are likely to get out of ... and Linux as platforms, REALbasic cannot be used (at least, at the time of writing) to build iPhone software All in all, REALbasic offers a lot of fun and productivity to the developer, and for ... Monitoring, Analysis, and Performance Tools .225 Part III: Supporting Tools .245 ■Chapter 13: Support Tools for the Busy Developer .247 ■Chapter 14: Usability and Accessibility...
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A reference guide for training design development and dilivery
Ngày tải lên :
25/10/2016, 18:30
... the job performance of your trainees and the productivity of your organization xv Acknowledgments Some of the information in Part of this book is adapted from Fundamentals of Training: Design, Development, ... Brethower, D M 2000 “The relevance of performance improvement to instructional design. ” In The ASTD Handbook of Training Design and Delivery: A Comprehensive Guide to Creating and Delivering Training Programs—Instructor-Led, ... communication, understand the meaning of metaphors and symbolism, or translate words to symbols and vice versa For instance, an employee at a warehouse handling export of m erchandise should be...
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principles of chemical reactor analysis and design new tools for industrial chemical reactor operations
Ngày tải lên :
01/04/2014, 10:36
... reliability of predicting the flow patters, (ii) ease of incorporating of the chemical kinetics and adequacy of the physical and chemical representations, (iii) scale of resolution for the application and ... of mass, and its units are mole extent For example, for Reaction 2.2.1, one extent means that one mole of CO reacts with half a mole of O2 to form one mole of CO2 and it represents 44 units of ... formation of undesirable products (by side reactions), and (iii) the amount of heat that should be transferred For example, if a low concentration of the reactants suppresses the formation of the...
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Validation of brief screening tools for depressive and alcohol use disorders among TB and HIV patients in pdf
Ngày tải lên :
11/08/2014, 15:22
... 76% for current MDD Similarly, at a cut -of score of 24 for women and 20 for men, the AUDIT yielded a sensitivity of 60% and PPV of 60% for women, and a sensitivity of 55% and PPV of 50% men for ... cut-off score of the CES-D in screening for current MDD was 22 This achieved a sensitivity of 73% and PPV of 76% (Figure 3A) For the AUDIT, the optimum cut-off score for screening AUDs was 24 for ... CES-D and AUDIT met the criterion of having cut-off scores that simultaneously have moderate to high sensitivities and PPVs At a cut-off of 22, the CES-D yielded a sensitivity of 73% and PPV of...
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Báo cáo y học: " Design, assembly, and validation of a nose-only inhalation exposure system for studies of aerosolized viable influenza H5N1 virus in ferrets" ppt
Ngày tải lên :
12/08/2014, 04:20
... delivery system, are needed for such a study Methods Class III glovebox A class III IsoGARD® Glovebox (The Baker Company, Sanford, ME) was used to house the NBIES The class III glovebox has a High ... equipment, animal holders, samplers, a class III glovebox, and the pumps, flow meters, and other equipment required for the control, balancing, and measurement of airflows and aerosols It is housed within ... the flow rates used for the NBIES for exposures) deliver a dry and uniform particle size to each of the NBIES' five ports Therefore, inhalation (and presumably lung deposition) of the generated...
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Báo cáo y học: "Optimal design and validation of antiviral siRNA for targeting HIV-1" potx
Ngày tải lên :
13/08/2014, 05:22
... grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to YN, KU-T, KS, and YT), the Ministry of Health, Labour and Welfare of Japan (to YT), and the Japan Health ... expected to overwhelm the high level of sequence diversity of the HIV-1 genome, and also to reduce the chances of viral mutational escapes Total of 216 highly conserved (>70%) siRNA targets identified ... contributions YN performed the computational analyses and the target mRNA cleavage assays, participated in the design of the study, and drafted the manuscript KN and TO performed the viral replication...
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Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
Ngày tải lên :
25/10/2012, 10:45
... authors made substantial contributions to conception and design, and to the analysis and interpretation of the data TRM and GWC handled acquisition of data All authors contributed to the manuscript ... effective Because of similarities in both the descriptive characteristics of the study populations of biologic and non-biologic DMARD users and the performance characteristics of the effectiveness ... used for the analysis were from the administrative claims data To test the performance of the effectiveness algorithm and to see whether it was similar for non-biologic RA treatments, we performed...
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Design, fabrication, and characterization of a solenoidsystem to generate magnetic field for an ECR proton source
Ngày tải lên :
22/12/2013, 08:58
... coils 20 mm, width to be 70 mm and 80 mm for middle and side solenoid coils respectively Three solenoid coils were used to get; (i) mirror field, (ii) flat field, and (iii) off-resonance field configuration ... is capable of producing off-resonance, mirror, and flat magnetic field configurations A mirror ratio of 1·1 and a maximum flat field of 1400 G has been obtained The measured values and the design values ... varying the size of the solenoid coils, thickness of iron jacket, and amp-turns (NI) The optimum values of NI for the side and middle solenoid coils were obtained to be 12950 and 8250 respectively...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
Ngày tải lên :
19/02/2014, 12:20
... by MII argues against a role for a3 in the formation of native MII binding sites, but may reflect the Vc1.1 scarcity of these sites in the investigated brain tissues and/ or the formation of low ... still be present in the snails and could supply novel ligands for mammalian nAChRs (for evolution, diversity and biosynthesis of a-conotoxins see [30,31]) ImI and ImII The first a-conotoxin showing ... syndrome and certain forms of epilepsy and schizophrenia [24,25] However, the therapeutic use of nicotine is hindered by its adverse effects on the cardiovascular and Ó FEBS 2004 Pharmacology of neuronally...
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Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt
Ngày tải lên :
19/02/2014, 13:20
... conformation of backbone had an interproton error of less ˚ than 0.2 A compared to upper and lower boundaries of distances from ROE/NOE data and (b) the conformation had / angles within 30° of ... CD2 and CD58 interaction results in the formation of E-rosettes The ability of each of the designed CD2 peptides to inhibit CD2–CD58 interaction was evaluated by inhibition of E-rosette formation ... possibility of a type II b-turn at Glu2-Arg3-Gly4-Ser5 residues and a type III b-turn at Leu7-Val8-Ala9-Glu10, respectively [31] Therefore, the structure of peptide cER consists of two b-turns,...
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