toll like receptors and their regulatory mechanisms
Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
Ngày tải lên :
12/08/2014, 18:21
... member of an expanding toll- like receptor family Gene 1999, 231:59-65 Du X, Poltorak A, Wei Y, Beutler B: Three novel mammalian toll- like receptors: gene structure, expression, and evolution Eur ... morphogenesis and has many similarities to Toll The extracellular regions of Toll and 18W contain multiple leucine-rich repeats and carboxyl-terminal cysteine-rich domains [12] Drosophila Toll signaling ... TIR, Toll/ IL-1 receptor (IL-1R1) This expanding IL-1R1 -like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant (tobacco) protein [7,8] In Drosophila, Toll...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
Ngày tải lên :
09/08/2014, 10:21
... involves Toll- like receptors and J Exp Med 2005, 202:1575-1585 Kariko K, Buckstein M, Ni H, Weissman D: Suppression of RNA recognition by Toll- like receptors: the impact of nucleoside modification and ... TLR9 This and other unidentified mechanisms might be responsible for rendering mammalian DNA and RNA from apoptotic and necrotic cells stimulatory to nucleic acid sensing TLRs Toll- like receptors ... [10,11] DNA and Toll- like receptor activation Several mechanisms serve to promote the specificity of responses to nucleic acids, so that innate immune cells sense and respond to viral and bacterial...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
Ngày tải lên :
09/08/2014, 14:21
... Berg WB, Radstake TR: The expression of toll- like receptors and in rheumatoid arthritis synovium is increased and costimulation of toll- like receptors 3, 4, and 7/8 results in synergistic cytokine ... Kyburz D: Overexpression of toll- like receptors and in synovial tissue from patients with early rheumatoid arthritis: toll- like receptor expression in early and longstanding arthritis Arthritis ... Osteoarthritis and Toll- like receptors Synovial inflammation is increasingly recognised as an important pathophysiological process in OA, and endogenous ligands released as a consequence of synovial and...
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Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
Ngày tải lên :
09/08/2014, 14:22
... receptors TLR7 and TLR9 in IFNAR2-/- mice Activationof Toll- like receptors TLR7 and TLR9 in IFNAR2-/- mice (a) B cells were purified from pristane-treated wild-type (WT) or IFNAR2-/- mice, and proliferation ... Expression of Toll- like receptors TLR7 and TLR9 in IFNAR2-/- B cells cells (a) B cells were purified from wild-type (WT) or IFNAR2-/- mice using magnetic beads RNA was extracted and the relative ... dependent on the TAM receptors [29] and both SOCS1-/- and TAM receptor triple-knockout mice develop spontaneous lupus -like autoimmunity [49,50] The expressions of the TAM receptors themselves...
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Báo cáo y học: "Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages" docx
Ngày tải lên :
08/08/2014, 16:23
... expression of Toll- like receptor in human cells J Leukoc Biol 2001; 69(3): 474-81 17 Zarember KA, Godowski PJ Tissue expression of human Toll- like receptors and differential regulation of Toll- like receptor ... activate Toll- like receptors at distinct cellular compartments Eur J Immunol 2002; 32(7): 1958-68 22 Muzio M, Bosisio D, Polentarutti N, et al Differential expression and regulation of toll- like receptors ... between toll- like receptors Proc Natl Acad Sci U S A 2000; 97(25): 13766-71 11 Underhill DM, Ozinsky A, Hajjar AM, et al The Toll- like receptor is recruited to macrophage phagosomes and discriminates...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
Ngày tải lên :
11/08/2014, 03:20
... Non-Microbial Acute inflammation Innate Immunity Adaptive Immunity Toll- like receptors (TLRs) NOD -like receptors (NLRs) RIG -like receptors (RLRs) CD4 and CD8 T cells Antigen-specific B cells DEFICIENT innate ... mediated by Toll- like receptor Nature 2001, 410(6832):1099-1103 Alexopoulou L, Holt AC, Medzhitov R, Flavell RA: Recognition of doublestranded RNA and activation of NF-kappaB by Toll- like receptor ... Oligosaccharides of Hyaluronan activate dendritic cells via toll- like receptor J Exp Med 2002, 195(1):99-111 Tsan MF, Gao B: Endogenous ligands of Toll- like receptors J Leukoc Biol 2004, 76(3):514-519 Urbonaviciute...
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Báo cáo y học: "Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response" ppt
Ngày tải lên :
11/08/2014, 08:21
... 165:5392-6 Wetzler LM: The role of Toll- like receptor in microbial disease and immunity Vaccine 2003, 21(Suppl 2):S55-S60 Dabbagh K, Lewis DB: Toll- like receptors and T-helper-1/Thelper-2 responses ... Receptor small expression in unstimulated and stimulated Toll- like5 primary (TLR) airway epithelial cells (SAEC) Toll- like Receptor (TLR) expression in unstimulated and stimulated primary small airway ... IL-4 IL-4 IL-13 Figure mRNA expression of Toll- like Receptors (TLR) in stimulated primary small-airway-epithelial cells (SAEC) mRNA expression of Toll- like Receptors (TLR) in stimulated primary small-airway-epithelial...
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Báo cáo y học: " Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes" pdf
Ngày tải lên :
12/08/2014, 14:20
... receptor and toll- like receptors (TLRs) [6-8] Although TLRs are not implicated in the uptake of microorganisms, binding of their ligands activates monocytes, macrophages and dendritic cells, and triggers ... PJ: Tissue expression of human Toll- like receptors and differential regulation of Toll- like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines J Immunol 2002, ... Takeda K, Kaisho T, Akira S: Toll- like receptors Annu Rev Immunol 2003, 21:335-376 Akira S, Takeda K, Kaisho T: Toll- like receptors: critical proteins linking innate and acquired immunity Nat Immunol...
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Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx
Ngày tải lên :
12/08/2014, 19:21
... Homologous to Toll pathway The Toll- like receptor (TLR) and tumor necrosis factor (TNF) pathways, represented as Toll and imd pathways in Drosophila, are arranged in tandem in the mammalian host, and are ... and induces production of proteases and prostaglandins [24] that contribute to inflammation on a local level The IL-1 receptor has Toll/ IL1/resistance (TIR) domains similar to the Toll- like receptors ... mediated by Toll- like receptor Nature 2001, 410:1099-1103 39 Alexopoulou L, Holt AC, Medzhitov R, Flavell RA: Recognition of double-stranded RNA and activation of NF-kappaB by Tolllike receptor...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
Ngày tải lên :
23/03/2014, 04:20
... recognized by other receptors For example, vertebrate steroid hormone receptors (such as GRs, mineralcorticoid receptors, progesterone receptors and androgen Arthropod nuclear receptors receptors) bind ... hormone receptors (TRs), retinoic acid receptors (RARs), vitamin D receptors (VDRs) and peroxisome proliferator-activated receptors (PPARs) in mammals The second family, NR2, contains RXRs and hepatocyte ... BtEcR and TmEcR were similar, as anticipated by their sequence similarity In the PonA-bound HvEcR-LBD complex, the LBD is composed of 12 helices and three small b-strands, and possesses a long and...
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Báo cáo khoa học: Identification of rice TUBBY-like genes and their evolution Qingpo Liu docx
Ngày tải lên :
23/03/2014, 07:20
... 5, 7, 8, 11 and 12 By contrast with only one OsTLP found on chromosomes 3, 4, 7, 8, 11 and 12, three (OsTLP5, OsTLP9 and OsTLP12), two (OsTLP8 and OsTLP13) and three (OsTLP1, OsTLP10 and OsTLP11) ... within the fifth (E5, site 103) and ninth (E9A, site 312; E9B, site 319) b-strands, and the loop between E9A and E9B (sites 315 and 317) (supplementary Fig S1) TUBBY -like genes in rice Santagata ... pairs (OsTLP6 ⁄ and OsTLP7 ⁄ 14) may be the result of recent segmental duplication of chromosomes 11 and 12 and chromosomes and 7, respectively [13,14] With regard to OsTLP8 and OsTLP13, they...
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báo cáo hóa học: " Toll-like receptors in cerebral ischemic inflammatory injury" pdf
Ngày tải lên :
19/06/2014, 22:20
... nervous system in chronic pain: the role of Toll- like receptors Cell Mol Life Sci 2007, 64:1128-1136 69 Tsan MF, Gao B: Endogenous ligands of Toll- like receptors J Leukoc Biol 2004, 76:514-519 doi:10.1186/1742-2094-8-134 ... Lehnardt S: Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll- like receptor-mediated neuronal injury Glia 2010, 58:253-263 Kielian T: Toll- like receptors in central nervous ... Stenzel-Poore MP: Toll- like receptor signaling in endogenous neuroprotection and stroke Neuroscience 2009, 158:1007-1020 Carty M, Bowie AG: Evaluating the role of Toll- like receptors in diseases...
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Báo cáo y học: "NOD-like receptors and inflammation" pot
Ngày tải lên :
09/08/2014, 13:22
... proteins share homology in their signalling domains with IL-1RI; this family includes Drosophila Toll, plant R proteins, and mammalian TLRs and NLRs CARD, caspase activation and recruitment; IL-1RI, ... leucine rich repeat and pyrin domain containing 1; NLR, NOD -like receptor; PYD, pyrin domain; TLR, Toll- like receptor the PRRs provide an effective recognition system for both PAMPs and damage-associated ... and colleagues [129] reporting similar responses to TLR ligands in wildtype and NOD2-/- cells, and indeed an increase in IL-6 in wild-type NOD2 cells on stimulation with Pam3CSK4, a TLR2 ligand...
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Báo cáo y học: " Gut flora enhance bacterial clearance in lung through toll-like receptors 4" docx
Ngày tải lên :
10/08/2014, 10:20
... Infect Immun 2009, 77:568-575 Medzhitov R: Toll- like receptors and innate immunity Nat Rev Immunol 2001, 1:135-145 Takeda K, Kaisho T, Akira S: Toll- like receptors Annu Rev Immunol 2003, 21:335-376, ... pneumonia through Toll- like receptors Shock 2011, 36:67-75 doi:10.1186/1423-0127-18-68 Cite this article as: Tsay et al.: Gut flora enhance bacterial clearance in lung through toll- like receptors Journal ... microflora by toll- like receptors is required for intestinal homeostasis Cell 2004, 118:229-241 Wang X, Moser C, Louboutin JP, Lysenko ES, Weiner DJ, Weiser JN, Wilson JM: Toll- like receptor...
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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
Ngày tải lên :
12/08/2014, 02:20
... electrons to receptors other than CO2 and the most likely candidate acceptor is PTOX [73] The alternative electron flow eases the excitation pressure on PSII by the reduction of oxygen and thus prevents ... community and the relative abundance of specific g20 genotypes In Rhode Island’s coastal waters Sandaa and Larsen [34] also observed seasonal variations in the abundance of cyanophages and in cyanomyovirus ... genomes of the T4 -like phages with only Aeh1 and KVP40 [44] of other T4 -like phage having genomes of comparable size The general properties of cyanophage genomes such as mol G+C content and % of genome...
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Báo cáo y học: "Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synoviu" doc
Ngày tải lên :
12/08/2014, 15:22
... Res Ther 2011, 13:R33 Kawai T, Akira S: The role of pattern-recognition receptors in innate immunity: update on Toll- like receptors Nat Immunol 2010, 11:373-384 Brennan FM, McInnes IB: Evidence ... in rheumatoid arthritis J Clin Invest 2008, 118:3537-3545 Brentano F, Kyburz D, Gay S: Toll- like receptors and rheumatoid arthritis Methods Mol Biol 2009, 517:329-343 Shiozawa K, Hino K, Shiozawa ... A, Giddins G, Feldmann M, Brennan F, Foxwell BM: The Toll- like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid...
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Báo cáo y học: " Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis" ppsx
Ngày tải lên :
12/08/2014, 16:20
... immunity and toll- like receptors: clinical implications of basic science research J Pediatr 2004, 144:421-429 Sabroe I, Parker LC, Wilson AG, Whyte MK, Dower SK: Toll- like receptors: their role ... PJ: Tissue expression of human Tolllike receptors and differential regulation of Toll- like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines J Immunol 2002, 168:554-561 ... innate and adaptive immunity Nat Immunol 2004, 5:971-974 Medzhitov R: Toll- like receptors and innate immunity Nat Rev Immunol 2001, 1:135-145 Gelman AE, Zhang J, Choi Y, Turka LA: Toll- like receptor...
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Báo cáo y học: "Toll-like receptors: the key to the stable door" pptx
Ngày tải lên :
12/08/2014, 18:21
... cell lines expressing Toll- like receptors J Immunol 2000, 164:966-972 Liu S, Salyapongse AN, Geller DA, Vodovotz Y, Billiar TR: Hepatocyte toll- like receptor expression in vivo and in vitro: role ... innate immune system is defined by cooperation between Toll- like receptors Proc Natl Acad Sci USA 2000, 97:13766-13771 Vasselon T, Detmers PA: Toll receptors: a central element in innate immune responses ... Competing interests None declared References Opal S, Huber CE: Bench-to-bedside review: Toll- like receptors and their role in septic shock Crit Care 2002, 6:125136 Angus DC, Linde-Zwirbe A, Lidicker...
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Báo cáo y học: "Hypoglycemic herbs and their action mechanisms" docx
Ngày tải lên :
13/08/2014, 15:21
... levels and serum content of TC, TG, LDL-c, increased HDL-c and NO level, and blocked the increase of SOD and GSH-px levels [52,53] Multiple mechanisms may be responsible for weight reduction and ... Src-homology-collagen -like protein (SHC) and multifunctional docking proteins IRS-1 and IRS-2 The interaction of insulin and IR activates its tyrosine activity and phosphorylates the coupled SHC and subsequently activates, ... β-cell, adipocytes and muscles Ethyl acetate (EA) extract of bitter melon activates peroxisome proliferator receptors (PPARs) α and γ [46,47], modulates the phosphorylation of IR and its downstream...
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Investigation of interleukin 1b synthesis and secretion by dendritic cells interplay between toll like receptor and FCG receptor
Ngày tải lên :
08/11/2015, 17:01
... Comparison between innate immunity and adaptive immunity 1.2 Comparison of different DC subsets 1.3 Toll- like receptors and their ligands 21 1.4 Phagocytic receptors for microbes 29 1.5 General ... individual TLRs are summarized in Table 1.3 20 Table 1.3 Toll- like receptors and their ligands TLR family TLR1 TLR2 TLR3 TLR4 TLR4 TLR5 TLR6 TLR7 Ligands (origin) Tri-acyl lipopeptides (bacteria, mycobacteria) ... (MR), scavenger receptor (SR) and complement receptor (CR); and (ii) those that sense pathogens and lead to the activation of pro-inflammatory pathways, e.g Toll- like receptors (TLRs) The principle...
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